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This paper deals with the design of an Active Fault Tolerant Control (AFTC) approach for polytopic uncertain Linear Parameter-Varying (LPV) systems subject to uncertainties and actuator faults. First, a fault estimation method is developed by integrating robust observer design with zonotopic techniques. The proposed observer is developed using L∞ norm to attenuate the effects of the uncertainties and to improve the accuracy of the estimation. Then, an AFTC strategy is used to compensate actuator fault effect and maintain system stability. Finally, the effectiveness of the proposed method is demonstrated by a case study on a 4.8MW wind turbine benchmark system.