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Yoga wisdom at work : finding sanity off the mat and on the job
\"Yoga practitioners fight work stress with stretching and breathing exercises-but does yoga stop when you step off the mat? In this surprising book, the authors show why poses-asanas-are just one part of yoga practice. There are seven other \"limbs\" of yoga that are often neglected, especially during the workday\"-- Provided by publisher.
Book
The Dose Response Multicentre Investigation on Fluid Assessment (DoReMIFA) in critically ill patients
Background
The previously published “Dose Response Multicentre International Collaborative Initiative (DoReMi)” study concluded that the high mortality of critically ill patients with acute kidney injury (AKI) was unlikely to be related to an inadequate dose of renal replacement therapy (RRT) and other factors were contributing. This follow-up study aimed to investigate the impact of daily fluid balance and fluid accumulation on mortality of critically ill patients without AKI (N-AKI), with AKI (AKI) and with AKI on RRT (AKI-RRT) receiving an adequate dose of RRT.
Methods
We prospectively enrolled all consecutive patients admitted to 21 intensive care units (ICUs) from nine countries and collected baseline characteristics, comorbidities, severity of illness, presence of sepsis, daily physiologic parameters and fluid intake-output, AKI stage, need for RRT and survival status. Daily fluid balance was computed and fluid overload (FO) was defined as percentage of admission body weight (BW). Maximum fluid overload (MFO) was the peak value of FO.
Results
We analysed 1734 patients. A total of 991 (57 %) had N-AKI, 560 (32 %) had AKI but did not have RRT and 183 (11 %) had AKI-RRT. ICU mortality was 22.3 % in AKI patients and 5.6 % in those without AKI (
p
< 0.0001). Progressive fluid accumulation was seen in all three groups. Maximum fluid accumulation occurred on day 2 in N-AKI patients (2.8 % of BW), on day 3 in AKI patients not receiving RRT (4.3 % of BW) and on day 5 in AKI-RRT patients (7.9 % of BW). The main findings were: (1) the odds ratio (OR) for hospital mortality increased by 1.075 (95 % confidence interval 1.055–1.095) with every 1 % increase of MFO. When adjusting for severity of illness and AKI status, the OR changed to 1.044. This phenomenon was a continuum and independent of thresholds as previously reported. (2) Multivariate analysis confirmed that the speed of fluid accumulation was independently associated with ICU mortality. (3) Fluid accumulation increased significantly in the 3-day period prior to the diagnosis of AKI and peaked 3 days later.
Conclusions
In critically ill patients, the severity and speed of fluid accumulation are independent risk factors for ICU mortality. Fluid balance abnormality precedes and follows the diagnosis of AKI.
Journal Article
Within you is the power : (around the world with Dr. Murphy)
\"One of three classic reissues by the mega-selling author of The Power of Your Subconscious Mind to inaugurate TarcherPerigee's exciting new line, The Joseph Murphy Library of Success! In this deeply practical and engaging guidebook, Joseph Murphy takes you into different cultures and ancient teachings from around the world to expose you to the unadorned truth of who you really are: a physical temple of cosmic power that is waiting to be unleashed by exercises, prayers, and techniques which have brought abudance and power to men and women across the ages\"-- Provided by publisher.
Book
A Comprehensive Cohort Analysis Comparing Growth and GH Therapy Response in IGF1R Mutation Carriers and SGA Children
Abstract
Context
IGF1 receptor mutations (IGF1RM) are rare; however, patients exhibit pronounced growth retardation without catch-up. Although several case reports exist, a comprehensive statistical analysis investigating growth profile and benefit of recombinant human growth hormone (rhGH) treatment is still missing.
Objective and methods
Here, we compared IGF1RM carriers (n = 23) retrospectively regarding birth parameters, growth response to rhGH therapy, near final height, and glucose/insulin homeostasis to treated children born small for gestational age (SGA) (n = 34). Additionally, health profiles of adult IGF1RM carriers were surveyed by a questionnaire.
Results
IGF1RM carriers were significantly smaller at rhGH initiation and had a diminished first-year response compared to SGA children (Δ height standard deviation score: 0.29 vs. 0.65), resulting in a lower growth response under therapy. Interestingly, the number of poor therapy responders was three times higher for IGF1RM carriers than for SGA patients (53 % vs. 17 %). However, most IGF1RM good responders showed catch-up growth to the levels of SGA patients. Moreover, we observed no differences in homeostasis model assessment of insulin resistance before treatment, but during treatment insulin resistance was significantly increased in IGF1RM carriers compared to SGA children. Analyses in adult mutation carriers indicated no increased occurrence of comorbidities later in life compared to SGA controls.
Conclusion
In summary, IGF1RM carriers showed a more pronounced growth retardation and lower response to rhGH therapy compared to non-mutation carriers, with high individual variability. Therefore, a critical reevaluation of success should be performed periodically. In adulthood, we could not observe a significant influence of IGF1RM on metabolism and health of carriers.
Journal Article
Living the reiki way : reiki principles for everyday living
\"Practicing Reiki is not simply about healing others--it is also about healing yourself and growing spiritually. In Living the Reiki Way, Penelope Quest offers practical and spiritual guidance on how you can absorb Reiki principles into your everyday life. Adapted from Dr. Mikao Usui's original Reiki healing system, Penelope offers six key principles for us to live by: --Live \"in the now\" --Live without anger --Live without worry --Live with gratitude --Live with kindness --Work honestly and diligently In Living the Reiki Way, she guides us through the meanings and implications of each principle--and explains how they can help us achieve long-term happiness and contentment\"-- Provided by publisher.
Book
Hypoxia-induced transcription factor signaling is essential for larval growth of the mosquito Aedes aegypti
Gut microbes positively affect the physiology of many animals, but the molecular mechanisms underlying these benefits remain poorly understood. We recently reported that bacteria-induced gut hypoxia functions as a signal for growth and molting of the mosquito Aedes aegypti. In this study, we tested the hypothesis that transduction of a gut hypoxia signal requires hypoxia-induced transcription factors (HIFs). Expression studies showed that HIF-α was stabilized in larvae containing bacteria that induce gut hypoxia but was destabilized in larvae that exhibit normoxia. However, we could rescue growth of larvae exhibiting gut normoxia by treating them with a prolyl hydroxylase inhibitor, FG-4592, that stabilized HIF-α, and inhibit growth of larvae exhibiting gut hypoxia by treating them with an inhibitor, PX-478, that destabilized HIF-α. Using these tools, we determined that HIF signaling activated the insulin/insulin growth factor pathway plus select mitogen-activated kinases and inhibited the adenosine monophosphate-activated protein kinase pathway. HIF signaling was also required for growth of the larval midgut and storage of neutral lipids by the fat body. Altogether, our results indicate that gut hypoxia and HIF signaling activate multiple processes in A. aegypti larvae, with conserved functions in growth and metabolism.
Journal Article
A year without fear : 365 days of magnificence
\" Career coach and Harvard-trained lawyer Tama Kieves presents 365 tidbits of easy-to-digest wisdom in a day-by-day format that readers will love! In this day-by-day book, motivational speaker, career coach, and Harvard-trained lawyer Tama Kieves presents the reader with 365 days worth of inspiration for overcoming fear, conquering obstacles, and achieving their life's greatest work. With morsels of wisdom presented in an easy-to-action format, this book will help readers to realize and achieve their true destiny! \"-- Provided by publisher.
Book
Early-late life trade-offs and the evolution of ageing in the wild
Empirical evidence for declines in fitness components (survival and reproductive performance) with age has recently accumulated in wild populations, highlighting that the process of senescence is nearly ubiquitous in the living world. Senescence patterns are highly variable among species and current evolutionary theories of ageing propose that such variation can be accounted for by differences in allocation to growth and reproduction during early life. Here, we compiled 26 studies of free-ranging vertebrate populations that explicitly tested for a trade-off between performance in early and late life. Our review brings overall support for the presence of early-late life tradeoffs, suggesting that the limitation of available resources leads individuals to trade somatic maintenance later in life for high allocation to reproduction early in life. We discuss our results in the light of two closely related theories of ageing—the disposable soma and the antagonistic pleiotropy theories—and propose that the principle of energy allocation roots the ageing process in the evolution of life-history strategies. Finally, we outline research topics that should be investigated in future studies, including the importance of natal environmental conditions in the study of trade-offs between early-and late-life performance and the evolution of sex-differences in ageing patterns.
Journal Article
It's not your money : how to live fully from divine abundance
\"From the author of the acclaimed Outrageous Openness, a witty and spirited guide to radically releasing the burden of financial fears It's natural to crave prosperity. Some seek to manifest it in myriad ways--using anything from vision boards to writing a pretend check for a million dollars from the Bank of Divinity. Yet whatever comes, or doesn't, the mind always seems to want more. But what if there was a whole other way? Instead of grasping and chasing, what if we offered everything--our money (or lack of it), our triumphs, our problems, our desires--fully back to Love? What if this offering itself was actually the secret to abundance? Tosha Silver, internationally beloved spiritual guide, has created a practical and powerful financial book unlike any other. Leading you through a deeply transformative eight-week process, she shares the mental, emotional, and spiritual steps that anyone can take to learn to fully receive and prosper. Her step-by-step guidance is filled with prayers, meditations, and stories to help you find and heal the source of these fears and unworthiness. As you come to know you are part of something larger--something that you serve and that longs to serve you--you begin to feel a new sense of freedom and abundance\"-- Provided by publisher.
Book
Optimal energy allocation trade-off driven by size-dependent physiological and demographic responses to warming
Body size–dependent physiological effects of temperature influence individual growth, reproduction, and survival, which govern animal population responses to global warming. Considerable knowledge has been established on how such effects can affect population growth and size structure, but less is known of their potential role in temperature-driven adaptation in life-history traits. In this study, we ask how warming affects the optimal allocation of energy between growth and reproduction and disentangle the underlying fitness trade-offs. To this end, we develop a novel dynamic energy budget integral projection model (DEB–IPM), linking individuals’ size- and temperature-dependent consumption and maintenance via somatic growth, reproduction, and size-dependent energy allocation to emergent population responses. At the population level, we calculate the long-term population growth rate (fitness) and stable size structure emerging from demographic processes. Applying the model to an example of pike (Esox lucius), we find that optimal energy allocation to growth decreases with warming. Furthermore, we demonstrate how growth, fecundity, and survival contribute to this change in optimal allocation. Higher energy allocation to somatic growth at low temperatures increases fitness through survival of small individuals and through the reproduction of larger individuals. In contrast, at high temperatures, increased allocation to reproduction is favored because warming induces faster somatic growth of small individuals and increased fecundity but reduced growth and higher mortality of larger individuals. Reduced optimum allocation to growth leads to further reductions in body size and an increasingly truncated population size structure with warming. Our study demonstrates how, by incorporating general physiological mechanisms driving the temperature dependence of life-history traits, the DEB–IPM framework is useful for investigating the adaptation of size-structured organisms to warming.
Journal Article