Explore the vast range of titles available.

ContextTangled commits are changes to software that address multiple concerns at once. For researchers interested in bugs, tangled commits mean that they actually study not only bugs, but also other concerns irrelevant for the study of bugs.ObjectiveWe want to improve our understanding of the prevalence of tangling and the types of changes that are tangled within bug fixing commits.MethodsWe use a crowd sourcing approach for manual labeling to validate which changes contribute to bug fixes for each line in bug fixing commits. Each line is labeled by four participants. If at least three participants agree on the same label, we have consensus.ResultsWe estimate that between 17% and 32% of all changes in bug fixing commits modify the source code to fix the underlying problem. However, when we only consider changes to the production code files this ratio increases to 66% to 87%. We find that about 11% of lines are hard to label leading to active disagreements between participants. Due to confirmed tangling and the uncertainty in our data, we estimate that 3% to 47% of data is noisy without manual untangling, depending on the use case.ConclusionTangled commits have a high prevalence in bug fixes and can lead to a large amount of noise in the data. Prior research indicates that this noise may alter results. As researchers, we should be skeptics and assume that unvalidated data is likely very noisy, until proven otherwise.

[This corrects the article DOI: 10.3389/fphar.2024.1412593.].

This paper presents an isoparametric tangled finite element method (i-TFEM) method for handling tangled high order/curvilinear meshes. Tangled elements, i.e. elements with negative Jacobian determinant, frequently occur during various stages of analysis and optimization, leading to erroneous results in standard finite element method (FEM). The proposed i-TFEM is an extension of standard FEM to allow for tangled elements. Specifically, a novel variational formulation is proposed that leads to a simple modification of the standard FEM stiffness matrix and additional piece-wise compatibility constraints. Moreover, i-TFEM reduces to the standard FEM for non-tangled (regular) meshes. The accuracy of the proposed i-TFEM is demonstrated for tangled 9-node quadrilateral (Q9) and 6-node triangular (T6) elements. Numerical experiments involving linear and nonlinear elasticity and Poisson problems illustrate that the accuracy and convergence rate of the proposed i-TFEM over a tangled mesh is comparable to that of the standard FEM over a non-tangled mesh.

How growth, microtubule dynamics, and cell-cycle progression are coordinated is one of the unsolved mysteries of cell biology. A maize mutant, tangled1, with known defects in growth and proper division plane orientation, and a recently characterized cell-cycle delay identified by time-lapse imaging, was used to clarify the relationship between growth, cell cycle, and proper division plane orientation. The tangled1 mutant was fully rescued by introduction of cortical division site localized TANGLED1-YFP. A CYCLIN1B destruction box was fused to TANGLED1-YFP to generate a line that mostly rescued the division plane defect but still showed cell-cycle delays when expressed in the tangled1 mutant. Although an intermediate growth phenotype between wild-type and the tangled1 mutant was expected, these partially rescued plants grew as well as wild-type siblings, indicating that mitotic progression delays alone do not alter overall growth. These data indicate that division plane orientation, together with proper cell-cycle progression, is critical for plant growth.

Generating tangle-free high-quality hexahedral meshes is an ongoing challenge. Tangled meshes, i.e., meshes containing negative Jacobian elements, are unsuitable for finite element (FE) simulations as they lead to erroneous results. Consequently, many untangling methods have been proposed; however, untangling is not always achievable.The present paper addresses this challenge by allowing tangled meshes for FE analysis with the use of the isoparametric tangled finite element method (i-TFEM). The proposed method efficiently handles complex configurations of tangled elements, making it suitable for real-world scenarios. By introducing minor modifications to standard FEM, i-TFEM offers an easy implementation and reduces to standard FEM for non-tangled meshes. Numerical experiments, involving both linear and nonlinear elasticity, demonstrate the accuracy, convergence characteristics, and applicability of the method to real-world tangled meshes. The results emphasize the importance of reevaluating mesh quality indicators for tangled meshes.

The dominance of sex in Metazoa is enigmatic. Sexual species allocate resources to the production of males, while potentially facing negative effects such as the loss of well‐adapted genotypes due to recombination, and exposure to diseases and predators during mating. Two major hypotheses have been put forward to explain the advantages of parthenogenetic versus sexual reproduction in animals, that is, the Red Queen hypothesis and the Tangled Bank/Structured Resource Theory of Sex. The Red Queen hypothesis assumes that antagonistic predator—prey/ parasite–host interactions favor sex. The Structured Resource Theory of Sex predicts sexual reproduction to be favored if resources are in short supply and aggregated in space. In soil, a remarkable number of invertebrates reproduce by parthenogenesis, and this pattern is most pronounced in oribatid mites (Oribatida, Acari). Oribatid mites are abundant in virtually any soil across very different habitats, and include many sexual and parthenogenetic (thelytokous) species. Thereby, they represent an ideal model group to investigate the role of sexual versus parthenogenetic reproduction across different ecosystems and habitats. Here, we compiled data on oribatid mite communities from different ecosystems and habitats across biomes, including tropical rainforests, temperate forests, grasslands, arable fields, salt marshes, bogs, caves, and deadwood. Based on the compiled dataset, we analyzed if the percentage of parthenogenetic species and the percentage of individuals of parthenogenetic species are related to total oribatid mite density, species number, and other potential driving factors of the reproductive mode including altitude and latitude. We then interpret the results in support of either the Red Queen hypothesis or the Structured Resource Theory of Sex. Overall, the data showed that low density of oribatid mites due to harsh environmental conditions is associated with high frequency of parthenogenesis supporting predictions of the Structured Resource Theory of Sex rather than the Red Queen hypothesis.

The purpose of this study was to predict the four cold-heat patterns in patients who have the subjective symptoms of the cold-heat pattern described in the International Classification of Diseases Traditional Medicine Conditions - Module 1 by applying a machine learning algorithm. Subjects were first-visit Kampo outpatients at six institutions who agreed to participate in this multicenter prospective observational study. The cold pattern model and the heat pattern model were created separately with 148 symptoms, body mass index, blood pressure (systolic and diastolic), age, and sex. Along with a single cold or heat pattern, the tangled heat/cold pattern is defined as being predicted by both cold and heat patterns, while the moderate (heat/cold) pattern is defined as being predicted by neither the cold pattern nor the heat pattern. We included 622 participants (mean age ±standard deviation, 54.4 ± 16.9; with female 501). The accuracy, macro-recall, precision, and F1-score of a combination of the two prediction models were 96.7%, 93.2%, 85.6%, and 88.5% respectively. The important items were compatible with the definitions of the cold-heat pattern. We developed a prediction model on cold-heat patterns with data from patients whose subjective cold/heat-related symptoms matched the cold-heat pattern diagnosis by the physician.

This study was conducted to objectively evaluate the degree of detangling needed to develop the effectiveness of cosmetic hair ingredients to prevent hair tangles. To evaluate the degree of hair tangling, the frictional force applied when combing the hair was measured. The tooth spacing of the comb used in the evaluation was examined, and it was confirmed that the 4 mm interval comb was suitable as there was a large difference in combability between different treatments and the deviation was small. To create samples to standardize hair tangles, spinning 25 cm or more of wet hair on a spinner for 5 min was found to be best for observing differences between treatments. In the case of hair shorter than 25 cm, tangles did not occur even when spun using a tool, but a suitable sample for evaluating tangles was obtained by rubbing the hair by hand about 15 times. When testing combability, the distance the comb moves until it reaches 9.8 N is considered to be proportional to the detangling efficacy, and the degree of tangling is evaluated based on the section detangling rate, which is the distance the comb travels to reach 9.8 N divided by the total tress length. As a result of evaluating the contact angle of tangled hair using an atomic force microscope (AFM) and a scanning electron microscope (SEM), it was found that the contact angle of the cuticle surface for the tangled part was larger than that of the straight part and the cuticle was damaged. After immersing tangled hair in rice bran extract containing six OH groups, the contact angle changed from 103° to 95°, which is the level of the straight part, and an increase in the section detangling rate of the hair was observed. As a result, it was suggested that the detangling efficacy could be evaluated by applying this evaluation method using the section detangling rate.

Following a severe drought in the late 1970s and early 1980s, the invasive shrub Prosopis, a kind of mesquite native to South America, was introduced by international organizations to locations across Kenya’s drylands, including the Turkana region in the far north. Prosopis, known as etirae in Turkana, was envisaged as a solution to a range of problems, including deforestation, fuelwood shortages and general environmental deterioration. While exacerbated by drought, these problems were perceived to reflect a much more fundamental crisis, with prevalent views at the time envisaging pastoralism as unsustainable, destructive and in need of overhaul – a narrative dating to colonial times that has since been discredited. Since its introduction, etirae has spread relentlessly, invading riparian land, encroaching on cultivation plots and growing to new heights and thicknesses. Investigating its entanglements with Turkana livelihoods and economic relationships is also a process of understanding how it has braided its way through contested processes of social change, and how it has come to be intertwined with conceptions of cascading crisis quite distinct from the narratives that led to its initial introduction. Implications emerge regarding both the complicated biological residues of past development interventions and the totalizing crisis-oriented narratives that shape drylands development in the current era of climate change.

The production of high safety automotive structural parts with cast aluminum alloy still faces significant challenges, particularly in terms of comprehensive mechanical properties and performance consistency. To illustrate this point, the automotive battery enclosure made of AlSi10MgMn alloy material was used as an example to examine mechanical properties and bifilm defects. The study analyzed the room temperature mechanical properties of the test bars by using the ultimate tensile strength (UTS) and %Elongation values obtained through the two-parameter Weibull distribution analysis method. Additionally, the fracture surface of the tensile samples was analyzed by scanning electron microscopy (SEM), and the energy-dispersive X-ray spectrometry (EDS) technique was used to analyze the composition of the bifilm defects. The results show an average tensile strength of 273.4 MPa and %Elongation of 6.0% in the tensile sample, while the Weibull moduli of the average tensile strength and %Elongation are small. The fracture surface of the tensile sample shows typical bifilm defects, with the microscopic metallographic images showing curved and tangled cracks. The bifilm defects were combined with Al6(MnFe)Si, β-AlFeMnSi, and Si phase at the grain boundary, resulting in the formation of a compound defect. Furthermore, the complex inner surfaces of the bifilm were made up of typical fold, wrinkle, and cavity features. Due to the mechanical folding of the bifilm, gaps are observed at the boundary between the oxide film and the substrate.