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Accurate diagnosis is essential for effective cancer treatment, particularly in peritoneal surface malignancies, where failure to detect metastatic lesions can mislead the treatment plan. This study assessed the diagnostic accuracy of staging laparoscopy using the integration of artificial intelligence (AI)‐guided photodynamic diagnosis (PDD) with the photosensitizer Phonozen, activated at 405 nm in a rabbit model. To create peritoneal carcinomatosis, VX2 cells were inoculated laparoscopically into the peritoneum of female white New Zealand rabbits. Conventional and PDD‐guided laparoscopy utilized a customized light source that emitted broad‐spectrum white light or 405‐nm blue light, respectively. The surgical procedure comprised a tripartite approach: exploration and labeling of suspected nodules under white‐light visualization, identification of additional metastatic tumors under blue‐excitation fluorescent light, and confirmatory open laparotomy to locate overlooked nodules by palpation. Our results showed that the initial experimental data from 371 nodules in 14 rabbits, comparing conventional diagnostic laparoscopy and PDD, showed increased detection sensitivity from 67% ± 1.9% (conventional) to 98% ± 0.7% (PDD) in the small‐size nodule. In the second experimental data set from 265 nodules in 10 rabbits, the addition of a real‐time AI algorithm further increased the sensitivity to 100% ± 0.0%. Combining PDD with AI enhances the detection of peritoneal cancer metastasis in staging laparoscopy. This study demonstrates the potential of combining photodynamic diagnosis (PDD) with artificial intelligence (AI) to significantly improve the detection of peritoneal metastases in a rabbit model. The PDD‐AI approach has substantial clinical implications, particularly in the early detection of peritoneal carcinomatosis, which is crucial for effective surgical planning, optimizing treatment strategies, and reducing cancer recurrence. The findings suggest that PDD‐AI could become a valuable tool in managing peritoneal surface malignancies, such as advanced gastric cancer, leading to improved patient outcomes.

To evaluate the effect of transcatheter arterial embolization (TAE) on metastatic bone tumors in an experimental study. Fifteen Japanese white rabbits were transplanted with VX2 sarcoma cells into the iliac crest. In 10 rabbits, the arterial supply to the iliac bone tumors, internal iliac artery and iliolumbar artery were then embolized with particles of gelatin sponge. The therapeutic effect was evaluated by comparison with the natural course of control tumors in the other five rabbits. After TAE, extensive necrosis, fibrosis, and vacuolization within the tumors were confirmed histologically. In the control rabbits, 19% +/- 7% of the entire tumor was found to be spontaneous tumor necrosis; in contrast, the tumors of the TAE group showed necrosis as 62% +/- 22% of the entire tumor. In one TAE group rabbit, no active tumor cell could be detected in the residual tumor. TAE was found to be an effective treatment for bone tumors in an experimental model.