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"Walls"
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Structural evolution of a fungal cell wall protein family for β-glucan-binding and cell separation
Fungal cell walls are dynamic extracellular structures essential for growth and morphogenesis, making them prime targets for antifungal drugs and the host immune system. Although many protein families involved in the synthesis, crosslinking, and degradation of cell wall polymers are known, the molecular functions and structural evolution of most cell wall proteins remain poorly understood. Our in-depth structural, functional, and phylogenetic analysis of the fungal SUN domain protein family sheds light on a central question: how specific protein families have evolved structurally to enable dynamic cell wall remodeling during growth and division. Moreover, this work identifies precise structural targets within the fungal cell wall that could guide the development of novel diagnostics and therapeutics against life-threatening fungal infections.
Journal Article
Talking walls : discover your world
An illustrated description of walls around the world and their significance, from the Great Wall of China to the Berlin Wall.
Book
Cardiac αVβ3 integrin expression following acute myocardial infarction in humans
ObjectiveMaladaptive repair contributes towards the development of heart failure following myocardial infarction (MI). The αvβ3 integrin receptor is a key mediator and determinant of cardiac repair. We aimed to establish whether αvβ3 integrin expression determines myocardial recovery following MI.Methods18F-Fluciclatide (a novel αvβ3-selective radiotracer) positron emission tomography (PET) and CT imaging and gadolinium-enhanced MRI (CMR) were performed in 21 patients 2 weeks after ST-segment elevation MI (anterior, n=16; lateral, n=4; inferior, n=1). CMR was repeated 9 months after MI. 7 stable patients with chronic total occlusion (CTO) of a major coronary vessel and nine healthy volunteers underwent a single PET/CT and CMR.Results18F-Fluciclatide uptake was increased at sites of acute infarction compared with remote myocardium (tissue-to-background ratio (TBRmean) 1.34±0.22 vs 0.85±0.17; p<0.001) and myocardium of healthy volunteers (TBRmean 1.34±0.22 vs 0.70±0.03; p<0.001). There was no 18F-fluciclatide uptake at sites of established prior infarction in patients with CTO, with activity similar to the myocardium of healthy volunteers (TBRmean 0.71±0.06 vs 0.70±0.03, p=0.83). 18F-Fluciclatide uptake occurred at sites of regional wall hypokinesia (wall motion index≥1 vs 0; TBRmean 0.93±0.31 vs 0.80±0.26 respectively, p<0.001) and subendocardial infarction. Importantly, although there was no correlation with infarct size (r=0.03, p=0.90) or inflammation (C reactive protein, r=−0.20, p=0.38), 18F-fluciclatide uptake was increased in segments displaying functional recovery (TBRmean 0.95±0.33 vs 0.81±0.27, p=0.002) and associated with increase in probability of regional recovery.Conclusion18F-Fluciclatide uptake is increased at sites of recent MI acting as a biomarker of cardiac repair and predicting regions of recovery.Trial registration numberNCT01813045; Post-results.
Journal Article
Ancient city walls in China : a heritage rediscovered
\"In numerous civilizations throughout world history city walls were an indispensable part of every city. In China they can be traced back to the 21th century BC as fortified symbols of power and manifestation of the Middle Kingdom. In the course of the country's long history several thousand have been erected, varying enormously in form, length, construction technology, functionality and significance. These city walls represent a unique heritage and a central identification factor from which to gain access to the self-image of Chinese culture. After years of decay and ignorance, it was only a few decades ago that they were discovered as cultural monuments and the securing and restoration work began. The city walls recorded in the statistics today, of which a selection is presented in this book by new and historic photos, range from wall ruins in the ground via about 150 with a length of more than one kilometer to the famous fortification of Nanjing, which still has more than 20 kilometers standing.\" -- amazon
Book
Plant cell wall integrity maintenance in model plants and crop species-relevant cell wall components and underlying guiding principles
The walls surrounding the cells of all land-based plants provide mechanical support essential for growth and development as well as protection from adverse environmental conditions like biotic and abiotic stress. Composition and structure of plant cell walls can differ markedly between cell types, developmental stages and species. This implies that wall composition and structure are actively modified during biological processes and in response to specific functional requirements. Despite extensive research in the area, our understanding of the regulatory processes controlling active and adaptive modifications of cell wall composition and structure is still limited. One of these regulatory processes is the cell wall integrity maintenance mechanism, which monitors and maintains the functional integrity of the plant cell wall during development and interaction with environment. It is an important element in plant pathogen interaction and cell wall plasticity, which seems at least partially responsible for the limited success that targeted manipulation of cell wall metabolism has achieved so far. Here, we provide an overview of the cell wall polysaccharides forming the bulk of plant cell walls in both monocotyledonous and dicotyledonous plants and the effects their impairment can have. We summarize our current knowledge regarding the cell wall integrity maintenance mechanism and discuss that it could be responsible for several of the mutant phenotypes observed.
Journal Article
Building physics of the envelope : principles of construction
The facade is the building's interface with its environment. It is here that building physics parameters such as heat, humidity, sound and light interact with the building. All these influences need to be controlled by the building envelope in order to ensure the comfort of the user and the functional performance of the architecture. This introduction explains the most important phenomena and then relates them to design and building practice - which materials react in which way to these factors? How do facade systems deal with heat, humidity, sound and light? This practice-oriented book, which is the result of cooperation between an architect and a structural engineer, describes the most important facade materials and constructions under the aspect of their building physics performance.
Book
Protein QID74 protects the cell wall of Trichoderma from degradation caused by its own chitinase, which lacks a carbohydrate-binding module
This study uncovers a unique survival strategy in Trichoderma . By lacking a carbohydrate-binding module, Trichoderma ’s chitinase can effectively degrade host cell walls while minimizing self-damage. The protective protein QID74 further safeguards the cell wall by binding to the chitinase. This research offers novel insights into fungal biology and ecology, with potential applications in developing sustainable biocontrol agents.
Journal Article
Mechanistic insights into SteAB regulation of cell wall hydrolase RipA in Mycobacterium tuberculosis
Peptidoglycan (PG) is a major component of the bacterial cell wall. A flexible but strong PG mesh encloses the cell, conferring mechanical resistance and preventing cell lysis. This PG mesh is continually remodeled during the bacterial life by the coordinated action of tightly regulated PG-hydrolases and synthetases. Here, we report the structural characterization of the M. tuberculosis SteAB system, which regulates the action of the major enzyme responsible for disassembling the PG mesh to allow daughter cell separation at the end of cell division. The proposed model for the septal control of PG hydrolysis illustrates how the transmembrane SteAB complex can promote enzyme activation and provides structural information that may help target the activation mechanism for antibiotic development.
Journal Article