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Professional C# and .NET
Get the latest coverage of the newest features in C#9 and.NET 5
In Professional C# and.NET: 2021 Edition, Microsoft MVP for Visual Studio and Development Technologies and veteran developer, Christian Nagel, delivers a comprehensive tour of the new features and capabilities of C#9 and.NET 5.
Experienced programmers making the transition to C# will benefit from the author's in-depth explorations to create Web- and Windows applications using ASP.NET Core, Blazor, and WinUI using modern application patterns and new features offered by.NET including Microservices deployed to Docker images, GRPC, localization, asynchronous streaming, and much more.
The book also offers:
* Discussions of the extension of.NET to non-Microsoft platforms like OSX and Linux
* Explanations of the newest features in C#9, including support for record types, and enhanced support for tuples, pattern matching, and nullable reference types
* Integrating.NET applications with Microsoft Azure services such as Azure App
* Configuration, Azure Key Vault, Azure Functions, the Azure Active Directory, and others Downloadable code examples from wrox.com and github.com with online updates for C# 10 and.NET 6
Perfect for programmers with a background in C#, Visual Basic, Java, or C/C++, Professional C# and.NET: 2021 Edition will also earn a place in the libraries of software architects seeking an up-to-date and fulsome treatment of the latest C# and.NET releases.
eBook
How to Attack and Defend Your Website
How to Attack and Defend Your Website is a concise introduction to web security that includes hands-on web hacking tutorials.The book has three primary objectives: to help readers develop a deep understanding of what is happening behind the scenes in a web application, with a focus on the HTTP protocol and other underlying web technologies; to.
eBook
TargetNet: a web service for predicting potential drug–target interaction profiling via multi-target SAR models
Drug–target interactions (DTIs) are central to current drug discovery processes and public health fields. Analyzing the DTI profiling of the drugs helps to infer drug indications, adverse drug reactions, drug–drug interactions, and drug mode of actions. Therefore, it is of high importance to reliably and fast predict DTI profiling of the drugs on a genome-scale level. Here, we develop the TargetNet server, which can make real-time DTI predictions based only on molecular structures, following the spirit of multi-target SAR methodology. Naïve Bayes models together with various molecular fingerprints were employed to construct prediction models. Ensemble learning from these fingerprints was also provided to improve the prediction ability. When the user submits a molecule, the server will predict the activity of the user’s molecule across 623 human proteins by the established high quality SAR model, thus generating a DTI profiling that can be used as a feature vector of chemicals for wide applications. The 623 SAR models related to 623 human proteins were strictly evaluated and validated by several model validation strategies, resulting in the AUC scores of 75–100 %. We applied the generated DTI profiling to successfully predict potential targets, toxicity classification, drug–drug interactions, and drug mode of action, which sufficiently demonstrated the wide application value of the potential DTI profiling. The TargetNet webserver is designed based on the Django framework in Python, and is freely accessible at
http://targetnet.scbdd.com
.
Journal Article
WildFly
This book is an easy-to-follow guide full of hands-on examples of administration tasks and valuable information about security. Each topic is explained and placed in context, and for the more inquisitive readers, there are more in-depth details of the concepts used. If you are an application server administrator or a Java developer with some experience with previous versions of JBoss AS and you want to familiarize yourself with WildFly, then this book is ideal for you.
eBook
Hybrid cloud for architects
Hybrid cloud is currently the buzz word in the cloud world. Organizations are planning to adopt hybrid cloud strategy due to its advantages such as untested workloads, cloud-bursting, cloud service brokering and so on. This book will help you understand the dynamics, design principles, and deployment strategies of a Hybrid Cloud. You will start by understanding the concepts of hybrid cloud and the problems it solves as compared to a stand-alone public and private cloud. You will be delving into the different architecture and design of hybrid cloud. The book will then cover advanced concepts such as building a deployment pipeline, containerization strategy, and data storage mechanism. Next up, you will be able to deploy an external CMP to run a Hybrid cloud and integrate it with your OpenStack and AWS environments. You will also understand the strategy for designing a Hybrid Cloud using containerization and work with pre-built solutions like vCloud Air, VMware for AWS, and Azure Stack. Finally, the book will cover security and monitoring related best practices that will help you secure your cloud infrastructure. By the end of the book, you will be in a position to build a hybrid cloud strategy for your organization.
eBook
SRT-Server: powering the analysis of spatial transcriptomic data
Background
Spatial resolved transcriptomics (SRT) encompasses a rapidly developing set of technologies that enable the measurement of gene expression in tissue while retaining spatial localization information. SRT technologies and the enabled SRT studies have provided unprecedent insights into the structural and functional underpinnings of complex tissues. As SRT technologies have advanced and an increasing number of SRT studies have emerged, numerous sophisticated statistical and computational methods have been developed to facilitate the analysis and interpretation of SRT data. However, despite the growing popularity of SRT studies and the widespread availability of SRT analysis methods, analysis of large-scale and complex SRT datasets remains challenging and not easily accessible to researchers with limited statistical and computational backgrounds.
Results
Here, we present SRT-Server, the first webserver designed to carry out comprehensive SRT analyses for a wide variety of SRT technologies while requiring minimal prior computational knowledge. Implemented with cutting-edge web development technologies, SRT-Server is user-friendly and features multiple analytic modules that can perform a range of SRT analyses. With a flowchart-style interface, these different analytic modules on the SRT-Server can be dragged into the main panel and connected to each other to create custom analytic pipelines. SRT-Server then automatically executes the desired analyses, generates corresponding figures, and outputs results—all without requiring prior programming knowledge. We demonstrate the advantages of SRT-Server through three case studies utilizing SRT data collected from two common platforms, highlighting its versatility and values to researchers with varying analytic expertise.
Conclusions
Overall, SRT-Server presents a user-friendly, efficient, effective, secure, and expandable solution for SRT data analysis, opening new doors for researchers in the field. SRT-Server is freely available at
https://spatialtranscriptomicsanalysis.com/
.
Journal Article
Messaging Protocols for IoT Systems—A Pragmatic Comparison
There are a dozen messaging protocols proposed for IoT systems. Choosing one for a new design is complicated, and a non-optimal selection can result in slower development and higher design costs. This paper aims to help select appropriate protocols, considering IoT applications’ specificity and communication requirements. We have identified the protocol features that are significant for the design and operation of IoT systems. This paper gives a substantial comparison of the protocols using the features and is based on a thorough analysis of the protocol specifications. The results contain an assessment of the suitability of the protocols for the defined types of IoT devices and the identified communication purposes. We conclude the comparison with some recommendations of the protocol selection and usage.
Journal Article