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Building on our earlier research (Case and Deaton 2015), we find that mortality and morbidity among white non-Hispanic Americans in midlife since the turn of the century continued to climb through 2015. Additional increases in drug overdoses, suicides, and alcohol-related liver mortality—particularly among those with a high school degree or less—are responsible for an overall increase in all-cause mortality among whites. We find marked differences in mortality by race and education, with mortality among white non-Hispanics (males and females)risingfor those without a college degree, andfallingfor those with a college degree. In contrast, mortality rates among blacks and Hispanics have continued to fall, irrespective of educational attainment. Mortality rates in comparably rich countries have continued their premillennial fall at the rates that used to characterize the United States. Contemporaneous levels of resources—particularly slowly growing, stagnant, and even declining incomes—cannot provide a comprehensive explanation for poor mortality outcomes. We propose a preliminary but plausible story in whichcumulative disadvantagefrom one birth cohort to the next—in the labor market, in marriage and child outcomes, and in health—is triggered by progressively worsening labor market opportunities at the time of entry for whites with low levels of education. This account, which fits much of the data, has the profoundly negative implication that policies—even ones that successfully improve earnings and jobs, or redistribute income—will take many years to reverse the increase in mortality and morbidity, and that those in midlife now are likely to do worse in old age than the current elderly. This is in contrast to accounts in which resources affect health contemporaneously, so that those in midlife now can expect to do better in old age as they receive Social Security and Medicare. None of this, however, implies that there are no policy levers to be pulled. For instance, reducing the overprescription of opioids should be an obvious target for policymakers.

One-third of global forest is harvested for timber, generating ~US$1.5 trillion annually. High-severity wildfires threaten this timber production. Here we combine global maps of logging activity and stand-replacing wildfires to assess how much timber-producing forest has been lost to wildfire this century, and quantify spatio-temporal changes in annual area lost. Between 2001 and 2021, 18.5–24.7 million hectares of timber-producing forest—an area the size of Great Britain—experienced stand-replacing wildfires, with extensive burning in the western USA and Canada, Siberian Russia, Brazil and Australia. Annual burned area increased significantly throughout the twenty-first century, pointing to substantial wildfire-driven timber losses under increasingly severe climate change. To meet future timber demand, producers must adopt new management strategies and emerging technologies to combat the increasing threat of wildfires.Wildfires have caused widespread and increasingly severe losses within timber-producing forests in recent decades, according to maps of logging activity and wildfires.

The attention being paid to ethics education in accounting has been increasing, especially after the corporate accounting scandals at the turn of the century. This paper provides a comprehensive overview of the existing research in the field of ethics education in accounting. To synthesize past research, a bibliometric analysis that references 134 primary studies is performed and three bibliometric methods are applied. First, we visualize the historical evolution of ethics education in accounting research through historiography. Second, we use bibliographic coupling to identify clusters of ethics education in accounting research before, during, and after major corporate scandals. Third, we perform a co-word analysis to connect the identified patterns into a map of a contextual space. The results reveal, in each decade, not only an increasing academic focus on this field of research, but also an increasing number of different research clusters. While the clusters Factors affecting moral judgement, Perception of ethics, and Lack of ethics topics in the last research period develop further from the respective clusters in the previous periods, Accounting beyond technical skills, Integration of ethics in accounting education, Use of developed ethics frameworks, and Professional values on the contrary develop anew in the last decade, as a consequence of a growing demand for teaching ethics. Overall, the paper presents the development patterns of ethics education in accounting research and sets up a research agenda that encourages future research.

After reaching a nadir at the turn of the century, syphilis rates in the United States have increased since 2000. Treponema pallidum may disseminate to the central nervous system within hours to days after inoculation. In this review, we focus on knowledge gaps and areas of controversy in neurosyphilis epidemiology, diagnosis, and management. Modern estimates of the prevalence of neurosyphilis are hindered by the lack of consistent reporting data and are based on relatively small retrospective cohort studies. The various diagnostic modalities for neurosyphilis have significant limitations. Although several novel biomarkers for neurosyphilis have been evaluated, none to date have found a place in clinical practice. The role of a cerebrospinal fluid examination in patients without neurological symptoms continues to be an area of controversy, whereas the data for the use of antibiotic regimens other than intravenous aqueous or intramuscular procaine penicillin for the treatment of neurosyphilis are limited. As syphilis incidence continues to increase unabated in many countries around the world, it is critical to address these gaps of knowledge.

Over the past fifty years, intellectual property has not played a major role in the spread of assisted reproductive technology, but with in vitro gametogenesis — a technique likely to dominate the future of reproduction — it might.

The world’s current model for economic development is unsustainable. It encourages high levels of resource extraction, consumption, and waste that undermine positive environmental outcomes. Transitioning to a circular economy (CE) model of development has been proposed as a sustainable alternative. Artificial intelligence (AI) is a crucial enabler for CE. It can aid in designing robust and sustainable products, facilitate new circular business models, and support the broader infrastructures needed to scale circularity. However, to date, considerations of the ethical implications of using AI to achieve a transition to CE have been limited. This article addresses this gap. It outlines how AI is and can be used to transition towards CE, analyzes the ethical risks associated with using AI for this purpose, and supports some recommendations to policymakers and industry on how to minimise these risks.

Today, it seems impossible to discuss historians’ encounter with post-structuralist theory, the ensuing triumphant surge of the cultural turn, and the establishment of what scholars have recently called the postcultural historiography without the help of such paramount concepts of post-structuralist analysis as contingency, variability, instability, open-endedness, and so on. Having defined the last forty years of theoretical and methodological developments in history, these nowadays conventional tools of critique and interpretation have grown to become synonymous with the post-structuralist conceptual promise and outcome. This article questions this standard and exceptionally generous account. What if, the article asks, we start our account not with the resolute assertion of the radical contingency and variability of the post-structuralist view of history, but with something more fundamental to it—its own fixed and totalizing presuppositions? To show how an intellectual agenda opposed to fixed and totalizing reasoning can end up operating with fixed and totalizing logics of its own, the essay turns to Michel Foucault and his momentous career, to be traced from the 1960s to the 1980s.

Muskoxen (Ovibos moschatus) are an integral component of Arctic biodiversity. Given low genetic diversity, their ability to respond to future and rapid Arctic change is unknown, although paleontological history demonstrates adaptability within limits. We discuss status and limitations of current monitoring, and summarize circumpolar status and recent variations, delineating all 55 endemic or translocated populations. Acknowledging uncertainties, global abundance is ca 170 000 muskoxen. Not all populations are thriving. Six populations are in decline, and as recently as the turn of the century, one of these was the largest population in the world, equaling ca 41% of today’s total abundance. Climate, diseases, and anthropogenic changes are likely the principal drivers of muskox population change and result in multiple stressors that vary temporally and spatially. Impacts to muskoxen are precipitated by habitat loss/degradation, altered vegetation and species associations, pollution, and harvest. Which elements are relevant for a specific population will vary, as will their cumulative interactions. Our summaries highlight the importance of harmonizing existing data, intensifying long-term monitoring efforts including demographics and health assessments, standardizing and implementing monitoring protocols, and increasing stakeholder engagement/contributions.

In this groundbreaking book, Ilham Khuri-Makdisi establishes the existence of a special radical trajectory spanning four continents and linking Beirut, Cairo, and Alexandria between 1860 and 1914. She shows that socialist and anarchist ideas were regularly discussed, disseminated, and reworked among intellectuals, workers, dramatists, Egyptians, Ottoman Syrians, ethnic Italians, Greeks, and many others in these cities. In situating the Middle East within the context of world history, Khuri-Makdisi challenges nationalist and elite narratives of Mediterranean and Middle Eastern history as well as Eurocentric ideas about global radical movements. The book demonstrates that these radical trajectories played a fundamental role in shaping societies throughout the world and offers a powerful rethinking of Ottoman intellectual and social history.

Well before the turn of the century, it had become clear that archaeology's aspiration to study the past was, true to the modern project, a pretext for a deeper desire to fabricate its objects. Material culture, materiality, the material past, material residues, heritage—the objects of interpretive (post-processual) archaeology could only be characterized as a continuation of this modern project. While finding symmetry was tied to an upheaval from this mode of disciplinary production, it may now be characterized as one cue among others in more agile archaeological theory. After briefly contrasting archaeological thought before and after the turn of the century, this article sketches out some of the core features of an object-oriented approach to things, including symmetry, irreduction, emergent causality, and strangeness, among others. It then outlines how, by finding our way alongside things, we might aspire to ever more creative work with archaeological objects and their pasts. Finally, it closes with a few words on Posthumanism.