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Objective To compare the efficacy and safety of vertebroplasty through different pedicle approaches in the treatment of osteoporotic vertebral compression fracture osteoporotic vertebral compression fractures (OVCF) by network meta-analysis. Methods Pubmed, Embase, Cochrane Library, Web of Science. Database for literature retrieval, retrieval time from the establishment of the database to April 2023, the randomized controlled trials of unilateral vertebroplasty (UVP), bilateral vertebroplasty (BVP), unilateral kyphoplasty (UKP), bilateral kyphoplasty (BKP), curved vertebroplasty (CVP) and curved kyphoplasty (CKP) were screened, evaluated and the data were extracted and included in the analysis. STATA 15.0 and ReMan 5.3 were used for data analysis. This study was registered in the National Institute for Health Research (NIHR) with the registration number CRD42023405181. Results This study included 16 articles with a total of 1712 patients. The order of visual analogue scale (VAS) improvement from good to bad is CVP > BVP > UVP > CKP > BKP > UKP. The order of kyphotic angles improvement from good to bad is CKP > UKP > UKP > UVP > BVP > CVP. The order of bone cement injection from less to more is UVP > CVP > UKP > CKP > BVP > BKP. The order of bone cement leakage rate from less to more is CKP > CVP > UKP > BKP > UVP > BVP. The order of X-ray exposure time from less to more is CKP > CVP > UVP > BVP > UKP > BKP. The order of operation time from less to more is CVP > UVP > UKP > CKP > BVP > BKP. Conclusion For patients with kyphotic angles, kyphoplasty has unique advantages in improving kyphotic angles. But generally speaking, curved approach can optimize the distribution of bone cement through unilateral approach to achieve the orthopedic effect of bilateral approach, which is a minimally invasive technique with better curative effect and higher safety in the treatment of OVCF.

Purpose The purpose of the present study is to identify independent risk factors for the occurrence of cement leakage (CL) during percutaneous vertebroplasty (PVP) for four different leakage types in treating osteoporotic vertebral compression fractures (OVCFs). Methods We retrospectively reviewed 292 patients who underwent PVP for single-level OVCF from January 2009 to March 2011. The influences of several potential risk factors that might affect the occurrence of CL were assessed using univariate and multivariate analyses. Cement leakage was evaluated by computed tomography and classified into four different types: through the basivertebral vein (B-type), the segmental vein (S-type), a cortical defect (C-type), and intradiscal leakage (D-type). Results Cement leakage was found in 227 of the 292 treated vertebrae. None of the parameters showed a statistically significant effect by univariate analysis. However, multivariate analysis showed that cement viscosity was an independent risk factor in B-type CL, fracture severity and fracture type were in S-type CL, fracture severity and presence of cleft on MRI were in C-type CL, and fracture severity, cortical disruption on MRI, presence of cleft on MRI and cement viscosity were in D-type CL. Conclusion Each different vertebral fracture pattern has its own risk factors for CL. Identification of the above predicting factors for CL preoperatively might be helpful for more rigorous and strict patient selection criteria for the appropriate candidates for PVP.

Background Vertebral height loss of fractured vertebrae treated by percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fracture (OVCFs) during follow-up had been reported. Mostly, vertebral height loss and its relevant terms (e.g., “recompression”, “recollapse” and “refracture”) were defined according to immediate postoperative vertebral height as the baseline in published studies. By contrast, vertebral height deterioration (VHD) was defined according to preoperative vertebral height as the baseline in the present study. The aim of the study was to reveal predictors for VHD in fractured vertebrae operated by percutaneous vertebroplasty (PVP), with a specific focus on surgical factors. Methods All patients with OVCFs treated by PVP between April 2016 and September 2018 were retrospectively reviewed. Patients were followed up for at least 12 months after procedure according to treatment protocol. VHD was defined as the presence of a decrease of vertebral height at final follow-up compared to preoperative. Clinical, radiological and surgical factors that might affect occurrence of VHD were assessed using univariate and multivariate analyses. Results A total of 543 patients (females 80%, age 73.2 ± 8.1 years) with 681 fractured vertebrae who underwent PVP were enrolled. Mean follow-up time was 28.9 ± 13.4 months (range, 12–59 months). Incidence of VHD in fractured vertebrae was 48.9% (333/681). One clinical factor and four radiological factors, including fracture age (OR = 0.513, 95% CI 0.385–0.683, p  = 0.000), fracture location (OR = 2.878, 95% CI 1.994–4.152, p  = 0.000), fracture severity (OR = 0.521, 95% CI 0.386–0.703, p  = 0.000), cortical defect on lateral wall (OR = 2.535, 95% CI 1.351–4.758, p  = 0.004) and intravertebral cleft (OR = 2.362, 95% CI 1.488–3.750, p  = 0.000), were independent predictors for VHD. However, all the surgical factors evaluated were not significant in final model analysis. Conclusions Surgical factors might play a negligible effect on VHD. VHD might be due to natural course of fracture/osteoporosis.

The aim of this research was to conduct randomized trials assessing the extent of cement diffusion following robot-assisted percutaneous vertebroplasty (R-PVP) for osteoporotic vertebral compression fractures (OVCF). A total of 96 OVCF patients meeting the inclusion criteria and admitted between January 2023 and November 2023 were included in the study. Among them, 48 patients were assigned to the robotic-assisted PVP group (R-PVP group) and 48 patients were assigned to the traditional PVP group (PVP group). The study examined the differences in age, sex, BMD T-value, fracture segment, preoperative, postoperative, and 3-month postoperative visual analogue scale (VAS) and Oswestry disability index (ODI) pain scores, fluoroscopic dose, frequency of fluoroscopy, volume of bone cement injected, angle of puncture abduction, degree of cement diffusion, and bone cement spillage among the two patient groups. A logistic regression model was employed to analyze the factors influencing the extent of postoperative bone cement diffusion. The findings indicated that the R-PVP group exhibited a significantly larger puncture abduction angle, improved postoperative cement dispersion, increased cement injection volume, and decreased incidence of cement spillage compared to the PVP group. Furthermore, the R-PVP group demonstrated superior outcomes in these aspects, as well as lower intraoperative fluoroscopic frequency and radiation exposure. Additionally, bone density, puncture abduction angle, cement injection volume, and surgical approach were identified as independent factors associated with the extent of postoperative cement dispersion.

Background Osteoporotic vertebral compression fractures (OVCF) severely affect the quality of life in the aged population. Percutaneous vertebroplasty (PVP) alleviates pain and stabilizes vertebrae, but suboptimal bone cement distribution can cause complications. Hence, this study aimed to clarify whether a new technique for PVP, using a curved guide wire, enhances the distribution of bone cement and improves clinical outcomes in patients with OVCF. Methods Patients with single-segment OVCF underwent PVP or curved guide wire percutaneous vertebroplasty (C-PVP). Propensity score matching (PSM) was employed to balanced the baseline characteristics. The primary outcomes were the visual analog scale (VAS) and Oswestry disability index (ODI) scores. The secondary outcomes included assessments of bone cement distribution, bone cement injection volume, radiological parameters, and general clinical results. Additionally, Complications and adverse events were documented. Results After PSM analysis, each group comprised 54 patients, which significantly reduced baseline differences. The C-PVP group showed better clinical outcomes compared to the traditional PVP group. One month after surgery, the C-PVP group had significantly lower VAS and ODI scores ( p  < 0.001). These improvements persisted at six months and the final follow-up. Additionally, bone cement distribution scores were better ( p  < 0.001), injection volume was higher ( p  = 0.03), leakage was less frequent ( p  = 0.02), and adjacent vertebral fractures occurred less frequently ( p  = 0.04) in the C-PVP group. Radiological parameters and overall clinical outcomes revealed no significant differences between the two groups. Conclusion The use of curved guide wire in PVP significantly improves bone cement distribution and injection volume, resulting in better clinical efficacy in patients with OVCF.

Objective To investigate whether the unilateral posterosuperior approach PVP is superior to the traditional unilateral transpedicular approach in the treatment of acute osteoporotic vertebral compression fractures (OVCFs). Methods A retrospective study was conducted on 167 patients with single-segment acute OVCFs admitted to our hospital from September 2019 to March 2022. Patients were divided into two groups according to the type of intraoperative approach used: the unipedicular posterosuperior approach vertebroplasty (UPV) group ( n  = 85) and the unilateral transpedicular approach vertebroplasty (UTV) group ( n  = 82). Surgical data, including operation time, blood loss, fluoroscopy frequency, puncture needle crossing the midline during surgery, and bone cement injection volume, were collected. Imaging data, such as vertebral height, distribution of bone cement, and cement leakage, were analyzed. Clinical efficacy indicators, including the Visual analogue scale (VAS) score and Oswestry Disability Index (ODI), were compared. Additionally, the occurrence of vertebral refracture, adjacent vertebral fracture, and postoperative complications were assessed. Results Both groups were followed up for an average of 13.6 months (range: 12–24 months). No statistically significant differences were detected between the UPV and UTV groups in terms of the VAS and ODI scores or the vertebral height. The two groups had similar blood loss rates, fluoroscopy frequencies, and operation times. However, the UPV group presented a greater volume of bone cement injected and a better dispersion pattern of bone cement (10.75 ± 0.48 vs. 7.56 ± 1.86) ( P  < 0.05). The occurrence of vertebral collapse after surgery was positively correlated with the distribution of bone cement. Cement leakage was observed in 5 patients in the UPV group and 10 patients in the UTV group. The UPV group had 2 cases of adjacent vertebral refracture within six months, whereas the UTV group had 5 cases. One adverse event, pneumothorax, occurred in the UPV group. However, due to the retrospective nature of the study, there was a lack of control over confounding variables such as age, bone mineral density, and comorbidities, which may affect the interpretation of the results. Conclusions PVP via the unilateral approach effectively relieves back pain in patients with OVCFs. The unilateral posterosuperior approach allows for the injection of a greater volume of bone cement, resulting in a more even distribution within the vertebral body. However, caution should be exercised to avoid excessive lateral puncture points.

Purpose Leakage is the most common complication of percutaneous cement augmentation of the spine. The viscosity of the polymethylmethacrylate (PMMA) cement is strongly correlated with the likelihood of cement leakage. We hypothesized that cement leakage can be reduced by sequential cement injection in a vertebroplasty model. Methods A standardized vertebral body substitute model, consisting of aluminum oxide foams coated by acrylic cement with a preformed leakage path, simulating a ventral vein, was developed. Three injection techniques of 6 ml PMMA were assessed: injection in one single step (all-in-one), injection of 1 ml at the first and 5 ml at the second step with 1 min latency in-between (two-step), and sequential injection of 0.5 ml with 1-min latency between the sequences (sequential). Standard PMMA vertebroplasty cement was used; each injection type was tested on ten vertebral body substitute models with two possible leakage paths per model. Leakage was assessed by radiographs using a zonal graduation: intraspongious = no leakage and extracortical = leakage. Results The leakage rate was significantly lower in the “sequential” technique (2/20 leakages) followed by “two-step” (15/20) and “all-in-one” (20/20) techniques ( p  < 0.001). The RR for a cement leakage was 10.0 times higher in the “all-in-one” compared to the “sequential” group (95 % confidence intervals 2.7–37.2; p  < 0.001). Conclusions The sequential cement injection is a simple approach to minimize the risk for leakage. Taking advantage of the temperature gradient between body and room temperature, it is possible to increase the cement viscosity inside the vertebra while keeping it low in the syringe. Using sequential injection of small cement volumes, further leakage paths are blocked before further injection of the low-viscosity cement.

Background Osteoporotic vertebral compression fractures affect a large number of elderly people and cause significant issues with pain and mobility. Percutaneous vertebroplasty (PVP) and kyphoplasty (PKP) are employed to treat those who remain symptomatic, with comparable clinical outcomes. Although PVP is faster and less expensive, concerns around cement-leakage complications make PKP perceptively safer. Methods By means of systematic review, we sought to ascertain whether PVP did carry a higher risk of cement-leakage and associated symptomatic complications (neural compromise, pulmonary embolism and need for emergency decompression surgery). Results Our search of 138 articles returned six studies after shortlisting and manual review: three randomised-controlled trials, and three retrospective comparative studies which met our criteria and directly compared cement-leakage rates and complications between the two treatments. 532 PVPs and 493 PKPs recorded 213 (39.3%) and 143 (28.9%) leaks, respectively ( p < 0.0005). Of these, no leaks resulted in any of the aforementioned leak-related complications. No meta-analysis was performed due to heterogeneity of the data. Conclusions We therefore concluded that whilst PVP does result in more cement leaks, this does not appear to be clinically significant. Further studies would add weight to this conclusion, and cost-effectiveness should be assessed to restore confidence in PVP. Level of evidence Level III Evidence.

ObjectiveTo evaluate the incidence and risk factors for ICE during a PV.Materials and methodsSingle-center retrospective analysis of 1512 consecutive patients who underwent 1854 PV procedures for osteoporotic (34 %), malignant (39.9 %) or other cause (26.1 %) of vertebral compression fractures (VCFs)/spine tumor lesions. Only thoracic or lumbar PVs were included. PVs were performed with polymethylmethacrylate (PMMA) low-viscosity bone cement under fluoroscopic guidance. Chest imaging (X-ray or CT) was performed the same day after PV in patients with high clinical suspicion of ICE. All post-procedural chest-imaging examinations were reviewed, and all ICEs were agreed upon in consensus by two radiologists.ResultsICEs were detected in 72 patients (92 cement embolisms). In 86.1 % of the cases, concomitant pulmonary artery cement leakage was detected. Symptomatic ICEs were observed in six cases (8.3% of all ICEs; 0.32% of all PV procedures). No ICE led to death or permanent sequelae. Multiple levels treated during the same PV session were associated with a higher ICE rate [OR: 3.59, 95% CI: (1.98-6.51); p < 0.001]; the use of flat panel technology with a lower ICE occurrence [OR: 0.51, 95% CI: (0.32-0.83); p = 0.007].ConclusionIntracardiac cement embolism after PV has a low incidence (3.9 % in our study). Symptomatic complications related to ICE are rare (0.3%); none was responsible for clinical sequelae in our series.Key Points• The incidence of intracardiac cement embolism (ICE) during PVP is low (3.9%).• Having a high number of treated vertebrae during the same session is a significant risk factor for ICE.• Symptomatic intracardiac cement embolisms have a low incidence (8.3% of patients with ICE).

AbstractObjectiveTo assess whether percutaneous vertebroplasty results in more pain relief than a sham procedure in patients with acute osteoporotic compression fractures of the vertebral body.DesignRandomised, double blind, sham controlled clinical trial.SettingFour community hospitals in the Netherlands, 2011-15.Participants180 participants requiring treatment for acute osteoporotic vertebral compression fractures were randomised to either vertebroplasty (n=91) or a sham procedure (n=89).InterventionsParticipants received local subcutaneous lidocaine (lignocaine) and bupivacaine at each pedicle. The vertebroplasty group also received cementation, which was simulated in the sham procedure group.Main outcome measuresMain outcome measure was mean reduction in visual analogue scale (VAS) scores at one day, one week, and one, three, six, and 12 months. Clinically significant pain relief was defined as a decrease of 1.5 points in VAS scores from baseline. Secondary outcome measures were the differences between groups for changes in the quality of life for osteoporosis and Roland-Morris disability questionnaire scores during 12 months’ follow-up.ResultsThe mean reduction in VAS score was statistically significant in the vertebroplasty and sham procedure groups at all follow-up points after the procedure compared with baseline. The mean difference in VAS scores between groups was 0.20 (95% confidence interval −0.53 to 0.94) at baseline, −0.43 (−1.17 to 0.31) at one day, −0.11 (−0.85 to 0.63) at one week, 0.41 (−0.33 to 1.15) at one month, 0.21 (−0.54 to 0.96) at three months, 0.39 (−0.37 to 1.15) at six months, and 0.45 (−0.37 to 1.24) at 12 months. These changes in VAS scores did not, however, differ statistically significantly between the groups during 12 months’ follow-up. The results for secondary outcomes were not statistically significant. Use of analgesics (non-opioids, weak opioids, strong opioids) decreased statistically significantly in both groups at all time points, with no statistically significant differences between groups. Two adverse events occurred in the vertebroplasty group: one respiratory insufficiency and one vasovagal reaction.ConclusionsPercutaneous vertebroplasty did not result in statistically significantly greater pain relief than a sham procedure during 12 months’ follow-up among patients with acute osteoporotic vertebral compression fractures.Trial registrationClinicalTrials.gov NCT01200277.