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In the context of monks traveling westward in search of Buddhist scriptures, their travelogues emerged during the fourth to the sixth centuries as a new channel for producing knowledge about the Western Regions, distinct from official sources. The fundamental reason monks wrote these travelogues was to enhance the sanctity of their journeys and the scriptures. Additionally, they fulfilled the demands among Buddhists for information about Buddhism in Central Asia and India. The knowledge about the Western Regions in these travelogues was referenced in works by Chinese scholars, such as the Weishu, Beishi, Shuijing zhu, and Luoyang qielan ji, thereby expanding the audience for such knowledge. Even after the original texts were lost, their content continued to be transmitted through these citations. However, while Chinese scholars often criticized these travelogues for some absurd accounts and made adaptations or deletions, they were nonetheless compelled to utilize the unique knowledge these travelogues offered about the Western Regions.

In examining wares discovered from the cultures of Sanxingdui and Jinsha and from the former site of the ancient kingdom of Dian in Sichuan and Yunnan provinces, this article highlights a number of shared features and trends that suggest a continued artistic, technological and cultural transmission through time and space. The article aims to supplement established theories on the rich material culture of this region. It will look in particular at the development of its striking bronze metallurgy, largely deriving from the established traditions of the Yellow River valley in China’s Bronze Age. It highlights the function of a dense network of trading routes, referred to in modern scholarship as the “Southwest Silk Road”, as an important facilitator of cultural and artistic exchange and reciprocation from ancient times.

The spread of Taoism to the Western Regions marked the movement of Central Plains culture to the frontier, demonstrating its influence on local society. During the Han Dynasty, Central Plains culture had reached the Western Regions. With the deification of Laozi and his becoming the founder of Taoism, the story “Laozi converting the barbarians” (Laozi huahu 老子化胡), which claimed that Laozi journeyed to the west and taught the Hu people, provided the impetus for the spread of Taoism to the Western Regions. The Tang imperial family venerated Laozi and regarded Taoism as the state religion. Laozi belief, including the veneration of the man himself, his writings, his stories, and the precepts claimed to be related to him, was also used to assist in the Tang Dynasty’s governance of the Western Regions. Following the Tang Dynasty’s decline, the Central Plains’ influence receded from the Western Regions. However, due to the relaxed religious environment in the Western Regions, Taoism, which was representative of Central Plains culture, still survived there. Moreover, Taoism attempted to incorporate Islam in the Western Regions into its divine system by huahu, which might be related to the early history of exchange between the two religions.

Aging is a significant contributing factor to degenerative diseases such as cancer. The extent of DNA methylation in human cells indicates the aging process and screening for age-related methylation sites can be used to construct epigenetic clocks. Thereby, it can be a new aging-detecting marker for clinical diagnosis and treatments. Predicting the biological age of human individuals is conducive to the study of physical aging problems. Although many researchers have developed epigenetic clock prediction methods based on traditional machine learning and even deep learning, higher prediction accuracy is still required to match the clinical applications. Here, we proposed an epigenetic clock prediction method based on a Resnet neuro networks model named ResnetAge. The model accepts 22,278 CpG sites as a sample input, supporting both the Illumina 27K and 450K identification frameworks. It was trained using 32 public datasets containing multiple tissues such as whole blood, saliva, and mouth. The Mean Absolute Error (MAE) of the training set is 1.29 years, and the Median Absolute Deviation (MAD) is 0.98 years. The Mean Absolute Error (MAE) of the validation set is 3.24 years, and the Median Absolute Deviation (MAD) is 2.3 years. Our method has higher accuracy in age prediction in comparison with other methylation-based age prediction methods.

This article presents an analysis of the research material collected at the site of Dul-dul at in Aravan, in the Fergana Valley, Kyrgyzstan. It is an archaeological site featuring petroglyphs representing equine and other figures with human and non-human characteristics. It is also a pilgrimage and ritual site for healing and fertility-related spiritual practices. Pilgrims, healers and local inhabitants conceptualise the rock covered by petroglyphs as the site inhabited by agentive beings. The paper demonstrates how the petroglyphs of Aravan are involved in a constant transformation of the rock through interaction and relationships formed with it by human and non-human beings.

The aim of this study was to investigate the effects of gain-of-function (GOF) E76K-mutant Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) on the biological behaviors of glioblastoma (GBM) cells, and explore the molecular mechanisms of GBM progression. Firstly, a negative control vector and vectors overexpressing SHP2 and E76K-mutant SHP2 were transduced into GBM cells (U87 and A172) using a lentivirus. The effect of GOF-mutant SHP2 on proliferation was measured using the MTT assay, flow cytometry, colony formation assay, and soft agar assay. Moreover, the migration and invasion of GBM cells were determined through the transwell assay. Related proteins of the extracellular signal-regulated kinase/cAMP response element binding protein (ERK/CREB) pathway were detected by Western blotting analysis. A xenograft model was established to confirm the tumor-promoting effect of GOF-mutant SHP2 in vivo. Finally, ERK was inhibited using a mitogen-activated protein kinase/ERK kinase inhibitor (U0126) to further explore the molecular mechanism of GOF-mutant SHP2 affecting GBM cells. After transduction, the expression of SHP2 in the SHP2-mutant and SHP2-overexpression groups was higher than that observed in the control and normal groups. Our data indicated that GOF-mutant SHP2 enhanced the abilities of GBM cells for proliferation, migration, and invasion in vitro, and promoted tumor growth in vivo. Mechanistically, the ERK/CREB pathway was activated, and the levels of relevant proteins were increased in the SHP2-mutant group. Furthermore, following inhibition of ERK in the GOF-SHP2 mutant group, the activation of CREB was also depressed, and the malignant biological behaviors were weakened accordingly. The GOF-mutant SHP2 promoted GBM cell proliferation, metastasis, and tumor growth through the ERK/CREB pathway, providing a promising target for the treatment of GBM.

In thousands of years from the Pre-Qin Dynasty to the Qing Dynasty, crimson represents sacredness and good fortune in several dynasties and is honored in the hierarchy of colors. Meanwhile, introduction to the exotic Materia Medica for dyeing from the Silk Road trade greatly expands the dyeing category of red color. The exotic red dyestuff is eventually integrated into the red culture of the Central Plains through the localization process. Therefore, it becomes the color symbol on behalf of Chinese nation.

Tokharistan of which its history dates back to early periods is important geography which draws the attention of powerful tribes from the early periods of humanity. Tokharistan has been a focus of the struggle between the forces which desire to be rulers on Khorasan and Transoxiana soils and had different rulers throughout history. These struggles emerged from political reasons as well as economic reasons. When its geographic features are scrutinized, it can be observed that Tokharistan is located in one of the most important crossing points of trade routes on east-west and north-south directions. The most famous trade route is the Silk Road.

It is assured that alfalfa (Medicago sativa L.) was introduced in Han dynasty. There are cognitive differences on whether Zhang Qian introduced alfalfa. Based on the previous studies, research inductive method was used. The relationship between Zhang Qian and alfalfa introduction was analyzed from the motivation, experience and influence of Zhang Qian to the Western Regions and the image generation of Zhang Qian brought back alfalfa's seeds. Till to now, there are four opinions about Zhang Qian introducing Alfalfa seeds, including : (1) Zhang Qian introduced alfalfa seeds;(2) Zhang Qian did not introduce alfalfa seeds;(3) the information of Zhang Qian transferring alfalfa;(4)for commemoration Zhang Qian to the Western Regions. Although there are not direct historical materials to support Zhang Qian brought alfalfa seed to Han dynasty, it believes and confirms that the introducing of alfalfa is inextricably interwoven with Zhang Qian's western travel. Zhangqian brought relative information from western regions during the introduction, which was the basis of non-native theory, and after that, Chinese began to plant alfalfa in Han dynasty., According to historical literatures, it is clear that the Chinese diplomat brought alfalfa seeds back to China. Alfalfa, as the favorite forage to Ferghana horse, have been already planted in Dawan in Han dynasty. Despite the debate, Zhangqian played an important pioneering role in introducing alfalfa.