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Foxfire approach : inspiration for classrooms and beyond
\"This collection of essays by Foxfire practitioners represents the wide range of adaptations by educators of the pedagogical orientation of the Foxfire Magazine and Foxfire Programs for Teachers\"--Back cover.
Book
Active Learning Query Strategies for Classification, Regression, and Clustering: A Survey
Generally, data is available abundantly in unlabeled form, and its annotation requires some cost. The labeling, as well as learning cost, can be minimized by learning with the minimum labeled data instances. Active learning (AL), learns from a few labeled data instances with the additional facility of querying the labels of instances from an expert annotator or oracle. The active learner uses an instance selection strategy for selecting those critical query instances, which reduce the generalization error as fast as possible. This process results in a refined training dataset, which helps in minimizing the overall cost. The key to the success of AL is query strategies that select the candidate query instances and help the learner in learning a valid hypothesis. This survey reviews AL query strategies for classification, regression, and clustering under the pool-based AL scenario. The query strategies under classification are further divided into: informative-based, representative-based, informative- and representative-based, and others. Also, more advanced query strategies based on reinforcement learning and deep learning, along with query strategies under the realistic environment setting, are presented. After a rigorous mathematical analysis of AL strategies, this work presents a comparative analysis of these strategies. Finally, implementation guide, applications, and challenges of AL are discussed.
Journal Article
Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial
Doubts exist regarding optimal second-line treatment options for HIV-1-infected patients in resource-limited settings. We assessed safety and efficacy of dolutegravir compared with ritonavir-boosted lopinavir, plus two nucleoside reverse transcriptase inhibitors (NRTIs) in adults in whom previous first-line antiretroviral therapy with a non-nucleoside reverse transcriptase inhibitor (NNRTI) plus two NRTIs has failed.
DAWNING is a phase 3b, open-label, parallel-group, non-inferiority, active-controlled trial done at 58 sites in 13 countries. Eligible adults were aged at least 18 years and, during at least 6 months of treatment with a first-line treatment containing an NNRTI and two NRTIs, had virological failure (confirmed HIV-1 RNA ≥400 copies per mL). Participants were randomly assigned by a central randomisation system to receive oral dolutegravir (50 mg once daily) or ritonavir-boosted lopinavir (800 mg lopinavir plus 200 mg ritonavir once daily or 400 mg plus 100 mg twice daily), plus two investigator-selected NRTIs (at least one fully active based on resistance testing at screening). The primary outcome was the proportion of participants achieving viral suppression (defined as plasma HIV-1 RNA <50 copies per mL) at week 48 using the snapshot algorithm and a non-inferiority margin of −12%. The primary analysis was done in an intention-to-treat-exposed (ITT-E) population of participants who received at least one dose of study medication, according to original group assignment. Safety was analysed in all participants who received at least one dose of study drug, according to which drug was received. The study was registered at ClinicalTrials.gov, number NCT02227238, and viiv-studyregister.com, number 200304.
Between Dec 11, 2014, and June 27, 2016, 968 adults were screened and 627 were randomly assigned to the dolutegravir group (n=312) or the ritonavir-boosted lopinavir group (n=315). Three patients in the ritonavir-boosted lopinavir group did not receive study medication and so 624 were included in the ITT-E population. At week 48, 261 (84%) of 312 participants in the dolutegravir group achieved viral suppression compared with 219 (70%) of 312 in the ritonavir-boosted lopinavir group (adjusted difference 13·8%; 95% CI 7·3–20·3). Non-inferiority was achieved on the basis of the 95% CI of the adjusted treatment difference having a lower bound greater than −12% (prespecified non-inferiority margin). Because the lower bound of the 95% CI is greater than zero (7·3%), superiority of dolutegravir was also concluded (p<0·0001). The safety profile for dolutegravir was favourable compared with that of ritonavir-boosted lopinavir. More grade 2–4 drug-related adverse events occurred with ritonavir-boosted lopinavir than dolutegravir (44 [14%] of 310 with ritonavir-boosted lopinavir vs 11 [4%] of 314 with dolutegravir), mainly driven by gastrointestinal disorders.
When administered with two NRTIs, dolutegravir was superior to ritonavir-boosted lopinavir at 48 weeks and can be considered a suitable option for second-line treatment.
ViiV Healthcare.
Journal Article
Pseudo‐active actuators: A concept analysis
The superior performance of active vibration control systems largely depends on the four‐quadrant controllable execution capability in the available force–velocity diagram of active actuators. Although semi‐active vibration control systems have the advantages of low energy consumption, simple structure, and high reliability, the system performance is not comparable to active control systems, due to the partial capability in only the first and third quadrants. On the basis of the comprehensive advantages of active and semi‐active actuators, to reform the design philosophy of semi‐active actuators to realize pseudo‐active actuators that have both mechanical properties of active actuators and energy consumption advantages of semi‐active actuators, that is, new semi‐active actuators with four‐quadrant controllable execution capability, will very likely cause a revolution in the related fields of mechanical design and system control. The basic design principle of pseudo‐active actuators that use semi‐active controllable actuators to achieve active actuator performance in the way of conceptual analysis is proposed. The proposed pseudo‐active actuators should consist of two half‐four‐quadrant actuators, that is, one is for the first and third quadrants and the other one for the second and fourth quadrants. This study employs two semi‐active controllable damping actuators and one mechanical compensation mechanism. One of the actuators provides the damping force in the first and third quadrants, and the other one combining with the mechanical compensation mechanism is for the second and fourth quadrants. A global mathematical model of the proposed actuator is established to describe the four different operational modes of the proposed actuator. It is proved that the two operational modes of the proposed actuator can realize active vibration control, and a case study of realizing active control is presented. The other two operational modes are compared with the conventional two‐degree‐of‐freedom model. More specifically, the application cases of the pseudo‐active operational mode of the proposed actuator in the quarter‐car/body‐powertrain suspension system are given, a pseudo‐active suspension named dual‐hook automobile suspension is presented. Furthermore, an equivalent expression of the electrical network is given for the mechanical network under different operational modes of the proposed actuator.
Journal Article
Learning-through-touring : mobilising learners and touring technologies to creatively explore the built environment
This book uncovers ways in which people interact with the built environment by exploring the spaces around, between and within buildings. The key idea embodied in the book is that learning through touring is haptic - the learner is a physical, cognitive and emotional participant in the process. It also develops the concept that tours, rather than being finished products, are designed to evolve through user participation and over time.
Book
An Introduction to Literary Debate in Late Medieval France
This volume immerses readers in a debate tradition that flourished in France during the late Middle Ages, focusing on two works that were both popular and controversial in their time and the discussions they sparked surrounding questions of women's agency, love, marriage, and honor.
eBook
A Low‐Profile and Low‐Noise 4 × 4 Tile‐Type K‐Band Receive Module Using 3D Stacked LTCC Technology
This paper presents a low‐profile K‐band 4 × 4 tile‐type receive module utilizing low temperature co‐fired ceramic (LTCC) technology, achieving per‐channel noise figure (NF) below 1.8 dB. The module architecture comprises a metallic shell, an LTCC components, a bottom cover plate, and four metallic fasteners. Three‐dimensional monolithic integration is achieved through stacked circuitry, advanced processing, and fuzz button interconnects. Critical NF optimization (< 1.8 dB) results from co‐designed LNA layer topology and fuzz button connector interfaces. Fabrication and testing demonstrate > 11.5 dB return loss, > 18.2 dB channel gain, < ± 8.5 phase error across 16 channels, < 1.8 dB NF, 8 mm profile height, and 1.18 g per‐channel mass. This design enables scalable low‐profile phased arrays with high G/T for satellite communication systems. This paper presents a low‐profile K‐band 4 × 4 tile‐type receive module utilizing LTCC technology, achieving per‐channel NF below 1.8 dB. The module architecture comprises a metallic shell, an LTCC components, a bottom cover plate, and four metallic fasteners.
Journal Article