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This paper is devoted to the fastening system that consists of a number of anchors of approximately equal effective embedment depth, called “anchor group”, embedded into hardened concrete, used to transmit forces transverse to the anchors from an attachment to the concrete. The anchor group is far from the edges and is subjected to no more than marginal axial forces. Being post-installed, rather than cast-in, the embedded end of each anchor is not hooked, and no nuts, washers, or plates are attached to the embedded shaft. The paper focuses on the transverse forces that can be transmitted across an anchor group from an attachment to the concrete. The paper provides an analytical model for predicting the maximum (ultimate) shear force that an anchor group can bear, thus called “shear strength”. The model hence allows the structural designer to predict the shear strength of an anchor group post-installed into concrete. The model is based on five mechanical assumptions, which were established from a wide-ranging numerical analysis. Model predictions turned out to be, on average, 20% lower than the results of experiments performed on cast-in anchor groups borrowed from literature. The comparison verifies model accuracy, considering that the tested anchor groups benefitted from the extra-strength furnished by nuts and washers attached to the embedded shaft. Model predictions were also compared to code provisions; the former resulted to be up to one third of the latter. The paper presents and comments those comparisons, as well as all mathematical development. Applications of the model to wide-ranging case studies is presented and discussed as well.

The existing mechanical and grouting anchors mostly use the expansion shell method to form a cavity on the borehole wall, and the cement slurry is poured to form multiple enlarged head plates, but the operation is more difficult and the diameter of the formed plate is smaller. In this paper, a new type of large-diameter multi-plate soil anchor and its reaming cavity forming tool are proposed, which can make the operation easier and form a large-diameter enlarged head plate. In order to study the influence of the diameter of anchor plate, the number of anchor plates and the spacing of anchor plates on the vertical uplift capacity of the large-diameter multi-plate soil anchor, 25 sets of comparative models were established for simulation analysis. The finite difference method of FLAC 3D software is used to simulate the model. It is found that when the length of the anchor is 6 m and the diameter of the anchor rod body is 150 mm, the optimal diameter of the anchor plate of the large diameter multi-plate soil anchor is 590 mm, the optimal number of anchor plates is 6, and the optimal anchor plate spacing is 800 mm, which means the action range of the anchor plate on the lower soil is about 5 times the diameter of the bolt. When the number of anchor plates is too small or the spacing between anchor plates is too large, the structural advantages of large-diameter multi-plate soil anchor cannot be fully utilized, resulting in a decrease in the ultimate uplift capacity. When the number of anchor plates is too large or the spacing between anchor plates is too small, the stress superposition effect occurs in the soil, and the through shear failure occurs, which leads to the decline of the ultimate uplift capacity. Under the condition that the number of anchor plates and the spacing of anchor plates are fixed, the larger the diameter of the anchor plate is, the larger the ultimate pull-out capacity of the large-diameter multi-plate soil anchor is, the smaller the vertical failure displacement of the anchor head is, but the increase of the uplift capacity is gradually reduced. The creep rate of the new large-diameter multi-plate soil anchor bolt is 0.91 mm, and the creep rate of equal-diameter soil anchor bolt is 1.69 mm. It is verified that the new large-diameter multi-plate soil anchor can be effectively applied to various projects.

Purpose Suture anchors are commonly used to repair rotator cuff tendons in arthroscopy surgery, and several anchor materials have been created to maximize pull-out strength and minimize iatrogenic damage. We hypothesized that all-suture anchors have biomechanical properties equivalent to those of conventional anchors. Our purpose is to compare the biomechanical properties of different anchors used for rotator cuff repair. Methods The Embase, PubMed, Cochrane, and Scopus databases were searched for biomechanical studies on various suture anchors. The search keywords included rotator cuff tears and suture anchors, and two authors conducted study a selection, risk of bias assessment, and data extraction. The failure load, stiffness, and displacement were calculated using the mean differences with 95% confidence intervals (CIs). Failure modes were estimated using summary odds ratios with 95% CIs. The surface under the cumulative ranking curve was used for the relative ranking probabilities. A sensitivity analysis was performed by excluding studies using synthetic bones. Results The polyetheretherketone (PEEK) ( p  < 0.001) and all-suture anchors ( p  < 0.001) had higher failure loads than the biocomposite anchors, whereas no significant difference was observed in stiffness among the anchors. The all-suture ( p  = 0.006) and biocomposite anchors ( p  < 0.001) had displacements higher than the metal anchors. The relative ranking of the included anchors in failure loads and displacement changed in sensitivity analysis. The meta-analysis did not find significant differences, but the relative ranking probabilities suggested that all-suture anchor had a higher rate of anchor pull-out and a lower rate of eyelet or suture breakage. In contrast, the metal anchors were associated with a higher number of eyelet breakage episodes. Conclusions All-suture anchors showed significantly higher failure loads than the biocomposite anchors and similar cyclic displacements to the biocomposite and PEEK anchors. There were no significant differences in stiffness between all-suture and conventional suture anchors. The relative ranking of biomechanical properties changed in sensitivity analysis, suggesting the potential effect of bone marrow density. Level of Evidence Level IV.

Anchors may exhibit various complicated behaviors in the seabed, especially for deepwater anchors including gravity installed anchors (GIAs) and drag embedment plate anchors (drag anchors), stimulating the development of an efficient analytical tool that applies to a variety of anchors. The present paper introduces a unified model for analyzing different anchor behaviors in both clay and sand, consisting of unified concepts, mechanical models, and analytical procedure. The kinematic behaviors of the anchors are classified uniformly as three types, i.e., diving, pulling out, and keying. By utilizing the least-force principle, various anchor properties, such as the ultimate pullout capacity (UPC), failure mode, movement direction, embedment loss, and kinematic trajectory, can all be determined by the combination and analysis of the three behaviors. Applications of the model are demonstrated summarily, by solving the UPC and the failure mode of anchor piles and suction anchors, the kinematic trajectory of drag anchors in a single soil layer or layered soils, the maximum embedment loss (MEL) of suction embedded plate anchors (SEPLAs) and OMNI-Max anchors, and the kinematic behavior of OMNI-Max anchors. Compared to existing theoretical methods, this unified model shows strong applicability and potentiality in solving a variety of behaviors and properties of different anchors under complicated seabed conditions.

Alternative splicing has been shown to causally contribute to the epithelial–mesenchymal transition (EMT) and tumor metastasis. However, the scope of splicing factors that govern alternative splicing in these processes remains largely unexplored. Here we report the identification of A-Kinase Anchor Protein (AKAP8) as a splicing regulatory factor that impedes EMT and breast cancer metastasis. AKAP8 not only is capable of inhibiting splicing activity of the EMT-promoting splicing regulator hnRNPM through protein–protein interaction, it also directly binds to RNA and alters splicing outcomes. Genome-wide analysis shows that AKAP8 promotes an epithelial cell state splicing program. Experimental manipulation of an AKAP8 splicing target CLSTN1 revealed that splice isoform switching of CLSTN1 is crucial for EMT. Moreover, AKAP8 expression and the alternative splicing of CLSTN1 predict breast cancer patient survival. Together, our work demonstrates the essentiality of RNA metabolism that impinges on metastatic breast cancer. Splice isoform switching regulated by the heterogeneous nuclear ribonucleoprotein M (hnRNPM) induces EMT and metastasis. Here, the authors report that AKAP8 is a metastasis suppressor that inhibits the splicing activity of hnRNPM and antagonizes genome-wide EMT-associated alternative splicing to maintain epithelial cell state.

This paper gives a systematic study of Sobolev, Besov and Triebel-Lizorkin spaces on a noncommutative d-torus \\mathbb{T}^d_\\theta (with \\theta a skew symmetric real d\\times d-matrix). These spaces share many properties with their classical counterparts. The authors prove, among other basic properties, the lifting theorem for all these spaces and a Poincar type inequality for Sobolev spaces.

A Ship’s anchor makes a ship to be at a fixed location against currents and winds when ship is in rest position. Purpose of anchor is to restrict the drifting of ship, which is occurs due to the currents. Even though there are many different types of anchor, present paper intended to do design and analysis on stockless anchor AC14 type. Project aims to determine the equivalent von-mises stress and maximum deformation in anchor when subjected to proof test. Proof test load is decided based on the mass of the anchor. (Reference is taken for the relationship of proof test load and mass of the anchor. Solid modeling of Stockless ship anchor model is carried out on NX 11.0 and modal analysis of ship anchor is carried out using ANSYS 16.0

Congenital nephrogenic diabetes insipidus (NDI) is characterized by the inability of the kidney to concentrate urine. Congenital NDI is mainly caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R), leading to impaired aquaporin-2 (AQP2) water channel activity. So far, treatment options of congenital NDI either by rescuing mutant V2R with chemical chaperones or by elevating cyclic adenosine monophosphate (cAMP) levels have failed to yield effective therapies. Here we show that inhibition of A-kinase anchoring proteins (AKAPs) binding to PKA increases PKA activity and activates AQP2 channels in cortical collecting duct cells. In vivo, the low molecular weight compound 3,3′-diamino-4,4′-dihydroxydiphenylmethane (FMP-API-1) and its derivatives increase AQP2 activity to the same extent as vasopressin, and increase urine osmolality in the context of V2R inhibition. We therefore suggest that FMP-API-1 may constitute a promising lead compound for the treatment of congenital NDI caused by V2R mutations. Patients suffering from congenital nephrogenic diabetes insipidus (NDI) fail to concentrate urine due to mutations in vasopressin type 2 receptor (V2R). Here Ando et al. show that agents disrupting the interaction between PKA and AKAPs restore aquaporin-2 activity downstream of V2R, offering a therapeutic approach for the treatment of NDI.

We discuss recent work for causal inference and predictive robustness in a unifying way. The key idea relies on a notion of probabilistic invariance or stability: it opens up new insights for formulating causality as a certain risk minimization problem with a corresponding notion of robustness. The invariance itself can be estimated from general heterogeneous or perturbation data which frequently occur with nowadays data collection. The novel methodology is potentially useful in many applications, offering more robustness and better \"causal-oriented\" interpretation than machine learning or estimation in standard regression or classification frameworks.

Protein kinase A (PKA) directly phosphorylates aquaporin-2 (AQP2) water channels in renal collecting ducts to reabsorb water from urine for the maintenance of systemic water homeostasis. More than 50 functionally distinct PKA-anchoring proteins (AKAPs) respectively create compartmentalized PKA signaling to determine the substrate specificity of PKA. Identification of an AKAP responsible for AQP2 phosphorylation is an essential step toward elucidating the molecular mechanisms of urinary concentration. PKA activation by several compounds is a novel screening strategy to uncover PKA substrates whose phosphorylation levels were nearly perfectly correlated with that of AQP2. The leading candidate in this assay proved to be an AKAP termed lipopolysaccharide-responsive and beige-like anchor protein (LRBA). We found that LRBA colocalized with AQP2 in vivo, and Lrba knockout mice displayed a polyuric phenotype with severely impaired AQP2 phosphorylation. Most of the PKA substrates other than AQP2 were adequately phosphorylated by PKA in the absence of LRBA, demonstrating that LRBA-anchored PKA preferentially phosphorylated AQP2 in renal collecting ducts. Further-more, the LRBA–PKA interaction, rather than other AKAP–PKA interactions, was robustly dissociated by PKA activation. AKAP–PKA interaction inhibitors have attracted attention for their ability to directly phosphorylate AQP2. Therefore, the LRBA–PKA interaction is a promising drug target for the development of anti-aquaretics.