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"TOLERANCE"
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From tolerance allocation to tolerance-cost optimization: a comprehensive literature review
It is widely acknowledged that the allocation of part tolerances is a highly responsible task due to the complex repercussions on both product quality and cost. As a consequence, since its beginnings in the 1960s, least-cost tolerance allocation using optimization techniques, i.e. tolerance-cost optimization, was continuously in focus of numerous research activities. Nowadays, increasing cost and quality pressure, availability of real manufacturing data driven by Industry 4.0 technologies, and rising computational power result in a continuously growing interest in tolerance-cost optimization in both research and industry. However, inconsistent terminology and the lack of a classification of the various relevant aspects is an obstacle for the application of tolerance-cost optimization approaches. There is no literature comprehensively and clearly summarizing the current state of the art and illustrating the relevant key aspects. Motivated to overcome this drawback, this article provides a comprehensive as well as detailed overview of the broad research field in tolerance-cost optimization for both beginners and experts. To facilitate the first steps for readers who are less familiar with the topic, the paper initially outlines the fundamentals of tolerance-cost optimization including its basic idea, elementary terminology and mathematical formulation. These fundamentals serve as a basis for a subsequent detailed discussion of the key elements with focus on the different characteristics concerning the optimization problem, tolerance-cost model, technical system model and the tolerance analysis model. These aspects are gathered and summarized in a structured mind map, which equips the reader with a comprehensive graphical overview of all the various facets and aspects of tolerance-cost optimization. Beside this, the paper gives a retrospect of the past fifty years of research in tolerance cost-optimization, considering 290 relevant publications. Based thereon, current issues and future research needs in tolerance-cost optimization were identified.
Journal Article
Phytomelatonin: a universal abiotic stress regulator
This review summarizes phytomelatonin-modulated stress responses and plant development pathways, and highlights interactions between melatonin and other phytohormones.
Abstract
Melatonin, a derivative of tryptophan, was first detected in plant species in 1995 and it has been shown to be a diverse regulator during plant growth and development, and in stress responses. Recently, great progress has been made towards determining the detailed functions of melatonin in plant responses to abiotic stress. Melatonin priming improves plant tolerance to cold, heat, salt, and drought stresses through regulation of genes involved in the DREB/CBF, HSF, SOS, and ABA pathways, respectively. As a scavenger of free radicals, melatonin also directly detoxifies reactive oxygen species, thus alleviating membrane oxidation. Abiotic stress-inhibited photosynthesis is partially recovered and metabolites accumulate in the presence of melatonin, leading to improved plant growth, delayed leaf senescence, and increased stress tolerance. In this review, we summarize the interactions of melatonin with phytohormones to regulate downstream gene expression, protein stabilization, and epigenetic modification in plants. Finally, we consider the need for, and approaches to, the identification of melatonin receptors and components during signaling transduction pathways.
Journal Article
Combined transcriptomic and metabolomic analyses of high temperature stress response of quinoa seedlings
Background
Quinoa (
Chenopodium quinoa
Willd.) originates in high altitude areas, such as the Andes, and has some inherent characteristics of cold, drought, and salinity tolerance, but is sensitive to high temperature.
Results
To gain insight into the response mechanism of quinoa to high temperature stress, we conducted an extensive targeted metabolomic study of two cultivars, Dianli-3101 and Dianli-3051, along with a combined transcriptome analysis. A total of 794 metabolites and 54,200 genes were detected, in which the genes related to photosynthesis were found down-regulated at high temperatures, and two metabolites, lipids and flavonoids, showed the largest changes in differential accumulation. Further analysis of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and transcription factors revealed that quinoa inhibits photosynthesis at high temperatures, and the possible strategies being used for high temperature stress management are regulation of heat stress transcription factors (
HSFs
) to obtain heat tolerance, and regulation of purine metabolism to enhance stress signals for rapid response to high temperature stress. The tolerant genotype could have an enhanced response through lower purine levels. The induction of the stress response could be mediated by
HSF
transcription factors. The results of this study may provide theoretical references for understanding the response mechanism of quinoa to high temperature stress, and for screening potential high temperature tolerant target genes and high temperature tolerant strains.
Conclusions
These findings reveal the regulation of the transcription factor family
HSF
and the purinergic pathway in response to high temperature stress to improve quinoa varieties with high temperature tolerance.
Journal Article
Locke on toleration
\"John Locke's Letter Concerning Toleration (1689) is one of the most widely-read texts in the political theory of toleration, and a key text for the liberal tradition. However, Locke also defended toleration more extensively in three subsequent Letters, which he wrote in response to criticism by an Anglican cleric, Jonas Proast. This edition, which includes a new translation of the original Letter, by Michael Silverthorne, enables readers to assess John Locke's theory of toleration by studying both his classic work and essential extracts from the later Letters. An introduction by Richard Vernon sets Locke's theory in its historical context and examines the key questions for contemporary political theorists which arise from this major work in the history of political thought\"-- Provided by publisher.
Book
Trained immunity, tolerance, priming and differentiation: distinct immunological processes
The similarities and differences between trained immunity and other immune processes are the subject of intense interrogation. Therefore, a consensus on the definition of trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects, is necessary for advancing this field of research. Here we aim to establish a common framework that describes the experimental standards for defining trained immunity.
Journal Article