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Neuromodulation Image of the tentacle writhing behavior evoked in the small freshwater polyp Hydra vulgaris upon treatment with the semiconductor conjugated oligomer ETE‐S. Hydra is an attractive animal model for neuromodulation due to its limited behavioral capacity and a nervous system organized in spatially defined neuronal networks, which can promptly response to precise interrogation. In article 2400962, Silvia Santillo, Claudia Tortiglione, and co‐workers review recent data on the double function showed by thiophene based trimer in Hydra, showing intriguing possibilities offered by this model organism in the field of organic bioelectronics for both neuromodulation and in situ production of conducting interfaces.

The technology of wearable medical equipment has advanced to the point where it is now possible to monitor the electrocardiogram and electromyogram comfortably at home. The transition from wet Ag/AgCl electrodes to various types of gel-free dry electrodes has made it possible to continuously and accurately monitor the biopotential signals. Fabrics or textiles, which were once meant to protect the human body, have undergone significant development and are now employed as intelligent textile materials for healthcare monitoring. The conductive textile electrodes provide the benefit of being breathable and comfortable. In recent years, there has been a significant advancement in the fabrication of wearable conductive textile electrodes for monitoring biopotential signals. This review paper provides a comprehensive overview of the advances in wearable conductive textile electrodes for biopotential signal monitoring. The paper covers various aspects of the technology, including the electrode design, various manufacturing techniques utilised to fabricate wearable smart fabrics, and performance characteristics. The advantages and limitations of various types of textile electrodes are discussed, and key challenges and future research directions are identified. This will allow them to be used to their fullest potential for signal gathering during physical activities such as running, swimming, and other exercises while being linked into wireless portable health monitoring systems.

Non-contact electrodes have garnered significant attention as an alternative non-invasive biopotential measurement method that offers advantages such as improved subject comfort and ease of integration into everyday environments. Despite these benefits, ensuring consistent signal quality over time remains a critical challenge, particularly in applications like electrocardiography (ECG), where accuracy and reliability are paramount. This study investigates the temporal stability of signal quality in non-contact biopotential electrodes, with a primary focus on ECG monitoring. Our measurements showed a significant change in the recorded signal quality during prolonged measurement periods, which impacts the integrity and reliability of the measurements. Furthermore, it significantly impacts any shorter (<10 min) consecutive measurements of influential parameters (such as properties of electrodes, dielectric, etc.) since it removes the crucial ceteris paribus principle: the signal may not change just due to the change in influential parameters, but also due to the passage of time. Through a series of controlled experiments, we analyze how factors such as temperature, pressure on the electrodes, and humidity influence signal quality over extended durations (10 min or more). The results demonstrate key insights into the temporal dynamics of non-contact electrode performance, identifying potential sources of signal degradation and avenues for mitigation.

Human tissues own conductive properties, and the electrical activity produced by human organs can propagate throughout the body due to neuro transmitters and electrolytes. Therefore, it might be reasonable to hypothesize correlations and similarities between electrical activities among different parts of the body. Since no works have been found in this direction, the proposed study aimed at overcoming this lack of evidence and seeking analogies between the brain activity and the electrical activity of non-cerebral locations, such as the neck and wrists, to determine if i) cerebral parameters can be estimated from non-cerebral sites, and if ii) non-cerebral sensors can replace cerebral sensors for the evaluation of the users under specific experimental conditions, such as eyes open or closed. In fact, the use of cerebral sensors requires high-qualified personnel, and reliable recording systems, which are still expensive. Therefore, the possibility to use cheaper and easy-to-use equipment to estimate cerebral parameters will allow making some brain-based applications less invasive and expensive, and easier to employ. The results demonstrated the occurrence of significant correlations and analogies between cerebral and non-cerebral electrical activity. Furthermore, the same discrimination and classification accuracy were found in using the cerebral or non-cerebral sites for the user’s status assessment.

The use of wearable sensors for health monitoring is rapidly growing. Over the past decade, wearable technology has gained much attention from the tech industry for commercial reasons and the interest of researchers and clinicians for reasons related to its potential benefit on patients’ health. Wearable devices use advanced and specialized sensors able to monitor not only activity parameters, such as heart rate or step count, but also physiological parameters, such as heart electrical activity or blood pressure. Electrocardiogram (ECG) monitoring is becoming one of the most attractive health-related features of modern smartwatches, and, because cardiovascular disease (CVD) is one of the leading causes of death globally, the use of a smartwatch to monitor patients could greatly impact the disease outcomes on health care systems. Commercial wearable devices are able to record just single-lead ECG using a couple of metallic contact dry electrodes. This kind of measurement can be used only for arrhythmia diagnosis. For the diagnosis of other cardiac disorders, additional ECG leads are required. In this study, we characterized an electronic interface to be used with multiple contactless capacitive electrodes in order to develop a wearable ECG device able to perform several lead measurements. We verified the ability of the electronic interface to amplify differential biopotentials and to reject common-mode signals produced by electromagnetic interference (EMI). We developed a portable device based on the studied electronic interface that represents a prototype system for further developments. We evaluated the performances of the developed device. The signal-to-noise ratio of the output signal is favorable, and all the features needed for a clinical evaluation (P waves, QRS complexes and T waves) are clearly readable.

High‐density electroencephalography (HD‐EEG) is currently limited to laboratory environments since state‐of‐the‐art electrode caps require skilled staff and extensive preparation. We propose and evaluate a 256‐channel cap with dry multipin electrodes for HD‐EEG. We describe the designs of the dry electrodes made from polyurethane and coated with Ag/AgCl. We compare in a study with 30 volunteers the novel dry HD‐EEG cap to a conventional gel‐based cap for electrode‐skin impedances, resting state EEG, and visual evoked potentials (VEP). We perform wearing tests with eight electrodes mimicking cap applications on real human and artificial skin. Average impedances below 900 kΩ for 252 out of 256 dry electrodes enables recording with state‐of‐the‐art EEG amplifiers. For the dry EEG cap, we obtained a channel reliability of 84% and a reduction of the preparation time of 69%. After exclusion of an average of 16% (dry) and 3% (gel‐based) bad channels, resting state EEG, alpha activity, and pattern reversal VEP can be recorded with less than 5% significant differences in all compared signal characteristics metrics. Volunteers reported wearing comfort of 3.6 ± 1.5 and 4.0 ± 1.8 for the dry and 2.5 ± 1.0 and 3.0 ± 1.1 for the gel‐based cap prior and after the EEG recordings, respectively (scale 1–10). Wearing tests indicated that up to 3,200 applications are possible for the dry electrodes. The 256‐channel HD‐EEG dry electrode cap overcomes the principal limitations of HD‐EEG regarding preparation complexity and allows rapid application by not medically trained persons, enabling new use cases for HD‐EEG. We describe the design and validation of a novel 256‐channel high‐density electroencephalography (HD‐EEG) cap comprising dry electrodes made from polyurethane and coated with Ag/AgCl. We compare in a study with 30 volunteers the novel dry HD‐EEG cap to a conventional gel‐based cap for electrode‐skin impedances, resting state EEG, visual evoked potentials, applicability, and wear. The 256‐channel HD‐EEG dry electrode cap overcomes the principal limitations of HD‐EEG regarding preparation complexity and allows rapid application by not medically trained persons, enabling new use cases for HD‐EEG.

Dry electrodes offer an accessible continuous acquisition of biopotential signals as part of current in-home monitoring systems but often face challenges of high-contact impedance that results in poor signal quality. The performance of dry electrodes could be affected by electrode material and skin hydration. Herein, we investigate these dependencies using a circuit skin-electrode interface model, varying material and hydration in controlled benchtop experiments on a biomimetic skin phantom simulating dry and hydrated skin. Results of the model demonstrate the contribution of the individual components in the circuit to total impedance and assist in understanding the role of electrode material in the mechanistic principle of dry electrodes. Validation was performed by conducting in vivo skin-electrode contact impedance measurements across ten normative human subjects. Further, the impact of the electrode on biopotential signal quality was evaluated by demonstrating an ability to capture clinically relevant electrocardiogram signals by using dry electrodes integrated into a toilet seat cardiovascular monitoring system. Titanium electrodes resulted in better signal quality than stainless steel electrodes. Results suggest that relative permittivity of native oxide of electrode material come into contact with the skin contributes to the interface impedance, and can lead to enhancement in the capacitive coupling of biopotential signals, especially in dry skin individuals.

Intrinsically conducting polymers (ICPs), such as polyacetylene, polyaniline, polypyrrole, polythiophene, and poly(3,4‐ethylenedioxythiophene) (PEDOT), can have important application in flexible electronics owing to their unique merits including high conductivity, high mechanical flexibility, low cost, and good biocompatibility. The requirements for their application in flexible electronics include high conductivity and appropriate mechanical properties. The conductivity of some ICPs can be enhanced through a postpolymerization treatment, the so‐called “secondary doping.” A conducting polymer film with high conductivity can be used as flexible electrode and even as flexible transparent electrode of optoelectronic devices. The application of ICPs as stretchable electrode requires high mechanical stretchability. The mechanical stretchability of ICPs can be improved through blending with a soft polymer or plasticization. Because of their good biocompatibility, ICPs can be modified as dry electrode for biopotential monitoring and neural interface. In addition, ICPs can be used as the active material of strain sensors for healthcare monitoring, and they can be adopted to monitor food processing, such as the fermentation, steaming, storage, and refreshing of starch‐based food because of the resistance variation caused by the food volume change. All these applications of ICPs are covered in this review article. Because they combine the merits of metals and plastics, intrinsically conducting polymers can have important application in flexible electronic devices and systems, such as flexible electrode particularly the transparent electrode of optoelectronic devices, stretchable electrode, dry biopotential electrode, neural interface, and strain sensors for healthcare monitoring and food processing monitoring.

In this work, we propose a wireless wearable system for the acquisition of multiple biopotentials through charge transfer electrostatic sensors realized in MEMS technology. The system is designed for low power consumption and low invasiveness, and thus candidates for long-time monitoring in free-living conditions, with data recording on an SD or wireless transmission to an external elaborator. Thanks to the wide horizon of applications, research is very active in this field, and in the last few years, some devices have been introduced on the market. The main problem with those devices is that their operation is time-limited, so they do not match the growing demand for long monitoring, which is a must-have feature in diagnosing specific diseases. Furthermore, their versatility is hampered by the fact that they have been designed to record just one type of signal. Using ST-Qvar sensors, we acquired an electrocardiogram trace and single-channel scalp electroencephalogram from the frontal lobes, together with an electrooculogram. Excellent results from all three types of acquisition tests were obtained. The power consumption is very low, demonstrating that, thanks to the MEMS technology, a continuous acquisition is feasible for several days.

A general overview is provided on the neuromodulatory function of thiophene‐based semiconductors discovered and characterized in the invertebrate model organism, the cnidarian Hydra vulgaris. The small freshwater polyp Hydra is an attractive animal model for neuromodulation due to its simple body anatomy and a nervous system with hundreds to thousands of neurons organized in distinct circuits, each controlling a limited set of behaviors. With the aim of characterizing the polymerization of the thiophene‐based trimers in the soft tissues of this simple model, an unexpected animal behavior is observed in addition to polymerization, and the neurons involved and the possible underlying mechanisms are identified. To date, the neuromodulatory action of these compounds in other in vivo models has not been observed. Here, the recent data on the double function showed by thiophene‐based trimers in Hydra is summarized, from the polymerization into conductive structures driven by endogenous enzymatic activities to neuromodulatory action on specific neuronal circuits. The data open intriguing research possibilities offered by this model organism in the field of organic bioelectronics for both neuromodulation and in situ production of conducting interfaces to influence biological processes and functions. Semiconducting organic compounds, thiophene‐based, modify the rhythmic electrical activity of the cnidarian Hydra vulgaris acting on specific neuronal circuits. The ETE‐S trimer also forms electronically conducting wires in the living tissues of the animal. These data open intriguing research possibilities in the field of organic bioelectronics for both neuromodulation and in situ production of conducting interfaces to influence biological processes and functions.