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Bat-Mite's big blunder
Batman must quickly round up Gotham's greatest supervillains after they escape from Arkham Asylum, so gets some extra help from the alien imp Bat-Mite.
Book
O5 Exploring the impact of platelet activation on plasmin generation
BackgroundFibrinolysis is the process by which fibrin clots are degraded via the action of plasmin. A novel high throughput plasmin generation (PG) assay has been developed and has potential as a clinical tool. Platelets modulate fibrinolysis through release of the precursor of plasmin, plasminogen, plasminogen activator inhibitor 1 (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI). Our work has shown platelets also anchor plasminogen to their surface.AimTo investigate the impact of platelets on PG using a novel assay.MethodPlatelet-rich plasma (PRP) and matched platelet-poor plasma (PPP) was collected from healthy donors. PG was quantified by fluorogenic substrate in plasma (22%) clotted using tissue factor (1 pM), and CaCl2 (16.7 mM) with tissue plasminogen activator (17.8 nM). PRP was analysed ± stimulation with collagen (CRP-XL, 1 µg/ml) and thrombin (TRAP-6, 30 µM) platelet receptor agonists. Fluorescence was read every 20 s for 30 min (37°C). A neutralising antibody to PAI-1 (5 µg/ml); the cofactor for TAFI, thrombomodulin (TM; 20 nM); and inhibitor of TAFIa, carboxypeptidase inhibitor (CPI; 25 µg/ml), were included in some experiments.ResultsUnstimulated PRP reduced the plasmin peak (49.2±2.8 nM) compared to matched PPP (69.1±7.4 nM). In contrast, stimulation of PRP enhanced the plasmin peak (49.2±2.8 nM to 63.7±4.2 nM) and shortened the lag time (4.6±0.06 min to 3.4±0.1 min) compared to unstimulated PRP. Neutralising PAI-1 had no impact on PG. TM significantly reduced PG to a similar degree in matched PPP (11.3±2.7 nM) and PRP (12.8±3.2 nM) and could be recovered to baseline with CPI.ConclusionThe PG assay was not sensitive to the inhibitory impact of platelet-derived PAI-1. The inhibitory effect of the TM-TAFIa complex was comparable in stimulated PRP and PPP. Interestingly, inclusion of platelet agonists significantly augmented PG, potentially by facilitating assembly of profibrinolytic proteins on the activated platelet membrane.
Journal Article
Mean
\"Set in the same world as Justin Sayre's previous books, Husky and Pretty, Mean explores the private and public life of Ellen, who is confident, cool, and, according to Davis, mean. But if speaking the truth and being unconcerned with petty gossip makes you mean, Ellen is fine with that. Besides, she has her own issues to deal with as middle school becomes a virtual battlefield of pubescent zombies, not unlike the obstacles in the video games she loves to play. Escaping into the world of online video games provides only temporary relief. In time she learns that being honest, even when it hurts, is the only weapon she can truly rely on\"--Amazon.com.
Book
First Case Report of Mange in Molossus molossus
There are many records of the family Sarcoptidae in bats. The species Notoedres (Notoedres) yunkeri has been reported only once, parasitizing a molossid bat in Panama. In the present study, we expand the occurrence of the species to Brazil.
Journal Article
Dodge City : Wyatt Earp, Bat Masterson, and the wickedest town in the American West
\"Dodge City, Kansas, is a place of legend. The town that started as a small military site exploded with the coming of the railroad, cattle drives, eager miners, settlers, and various entrepreneurs passing through ... Before long, Dodge City's streets were lined with saloons and brothels and its populace was thick with gunmen, horse thieves, and desperadoes ... By the 1870s, Dodge City was known as the most violent and turbulent town in the West. Enter Wyatt Earp and Bat Masterson ... The true story of their friendship, romances, gunfights, and adventures, along with the remarkable cast of characters they encountered along the way ... has gone largely untold--lost in the haze of Hollywood films and western fiction--until now\"-- Provided by publisher.
Book
First Case Report of Mange in Molossus molossus in Minas Gerais State, Brazil
There are many records of the family Sarcoptidae in bats. The species Notoedres (Notoedres) yunkeri has been reported only once, parasitizing a molossid bat in Panama. In the present study, we expand the occurrence of the species to Brazil. Key words: mange mite, notoedric mange, Chiroptera, Neotropical region, Brazil
Journal Article