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Effective education for health volunteers plays a pivotal role, considering their contribution to promoting community health. Given the aging population and its associated challenges, it is crucial to develop effective and low-cost programs to enhance the knowledge and attitudes of health volunteers and improve the quality of life for older adults. This study investigated the effect of active aging education on the knowledge and attitudes of health volunteers. This study was conducted from November 2023 to February 2024 on 86 health volunteers at comprehensive health centers in Shiraz City. The volunteers were randomly divided into two groups: intervention and control. The data collection tool was a questionnaire. Following the pre-test, the content was delivered in six training sessions. Post-tests were administered to both groups immediately after the intervention and two months later. The data were analyzed using SPSS version 23, employing frequency analysis, the Chi-square test, the t-test, and repeated measures tests. A significance level of 0.05 was considered. The findings revealed that health volunteers' knowledge significantly increased after the educational intervention. There was a statistically significant difference in the mean knowledge score in the intervention group at the three-time points (before, immediately after, and two months after the intervention) based on the repeated measures test (P < 0.001). Additionally, the attitude of health volunteers improved significantly following the educational intervention (P < 0.001). Trained volunteers can effectively convey critical health and cultural messages, make informed decisions, and enhance the local population's access to primary healthcare. The results of this study demonstrate that the active aging educational intervention improved the knowledge and attitudes of health volunteers. Therefore, leveraging the potential of health volunteers to teach active aging can improve the health and well-being of the elderly population.

Peer influence processes have been documented extensively for a wide range of maladaptive adolescent behaviors. However, peer socialization is not inherently deleterious, and little is known about whether adolescents influence each other's prosocial behaviors, or whether some peers are more influential than others towards positive youth outcomes. This study addressed these questions using an experimental \"chat room\" paradigm to examine in vivo peer influence of prosocial behavior endorsement. A school-based sample of 304 early adolescents (55% female, 45% male; M(age) = 12.68) believed they were interacting electronically with same-gender grademates (i.e., \"e-confederates\"), whose peer status was experimentally manipulated. The participants' intent to engage in prosocial behaviors was measured pre-experiment and in subsequent \"public\" and \"private\" experimental sessions. Overall, the adolescents conformed to the e-confederates' prosocial responses in public; yet, these peer influence effects were moderated by the peer status of the e-confederates, such that youth more strongly conformed to the high-status e-confederates than to the low-status ones. There also was some evidence that these peer influence effects were maintained in the private session, indicating potential internalization of prosocial peer norms. These findings help bridge the positive youth development and peer influence literatures, with potential implications for campaigns to increase prosocial behaviors.

Psychological distress is prevalent in students and can predispose to psychiatric disorders. Recent findings indicate that distress might be linked to impaired cognitive performance in students. Experimental findings in healthy participants suggest that placebo interventions can improve cognition. However, whether non-deceptive (i.e., open-label, OLP) placebos can enhance cognitive function and emotional well-being is unclear. Using a randomized-controlled design we demonstrate a positive impact of OLP on subjective well-being (i.e., stress, fatigue, and confusion) after a 21-day OLP application in healthy students during midterm exams. OLP did not improve test performance, but, within the OLP group, test performance was positively correlated with measures of general belief in the benefit of medication. These results show that OLP can counteract negative effects of acute stress on psychological well-being and might improve cognitive performance if supported by positive treatment expectations. Additionally, our findings in healthy volunteers warrant further investigation in exploring the potential of OLP in reducing stress-related psychological effects in patients. The trial was preregistered at the German Clinical Trials Register on December 20, 2017 (DRKS00013557).

Background The aim of this randomized control trial is to test the impact of providing additional training and support to volunteers who are paired with youth of color in the Big Brothers Big Sisters (BBBS) community-based mentoring program. The aim of the intervention activities is to enhance the capacity of mentors to have more culturally responsive and informed interactions with their mentees of color, thereby strengthening the youth’s ethnic/racial identity and abilities to both cope with experiences of racism and contribute to causes that advance social justice. Methods Recruitment started in June 2022, with a goal of enrolling 240 dyads (i.e., “matches”), each consisting of a volunteer mentor and a youth of color aged 9- to 17-years old with whom they were paired through BBBS. Each match is assigned randomly to receive either standard BBBS services or to services that incorporate the intervention activities (i.e., approximately 3 h of initial training that is then supplemented with booster emails and in the context of the contacts that case managers have with mentors routinely in the program). The BBBS staff who are responsible for delivering the enhancements receive preparatory training as well as ongoing support with implementation. The study has a mixed-methods design. Survey data, on outcomes (e.g., ethnic/racial identity, sense of mattering, efficacy) aligned with the theory of change, are collected at multiple time points within 12 months from mentors, youth and their parent/guardian, and BBBS staff. Multiple qualitative interviews are conducted with a subset of youth, mentors, parents and BBBS staff to examine how the intervention works and how it impacts relationship development and youth outcomes over time. Integration of quantitative and qualitative data will aim to better understand whether and how the intervention works with respect to its potential influence on mentor attitudes (e.g., cultural humility), mentor-youth interactions, and emergent identities and capacities that have well-documented importance for the resilience and well-being of youth of color. Discussion This culturally tailored training and support intervention for volunteer mentors may be one way to increase the effectiveness of mentoring programs for youth of color. Study findings will have implications for youth mentoring programs and for other settings (e.g., schools, after school programs) in which children and adolescents form relationships with adults. Trial registration www.clinicaltrials.gov —Clinical Trial #NCT05391711; original 05.21.2022; Amendment 07.01.2022: study status was updated and more details were provided on outcome measures; Amendment 11/13/2022: sample size was modified, a few mentor outcome measures were added in the 12-months survey, the timing of a mentor measure was updated.

Given the interest in improving executive functions, the present study examines a promising combination of two training techniques: neurofeedback training (NFT) and working memory training (WMT). NFT targeted increasing the amplitude of individual’s upper Alpha frequency band at the parietal midline scalp location (Pz), and WMT consisted of an established computerized protocol with working memory updating and set-shifting components. Healthy participants (n = 140) were randomly allocated to five combinations of training, including visual search training used as an active control training for the WMT; all five groups were compared to a sixth silent control group receiving no training. All groups were evaluated before and after training for resting-state electroencephalogram (EEG) and behavioral executive function measures. The participants in the silent control group were unaware of this procedure, and received one of the training protocols only after study has ended. Results demonstrated significant improvement in the practice tasks in all training groups including non-specific influence of NFT on resting-state EEG spectral topography. There was only a near transfer effect (improvement in working memory task) for WMT, which remained significant in the delayed post-test (after 1 month), in comparison to silent control group but not in comparison to active control training group. The NFT + WMT combined group showed improved mental rotation ability both in the post-training and in the follow-up evaluations. This improvement, however, did not differ significantly from that in the silent control group. We conclude that the current training protocols, including their combination, have very limited influence on the executive functions that were assessed in this study.

Background Peers with lived experiences of being in recovery of mental health difficulties volunteering in non-governmental organizations (NGOs) to engage in peer support show significant promise in supporting personal recovery for individuals with similar mental health difficulties. “The ‘Paths to Everyday Life’ (PEER) intervention was evaluated in a randomized trial during 2020–2022. As part of a process evaluation, qualitative studies were conducted to explore the perspectives of both recipients and facilitators of the community-based peer support. This qualitative study, underpinned by critical realism, examined how the delivery of the intervention is achieved, the training, and the working conditions from the perspective of the peers volunteering in the NGO operating the project. Methods Nine peer volunteers were recruited for two focus groups ( n  = 8) and a telephone-based interview ( n  = 1). The semi-structured realist inspired interviews were audio recorded and transcribed verbatim. The analysis was guided by reflective thematic analysis and through an abductive framework based on knowledge in the field and the PEER intervention context. Data were coded and analysed in Nvivo software version 1.7 (QSR International). Results Two overarching themes were identified: (1) ‘The contradictory dual role of facilitating groups and sharing equally’; (2) ‘Equipped to facilitate groups’, as well as several sub-themes. In addition, a minor theme has been identified: (3) ‘Volunteer one-on-one peer support is unscripted’. Conclusion Peer volunteers providing group-based peer support in the community show significant promise. Training in trauma-informed, structured formats and fostering equal, reciprocal relationships among peer co-facilitators and participants greatly enhanced group impact. The organizational support and supervision enhanced peer volunteers’ preparedness for co-facilitation roles, yet the one-on-one peer support for community engagement, sought by only a few participants, requires further clarification and exploration. Trial registration ClinicalTrials.gov identifier: NCT04639167, Registered on Nov. 19, 2020.

To display goal-directed behavior, we must be able to resolve response conflicts that arise from processing various distractors. Such conflicts may be triggered by different kinds of distractor stimuli (e.g., priming and flanker stimuli), but it has remained largely unclear whether the functional and neurobiological underpinnings of both conflict types differ. We therefore investigated the functional relevance of the catecholamines dopamine and norepinephrine, which have been shown to increase the signal-to-noise ratio in neuronal processing and should therefore modulate response conflicts. In a double-blind, randomized, placebo-controlled study design, we examined the effect of methylphenidate (0.5 mg/kg) on both flanker-induced and priming-induced response conflicts in a group of n=25 healthy young adults. We used EEG recordings to examine event-related potentials in combination with source localization analyses to identify the cognitive-neurophysiological subprocesses and functional neuroanatomical structures modulated by methylphenidate. Compared with placebo, methylphenidate decreased flanker conflicts. This was matched by increased congruency effects in the fronto-central N2/P3 event-related potential complex and associated with modulations in the right inferior frontal gyrus. In contrast to this, methylphenidate did not modulate the size of prime-evoked conflicts. Our results suggest that catecholamine-driven increases in signal-to-noise ratio and neural gain control do not equally benefit differently evoked conflicts. This supports the hypothesis of an at least partly different neurobiological basis for flanker- and prime-evoked response conflicts. As the right inferior frontal gyrus plays an important role in inhibition, the catecholaminergic system may reduce flanker conflicts by supporting the inhibition of distracting information.

RationaleObsessive–compulsive disorder (OCD) is characterized by executive function impairment and by clinical responsivity to selective serotonin reuptake inhibitors (SSRIs). Executive planning deficits constitute a candidate endophenotype for OCD. It is not known whether this endophenotype is responsive to acute serotonin manipulation.ObjectiveThe study aimed to investigate the effects of acute SSRI administration on executive function in patients with OCD, first-degree relatives of patients with OCD, and healthy controls.MethodsA randomized double-blind cross-over study assessed the effects of single-dose escitalopram (20 mg) and placebo on executive planning in 24 patients with OCD, 13 clinically unaffected first-degree relatives of patients with OCD, and 28 healthy controls. Performance on a Tower of London task measuring executive planning was assessed 4 h after oral administration of the pharmacological challenge/placebo and compared across and within groups using a mixed model analysis of variance.ResultsOn the outcome measure of interest, i.e., the mean number of choices to obtain the correct solution, there was a marginally significant effect of group (F(2, 59) = 3.1; p = 0.052), with patients (least square (LS) mean 1.43; standard error [SE] 0.06; 95% confidence interval (CI), 1.31–1.55) and their relatives (LS mean 1.46; SE 0.08; 95% CI, 1.30–1.62) performing worse than matched healthy controls (LS mean 1.26; SE 0.05; 95% CI, 1.15–1.37) on placebo. There was a trend towards a significant group × treatment interaction (F(2, 58) = 2.8, p = 0.069), with post hoc tests showing (i) patients (p = 0.009; LS mean difference 0.23; SE 0.08) and relatives (p = 0.03; LS mean difference 0.22; SE 0.10) were more impaired compared to controls and (ii) escitalopram was associated with improved executive planning in patients with OCD (p = 0.013; LS mean difference 0.1; SE 0.04), but not other groups (both p > 0.1; controls: LS mean difference − 0.03; SE 0.04; relatives: LS mean difference 0.02; SE 0.05).ConclusionOur findings are consistent with a view that there is impaired executive planning in OCD and that this constitutes a behavioural endophenotype. In patients with OCD, but not in relatives, acute SSRI administration ameliorated this deficit. Further investigation is needed to understand common and differential involvement of neurochemical systems in patients with OCD and their relatives.

Background Social isolation and loneliness (SIL) worsens mortality and other outcomes among older adults as much as smoking. We previously tested the impact of the HOW R U? intervention using peer support from similar-aged volunteers and demonstrated reduced SIL among older adults discharged from the emergency department (ED). Generativity, defined as “the interest in establishing and guiding the next generation,” can provide an alternative theoretical basis for reducing SIL via intergenerational programs between members of younger and older generations. The current protocol will examine the impact of younger intergenerational volunteers providing the HOW RU? intervention. Methods In this randomized clinical trial, we will compare the following three arms: (1) the standard same-generation peer support HOW R U? intervention, (2) HOW R U? intervention delivered by intergenerational volunteers, and (3) a common wait-list control group. Outcome assessors will be blinded to the intervention. Trained volunteers will deliver 12 weekly telephone support calls. We will recruit participants ≥ 70 years of age with baseline loneliness (six-item De Jong loneliness score of 2 or greater) from two EDs. Research staff will assess SIL, depression, quality of life, functional status, generativity, and perceived benefit at baseline, at 12 weeks, and 24 weeks post-intervention. Discussion We hypothesize participants receiving the intergenerational intervention will show improved outcomes compared to the control group and peer support HOW R U? intervention. We also hypothesize that participants with higher perceptions of generativity will have greater reductions in SIL than their lower generativity counterparts. Aging is experienced diversely, and social interventions combatting associated SIL should reflect that diversity. As part of a program of research following the Obesity-Related Behavioral Intervention Trials (ORBIT) model, the findings of this RCT will be used to define which intervention characteristics are most effective in reducing SIL. Trial registration ClinicalTrials.gov NCT05998343 Protocol ID:21-0074E. Registered on 24 July 2023.

This double-blind, randomized, within-subjects design evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females, 10 males) underwent a functional magnetic resonance imaging scan while performing a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from serum and sequenced. Results showed that: (1) 600 mg of ibuprofen exhibited higher miR-27b-3p, miR-320b, miR-23b and miR-203a-3p expression than placebo; (2) higher mir-27b-3p was associated with lower insula activation during MID loss anticipation; and (3) there was an inverse relationship between miR-27b-3p and MID gain anticipation in bilateral putamen during placebo, a pattern attenuated by both 200 mg and 600 mg of ibuprofen. These findings are consistent with the hypothesis that miR-27b could be an important messaging molecule that is associated with regulating the processing of positive or negative valenced information.