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\"Charles Ulm and Charles Kingsford Smith were the original pioneers of Australian aviation. Together they succeeded in a number of record-breaking flights that made them instant celebrities in Australia and around the world: the first east-to-west crossing of the Pacific, the first trans-Tasman flight, Australia to New Zealand, the first flight from New Zealand to Australia. Business ventures followed for them, as they set up Australian National Airways in late 1928. Smithy was the face of the airline, happier in the cockpit or in front of an audience than in the boardroom. Ulm on the other hand was in his element as managing director. Ulm had the tenacity and organisational skills, yet Smithy had the charisma and the public acclaim. In 1932, Kingsford Smith received a knighthood for his services to flying, Ulm did not. Business setbacks and dramas followed, as Ulm tried to develop the embryonic Australian airline industry. ANA fought hard against the young Qantas, already an establishment favourite, but a catastrophic crash on the airline's regular route from Sydney to Melbourne and the increasing bite of the Great Depression forced ANA's bankruptcy in 1933. Desperate to drum up publicity for a new airline venture, Ulm's final flight was meant to demonstrate the potential for a regular trans-Pacific passenger service. Somewhere between San Francisco and Hawaii his plane, Stella Australis, disappeared. No trace of the plane or crew were ever found. In the years since his death, attention has focused more and more on Smithy, leaving Ulm neglected and overshadowed. This biography will attempt to rectify that, showing that Ulm was at least Smithy's equal as a flyer, and in many ways his superior as a visionary, as an organiser and as a businessman. His untimely death robbed Australia of a huge talent.\"--Amazon.com.

National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015. We mapped the most widely used list of causes amenable to personal health care developed by Nolte and McKee to 32 GBD causes. We accounted for variations in cause of death certification and misclassifications through the extensive data standardisation processes and redistribution algorithms developed for GBD. To isolate the effects of personal health-care access and quality, we risk-standardised cause-specific mortality rates for each geography-year by removing the joint effects of local environmental and behavioural risks, and adding back the global levels of risk exposure as estimated for GBD 2015. We employed principal component analysis to create a single, interpretable summary measure–the Healthcare Quality and Access (HAQ) Index–on a scale of 0 to 100. The HAQ Index showed strong convergence validity as compared with other health-system indicators, including health expenditure per capita (r=0·88), an index of 11 universal health coverage interventions (r=0·83), and human resources for health per 1000 (r=0·77). We used free disposal hull analysis with bootstrapping to produce a frontier based on the relationship between the HAQ Index and the Socio-demographic Index (SDI), a measure of overall development consisting of income per capita, average years of education, and total fertility rates. This frontier allowed us to better quantify the maximum levels of personal health-care access and quality achieved across the development spectrum, and pinpoint geographies where gaps between observed and potential levels have narrowed or widened over time. Between 1990 and 2015, nearly all countries and territories saw their HAQ Index values improve; nonetheless, the difference between the highest and lowest observed HAQ Index was larger in 2015 than in 1990, ranging from 28·6 to 94·6. Of 195 geographies, 167 had statistically significant increases in HAQ Index levels since 1990, with South Korea, Turkey, Peru, China, and the Maldives recording among the largest gains by 2015. Performance on the HAQ Index and individual causes showed distinct patterns by region and level of development, yet substantial heterogeneities emerged for several causes, including cancers in highest-SDI countries; chronic kidney disease, diabetes, diarrhoeal diseases, and lower respiratory infections among middle-SDI countries; and measles and tetanus among lowest-SDI countries. While the global HAQ Index average rose from 40·7 (95% uncertainty interval, 39·0–42·8) in 1990 to 53·7 (52·2–55·4) in 2015, far less progress occurred in narrowing the gap between observed HAQ Index values and maximum levels achieved; at the global level, the difference between the observed and frontier HAQ Index only decreased from 21·2 in 1990 to 20·1 in 2015. If every country and territory had achieved the highest observed HAQ Index by their corresponding level of SDI, the global average would have been 73·8 in 2015. Several countries, particularly in eastern and western sub-Saharan Africa, reached HAQ Index values similar to or beyond their development levels, whereas others, namely in southern sub-Saharan Africa, the Middle East, and south Asia, lagged behind what geographies of similar development attained between 1990 and 2015. This novel extension of the GBD Study shows the untapped potential for personal health-care access and quality improvement across the development spectrum. Amid substantive advances in personal health care at the national level, heterogeneous patterns for individual causes in given countries or territories suggest that few places have consistently achieved optimal health-care access and quality across health-system functions and therapeutic areas. This is especially evident in middle-SDI countries, many of which have recently undergone or are currently experiencing epidemiological transitions. The HAQ Index, if paired with other measures of health-system characteristics such as intervention coverage, could provide a robust avenue for tracking progress on universal health coverage and identifying local priorities for strengthening personal health-care quality and access throughout the world. Bill & Melinda Gates Foundation.

This book examines the role of banishment, a prevalent form of punishment largely neglected by scholars, in sixteenth-century Ulm, using the town's experience to uncover how early modern magistrates used expulsion to regulate and reorder society.

Traditional model predictive current control (MPCC) is heavily dependent on the accuracy of motor parameters and incurs high computational costs. To address these challenges, this paper proposes an enhanced model-free predictive current control (MFPCC) strategy based on ultra-local models (ULMs). Initially, a Kalman filter (KF) is used to estimate the current gain, while an adaptive sliding mode observer (SMO) is employed to estimate current disturbances. Subsequently, an equivalent transformation of the cost function is carried out in the αβ domain, and the voltage vector combinations are reduced to a single one via sector distribution. Hence, the proposed MFPCC is independent of motor parameters and capable of reducing computational complexity. Simulation and experimental results demonstrate that the proposed MFPCC method significantly improves computational efficiency and the robustness of current prediction, enabling precise current tracking even in the presence of motor parameter mismatches.

The Chilean Cybersyn project, an attempt to manage a nation’s economy by cybernetic methods, has evoked more and more interest in recent years. The project’s design lead and several team members were alumni of the Ulm School of Design—an institution that has been labelled “Bauhaus successor” and today is famous for a no-arts and method-led design approach with strong societal aspirations. The school also influenced the emerging design discipline in Latin America during the 1960s and 70s. This article reviews topics in the Ulm curriculum that influenced “Ulmian” thinking, but often remained unnoticed in design centred publications. Cybernetics, Operations Research and Information Theory and their relation to design are discussed and the related scholars are portrayed critically.

Since renewable energy sources (RESs) have an intermittent nature, conventional secondary frequency control, i.e., load frequency control (LFC), cannot mitigate the effects of variations in system frequency. Thus, this paper proposes incorporating ultralocal model (ULM) control into LFC to enhance microgrid (µG) frequency stability. ULM controllers are regarded as model-free controllers that yield high rejection rates for disturbances caused by load/RES uncertainties. Typically, ULM parameters are set using trial-and-error methods, which makes it difficult to determine the optimal values that will provide the best system performance and stability. To address this issue, the African vultures optimization algorithm (AVOA) was applied to fine-tune the ULM parameters, thereby stabilizing the system frequency despite different disturbances. The proposed LFC controller was compared with the traditional secondary controller based on an integral controller to prove its superior performance. For several contingencies, the simulation results demonstrated that the proposed controller based on the optimal ULM coupled with LFC could significantly promote RESs into the µG.

The estate of the Ulm city doctor Johann Franc (1649-1725) contains a previously unknown plague cure from the 18th century. It is based on the works “Auch das ein mensch zeichen gewun” by Engelin (around 1400), the “Pestbrief an die Frau von Plauen” (1366), “Der Sinn der höchsten Meister von Paris” (around 1350) and the Prague “Sendbrief” (1371). Franc compiled a new plague order in Latin from the writings available in the respective regional dialects from the period between 1349 and 1400.

The application of Model-Free Predictive Control (MFPC) in power electronic systems has garnered increasing attention. In this paper, MFPC control based on replacing the classical factory model with an ultra-local model (ULM) is studied. Generally, the Integral Sliding Mode Observer (ISMO) is used to estimate the unknown part in the ULM where the non-physical factor in the ULM is selected with approximate values ​​ranging from the nominal value of the system which is contrary to the concept of MFPC control. In this research, an improved adaptive integral sliding mode observer (AISMO) based MFPC (AISMO-MFPC ) is proposed to estimate this factor with the unknown function in the ULM equation. The new observer design enables the estimation of this factor based on the current error, which allows for independent prposedcontrol of the system parameters.To obtain the lowest current ripple, the concept of active vector execution time (AVET ) has been incorporated into the proposed control where two vectors are selected in the sampling period to minimize the cost function instead of selecting a single vector. ULM is also used to calculate AVET which facilitates the implementation of the imposed control. The combination of the proposed AISMO-MFPC and AVET gives faster system response and reduces the current ripple and lower harmonics, especially in case of mismatch parameters. Finally, the effectiveness of the proposed control is confirmed under various conditions by the presented simulation and experimental results.

Deep brain structures are supplied by perforating arteries, which are too thin to be observed with non-invasive and widely available clinical imaging methods. In moyamoya disease, main arteries in the base of the brain progressively narrow, and perforating arteries grow densely and tortuously to compensate the lack of blood supply in deep brain structures. The aim of this study is to evaluate the efficacy of transcranial ultrasound localization microscopy (ULM) in visualizing perforating arteries, utilizing a standard low-frame-rate ultrasound clinical scanner and contrast sequences commonly employed in hospital settings. This prospective single-center study included ischemic stroke patients not related to the study of perforating arteries, and moyamoya disease patients. Contrast-enhanced ultrasound sequences (CEUS) were performed by an experienced neurologist and the images acquired were used to perform post-processing ULM. ULM density maps were compared with conventional 3T TOF MRI and color Doppler imaging in both groups. We included a group of 15 control patients and another group of 9 moyamoya patients between March 2023 and March 2024. The patients had an average age of 45 ± 14 years (65% male). Perforating arteries were captured on all subjects, with a mean diameter of 0.8 ± 0.3 mm in control patients, while it was not possible with TOF MRI or color Doppler (P < 0.05). Moreover, ULM enabled to highlight differences between healthy subjects and those with moyamoya disease through track mean distance (P = 0.05). Using a low-frame-rate ultrasound scanner, CEUS and accessible post-processing tools, we demonstrate that transcranial ULM can facilitate the visualization and characterization of perforating arteries, even in cases where they were previously undetectable using standard non-invasive imaging techniques. We speculate that with the advent of high-frame-rate 3D ULM, this technique may find widespread utility in hospitals.

Azoospermia is a significant reproductive challenge. Differentiating between non-obstructive azoospermia (NOA) and obstructive azoospermia (OA) is crucial as each type requires distinct management strategies. Testicular microcirculation plays a profound role in spermatogenic functions. However, current diagnostic methods are limited in their ability to effectively elucidate this crucial connection. We employed ultrasound localization microscopy (ULM) to visualize testicular microcirculation in NOA and OA patients and quantified the testicular hemodynamic parameters. Pearson correlation analysis was conducted to investigate the inner connection between parameters of testicular microcirculation and clinical spermatogenic functions. We conducted multiple logistic regression analysis to establish a new diagnostic model that integrates follicle-stimulating hormone (FSH) and mean vascular diameter to distinguish NOA from OA. Our findings demonstrated significant differences in vascular parameters between NOA and OA, with NOA characterized by lower mean vascular diameter (p < 0.001), vessel density (p < 0.001), and fractal number (p < 0.001). Testicular volume showed a moderate positive correlation with mean vascular diameter (r = 0.419, p < 0.01) and vessel density (r = 0.415, p < 0.01); Mean vascular diameter exhibited negative correlations with both FSH (r = -0.214, p < 0.05) and age (r = -0.240, p < 0.05); FSH (r = -0.202, p < 0.05) and luteinizing hormone (LH) (r = -0.235, p < 0.05) were negatively correlated with mean blood flow velocity. The diagnostic model demonstrated an area under the curve (AUC) of 0.968. We also reported a method to map the vascular pressure distribution derived from the blood flow velocity generated by ULM. ULM provides a non-invasive and detailed assessment of testicular microvascular dynamics. The ULM-derived vascular parameters are able to connect testicular microcirculation to spermatogenic functions. The combination of FSH and mean vascular diameter enhances diagnostic precision and holds potential for distinguishing NOA from OA.