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Various foot structures are thought to influence forefoot plantar pressures during walking. High peak plantar pressures (PPP) during walking in people with diabetes mellitus (DM) and peripheral neuropathy (PN) can cause skin breakdown. The question addressed by this study is “What are the primary forefoot structural factors that predict regional PPP during walking in groups of people with and without DM and PN?” Twenty people with DM and PN (mean age 55±9 years, 6 female, 14 male, BMI=33±8) and 20 people without DM, matched for gender, age, and BMI were tested. Measures of foot structure were taken from three-dimensional images constructed from spiral X-ray computed tomography. Peak plantar pressure data were recorded during walking. Hierarchical multiple regression analysis was used to predict regional PPP at the great toe and five metatarsal heads from selected structural and walking variables. Metatarsal phalangeal joint angle (hammer toe deformity) was the most important variable predicting pressure, accounting for 19–45% of the PPP variance at five of the six locations in the DM group. Soft tissue thickness, hallux valgus, and forefoot arthropathy were the most important predictors of PPP in the control group. Combinations of structural and walking variables accounted for 47–71% of the variance in the DM group and 52–83% of the variance of PPP during walking in the control group. These structural variables, especially hammer toe deformity, should be considered in attempts to develop strategies to reduce excessive forefoot PPP that may contribute to skin breakdown or other injury.

Background Whilst post exercise ankle-brachial indices (ABI) are commonly used to help identify peripheral arterial disease (PAD), the role of post exercise toe pressures (TP) or toe-brachial indices (TBI) is unclear . The aim of this study was to determine, in a population without clinical signs of PAD, the effect that 30 s of weight-bearing heel raises has on TP and TBI values. Additionally, the ability of resting TP and TBI values to predict change in post-exercise values using the heel raise method was investigated. Methods Participants over the age of 18 with a resting TBI of ≥0.60 and ABI between 0.90 and 1.40, without diabetes, history of cardiovascular disease and not currently smoking were included. Following ten minutes of supine rest, right TP and bilateral brachial pressures were performed in a randomized order using automated devices. Participants then performed 30 s of weight-bearing heel raises, immediately after which supine vascular measures were repeated. Data were assessed for normality using the Shapiro-Wilk test. For change in TP and TBI values the Wilcoxon Signed-Rank Test was performed. For correlations between resting and change in post exercise values, the Spearman Rank Order Correlations were performed, and where significant correlation identified, a linear regression undertaken. Results Forty-eight participants were included. A statistically significant decrease was seen in the median TP from resting 103.00 mmHg (IQR: 89.00 to 124.75) to post exercise 98.50 mmHg (IQR: 82.00 to 119.50), z = − 2.03, p  = 0.04. This difference of 4.50 mmHg represents a 4.37% change and is considered a small effect size ( r  = 0.21). The median TBI also demonstrated a statistically significant decrease from resting 0.79 (IQR: 0.68 to 0.94) to post exercise 0.72 (IQR: 0.60 to 0.87), z = − 2.86, p  = < 0.01. This difference of 0.07 represents an 8.86% change and is considered a small effect size ( r  = 0.29). Linear regression demonstrated that resting TBI predicted 22.4% of the variance in post exercise TBI, p  = < 0.01, coefficients beta − 0.49. Conclusions Thirty seconds of weight-bearing heel raises resulted in a similar decrease in TBI values seen in longer periods of exercise. TP values also showed a decrease post exercise; however this was contrary to previous studies.

The diminished knee flexion associated with stiff-knee gait, a movement abnormality commonly observed in persons with cerebral palsy, is thought to be caused by an over-active rectus femoris muscle producing an excessive knee extension moment during the swing phase of gait. As a result, treatment for stiff-knee gait is aimed at altering swing-phase muscle function. Unfortunately, this treatment strategy does not consistently result in improved knee flexion. We believe this is because multiple factors contribute to stiff-knee gait. Specifically, we hypothesize that many individuals with stiff-knee gait exhibit diminished knee flexion not because they have an excessive knee extension moment during swing, but because they walk with insufficient knee flexion velocity at toe-off. We measured the knee flexion velocity at toe-off and computed the average knee extension moment from toe-off to peak flexion in 17 subjects (18 limbs) with stiff-knee gait and 15 subjects (15 limbs) without movement abnormalities. We used forward dynamic simulation to determine how adjusting each stiff-knee subject's knee flexion velocity at toe-off to normal levels would affect knee flexion during swing. We found that only one of the 18 stiff-knee limbs exhibited an average knee extension moment from toe-off to peak flexion that was larger than normal. However, 15 of the 18 limbs exhibited a knee flexion velocity at toe-off that was below normal. Simulating an increase in the knee flexion velocity at toe-off to normal levels resulted in a normal or greater than normal range of knee flexion for each of these limbs. These results suggest that the diminished knee flexion of many persons with stiff-knee gait may be caused by abnormally low knee flexion velocity at toe-off as opposed to excessive knee extension moments during swing.

Objectives: To investigate the long-term effects of the toe spreader on gait characteristics, pain, activity level and balance in individuals with chronic stroke who exhibited tonic toe flexion reflex. The secondary objectives were to determine the sample size for future studies and to assess compliance to the use of the toe spreader. Design: Single-blind, randomized controlled pilot trial. Setting: Outpatient clinic of a tertiary hospital in Singapore. Subjects: Nine ambulatory participants with tonic toe flexion reflex more than six months post stroke. Intervention: Control or customized toe spreader groups for six months. The toe spreader was made of Rolyan Ezemix elastomer putty and worn with sport sandals during ambulation. Main measures: Gait speed and plantar surface contact area, pain visual analogue scale (VAS), Berg Balance Scale, Modified Ashworth Scale, activity level measured on pedometer and compliance via logbook. Results: There were no significant differences between the groups. Both groups showed non-significant improvements in gait speed (toe spreader 0.34 (0.26) versus 0.37 (0.29) m/s; control 0.40 (0.27) versus 0.50 (0.17) m/s), activity level, step length of the hemiplegic leg and stride length at six months. All participants in the intervention group used the toe spreader less than 50% of the days, indicating suboptimal compliance. Conclusion: The use of the toe spreader did not result in significant improvements in any outcomes. Studies with sample sizes of at least 56 participants and strategies to increase compliance to the use of the toe spreader are recommended.

We used finite element analysis to study the mechanical stress distribution of a new intramedullary implant used for proximal interphalangeal joint (PIPJ) arthrodesis (PIPJA) to surgically correct the claw‐hammer toe deformity that affects 20% of the population. After geometric reconstruction of the foot skeleton from claw toe images of a 36–year‐old male patient, two implants were positioned, in the virtual model, one neutral implant (NI) and another one 10° angled (10°AI) within the PIPJ of the second through fourth HT during the toe‐off phase of gait and results were compared to those derived for the non‐surgical foot (NSF). A PIPJA was performed on the second toe using a NI reduced tensile stress at the proximal phalanx (PP) (45.83 MPa) compared to the NSF (59.44 MPa; p < 0.001). When using the 10°AI, the tensile stress was much higher at PP and middle phalanges (MP) of the same toe, measuring 147.58 and 160.58 MPa, respectively, versus 59.44 and 74.95 MPa at corresponding joints in the NSF (all p < 0.001). Similar results were found for compressive stresses. The NI reduced compressive stress at the second PP (−65.12 MPa) compared to the NSF (−113.23 MPa) and the 10°AI (−142 MPa) (all p < 0.001). The von Mises stresses within the implant were also significantly lower when using NI versus 10°AI (p < 0.001). Therefore, we do not recommend performing a PIPJA using the 10°AI due to the increase in stress concentration primarily at the second PP and MP, which could promote implant breakage.

Elevated plantar foot pressures during gait in diabetic patients with neuropathy have been suggested to result, among other factors, from the distal displacement of sub-metatarsal head (MTH) fat-pad cushions caused by to claw/hammer toe deformity. The purpose of this study was to quantitatively assess these associations. Thirteen neuropathic diabetic subjects with claw/hammer toe deformity, and 13 age- and gender-matched neuropathic diabetic controls without deformity, were examined. Dynamic barefoot plantar pressures were measured with an EMED pressure platform. Peak pressure and force–time integral for each of 11 foot regions were calculated. Degree of toe deformity and the ratio of sub-MTH to sub-phalangeal fat-pad thickness (indicating fat-pad displacement) were measured from sagittal plane magnetic resonance images of the foot. Peak pressures at the MTHs were significantly higher in the patients with toe deformity (mean 626 (SD 260) kPa) when compared with controls (mean 363 (SD 115) kPa, P<0.005). MTH peak pressure was significantly correlated with degree of toe deformity ( r=−0.74) and with fat-pad displacement ( r=−0.71) ( P<0.001). The ratio of force–time integral in the toes and the MTHs (toe-loading index) was significantly lower in the group with deformity. These results show that claw/hammer toe deformity is associated with a distal-to-proximal transfer of load in the forefoot and elevated plantar pressures at the MTHs in neuropathic diabetic patients. Distal displacement of the plantar fat pad is suggested to be the underlying mechanism in this association. These conditions increase the risk for plantar ulceration in these patients.

In ASTRAEA (NCT01860976), abatacept significantly increased American College of Rheumatology criteria 20% (ACR20) responses at Week 24 versus placebo in patients with psoriatic arthritis (PsA). This post hoc analysis explored relationships between prospectively identified baseline characteristics [poor prognostic factors (PPFs) ] and response to abatacept. Patients were randomized (1:1) to receive subcutaneous abatacept 125 mg weekly or placebo for 24 weeks; those without ≥ 20% improvement in joint counts at Week 16 switched to open-label abatacept. Potential predictors of ACR20 response were identified by treatment arm using multivariate analyses. Likelihood of ACR20 response to abatacept versus placebo was compared in univariate and multivariate analyses in subgroups stratified by the PPF, as defined by EULAR and/or GRAPPA treatment guidelines. Odds ratios (ORs) were generated using logistic regression to identify meaningful differences (OR cut-off: 1.2). 424 patients were randomized and treated (abatacept n = 213; placebo n = 211). In abatacept-treated patients, elevated C-reactive protein (CRP), high Disease Activity Score based on 28 joints (CRP), presence of dactylitis, and ≥ 3 joint erosions were identified as predictors of response (OR > 1.2). In placebo-treated patients, only dactylitis was a potential predictor of response. In the univariate analysis stratified by PPF, ACR20 response was more likely (OR > 1.2) with abatacept versus placebo in patients with baseline PPFs than in those without; multivariate analysis confirmed this finding. Response to abatacept versus placebo is more likely in patients with features indicative of high disease activity and progressive disease; these characteristics are recognized as PPFs in treatment guidelines for PsA.

The aims of study were: to observe gait parameters evolution for group of patients with surgery and conservative treatment; to compare these parameters for a group of matched patients with surgery and without; to compare these parameters with a group of asymptomatic children. Depending of the importance of the equinus in idiopathic toe walking (ITW) patients, conservative or surgical treatment could be proposed. Currently, there is no consensus about the treatment of ITW. ITW patients with surgical or conservative treatment and with two clinical gait analysis (CGA before and after treatment) were selected. Gait parameters have been used as: presence of first ankle rocker, peak ankle power generation, ankle passive dorsiflexion with extended and flexed knee. Paired and Unpaired t-test were used to analyse differences between the 2 CGA, between groups of treatment and with asymptomatic children. Sixteen ITW patients were treated surgically with a mean age at baseline of 8.6y and a follow-up time of 2.1y. Thirteen ITW patients were treated conservatively with mean age at baseline of 6.5y and a follow-up time of 3.0y. Only surgery group had a significant improvement in passive ankle dorsiflexion. Both groups significantly improved their parameters. Ten patients in each group were similar in terms of passive ankle dorsiflexion at the first CGA. Passive dorsiflexion and ankle power were significantly greater for the surgery group at the second CGA. Parameters were significantly lower compared to asymptomatic children. Regardless of the treatment, the gait quality of the ITW patients improves over time but does not recover the gait of healthy children. This study was a therapeutic retrospective comparative study (level III).

A striatal toe is a misalignment of the hallux in dorsal flexion that frequently presents as a symptom of Parkinson’s disease and also atypical Parkinson syndromes. It can negatively impact patients during activities such as walking, putting on socks and shoes, and particularly while wearing shoes. It causes pain and thus induces a loss of quality of life. But, to date, we have few data on the topics of the prevalence, genesis, and therapy of striatal toe. Publications available on botulinum neurotoxin (BoNT) have demonstrated a positive effect in the treatment of striatal toe, although the current study data are also rather limited in this area. Commensurate approval studies have not yet been performed. We will introduce our contemporary data on therapy for striatal toe with BoNT and we will also discuss possible questions open for further study.

Background and Objectives: The interrelationship between thyroid function and the state of the cardiovascular system has been investigated both in preclinical and human studies. However, it remains unclear whether there is any association between thyroid hormones and features of subclinical cardiovascular dysfunction in euthyroid patients. Material and Methods: This study involved 45 people (females: 57.8%) with no thyroid disease who, during planned hospitalization, underwent thyroid ultrasound, determination of biochemical parameters of thyroid function, and measurement of ankle-brachial index (ABI) and toe-brachial index (TBI). People with signs of acute illness or a deterioration of their health were excluded. Results: Significant correlations were found between free triiodothyronine (FT3) and several parameters of both ABI (R = 0.347; p = 0.019 for the mean ABI taken from right side and left side values) and TBI (R = 0.396; p = 0.007 for the mean TBI taken from right side and left side values), as well as the maximal toe pressure (TP) taken from right side and left side values (R = 0.304; p = 0.045). Thyrotropin (TSH) was shown to be significantly correlated only with the maximal TBI value (taken from right side and left side values) (R = 0.318; p = 0.033), whereas free thyroxin (FT4) was shown to be significantly correlated only with the minimal TBI value (taken from right side and left side values) (R = 0.381; p = 0.01). Thyroid volume (TV) was shown to be correlated with TP (R = 0.4; p = 0.008 for the mean TP taken from right side and left side values) and some parameters of TBI value (R = 0.332; p = 0.028 for the mean TBI taken from right side and left side values), but no significant correlations were found between TVand ABI parameters. Patients with a mean ABI value ≤ 1.0 or a mean TBI value ≤ 0.75 have lower TSH, FT3, FT4, and TV than the rest of the study population, but the difference was statistically significant only for FT3. Conclusions: Even in a population of euthyroid patients with no diagnosed thyroid disease, there are some significant correlations between the volume and function of the thyroid gland and the selected features of subclinical cardiovascular dysfunction such as ABI and TBI.