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In light of recent alarming trends in human population growth, climate change, and other environmental modifications, a “Warning to humanity” manifesto was published in BioScience in 2017. This call reiterated most of the ideas originally expressed by the Union of Concerned Scientists in 1992, including the fear that we are “pushing Earth’s ecosystems beyond their capacities to support the web of life.” As subterranean biologists, we take this opportunity to emphasize the global importance and the conservation challenges associated with subterranean ecosystems. They likely represent the most widespread nonmarine environments on Earth, but specialized subterranean organisms remain among the least documented and studied. Largely overlooked in conservation policies, subterranean habitats play a critical role in the function of the web of life and provide important ecosystem services. We highlight the main threats to subterranean ecosystems and propose a set of effective actions to protect this globally important natural heritage.

We study Type IIB supergravity solutions with spacetime of the form AdS6×S2 warped over a Riemann surface Σ, where Σ includes punctures around which the super-gravity fields have non-trivial SL(2, R) monodromy. Solutions without monodromy have a compelling interpretation as near-horizon limits of (p, q) 5-brane webs, and the punctures have been interpreted as additional 7-branes in the web. In this work we provide further support for this interpretation and clarify several aspects of the identification of the supergravity solutions with brane webs. To further support the identification of the punctures with 7-branes, we show that punctures with infinitesimal monodromy match a probe 7-brane analysis using κ-symmetry. We then construct families of solutions with fixed 5-brane charges and punctures with finite monodromy, corresponding to fully back-reacted 7-branes. We compute the sphere partition functions of the dual 5d SCFTs and use the results to discuss concrete brane web interpretations of the supergravity solutions.

From 2022 March 18 to 21, NOAA Active Region (AR) 12967 was tracked simultaneously by Solar Orbiter at 0.35 au and Hinode/EIS at Earth. During this period, strong blueshifted plasma upflows were observed along a thin, dark corridor of open magnetic field originating at the AR’s leading polarity and continuing toward the southern extension of the northern polar coronal hole. A potential field source surface model shows large lateral expansion of the open magnetic field along the corridor. Squashing factor Q-maps of the large-scale topology further confirm super-radial expansion in support of the S-web theory for the slow wind. The thin corridor of upflows is identified as the source region of a slow solar wind stream characterized by ∼300 km s−1 velocities, low proton temperatures of ∼5 eV, extremely high density >100 cm−3, and a short interval of moderate Alfvénicity accompanied by switchback events. When the connectivity changes from the corridor to the eastern side of the AR, the in situ plasma parameters of the slow solar wind indicate a distinctly different source region. These observations provide strong evidence that the narrow open-field corridors, forming part of the S-web, produce some extreme properties in their associated solar wind streams.

Marine kelp forests cover 1/3 of our world's coastlines, are heralded as a nature-based solution to address socio-environmental issues, connect hundreds of millions of people with the ocean, and support a rich web of biodiversity throughout our oceans. But they are increasingly threatened with some areas reporting over 90% declines in kelp forest cover in living memory. Despite their importance and the threats they face, kelp forests are entirely absent from the international conservation dialogue. No international laws, policies, or targets focus on kelp forests and very few countries consider them in their national policy. The Kelp Forest Challenge addresses that gap. Together with 252 kelp experts, professionals, and citizens from 25 countries, the Kelp Forest Challenge was developed as a grassroots vision of what the world can achieve for kelp forest conservation. It is a global call to restore 1 million and protect 3 million hectares of kelp forests by 2040. This is a monumental challenge, that will require coordination across multiple levels of society and the mobilization of immense resources. Pledges may therefore include area for protection or restoration, enabling pledges which assist in conservation (funding, equipment, professional expertise, capacity building), or awareness-based pledges which increase awareness or education about kelp forests. Correspondingly, participants may be from government, scientific institutions, private sector, NGOs, community groups, or individuals. This challenge is the beginning of a 17-year mission to save our kelp forests and anyone and any organisation is invited to participate.

This paper discusses the design and construction of the gymnasium at Musashino University’s Musashino Campus in Tokyo, Japan. The project integrates a hybrid section combining steel and European redwood, addressing the need to blend the building harmoniously with the campus’s lush greenery. A key design challenge was to incorporate wood as a significant structural element while adhering to Japan’s stringent fire regulations. The solution involved a T-shaped steel section with a timber sandwich, preventing steel web buckling and achieving superior structural performance. Approximately 50 cubic meters of timber were used, enhancing both the aesthetic appeal and the environmental sustainability of the project. The hybrid approach allowed the beam string structure to meet design load requirements effectively. Full-scale testing confirmed the structural integrity and load-bearing capacity of the hybrid section, matching those of a full steel section.

Conservation, restoration and land management are increasingly implemented at landscape scales 1 , 2 . However, because species interaction data are typically habitat- and/or guild-specific, exactly how those interactions connect habitats and affect the stability and function of communities at landscape scales remains poorly understood. We combine multi-guild species interaction data (plant–pollinator and three plant–herbivore–parasitoid communities, collected from landscapes with one, two or three habitats), a field experiment and a modelling approach to show that multi-habitat landscapes support higher species and interaction evenness, more complementary species interactions and more consistent robustness to species loss. These emergent network properties drive improved pollination success in landscapes with more habitats and are not explained by simply summing component habitat webs. Linking landscape composition, through community structure, to ecosystem function, highlights mechanisms by which several contiguous habitats can support landscape-scale ecosystem services. Species interaction data, a field experiment and modelling of plant–insect communities show that landscapes with more habitat types support more even species, more complementary interactions, are more consistently robust to species loss, and confer greater pollination function.

Offshore large-module PV foundations are prone to vibration under the action of pulsating wind, causing structural damage. In this paper, based on the Davenport wind spectrum, the wind speed and wind pressure time history are simulated by the harmonic superposition method. The structure is modeled by SACS software, and the modal and wind vibration time history analysis is carried out. The results show that the wind vibration response is dominated by the overall motion, and the wind vibration coefficient based on the base shear is about 1.52. The wind vibration response is dominated by the fluctuating wind direction, but it causes vibration in both the orthogonal and vertical directions. The vertical vibration of the topside is obvious, and the whole produces torsional vibration. The stress level of the upper chord, the umbrella-shaped support, the web member connected to it, and the root area of the pile foundation are relatively high.

Steel frame infilled with composite plate shear wall (SF-CPSW) is an effective structure for lateral-load resisting. In the structural design, the vertical loads are primarily carried by the boundary SF, while the horizontal loads are expected to be totally carried by CPSW. CPSW incorporates the steel web and the concrete encasements. For the CPSW bays, the boundary SF also inevitably withstands the lateral-loads due to the coordinated deformations between boundary SF and CPSW. The available researches, however, have not given a certain shear force assignment between the boundary SF and CPSW. Furthermore, their interactions under the cyclic lateral-loading are unclear. This paper conducted a study on the load-resisting mechanism of SF-CPSW by a structural model test and finite element analyses. The deformation pattern, failure mode, internal forces, and interactions of structural members were investigated. The effects of steel web and concrete thicknesses, cross-sections of boundary SF, and axial compression ratio on the lateral-load resistance of SF-CPSW were assessed. The results indicated that the interactions of CPSW and boundary SF caused significant normal stresses at the corners of CPSW, reducing the shear strength of steel web. However, the concrete encasements and boundary SF compensate it and mutually improved the stiffness and ductility. According to the analysis results, the formulas of the lateral stiffness and strengths of SF-CPSW were proposed for its seismic design.

Identifying novel breast cancer biomarkers will improve patient stratification, enhance therapeutic outcomes, and help develop non-invasive diagnostics. We compared the proteomic profiles of whole-cell and exosomal samples of representative breast cancer cell subtypes to evaluate the potential of extracellular vesicles as non-invasive disease biomarkers in liquid biopsies. Overall, differentially-expressed proteins in whole-cell and exosome samples (which included markers for invasion, metastasis, angiogenesis, and drug resistance) effectively discriminated subtypes; furthermore, our results confirmed that the proteomic profile of exosomes reflects breast cancer cell-of-origin, which underscores their potential as disease biomarkers. Our study will contribute to identifying biomarkers that support breast cancer patient stratification and developing novel therapeutic strategies. We include an open, interactive web tool to explore the data as a molecular resource that can explain the role of these protein signatures in breast cancer classification. Graphical Abstract ( A ) We quantified proteomic profiles of breast cancer cells (BCCs) and breast cancer-derived exosomes (BCDEs) samples from four breast cancer cell lines representative of common breast cancer subtypes – Her2-positive (Her2, MDA-MB-453), Luminal A (LA, MCF7), Luminal B (LB, ZR-75), and triple-negative (TN, MDA-MB-231). ( B ) We independently performed four comparisons for BCCs and BCDEs, comparing each cell line against the remaining three. ( C ) We identified differentially-expressed proteins (DEPs) for BCCs and BCDEs, defined protein signatures, and functionally analyzed resulting networks. Through pathway inference analysis (PIA), we identified Kyoto Encyclopedia of genes and genomes (KEGG) subpaths and biological Gene Ontology (GO) terms that displayed differential activation. ( D ) We validated our proteomic signature using the Cancer Genome Atlas (TCGA) and the Cancer Proteome Atlas (TCPA) databases, verified that differentially-activated pathways in BCDEs caused a corresponding response in receptor cells, and confirmed that the BCDE proteomic signature reflects their cell-of-origin and identifies candidate disease biomarkers in liquid biopsies

Multi-cell thin-walled structures exhibit significant advantages in maximizing energy absorption and minimizing mass during vehicle crashes. Since the topological distribution of wall members has an appreciable effect on the crashworthiness, their design signifies an important area of research. As a major energy absorber, multi-cell tubes are more commonly encounter oblique loading in real life. Thus, this study aimed to optimize multi-cell cross-sectional configuration of tubal structures for multiple oblique loading cases. An integer coded genetic algorithm (ICGA) is introduced here to optimize topological distribution of multi-celled web members for single/multiple oblique impacting conditions. Specifically, material distribution in a form of allocating web wall thickness, starting from zero, is considered as design variables and maximization of energy absorption ( EA ) as the design objective under the predefined peak crushing force and structural mass constraints. The optimization allows generating uniform or non-uniform thickness distribution in different web wall configurations to maximize usage efficiency of material. Compared with the baseline structure, the optimized configurations largely improved the energy absorption in both single and multiple load cases. The examples demonstrate that the proposed ICGA-based design method not only provides a useful approach to searching for novel crashworthy structures in a systematic fashion, but also develops a series of novel multi-cell topologies for multiple oblique loading cases.