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"TRANSPLANTATION OF ORGANS"
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Introduction to organ transplantation
\"This second edition of the introduction to the field of organ transplantation provides an excellent overview of the tremendous progress made in recent decades, and gives a clear description of the current status of transplant surgery for students and trainees with an interest in this field. It opens with introductory chapters on the history of transplantation and the basic science of immunobiology, and then examines through an organ-based structure the practice of transplantation in each major system, from skin to intestine. This is a timely publication produced in line with the rapidly advancing field of transplantation.\" -- Publisher.
Book
The transplant imaginary
In The Transplant Imaginary, author Lesley Sharp explores the extraordinarily surgically successful realm of organ transplantation, which is plagued worldwide by the scarcity of donated human parts, a quandary that generates ongoing debates over the marketing of organs as patients die waiting for replacements. These widespread anxieties within and beyond medicine over organ scarcity inspire seemingly futuristic trajectories in other fields. Especially prominent, longstanding, and promising domains include xenotransplantation, or efforts to cull fleshy organs from animals for human use, and bioengineering, a field peopled with “tinkerers” intent on designing implantable mechanical devices, where the heart is of special interest. Scarcity, suffering, and sacrifice are pervasive and, seemingly, inescapable themes that frame the transplant imaginary. Xenotransplant experts and bioengineers at work in labs in five Anglophone countries share a marked determination to eliminate scarcity and human suffering, certain that their efforts might one day altogether eliminate any need for parts of human origin. A premise that drives Sharp’s compelling ethnographic project is that high-stakes experimentation inspires moral thinking, informing scientists’ determination to redirect the surgical trajectory of transplantation and, ultimately, alter the integrity of the human form.
eBook
Our bodies belong to God
Why has Egypt, a pioneer of organ transplantation, been reluctant to pass a national organ transplant law for more than three decades? This book analyzes the national debate over organ transplantation in Egypt as it has unfolded during a time of major social and political transformation—including mounting dissent against a brutal regime, the privatization of health care, advances in science, the growing gap between rich and poor, and the Islamic revival. Sherine Hamdy recasts bioethics as a necessarily political project as she traces the moral positions of patients in need of new tissues and organs, doctors uncertain about whether transplantation is a “good” medical or religious practice, and Islamic scholars. Her richly narrated study delves into topics including current definitions of brain death, the authority of Islamic fatwas, reports about the mismanagement of toxic waste predisposing the poor to organ failure, the Egyptian black market in organs, and more. Incorporating insights from a range of disciplines, Our Bodies Belong to God sheds new light on contemporary Islamic thought, while challenging the presumed divide between religion and science, and between ethics and politics.
eBook
A History of Organ Transplantation
Foreword by Clyde Barker and Thomas E. Starzl
A History of Organ Transplantationis a comprehensive and ambitious exploration of transplant surgery-which, surprisingly, is one of the longest continuous medical endeavors in history. Moreover, no other medical enterprise has had so many multiple interactions with other fields, including biology, ethics, law, government, and technology. Exploring the medical, scientific, and surgical events that led to modern transplant techniques, Hamilton argues that progress in successful transplantation required a unique combination of multiple methods, bold surgical empiricism, and major immunological insights in order for surgeons to develop an understanding of the body's most complex and mysterious mechanisms. Surgical progress was nonlinear, sometimes reverting and sometimes significantly advancing through luck, serendipity, or helpful accidents of nature.The first book of its kind,A History of Organ Transplantationexamines the evolution of surgical tissue replacement from classical times to the medieval period to the present day. This well-executed volume will be useful to undergraduates, graduate students, scholars, surgeons, and the general public. Both Western and non-Western experiences as well as folk practices are included.
eBook
Post-transplant diabetes mellitus in patients with solid organ transplants
Solid organ transplantation (SOT) is a life-saving procedure and an established treatment for patients with end-stage organ failure. However, transplantation is also accompanied by associated cardiovascular risk factors, of which post-transplant diabetes mellitus (PTDM) is one of the most important. PTDM develops in 10–20% of patients with kidney transplants and in 20–40% of patients who have undergone other SOT. PTDM increases mortality, which is best documented in patients who have received kidney and heart transplants. PTDM results from predisposing factors (similar to type 2 diabetes mellitus) but also as a result of specific post-transplant risk factors. Although PTDM has many characteristics in common with type 2 diabetes mellitus, the prevention and treatment of the two disorders are often different. Over the past 20 years, the lifespan of patients who have undergone SOT has increased, and PTDM becomes more common over the lifespan of these patients. Accordingly, PTDM becomes an important condition not only to be aware of but also to treat. This Review presents the current knowledge on PTDM in patients receiving kidney, heart, liver and lung transplants. This information is not only for transplant health providers but also for endocrinologists and others who will meet these patients in their clinics.Post-transplant diabetes mellitus (PTDM) is a common complication of solid organ transplantation that can result in increased mortality. This Review outlines the pathogenesis, diagnosis, treatment and prevention of PTDM.
Journal Article
Kidney for Sale by Owner
Over the past decade in the United States, nearly 6,000 people a year have died waiting for organ transplants. In 2003 alone, only 20,000 out of the 83,000 waiting for transplants received them--in anyone's eyes, a tragedy. Many of these deaths could have been prevented, and many more lives saved, were it not for the almost universal moral hand-wringing over the concept of selling human organs. Bioethicist Mark Cherry explores the why of these well-intentioned misperceptions and legislation and boldly deconstructs the roadblocks that are standing in the way of restoring health to thousands of people. If most Americans accept the notion that the market is the most efficient means to distribute resources, why should body parts be excluded? Kidney for Sale by Owner contends that the market is indeed a legitimate—and humane—way to procure and distribute human organs. Cherry stakes the claim that it may be even more just, and more compatible with many Western religious and philosophical traditions, than the current charity-based system now in place. He carefully examines arguments against a market for body parts, including assertions based on the moral views of John Locke, Immanuel Kant, and Thomas Aquinas, and shows these claims to be steeped in myth, oversimplification, and contorted logic. Rather than focusing on purported human exploitation and the irrational \"moral repugnance\" of selling organs, Cherry argues that we should focus on saving lives. Following on the thinking of the philosopher Robert Nozick, he demonstrates that, with regard to body parts, the important core humanitarian values of equality, liberty, altruism, social solidarity, human dignity, and, ultimately, improved health care are more successfully supported by a regulated market rather than by well meant, but misguided, prohibitions.
eBook