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"Turning points"
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PD-L1 and the dawn of modern cancer immunotherapy
Lieping Chen describes how his discoveries with PD-L1 yielded life-saving treatments for several cancers.
Journal Article
Finding the point of no return for cellular senescence
Eiji Hara is a professor at the Research Institute for Microbial Diseases, Osaka University, Japan. Eiji recalls the discovery of the basis for the irreversibility of cellular senescence, published in
Nature Cell Biology
in 2006.
Journal Article
A serendipitous discovery of a family of membrane remodelling proteins
Pietro De Camilli is a professor of neuroscience and of cell biology at Yale University, CT, as well as an investigator in the Howard Hughes Medical Institute. Pietro discusses how his group’s 1999
Nature Cell Biology
study linking amphiphysin with dynamin in clathrin-mediated endocytosis came to be.
Journal Article
The joy of scientific discoveries and interactions
Danfeng Cai, an assistant professor in the Department of Biochemistry and Molecular Biology at the Johns Hopkins Bloomberg School of Public Health, discusses her career path, including her work on the biomolecular condensation of YAP, and her excitement in her ongoing work on transcriptional condensates.
Journal Article
Changing course at the dawn of a genomics revolution
Sarah Teichmann, head of cellular genetics at the Wellcome Sanger Institute, reflects on the dawn of the single-cell genomics era and a pivotal decision that changed the course of her career.
Journal Article
It started with a western
Maria Antonietta (Antonella) De Matteis is a professor of biology at the University of Naples Federico II and leads the cell biology programme at the Telethon Institute of Genetics and Medicine in Pozzuoli, Italy. Antonella recalls the beginning of her research program on phosphatidylinositol 4-phosphate (PI4P) at the Golgi, published in our pages in 1999 and 2004.
Journal Article
Orphan nuclear receptors joining the reprogramming club
Huck-Hui Ng is a senior group leader at the Genome Institute of Singapore of A*STAR. In this article, Ng revisits the 2009
Nature Cell Biology
study in which he and his team described the role of Esrrb in somatic cell reprogramming.
Journal Article
New neurons are born in the adult human brain
Rusty Gage describes how evidence for neurogenesis in the adult human hippocampus shaped our understanding of learning, memory and mental health.
Journal Article
Reprogramming the tumor immune microenvironment to treat glioblastoma
Johanna Joyce describes how disrupting tumor-associated macrophages showed the importance of the tumor microenvironment in treating cancer.
Journal Article