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Electricity and electronics for renewable energy technology : an introduction
\"Provides a foundational understanding of electricity and the methods and devices specific to electricity from renewable sources. The book begins with a brief explanation of the necessary mathematics and then: Addresses the basics of electricity and relationships, motors and generators, transformers, and networks and distribution; Tackles the key concepts associated with electronics, diodes and transistors, switching devices, and power converters; Covers digital electronics from number systems and logic circuits to encoders and decoders; Explores advanced subjects such as reactive power and the operation of a transistor\"--Provided by publisher.
Book
Medical Device Design - Innovation from Concept to Market
This book provides the bridge between engineering design and medical device development. There is no single text that addresses the plethora of design issues a medical devices designer meets when developing new products or improving older ones. It addresses medical devices' regulatory (FDA and EU) requirements--some of the most stringent engineering requirements globally. Engineers failing to meet these requirements can cause serious harm to users as well as their products' commercial prospects. This Handbook shows the essential methodologies medical designers must understand to ensure their products meet requirements. It brings together proven design protocols and puts them in an explicit medical context based on the author's years of academia (R&D phase) and industrial (commercialization phase) experience. This design methodology enables engineers and medical device manufacturers to bring new products to the marketplace rapidly.
The medical device market is a multi-billion dollar industry. Every engineered product for this sector, from scalpelsstents to complex medical equipment, must be designed and developed to approved procedures and standards. This book shows how.
Covers US, and EU and ISO standards, enabling a truly international approach, providing a guide to the international standards that practicing engineers require to understand.
Written by an experienced medical device engineers and entrepreneurs with products in the from the US and UK and with real world experience of developing and commercializing medical products.
eBook
EMC for Product Designers (4th Edition)
Widely regarded as the standard text on EMC, this book provides all the key information needed to meet the requirements of the latest EMC Directive. Most importantly, it shows how to incorporate EMC principles into the product design process, avoiding cost and performance penalties, meeting the needs of specific standards and resulting in a better overall product. As well as covering the very latest legal requirements, the Fourth Edition has been thoroughly updated in line with the latest best practice in EMC compliance and product design. Coverage has been considerably expanded to include the R&TTE and Automotive EMC Directives, as well the military aerospace standards of DEF STAN 59-41 and DO160E. A new chapter on systems EMC is included, while short case studies demonstrate how EMC product design is put into practice. Electronic design engineers, compliance engineers, regulatory engineers, test engineers, EMC consultants, and managers responsible for product compliance and product design will benefit from this book.
eBook
The arsenal of eighteenth-century chemistry : the laboratories of Antoine Laurent Lavoisier (1743-1794)
The first complete and detailed catalogue of Lavoisier's collection of instruments preserved at the Musée des Arts et Métiers in Paris. The story of the collection is carefully reconstructed and its instruments (all illustrated) are described in detail.
eBook
The danger within us : America's untested, unregulated medical device industry and one man's battle to survive it
A medical investigative journalist presents an unsettling exposâe of the underregulated medical device industry, revealing the corruption, greed, and deceit that have combined to render medical interventions a leading cause of death in America.
Book
Homeostatic regulation of STING by retrograde membrane traffic to the ER
Coat protein complex I (COP-I) mediates the retrograde transport from the Golgi apparatus to the endoplasmic reticulum (ER). Mutation of the
COPA
gene, encoding one of the COP-I subunits (α-COP), causes an immune dysregulatory disease known as COPA syndrome. The molecular mechanism by which the impaired retrograde transport results in autoinflammation remains poorly understood. Here we report that STING, an innate immunity protein, is a cargo of the retrograde membrane transport. In the presence of the disease-causative α-COP variants, STING cannot be retrieved back to the ER from the Golgi. The forced Golgi residency of STING results in the cGAS-independent and palmitoylation-dependent activation of the STING downstream signaling pathway. Surf4, a protein that circulates between the ER/ ER-Golgi intermediate compartment/ Golgi, binds STING and α-COP, and mediates the retrograde transport of STING to the ER. The STING/Surf4/α-COP complex is disrupted in the presence of the disease-causative α-COP variant. We also find that the STING ligand cGAMP impairs the formation of the STING/Surf4/α-COP complex. Our results suggest a homeostatic regulation of STING at the resting state by retrograde membrane traffic and provide insights into the pathogenesis of COPA syndrome.
COPA regulates Golgi to ER transport, and mutations lead to autoinflammation and disease through poorly understood mechanisms. Here, the authors show that disease-causing COPA variants prevent STING transport from the Golgi to the ER, leading to cGAS-independent activation of the STING pathway.
Journal Article
Gadgets & devices
\"The world of technology is moving at a fast pace. Many different types of electronic gadgets have come to rule our lives. Gizmos are gadgets or appliances that perform a specific function for personal or office use. They are the latest and the most futuristic devices. Gizmos may be small or large but each is able to perform a super task. They have the most recently introduced technologies. These innovative devices are likely to leave a huge impact on our future. Gadgets like laptops, digital cameras, iPods, printers, scanners, card readers, and PlayStations are all examples of gizmos\"-- Provided by publisher.
Book
Mastering Safety Risk Management for Medical and in Vitro Devices
When it comes to medical and in vitro devices, risk management starts with a design assurance process that helps practitioners identify, understand, analyze, and mitigate the risks of the healthcare product design for favorable benefit-risk assessment. Risk management actively follows the product's life cycle into production and post-market phases. This book offers a blueprint for implementing an effective risk management system. It provides risk management tools and a compliance framework for methods in conformance to ISO 13485:2016, ISO 14971:2019, European Union MDR, IVDR, and US FDA regulations (including the new FDA QMSR).
eBook