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Emotion recognition plays an important role in human–computer interactions. Recent studies have focused on video emotion recognition in the wild and have run into difficulties related to occlusion, illumination, complex behavior over time, and auditory cues. State-of-the-art methods use multiple modalities, such as frame-level, spatiotemporal, and audio approaches. However, such methods have difficulties in exploiting long-term dependencies in temporal information, capturing contextual information, and integrating multi-modal information. In this paper, we introduce a multi-modal flexible system for video-based emotion recognition in the wild. Our system tracks and votes on significant faces corresponding to persons of interest in a video to classify seven basic emotions. The key contribution of this study is that it proposes the use of face feature extraction with context-aware and statistical information for emotion recognition. We also build two model architectures to effectively exploit long-term dependencies in temporal information with a temporal-pyramid model and a spatiotemporal model with “Conv2D+LSTM+3DCNN+Classify” architecture. Finally, we propose the best selection ensemble to improve the accuracy of multi-modal fusion. The best selection ensemble selects the best combination from spatiotemporal and temporal-pyramid models to achieve the best accuracy for classifying the seven basic emotions. In our experiment, we take benchmark measurement on the AFEW dataset with high accuracy.

Pharmaceutical manufacturing and logistics rely on accurate prediction and decision making to safeguard product quality, delivery reliability, and patient outcomes. Despite rapid advances in artificial intelligence (AI) and machine learning (ML), few studies benchmark model performance across the diverse operational demands of global pharmaceutical supply chains. Predictive setbacks contribute to financial losses, reduced supply chain efficacy, and potential adverse health consequences, yet understanding these failures offers firms opportunities to refine strategy and strengthen resilience. Drawing on 1.2 million shipments spanning 39 countries, we compare traditional statistical models (ARIMA), ensemble methods (random forests, gradient boosting), and deep neural networks (LSTM, GRU, CNN, ANN) across pricing, demand forecasting, vendor management, and shipment planning. Gradient boosting produced the strongest pricing performance, while ARIMA delivered the lowest demand-forecasting errors but with limited explanatory power; neural networks captured nonlinear demand shocks and achieved superior maintenance-risk classification. We also identified three vendor performance clusters—high-performing, cost-efficient, and mixed-reliability vendors—enabling firms to better align shipment criticality with vendor capabilities by prioritizing high performers for urgent deliveries, leveraging cost-efficient vendors for non-urgent volumes, and managing mixed performers through targeted oversight. These insights highlight the value of our evidence-based roadmap for selecting algorithms in high-stakes healthcare logistics, in rapidly evolving, technologically complex global contexts where increasing algorithmic sophistication elevates the standards for safer, smarter pharmaceutical supply chains.

Background Therapeutics against the envelope (Env) proteins of human immunodeficiency virus type 1 (HIV-1) effectively reduce viral loads in patients. However, due to mutations, new therapy-resistant Env variants frequently emerge. The sites of mutations on Env that appear in each patient are considered random and unpredictable. Here we developed an algorithm to estimate for each patient the mutational state of each position based on the mutational state of adjacent positions on the three-dimensional structure of the protein. Methods We developed a dynamic ensemble selection algorithm designated k-best classifiers. It identifies the best classifiers within the neighborhood of a new observation and applies them to predict the variability state of each observation. To evaluate the algorithm, we applied amino acid sequences of Envs from 300 HIV-1-infected individuals (at least six sequences per patient). For each patient, amino acid variability values at all Env positions were mapped onto the three-dimensional structure of the protein. Then, the variability state of each position was estimated by the variability at adjacent positions of the protein. Results The proposed algorithm showed higher performance than the base learner and a panel of classification algorithms. The mutational state of positions in the high-mannose patch and CD4-binding site of Env, which are targeted by multiple therapeutics, was predicted well. Importantly, the algorithm outperformed other classification techniques for predicting the variability state at multi-position footprints of therapeutics on Env. Conclusions The proposed algorithm applies a dynamic classifier-scoring approach that increases its performance relative to other classification methods. Better understanding of the spatiotemporal patterns of variability across Env may lead to new treatment strategies that are tailored to the unique mutational patterns of each patient. More generally, we propose the algorithm as a new high-performance dynamic ensemble selection technique.

Malware is one of the most common security threats experienced by a user when browsing webpages. A good understanding of the features of webpages (e.g., internet protocol, port, URL, Google index, and page rank) is required to analyze and mitigate the behavior of malware in webpages. This main objective of this paper is to analyze the key features of webpages and to mitigate the behavior of malware in webpages. To this end, we conducted an empirical study to identify the features that are most vulnerable to malware attacks and its results are reported. To improve the feature selection accuracy, a machine learning technique called bagging is employed using the Weka program. To analyze these behaviors, phishing and botnet data were obtained from the University of California Irvine machine learning repository. We validate our research findings by applying honeypot infrastructure using the Modern Honeypot Network (MHN) setup in a Linode Server. As the data suffer from high variance in terms of the type of data in each row, bagging is chosen because it can classify binary classes, date classes, missing values, nominal classes, numeric classes, unary classes and empty classes. As a base classifier of bagging, random tree was applied because it can handle similar types of data such as bagging, but better than other classifiers because it is faster and more accurate. Random tree had 88.22% test accuracy with the lowest run time (0.2 sec) and a receiver operating characteristic curve of 0.946. Results show that all features in the botnet dataset are equally important to identify the malicious behavior, as all scored more than 97%, with the exception of TCP and UDP. The accuracy of phishing and botnet datasets is more than 89% on average in both cross validation and test analysis. Recommendations are made for the best practice that can assist in future malware identification.