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\"Present understanding of transition to turbulence has now been studied over one hundred and fifty years. The path the studies have taken posed it as a modal eigenvalue problem. Some researchers have suggested alternative models without being specific. First-principle based approach of receptivity is the route to build bridges among ideas for solving the Navier-Stokes equation for specific canonical problems. This book highlights the mathematical physics, scientific computing, and new ideas and theories for nonlinear analyses of fluid flows, for which vorticity dynamics remain central. This book is a blend of classic with distinctly new ideas, which establish different dynamics of flows, from genesis to evolution of disturbance fields with rigorously developed methods to tracing coherent structures amidst the seemingly random and chaotic fluid dynamics of transitional and turbulent flows\"-- Provided by publisher.

\"When you think of nickel, a 5-cent coin probably comes to mind. But nickel is used for so much more than manufacturing coins. Nickel and nickel-containing alloys are very important in our society. Nickel is used in the construction, transportation, power, high-tech and many other industries. This book tells the fascinating story of how nickel was discovered, how ore containing nickel is mined and extracted, the properties that make nickel so useful, and how nickel's many uses and applications make the high-tech world we live in possible. It also provides students with up-to-date resources to continue their research.\"-- Provided by publisher.

For almost fifty years, coal dominated the Navajo economy. But in 2019 one of the Navajo Nation's largest coal plants closed. This comprehensive new work offers a deep dive into the complex inner workings of energy shift in the Navajo Nation. Geographer Andrew Curley, a member of the Navajo Nation, examines the history of coal development within the Navajo Nation, including why some Diné supported coal and the consequences of doing so. He explains the Navajo Nation's strategic choices to use the coal industry to support its sovereignty as a path forward in the face of ongoing colonialism. Carbon Sovereignty demonstrates the mechanism of capitalism through colonialism and the construction of resource sovereignty, in both the Navajo Nation's embrace and its rejection of a coal economy. For the people of the Navajo Nation, energy sovereignty is dire and personal. Thanks to on-the-ground interviews with Diné coal workers, environmental activists, and politicians, Curley documents the real consequences of change as they happened. While some Navajo actors have doubled down for coal, others have moved toward transition. Curley argues that political struggles ultimately shape how we should understand coal, capitalism, and climate change. The rise and fall of coal magnify the nuance and complexity of change. Historical and contemporary issues intermingle in everyday life with lasting consequences.

This edited volume provides multidisciplinary and international insights into the policy, managerial and educational aspects of diverse students' transitions from education to employment. As employers require increasing global competence on the part of those leaving education, this research asks whether increasing multiculturalism in developed societies, often seen as a challenge to their cohesion, is in fact a potential advantage in an evolving employment sector. This is a vital and under-researched field, and this new publication in Springer's Technical and Vocational Education and Training series provides analysis both of theory and empirical data, submitted by researchers from nine nations including the USA, Oman, Malaysia, and countries in the European Union.The papers trace the origins of business demand for diversity in their workforce's skill set, including national, local and institutional contexts. They also consider how social, demographic, cultural, religious and linguistic diversity inform the attitudes of those seeking work--and those seeking workers. With clear suggestions for future research, this work on a topic of rising profile will be read with interest by educators, policy makers, employers and careers advisors.

EpCAM (epithelial cell adhesion molecule) was discovered four decades ago as a tumor antigen on colorectal carcinomas. Owing to its frequent and high expression on carcinomas and their metastases, EpCAM serves as a prognostic marker, a therapeutic target, and an anchor molecule on circulating and disseminated tumor cells (CTCs/DTCs), which are considered the major source for metastatic cancer cells. Today, EpCAM is reckoned as a multi-functional transmembrane protein involved in the regulation of cell adhesion, proliferation, migration, stemness, and epithelial-to-mesenchymal transition (EMT) of carcinoma cells. To fulfill these functions, EpCAM is instrumental in intra- and intercellular signaling as a full-length molecule and following regulated intramembrane proteolysis, generating functionally active extra- and intracellular fragments. Intact EpCAM and its proteolytic fragments interact with claudins, CD44, E-cadherin, epidermal growth factor receptor (EGFR), and intracellular signaling components of the WNT and Ras/Raf pathways, respectively. This plethora of functions contributes to shaping intratumor heterogeneity and partial EMT, which are major determinants of the clinical outcome of carcinoma patients. EpCAM represents a marker for the epithelial status of primary and systemic tumor cells and emerges as a measure for the metastatic capacity of CTCs. Consequentially, EpCAM has reclaimed potential as a prognostic marker and target on primary and systemic tumor cells.

\"In this provocative book, Nicholas Daly tracks the cultural effects of the population explosion of the nineteenth century, the 'demographic transition' to the modern world. As the crowded cities of Paris, London and New York went through similar transformations, a set of shared narratives and images of urban life circulated among them, including fantasies of urban catastrophe, crime dramas, and tales of haunted public transport, refracting the hell that is other people. In the visual arts, sentimental genre pictures appeared that condensed the urban masses into a handful of vulnerable figures: newsboys and flower-girls. At the end of the century, proto-ecological stories emerge about the sprawling city as itself a destroyer. This lively study excavates some of the origins of our own international popular culture, from noir visions of the city as a locus of crime, to utopian images of energy and community\"-- Provided by publisher.

Epithelial‐to‐mesenchymal transition (EMT) and its reverse mesenchymal‐to‐epithelial transition (MET) have been suggested to play crucial roles in metastatic dissemination of carcinomas. These phenotypic transitions between states are not binary. Instead, carcinoma cells often exhibit a spectrum of epithelial/mesenchymal phenotype(s). While epithelial/mesenchymal plasticity has been observed preclinically and clinically, whether any of these phenotypic transitions are indispensable for metastatic outgrowth remains an unanswered question. Here, we focus on epithelial/mesenchymal plasticity in metastatic dissemination and propose alternative mechanisms for successful dissemination and metastases beyond the traditional EMT/MET view. We highlight multiple hypotheses that can help reconcile conflicting observations, and outline the next set of key questions that can offer valuable insights into mechanisms of metastasis in multiple tumor models. Here, we focus on epithelial/mesenchymal plasticity in metastatic dissemination and propose alternative mechanisms for successful dissemination and metastases beyond the traditional EMT/MET view of single‐cell dissemination. We highlight multiple hypotheses that can help reconcile conflicting observations, and outline the next set of key questions that can offer valuable insights into mechanisms of metastasis in multiple tumor models.

\"In Migration, Reproduction and Society, Alejandro I. Canales offers a theoretical model for understanding the dilemmas presented by migration in the transformation of contemporary society. Aging and changing demographics in advanced societies make economic and social reproduction dependent upon the contributions made by immigration. However, these same demographic processes are conducive to ethnic transformations. The political dilemma facing advanced societies is that immigration is required to ensure their reproduction, but this entails becoming multicultural societies where the political hegemony of ethnic and demographic majorities becomes radically subverted. This paves the way to a pervasive political conflict already evident in the current immigration crisis in Europe just as in the revival of racism and xenophobia in the United States\"-- Provided by publisher.

How a cell changes from one stable phenotype to another one is a fundamental problem in developmental and cell biology. Mathematically, a stable phenotype corresponds to a stable attractor in a generally multi-dimensional state space, which needs to be destabilized so the cell relaxes to a new attractor. Two basic mechanisms for destabilizing a stable fixed point, pitchfork and saddle-node bifurcations, have been extensively studied theoretically; however, direct experimental investigation at the single-cell level remains scarce. Here, we performed live cell imaging studies and analyses in the framework of dynamical systems theories on epithelial-to-mesenchymal transition (EMT). While some mechanistic details remain controversial, EMT is a cell phenotypic transition (CPT) process central to development and pathology. Through time-lapse imaging we recorded single cell trajectories of human A549/Vim-RFP cells undergoing EMT induced by different concentrations of exogenous TGF-β in a multi-dimensional cell feature space. The trajectories clustered into two distinct groups, indicating that the transition dynamics proceeds through parallel paths. We then reconstructed the reaction coordinates and the corresponding quasi-potentials from the trajectories. The potentials revealed a plausible mechanism for the emergence of the two paths where the original stable epithelial attractor collides with two saddle points sequentially with increased TGF-β concentration, and relaxes to a new one. Functionally, the directional saddle-node bifurcation ensures a CPT proceeds towards a specific cell type, as a mechanistic realization of the canalization idea proposed by Waddington. Cells with the same genetic code can take on many different formss, or phenotypes, which have distinct roles and appearances. Sometimes cells switch from one phenotype to another as part of healthy growth or during disease. One such change is the epithelial-to-mesenchymal transition (EMT), which is involved in fetal development, wound healing and the spread of cancer cells. During EMT, closely connected epithelial cells detach from one another and change into mesenchymal cells that are able to migrate. Cells undergo a number of changes during this transition; however, the path they take to reach their new form is not entirely clear. For instance, do all cells follow the same route, or are there multiple ways that cells can shift from one state to the next? To address this question, Wang et al. studied individual lung cancer cells that had been treated with a protein that drives EMT. The cells were then imaged at regular intervals over the course of two to three days to see how they changed in response to different concentrations of protein. Using a mathematical analysis designed to study chemical reactions, Wang et al. showed that the cells transform into the mesenchymal phenotype through two main routes. This result suggests that attempts to prevent EMT, in cancer treatment for instance, would require blocking both paths taken by the cells. This information could be useful for biomedical researchers trying to regulate the EMT process. The quantitative approach of this study could also help physicists and mathematicians study other types of transition that occur in biology.