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Bridging the gap between the theoretical and real-life, Bonior looks at the biggest names, ideas, and studies in the history of psychology and translates their meaning to everyday situations and relationships.

In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mechanism remains unclear, here, we determined that LPS induced the extensive microstructural damage of bMEC, especially the mitochondria and endoplasmic reticulum. Then, the obvious reduction of mitochondrial membrane potential and expression changes of apoptosis-associated proteins (Bcl-2, Bax, and casepase-3) indicated that apoptosis signaling through the mitochondria should be responsible for the cell viability decrease. Next, the high-throughput cDNA sequencing (RNA-Seq) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were employed to verify that the MAPK and JAK-STAT signaling pathways also were the principal targets of LPS. Following, the critical proteins (ERK, JNK, p38, and c-jun) of the MAPK signaling pathways were activated, and the release of proinflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) regulated by NF-κB and MAPKs was significantly increased, which can promote a cascade of inflammation that induces cell injury and apoptosis. Meanwhile, CA significantly inhibited the activation of MAPKs and the release of proinflammatory cytokines in a dose-dependent manner, which were similar to its effects on the NF-κB activation that we previously published. So we concluded that CA regulates the proteins located in the upstream of multiple cell signal pathways which can reduce the LPS-induced activation of NF-κB and MAPKs, thus weakening the inflammatory response and maintaining cell structure and function, which accordingly inhibit apoptosis.

Aucune étude en France ne s’est intéressée à l’éventuelle réduction du stock patronymique imputable à la guerre de 1914-1918. L’objet de ce travail est d’estimer l’ampleur du phénomène en prenant en compte les effets aléatoires de la disparition des noms selon le modèle d’extinction de Galton-Watson, la distribution du nombre d’enfants par ménage et la proportion de patronymes selon le nombre de porteurs. Les estimations, sur la France entière et par département, sont établies sur la base du fichier des « Morts pour la France » et du fichier Insee des noms de familles. Si les pertes humaines imputables à la Grande Guerre sont inégalement distribuées sur le territoire, avec un nombre de morts plus élevé au nord d’une ligne La Rochelle-Mulhouse, les pertes patronymiques sont géographiquement différemment réparties et plus nombreuses dans les Pyrénées, en Corse et en Bretagne. Pour autant, les patronymes effectivement disparus ne représentent qu’une proportion faible (1,4%) de l’ensemble des patronymes des MPF. Par département, cette proportion est très variable et souvent en contradiction avec le modèle de Galton- Watson qui prévoit davantage de disparitions. Plusieurs explications sont avancées : elles tiennent au mode de constitution des deux fichiers et aux hypothèses démographiques formulées. The First World War and the Disappearance of Surnames in France: A Trial Estimation Based on the Galton–Watson Model The possible reduction of the stock of surnames attributable to the World War I (1914-1918) in France has not yet be explored. The aim of this work is to propose an estimate of this phenomenon taking into account the number of surnames disappearing according to the random extinction model described by Galton and Watson, the distribution of the number of children per households, and the proportion of surnames carried by a given number of bearers. Estimates have been based on the Ministry of Defense's electronic file which includes French soldiers killed during the First World War and on the Surname file produced by the Insee. While the human losses attributable to the World War I are unevenly distributed throughout the territory, showing a higher number north of a La Rochelle-Mulhouse line, the surname losses show a different geographical pattern with the numerous extinctions in Pyrenees, Corsica and Brittany. The extinction of surnames actually represents only a small proportion of all the surnames of the Dead for France (1,4%). By department, this observation is at odds with the Galton-Watson model which predicts a larger proportion of extinction due to the constitution of the two files, and the formulated demographic hypotheses.

Le Regne du vivant d'Alice Ferney est un plaidoyer écologique et un cri de révolte et de dénonciation contre la peche illicite et le braconnage en haute mer, inspiré de l'action du militant écologiste Paul Watson. La présente contribution met en évidence l'imaginaire écologique dans ce « roman-documentaire engagé » qui porte une réflexion sur le déclin et la dégradation de la biodiversité marine. Une lecture écocritique de ce texte va nous permettre de voir comment la question du monde naturel est abordée dans la fiction et comment la dégradation de notre environnement nous responsabilice pour la préservation de notre planete. L'approche choisie constitue une perspective méthodologique pour étudier et analyser les choix éthiques, esthétiques et émotionnels adoptés par l'auteure pour étaler un imaginaire écologique. Nous allons donc montrer comment Le Regne du vivant leve le voile sur certaines pratiques nettement abusives en portant une réflexion sur la menace de la biodiversité marine et les enjeux de la disparition des grands mammiferes marins. Nous allons également expliquer les implications formelles de l'auteure en vue de décrire d'une façon percutante la menace que subit le monde marin et les risques que de braves militants prennent pour essayer d'arreter le carnage et d'empecher la tuerie des especes marines.

Surviving in addition to his wife and mother are four sons; Wayne and his wife Frances of Surry, B.C., David and his wife Bonnie of Fredericton Junction, Steven and his wife Dawn of Saint John, Paul and his wife Violet of Saint John, three daughters; Sharon Connell and her husband Bill of Saint John, Elaine Larlee and her husband Larry of Plaster Rock, and Caroline Watson at home, four brothers, six sisters, 14 grandchildren, 3 great granddaughters, several nieces and nephews.

Cest avec un grand plaisir que nous marquons le 25e anniversaire de la Revue canadienne d'études cinématographiques en publiant deux numéros consécutifs. Le premier, 25.1, est consacré au cinéma canadien et québécois, tandis que le second traite du cinéma international. La diversité des articles nous semble particuliérement importante aussi bien au niveau du genre, de la langue que des pays qui y sont abordés.Nous présentons ici quatre articles portant sur quatre films bien différents.

On Mar 25 of the General Sessions conference of the Association of Operating Room Nurses, Vivian C. Watson presented the closing remarks by encouraging attendees to stimulate their spirits by sharing their knowledge. Videotaped highlights and award presentations are also provided for a rousing closing session.

Joan C. Watson a former longtime resident of Barrington Visitation for Joan C. Watson (nee Christensen), 83, will be from 3 to 8 p.m. Thursday, Dec. 3, at Ahlgrim Family Funeral Home, 201 N. Northwest Highway, Palatine. Services will be held at 10 a.m. Friday, Dec. 4, at the funeral home. Interment will be in Evergreen Cemetery, Barrington.

In the A final, Ed VanRanden led Whitehorse-1(3-0) with a hat trick as they dominated Whitehorse-2 (2-0-1), 7-1 and claimed first place. Stu Mackay, Jim Stephens and Terry Bergen each tacked on a goal and an assist for team 1 while Sean McAskie also found the back of the net. The C final pitted Whitehorse-C1 (2-0-1) against Watson Lake-C (1- 1-1). John Mahoney recorded a hat trick for Whitehorse while Bernie Heffner posted a pair of goals. Ron Pearson finished with three assists.

In a caustic July 13 letter to Oak Ridges MPP Frank Klees, who announced the funding when Ernie Eves was premier, Dr. [C. H. Watson] vented, asking, \"in the area of hospital expansion, why has ... preferential treatment (been given) to Southlake hospital while York Central quite literally starves?\" \"I got mad,\" Dr. Watson said Tuesday, explaining his letter. \"What piqued my frustration was seeing other areas in the province that aren't growing anywhere near the rate here in York, yet their hospitals expand. Our catchment area has to be growing at 15,000 to 20,000 people a year. The hospital's expansion was to begin four years ago this October and it's been a long time of seeming inactivity. Yes, I am frustrated.\" Dr. Watson said the delays to begin phase one redevelopment, a long awaited initiative to triple the size of emergency and diagnostic imaging departments, double the critical care unit, expand fracture, plastics and ophthalmology clinics and bring the number of patient beds to 506, is impacting negatively on staff and patients.