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Eiji Hara is a professor at the Research Institute for Microbial Diseases, Osaka University, Japan. Eiji recalls the discovery of the basis for the irreversibility of cellular senescence, published in Nature Cell Biology in 2006.

Pietro De Camilli is a professor of neuroscience and of cell biology at Yale University, CT, as well as an investigator in the Howard Hughes Medical Institute. Pietro discusses how his group’s 1999 Nature Cell Biology study linking amphiphysin with dynamin in clathrin-mediated endocytosis came to be.

Maria Antonietta (Antonella) De Matteis is a professor of biology at the University of Naples Federico II and leads the cell biology programme at the Telethon Institute of Genetics and Medicine in Pozzuoli, Italy. Antonella recalls the beginning of her research program on phosphatidylinositol 4-phosphate (PI4P) at the Golgi, published in our pages in 1999 and 2004.

Huck-Hui Ng is a senior group leader at the Genome Institute of Singapore of A*STAR. In this article, Ng revisits the 2009 Nature Cell Biology study in which he and his team described the role of Esrrb in somatic cell reprogramming.

Danfeng Cai, an assistant professor in the Department of Biochemistry and Molecular Biology at the Johns Hopkins Bloomberg School of Public Health, discusses her career path, including her work on the biomolecular condensation of YAP, and her excitement in her ongoing work on transcriptional condensates.

Sarah Teichmann, head of cellular genetics at the Wellcome Sanger Institute, reflects on the dawn of the single-cell genomics era and a pivotal decision that changed the course of her career.

After earning a PhD in Molecular Systems Biology from ETH Zurich and studying cancer metabolism as a postdoctoral fellow at MIT, Sarah-Maria Fendt started an independent research group in 2013 in a joint appointment at the Flemish Institute for Biotechnology (VIB) and the University of Leuven (KU Leuven) in Belgium.

Nancy Kleckner is the Herchel Smith professor of molecular biology at Harvard University. She recalls the evolution of her research interests from pure genetics, through biochemistry and molecular biology of DNA, to the roles of mechanical forces for whole-chromosome spatial patterning and dynamics.

[...]she found a splice site mutation in my sister's FLNC gene, which encodes filamin C, and proposed that it was the cause of my family's illness1. Using personal correspondence with FLNC researchers\"? and the Inflammatory Bowel Disease DNA database\", I learned that this variant is found in 1 out of 800 Ashkenazi Jews, but not in other ethnic groups. Because most people with DCM do not know they have it, we only found seven subjects to study, but strikingly, three of them carried my family's mutation (ref. 5 and our unpublished data). To help remedy this situation, I have authored a book, The Dressmaker's Mirror: Sudden Death, Genetics, and a Jewish Family's Secret\", that intertwines my family stories of generations of love, loss and resilience with insights into genetics and the ongoing genetic revolution.

Juliane Fonseca de Oliveira is a mathematician at CIDACS in Salvador, Bahia, Brazil. She describes her part in building an epidemiological model to analyze the diverse populations within the 100 Million Brazilians Cohort.