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Structural damage identification is a critical technique for ensuring the safety and reliability of large-scale civil structures. However, existing purely data-driven approaches based on deep learning still suffer from limited physical interpretability and generalization capability. To address this limitation, a physics-informed graph neural network framework, namely the Temporal Power Flow Graph Network (TPF-GNet), is proposed. The principal innovation of TPF-GNet is the Temporal Power Flow Propagation (TPFP) module, which explicitly characterizes energy transmission in structural dynamics and embeds dynamic power flow into the message-passing process of graph neural networks. TPF-GNet utilizes multi-sensor acceleration responses around a target node as input, reconstructs the target sensor’s acceleration time history by simulating the energy flow process, and enables unsupervised damage detection and localization through reconstruction errors. Numerical simulations and scaled benchmark frame tests demonstrate that TPF-GNet surpasses conventional GNN and LSTM baseline models in both accuracy and physical interpretability. The results demonstrate that incorporating dynamic power flow markedly improves the model’s ability to capture structural state changes induced by stiffness degradation or local damage. This study establishes a physics-constrained paradigm for structural health monitoring, particularly well-suited to engineering applications without damage labels.

Background This study aimed to explore the efficacy and safety of sintilimab combined with induction chemotherapy (IC) in locally advanced head and neck squamous cell carcinoma (HNSCC) patients. Methods A total of 163 patients were prospectively enrolled; 98 patients received IC only, and 65 patients received IC with sintilimab. Following neoadjuvant therapy, patients either underwent surgery (31.9%) or chemoradiotherapy (68.1%). Objective response rate (ORR), progression free survival (PFS), overall survival (OS), and toxicities between the two groups were compared. Results The ORR in the IC group was significantly lower than that in the IC with sintilimab group (68.4% vs 84.6%, P  = 0.019). Grade 3 or higher acute toxicity occurred in 15 (15.3%) and 12 (18.5%) patients in the IC and IC with sintilimab groups, respectively. However, this difference was not significant ( P  = 0.596). After follow-up with a median time of 28.0 months, the IC group had a 2-year PFS rate of 27% (95%CI: 18–36%), whereas the IC with sintilimab group had a 2-year PFS rate of 44% (95%CI: 32–56%), and this difference was significant ( P  = 0.041). The 2-year OS rates in the IC and IC with sintilimab groups were 61% (95%CI: 52–70%) and 70% (95%CI: 60–80%), respectively, the difference was not significant ( P  = 0.681). Conclusions Addition of sintilimab to IC could provide longer PFS time than traditional chemotherapy regimen, without increasing the toxicity events.

To improve the convective heat transfer in internal cooling channels of heavy-duty gas turbine blades, this study experimentally and numerically investigates the thermal performance of rectangular channels with hybrid pin-fins and micro V-ribs turbulators. The transient thermochromic liquid crystal (TLC) technique and ANSYS 2019 R3 (ICEM CFD 2019 R3, Fluent 2019 R3, CFD-Post 2019 R3) were employed under Reynolds numbers ranging from 10,000 to 50,000, with the numerical model rigorously validated against experimental data (the maximum RMSE is 2.5%). It is found that hybrid pin-fins and continuous V-ribs configuration exhibits the maximum heat transfer enhancement of 27.6%, with an average friction factor increase of 13.3% and 21.9% improvement in thermal performance factor (TPF) compared to the baseline pin-fin channel. In addition, compared to the baseline pin-fin channel, hybrid pin-fins and broken V-ribs configuration exhibits average heat transfer enhancement (Nu/Nu0) of 24.4%, an average friction factor increase of 7.2% and 22.5% improvement across the investigated Reynolds number range (10,000~50,000) based on computational results. The synergistic effects of hybrid pin-fin and micro V-rib structures demonstrate superior coolant flow control, offering a promising solution for next-generation turbine blade cooling designs. This work provides actionable insights for high-efficiency gas turbine thermal management.

Background and AimsESPB has shown variable efficiency. We evaluated the efficacy of ESPB in elective lumbar spinal fusion surgery patients with different surgical approachesMethodsRetrospectively 45 elective lumbar TPF patients with TLIF or TLIF+ALIF approaches were divided into 2 groups: general anesthesia (GA,n=24), general anesthesia with ESPB (GA+ESPB,n=21). Primary we analyzed efficacy of ESPB in terms of pain intensity in the first 48h. Secondary – fentanyl free patients and opioid consumption in the first 24h postoperatively. Comparative analysis (SPSS®v.28.0).P<0.05.ResultsOut of 45 patients (27 female),21 received GA+ESPB and 24 GA. Average age was 60.3±14.3 years. ESPB was performed in 17 TLIF and in 4 TLIF+ALIF patients. ESPB significantly reduced pain intensity at rest in both approaches 48h after surgery; p<0.05. GA+ESPB when compare with GA increased the number of fentanyl free patients immediately after surgery in TLIF (77%vs.29%;p=0.01) and TLIF+ALIF (82%vs.0%;p=0.004) approaches. For those with ESPB fentanyl infusion was started in 6.8±3.2h (23.5% of TLIF) and 8.9±7.6h (75% of TLIF+ALIF) after surgery. ESPB shortened fentanyl infusion time when compare with GA with mean difference(MD) 3.2±4.2h in TLIF;p=0.045, 6.7±5.3h in TLIF+ALIF;p=0.028. Only in TLIF+ALIF approach, ESPB reduced total fentanyl consumption compared with GA 1.43±0.45mg/24h vs.0.93±0.68mg/24h;p=0.015.ConclusionsESPB reduces pain at rest after lumbar fusion surgery and the number of patients requiring immediate postoperative fentanyl in both approaches, reducing the total fentanyl consumption and duration of infusion. However, application of ESPB not always provide enough analgesia to completely avoid fentanyl administration after surgery in the first 48h.

A numerical assessment of the heat transfer efficacy of a solar air heater (SAH) was carried out. The SAH is supplied with a porous metal foam layer to improve thermal mixing. Both the local thermal non-equilibrium (LTNE) and Darcy-extended Forchheimer (DEF) models were employed to forecast fluid and thermal transport within the partly filled SAH channel. The analysis was performed for various values of dimensionless foam layer lengths ( S = 0 - 1 ), pore densities ( ω = 10 - 40 PPI ), and Reynolds numbers ( R e = 4000 - 1 6 , 000 ) at a fixed value of layer thickness ( H f = 0.6 ). Based on the position of the porous layer, three distinct arrangements, marked as Case 1, Case 2, and Case 3, were explored. Regarding the parameters examined, the findings indicate a definite improvement in the average Nusselt number ( Nu ), but unfortunately, the friction factor also increases unfavorably. By reducing the length of the porous layer, a reasonable reduction in heat transfer rate and a significant decrease in pressure drop were noticed. The results showed about 26.64%, 48.73%, and 70.74% reductions in pressure drop by reducing the dimensionless foam length from 1 to 0.25, 0.5, and 0.75 respectively for ω = 10 at R e = 16 , 000 . On the other side, there are only about 11.05%, 23.11%, and 40.78% reductions in Nu . The exhaustive analysis of the thermal performance of SAH was conducted using the thermal performance factor (TPF), which considers the trade-off between the SAH channel’s potential for improved heat transmission and its cost for pressure loss. The TPF may reach a maximum of 2.82 compared to the empty channel when the metal foam layer is inserted with S = 1 , for ω = 10 , and R e = 16 , 000 .

Background/Aim: Although the efficacy of docetaxel, cisplatin, and 5-Fluorouracil (TPF) as induction chemotherapy has been confirmed, the therapeutic outcome and prognostic factors of concurrent chemoradiotherapy (CCRT) should be investigated. Patients and Methods: Laboratory data of patients who underwent CCRT for advanced squamous cell carcinoma (SCC) of the head and neck were investigated to clarify the grade of side effects. Survival rates and prognostic scores were also calculated. Multivariate analysis was performed to examine the prognostic factors of the patients. Results: Although there were significantly more advanced cases in the TPF group (n=72) than those in the cisplatin group (n=50), there were no significant differences in patient survival rates. In the TPF group, the lymphocyte count, albumin level, and C-reactive protein level of the patients before treatment were significantly correlated with patient outcomes. Conclusion: CCRT using the TPF regimen had remarkable treatment effects in advanced head and neck cancer.

High-efficiency video coding (HEVC) is the next generation standard of video coding. The deblocking filter (DF) constitutes a significant part of the HEVC decoder complexity. A three-step parallel framework (TPF) is proposed for the H.264/AVC DF, which is also suitable for HEVC except the third step. The third step of the TPF is replaced with a directed acyclic graph-based order. Experiments show that the proposed method dramatically accelerates more than the state-of-the-art parallel method.

The present investigations theoretically explored MXene-based dissimilar-shaped nanoparticle (CuO spherical, MWCNT cylindrical, Al 2 O 3 blade, graphene platelet, and Fe 3 O 4 brick shapes) hybrid nanofluids by 1% v/v, in a triple-tube heat exchanger (TTHX). The shape and surface effect thermophysical properties of nanofluids have been specified using a user-defined function. The operating fluid mass flow rate and temperature of inner (water), intermediate (hybrid nanofluids), and outer tubes(water) are 0.1kg s −1 at 30 ºC, 0.1–0.5kg s −1 at 70 ◦ C, and 0.1kg −1 s at 20 ºC, respectively. The comparative thermal performance (effectiveness, heat transfer, thermal enhancement factor, London factor, etc.), exergetic analysis (entropy production, exergy destruction, etc.), and cost–benefit ratio (CBR) have been explored. MXene-spherical hybrid nanofluid is 5.16% more efficient than water at 0.1kg s −1 in the TTHX system. MXene-cylindrical hybrid nanofluid exhibits 11.23% and 12.69% better heat transfer and performance index than DI water at the lowest mass flow rate in the TTHX system. MXene-platelet hybrid nanofluids show a reduced Nusselt number ratio for the tested mass flow rates. Entropy generation in MXene-cylindrical hybrid nanofluid is 24.11% lower than in DI water.The highest thermal performance factor (TPF) of MXene-cylindrical hybrid nanofluid in the TTHX is 1.65. The MXene-cylindrical hybrid nanofluid is the most economical in the TTHX system, followed by the MXene-brick hybrid nanofluid. Overall, Mxene-cylindrical hybrid nanofluids perform best in the TTHX system in terms of heat transfer rate, TPF, and CBR in the TTHX system.

Background The rate of toxic deaths related to induction chemotherapy in the treatment of locally advanced head and neck cancers is unacceptable and calls into question this therapeutic strategy, which is however highly effective in terms of rate and speed of response. The purpose of the study was to investigate predictive factors of toxicity of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (TPF) in locally advanced head and neck cancers (LAHNC). Methods Between June 2009 and December 2017, 113 patients treated consecutively with TPF were included retrospectively. Patients were receiving induction chemotherapy for either an inoperable cancer or laryngeal preservation. For inoperable cancer, induction chemotherapy was proposed to patients presenting either a large tumor with strong symptoms (dyspnea, dysphagia, pain) or a tumor with rapid progression. Risk factors were chosen among the initial patient and tumour characteristics and chemotherapy modalities. Results Eighty-nine patients (79%) were male; the median age was 58 years [32–71]. Sixty-nine (61%) patients were treated for inoperable cancer and 44 (39%) for laryngeal preservation. 45% had stage IVa cancer, 28% stage III and 25% stage IVb. Sixty percent of patients had a partial response after TPF, 22% had a complete response, 12% were stable, 5% were progressing, and 1% had a discordant response. Thirty-four patients (30%) received enteral feeding during induction chemotherapy with TPF. The possibility of oral feeding without a tube was predictive of a better response ( p  = 0.003). Seven (6%) patients died during TPF. There was an increased risk of death with preexisting liver dysfunction (liver dysmorphia on imaging or decrease prothrombin rate) ( p  = 0.032). There was an increased risk of grade ≥ 3 infection if an enteral feeding occurred during the period of induction chemotherapy (p = 0.03). Conclusions TPF induction chemotherapy had an 82% objective response rate with 6% toxic deaths. Nutritional status and the presence of hepatic dysfunction are significant risk factors to be taken into account in therapeutic decisions.

The aim of this study was to: (a) explore the potential mechanism of cancer cell sensitivity to cisplatin, docetaxel, and 5‐fluorouracil (TPF) in oral squamous cell carcinoma (OSCC) patients overexpressing growth differentiation factor 15 (GDF15); and (b) identify potential alternative agents for patients who might not benefit from inductive TPF chemotherapy. The results indicated that OSCC cells overexpressing GDF15 were sensitive to TPF through a caspase‐9‐dependent pathway both in vitro and in vivo. Immunoprecipitation combined with mass spectrometry revealed that the erbB2 protein was a potential GDF15‐binding protein, which was verified by coimmunoprecipitation. Growth differentiation factor 15 overexpression promoted OSCC cell proliferation through erbB2 phosphorylation, as well as downstream AKT and Erk signaling pathways. When GDF15 expression was blocked, the phosphorylation of both the erbB2 and AKT/Erk pathways was downregulated. When OSCC cells with GDF15 overexpression were treated with the erbB2 phosphorylation inhibitor, CI‐1033, cell proliferation and xenograft growth colony formation were significantly blocked (P < .05). Thus, GDF15‐overexpressing OSCC tumors are sensitive to TPF chemoagents through caspase‐9‐dependent pathways. Growth differentiation factor 15 overexpression promotes OSCC proliferation through erbB2 phosphorylation. Thus, ErbB2 inhibitors could represent potential targeted drugs or an alternative therapy for OSCC patients with GDF15 overexpression. Growth differentiation factor 15 (GDF15)‐overexpressing oral squamous cell carcinoma (OSCC) tumors are sensitive to cisplatin, docetaxel, and 5‐fluorouracil chemoagents through caspase‐9‐dependent pathways. GDF15 overexpression promotes OSCC proliferation through erbB2 phosphorylation. Thus, erbB2 inhibitors could represent potential targeted drugs or an alternative therapy for OSCC patients with GDF15 overexpression.