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Beluga whales
\"Discover facts about beluga whales, including physical features, habitat, life cycle, food, and threats to these ocean creatures. Photos, captions, and keywords supplement the narrative of this informational text\"-- Provided by publisher.
Book
Hillbilly : a cultural history of an American icon
In this pioneering work of cultural history, historian Anthony Harkins argues that the hillbilly-in his various guises of \"briar hopper,\" \"brush ape,\" \"ridge runner,\" and \"white trash\"-has been viewed by mainstream Americans simultaneously as a violent degenerate who threatens the modern order and as a keeper of traditional values of family, home, and physical production, and thus symbolic of a nostalgic past free of the problems of contemporary life. \"Hillbilly\" signifies both rugged individualism and stubborn backwardness, strong family and kin networks but also inbreeding and bloody feuds. Spanning film, literature, and the entire expanse of American popular culture, from D. W. Griffith to hillbilly music to the Internet, Harkins illustrates how the image of the hillbilly has consistently served as both a marker of social derision and regional pride. He traces the corresponding changes in representations of the hillbilly from late-nineteenth century America, through the great Depression, the mass migrations of Southern Appalachians in the 1940s and 1950s, the War on Poverty in the mid 1960s, and to the present day. and to the present day. Harkins also argues that images of hillbillies have played a critical role in the construction of whiteness and modernity in twentieth century America. Richly illustrated with dozens of photographs, drawings, and film and television stills, this unique book stands as a testament to the enduring place of the hillbilly in the American imagination.
eBook
Great white sharks
Did you know that great white sharks breathe by letting water flow into their open mouths or that they have about 300 teeth? These top predators are also at risk due to overhunting. Learn fascinating facts like these and more all in the pages of this book!
Book
At home in the Okavango
An ethnographic portrayal of the lives of white citizens of the Okavango Delta, Botswana, this book examines their relationships with the natural and social environments of the region. In response to the insecurity of their position as a European-descended minority in a postcolonial African state, Gressier argues that white Batswana have developed cultural values and practices that have allowed them to attain high levels of belonging. Adventure is common for this frontier community, and the book follows their safari lifestyles as they construct and perform localized identities in their interactions with dangerous wildlife, the broader African community, and the global elite via their work in the nature-tourism industry.
eBook
The great white shark
\"Fascinating images accompany information about the great white shark. The combination of high-interest subject matter and narrative text is intended for students in grades 3 through 7\"--Provided by publisher.
Book
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes of white adipose tissue (WAT) produces “white adipocytes” with characteristics of brown fat and leads to a reduction of adiposity and its metabolic complications. Although BMP4 is known to induce commitment of pluripotent stem cells to the adipocyte lineage by producing cells that possess the characteristics of preadipocytes, its effects on the mature white adipocyte phenotype and function were unknown. Forced expression of a BMP4 transgene in white adipocytes of mice gives rise to reduced WAT mass and white adipocyte size along with an increased number of a white adipocyte cell types with brown adipocyte characteristics comparable to those of beige or brite adipocytes. These changes correlate closely with increased energy expenditure, improved insulin sensitivity, and protection against diet-induced obesity and diabetes. Conversely, BMP4-deficient mice exhibit enlarged white adipocyte morphology and impaired insulin sensitivity. We identify peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1α) as the target of BMP signaling required for these brown fat-like changes in WAT. This effect of BMP4 on WAT appears to extend to human adipose tissue, because the level of expression of BMP4 in WAT correlates inversely with body mass index. These findings provide a genetic and metabolic basis for BMP4’s role in altering insulin sensitivity by affecting WAT development.
Journal Article
Great white sharks
Introduces readers to facts about great white sharks, including physical features, habitat, life cycle, food, and more.
Book
The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial
Growing evidence points to the pivotal role of vitamin D in the pathophysiology and treatment of major depressive disorder (MDD). However, there is a paucity of longitudinal research investigating the effects of vitamin D supplementation on the brain of MDD patients.
We conducted a double-blind randomized controlled trial in 46 MDD patients, who were randomly allocated into either VD (antidepressant medication + vitamin D supplementation) or NVD (antidepressant medication + placebos) groups. Data from diffusion tensor imaging, resting-state functional MRI, serum vitamin D concentration, and clinical symptoms were obtained at baseline and after an average of 7 months of intervention.
Both VD and NVD groups showed significant improvement in depression and anxiety symptoms but with no significant differences between the two groups. However, a greater increase in serum vitamin D concentration was found to be associated with greater improvement in depression and anxiety symptoms in VD group. More importantly, neuroimaging data demonstrated disrupted white matter integrity of right inferior fronto-occipital fasciculus along with decreased functional connectivity between right frontoparietal and medial visual networks after intervention in NVD group, but no changes in VD group.
These findings suggest that vitamin D supplementation as adjunctive therapy to antidepressants may not only contribute to improvement in clinical symptoms but also help preserve brain structural and functional connectivity in MDD patients.
Journal Article
Whitework embroidery : learn the stitches plus 30 step-by-step projects
\"Whitework Embroidery will show you how to make a variety of stitches including drawn work, pulled thread work, Hedebo, count work, and Schwalm. Full photo-illustrated instructions and all necessary patterns for each of 30 projects are included. Choose from a variety of elegant designs for the home and designs for baby including an heirloom christening gown, bonnet, bib, and booties\"--Publisher's description.
Book
Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype
Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that endothelial cell (EC) senescence induces metabolic disorders through the senescence-associated secretory phenotype. Senescence-messaging secretomes from senescent ECs induced a senescence-like state and reduced insulin receptor substrate-1 in adipocytes, which thereby impaired insulin signaling. We generated EC-specific progeroid mice that overexpressed the dominant negative form of telomeric repeat-binding factor 2 under the control of the Tie2 promoter. EC-specific progeria impaired systemic metabolic health in mice in association with adipose tissue dysfunction even while consuming normal chow. Notably, shared circulation with EC-specific progeroid mice by parabiosis sufficiently transmitted the metabolic disorders into wild-type recipient mice. Our data provides direct evidence that EC senescence impairs systemic metabolic health, and thus establishes EC senescence as a bona fide risk for age-related metabolic disease.
Vascular senescence is closely associated with individual ageing, while its causative role remains unclear. Here Barinda et al. generate endothelial cell-specific progeroind mice, and reveal that endothelial cell senescence directly induces metabolic disorders through senescence-messaging secretomes.
Journal Article