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Legal Aspects of Implementing the Cartagena Protocol on Biosafety
This book, the first in a series that focuses on treaty implementation for sustainable development, examines key legal aspects of implementing the Cartagena Protocol on Biosafety to the UN Convention on Biological Diversity (CBD) at national and international levels. The volume provides a serious contribution to the current legal and political academic debates on biosafety by discussing key issues under the Cartagena Protocol on Biosafety that affect the further design of national and international law on biosafety, and analyzing progress in the development of domestic regulatory regimes for biosafety. In the year of the fifth UN Meeting of the Parties to the Cartagena Protocol on Biosafety, at the signature of a new Nagoya-Kuala Lumpur Protocol on Liability and Redress, this timely book examines developments in biosafety law and policy.
eBook
Genetically Engineered Organisms, Wildlife, and Habitat
Since the first commercial introduction of transgenic corn plants in 1995, biotechnology has provided enormous benefits to agricultural crop production. Research is underway to develop a much broader range of genetically engineered organisms (GEOs), including fish, trees, microbes, and insects, that could have the potential to transform fields such as aquaculture, biofuels production, bioremediation, biocontrol, and even the production of pharmaceuticals . However, biotechnology is not without risk and continues to be an extremely controversial topic. Chief among the concerns is the potential ecological effects of GEOs that interact with wildlife and habitats.
The U.S. Geological Survey (USGS) is charged with providing scientific advice to inform federal agencies that manage wildlife and their habitats. USGS has identified biotechnology as one of its major challenges for future research. Seeing an opportunity to initiate a dialogue between ecologists and developers of GEOs about this challenge, the USGS and the National Research Council (NRC) held a two-day workshop in November of 2007, to identify research activities with the greatest potential to provide the information needed to assess the ecological effects of GEOs on wildlife and habitats. The workshop, designed to approach the research questions from a habitat, rather than transgenic organism, perspective, is summarized in this book.
eBook
GMOs
An overview of genetic modification and how this biotechnology affects food, humans, animals, and medicine. Includes a discussion of the ethical concerns of genetic biotechnology.
Book
The Intersection of International Law, Agricultural Biotechnology, and Infectious Disease
The Intersection of International Law, Agricultural Biotechnology, and Infectious Disease examines legal frameworks and perspectives for infectious disease and GMOs and argues for a more connective approach for future regulation.
eBook
Biological confinement of genetically engineered organisms
Genetically engineered organisms (GEOs) have been under development for more than 20 years while GE crops have been grown commercially during the last decade. During this time, a number of questions have cropped up concerning the potential consequences that certain GEOs might have on natural or managed ecosystems and human health. Interest in developing methods to confine some GEOs and their transgenes to specifically designated release settings has increased and the success of these efforts could facilitate the continued growth and development of this technology.
Biological Confinement of Genetically Engineered Organisms examines biological methods that may be used with genetically engineered plants, animals, microbes, and fungi. Bioconfinement methods have been applied successfully to a few non-engineered organisms, but many promising techniques remain in the conceptual and experimental stages of development. This book reviews and evaluates these methods, discusses when and why to consider their use, and assesses how effectively they offer a significant reduction of the risks engineered organisms can present to the environment.
Interdisciplinary research to develop new confinement methods could find ways to minimize the potential for unintended effects on human health and the environment. Need for this type of research is clear and successful methods could prove helpful in promoting regulatory approval for commercialization of future genetically engineered organisms.
eBook
Expression of Recombinant Antibodies
Recombinant antibodies are highly specific detection probes in research, diagnostics, and have emerged over the last two decades as the fastest growing class of therapeutic proteins. Antibody generation has been dramatically accelerated by in vitro selection systems, particularly phage display. An increasing variety of recombinant production systems have been developed, ranging from Gram-negative and positive bacteria, yeasts and filamentous fungi, insect cell lines, mammalian cells to transgenic plants and animals. Currently, almost all therapeutic antibodies are still produced in mammalian cell lines in order to reduce the risk of immunogenicity due to altered, non-human glycosylation patterns. However, recent developments of glycosylation-engineered yeast, insect cell lines, and transgenic plants are promising to obtain antibodies with \"human-like\" post-translational modifications. Furthermore, smaller antibody fragments including bispecific antibodies without any glycosylation are successfully produced in bacteria and have advanced to clinical testing. The first therapeutic antibody products from a non-mammalian source can be expected in coming next years. In this review, we focus on current antibody production systems including their usability for different applications.
Journal Article