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\"Opening a new fantasy trilogy from Hugo award winner Resnick, this novel offers an adventure through space and time as Eddie Raven tries to outrun the dark forces pursuing him. \"--Publisher's description.

Location-based augmented reality (AR) games, such as Pokémon GO and Harry Potter: Wizards Unite, have been shown to have a beneficial impact on the physical activity, social connectedness, and mental health of their players. In March 2020, global social distancing measures related to the COVID-19 pandemic prompted the AR games developer Niantic Inc to implement several changes to ensure continued player engagement with Pokémon GO and Harry Potter: Wizards Unite. We sought to examine how the physical and mental well-being of players of these games were affected during the unprecedented COVID-19 restriction period as well as how their video game engagement was affected. The aims of this study were to examine the impact of COVID-19-related social restrictions on the physical and mental well-being of AR game players; to examine the impact of COVID-19-related social restrictions on the use of video games and motivations for their use; and to explore the potential role of AR games (and video games in general) in supporting well-being during COVID-19-related social restrictions. A mixed methods web-based self-reported survey was conducted in May 2020, during which COVID-19-related social restrictions were enforced in many countries. Participants were recruited on the web via four subreddits dedicated to Pokémon GO or Harry Potter: Wizards Unite. Data collected included quantitative data on demographics, time spent playing video games, physical activity, and mental health; qualitative data included motivations to play and the impact of video games on mental health during COVID-19 lockdown. We report results for 2004 participants (1153/1960 male, 58.8%, average age 30.5 years). Self-reported physical activity during COVID-19-related social restrictions significantly decreased from 7.50 hours per week on average (SD 11.12) to 6.50 hours (SD 7.81) (P<.001). More than half of the participants reported poor mental health (925/1766, 52.4%; raw World Health Organization-5 Well-Being Index score <13). Female gender, younger age, and reduced exercise were significant predictors of poor mental health. Participants reported a significant increase in video game play time from 16.38 hours per week on average (SD 19.12) to 20.82 hours (SD 17.49) (P<.001). Approximately three quarters of the participants (n=1102/1427, 77.2%) reported that playing video games had been beneficial to their mental health. The changes made to Pokémon GO and Harry Potter: Wizards Unite were very well received by players, and the players continued to use these games while exercising and to maintain social connection. In addition to seeking an escape during the pandemic and as a form of entertainment, participants reported that they used video games for emotional coping and to lower stress, relax, and alleviate mental health conditions. AR games have the potential to promote physical and mental health during the COVID-19 pandemic. Used by populations under isolation and distress, these games can improve physical and mental health by providing virtual socialization, sustained exercise, temporal routine, and mental structure. Further research is needed to explore the potential of AR games as digital behavioral interventions to maintain human well-being in the wider population.

Relates the intertwining fates of former street gang leader Han Alister and headstrong Princess Raisa, as Han takes possession of an amulet that once belonged to an evil wizard and Raisa uncovers a conspiracy in the Grey Wolf Court.

Myths inform real-world decision making. Scientific simulation models can do the same. Neither reflects their real-world targets perfectly. They are most useful in an apophatic sense: employing them as the best tools available without confusing their indications with Truth. The actions and choices of wizards often reflect those of scientists; drawing parallels is informative and several questions will be explored within this framework. How is a climate scientist to respond when offered a Faustian agreement promising limited insights? As scientists, how might we better communicate scientific limits regarding which aspects of the future we can see clearly and which we cannot? Should we risk casting doubt on the as-good-as-it-gets science underlying anthropogenic climate change? If an electorate requires certainty of a threat before it will vote for action, are lies of omission or misrepresentation justified? Is it ethical for scientists whose research is relevant to the policy process to pause their typical vigorous scientific criticism of overinterpretation by others (particularly in sciences downstream from physical science) when their science is thought not adequate for purpose? Should scientists merely advise, presenting the relevant science as neutrally as they can, or advocate by emphasizing evidence that supports their preferred course of action, or become activists overselling their science to achieve well-motivated policy ends by whatever means required?

Thief-turned-wizard Han Alister joins forces with Raisa ana'Marianna, heir to the Queendom of the Fells, to defend her right to the Gray Wolf Throne.

\"Twelve-year-old Parker Quarry and his friends are in a race to find the missing pieces of an ancient helm before the mad sorcerer, Vesiroth, does. If they lose, it's the end of the world as they know it\"-- Provided by publisher.

Structure-based virtual screening plays an important role in drug discovery and complements other screening approaches. In general, protein crystal structures are prepared prior to docking in order to add hydrogen atoms, optimize hydrogen bonds, remove atomic clashes, and perform other operations that are not part of the x-ray crystal structure refinement process. In addition, ligands must be prepared to create 3-dimensional geometries, assign proper bond orders, and generate accessible tautomer and ionization states prior to virtual screening. While the prerequisite for proper system preparation is generally accepted in the field, an extensive study of the preparation steps and their effect on virtual screening enrichments has not been performed. In this work, we systematically explore each of the steps involved in preparing a system for virtual screening. We first explore a large number of parameters using the Glide validation set of 36 crystal structures and 1,000 decoys. We then apply a subset of protocols to the DUD database. We show that database enrichment is improved with proper preparation and that neglecting certain steps of the preparation process produces a systematic degradation in enrichments, which can be large for some targets. We provide examples illustrating the structural changes introduced by the preparation that impact database enrichment. While the work presented here was performed with the Protein Preparation Wizard and Glide, the insights and guidance are expected to be generalizable to structure-based virtual screening with other docking methods.

\"When sailors came to Ardhi's homeland, they plundered not only its riches, but its magic, too. Now disgraced islander Ardhi must retrieve what was stolen, but there are ruthless men after this power, men who will do anything to possess it ...\"--Page 4 of cover.

In 1195 AD, a celebrated Sufi scholar, poet and philosopher Muḥyī al-Dīn Ibn ʿArabī quit Muslim Spain for Africa. There, he first became acquainted with ʿuzābīyyah , which he described as the dark arts rooted in the soul’s power over mind and matter. Ibn ʿArabī referred to this power as himma . The Sufi shaykh Qaḍīb al-Bān, as well as the North African sorcerers Ibn ʿArabī encountered, could use this power to maim and kill humans. They were also said to be capable of creating new life forms with himma . The present study examines the specific types of himma they used and determines the supposed loci of this power in the body and soul. It also describes the standard methods used in Akbarian circles and North Africa to make oneself worthy of himma and identifies advantages and disadvantages of using this power to turn dreams into reality.