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Objective: The aim of the study was to compare the cleaning efficacy and plaque control of the straight and angled bristle design manual toothbrushes. Materials and Methods: It was a pilot randomized trial comprising 30 dental students divided into 2 groups (group I flat bristle design toothbrush and group II zig-zag bristle design toothbrush) with 15 in each group. Prebrushing and postbrushing plaque scores were recorded at the baseline and at the end of 4 weeks using Turesky modification of Quigley and Hein plaque index. Results: Plaque and gingival scores were reduced significantly at 1 month in group II with P < 0.05 than compared to group I where P > 0.05. Mean GI and plaque scores of the criss-cross design were reduced significantly after 1 month (P < 0.05). Intergroup comparisons revealed that plaque and gingival scores significantly reduced (P < 0.05) at 1-month interval. Conclusion: Bristle design has significant impact on plaque removal capacity of a toothbrush. Toothbrush with zig-zag bristle design is efficient in removing plaque than the flat design of a toothbrush.

Friction force models play a fundamental role for simulation of mechanical systems. Their choice affects the matching of numerical results with physically observed behavior. Friction is a complex phenomenon depending on many physical parameters and working conditions, and none of the available models can claim general validity. This paper focuses the attention on well-known friction models and offers a review and comparison based on numerical efficiency. However, it should be acknowledged that each model has its own distinctive pros and cons. Suitability of the model depends on physical and operating conditions. Features such as the capability to replicate stiction, Stribeck effect, and pre-sliding displacement are taken into account when selecting a friction formulation. For mechanical systems, the computational efficiency of the algorithm is a critical issue when a fast and responsive dynamic computation is required. This paper reports and compares eight widespread engineering friction force models. These are divided into two main categories: those based on the Coulomb approach and those established on the bristle analogy. The numerical performances and differences of each model have been monitored and compared. Three test cases are discussed: the Rabinowicz test and other two test problems casted for this occurrence.

Sensory hairs on the back of a fruit fly are lined up in neat rows. The orderliness of this arrangement has encouraged models based on organized specification of the hairs. Corson et al. now show that development is both less precise and more effective than that. They used mathematical modeling to recapitulate genetic effects as the developing epidermis becomes organized into enough rows and single lines of hairs. Their work suggests that the sensory field develops through self-organizing patterning that can adjust to the size of the epidermis. Science , this issue p. eaai7407 Distributed and flexible patterning combines with cell-cell interactions to establish rows of sensory bristles on the fly thorax. The emergence of spatial patterns in developing multicellular organisms relies on positional cues and cell-cell communication. Drosophila sensory organs have informed a paradigm in which these operate in two distinct steps: Prepattern factors drive localized proneural activity, then Notch-mediated lateral inhibition singles out neural precursors. Here we show that self-organization through Notch signaling also establishes the proneural stripes that resolve into rows of sensory bristles on the fly thorax. Patterning, initiated by a gradient of Delta ligand expression, progresses through inhibitory signaling between and within stripes. Thus, Notch signaling can support self-organized tissue patterning as a prepattern is transduced by cell-cell interactions into a refined arrangement of cellular fates.

The aim of this study is to clarify the deflection, splaying, and abrasion of single tufts of polybutylene terephthalate (PBT) toothbrushes after use. A single-center randomized controlled trial is performed. The changes in deflection, bristle splaying, and abrasion are investigated for the middle single tuft of the top line (top–middle tuft) and the middle single tuft of the bottom line (bottom–middle tuft) of PBT toothbrushes with medium stiffness after 1 month, 2 months, and 3 months of use by 34 participants. A soft-material bending-resistance tester is used to assess the deflection of the single tufts. The deflection value of the top–middle tuft significantly increased after 1 month of use compared with the baseline. In contrast, the deflection of the bottom–middle tuft significantly increased after 3 months of use compared with the baseline and after 1 month and 2 months of use. Importantly, the change in deflection was distinctly different between the top– and bottom–middle tufts. The bristle splaying of both tufts significantly increased after use, but a significant change in bristle abrasion was not found. The bending stiffness of the top tuft of a PBT toothbrush may decrease more rapidly than that of the bottom tuft with use.

The most common and numerous island type across the Pacific basin are atolls. Even though these island systems harbor only a few endemic species, atolls are globally important nesting sites for seabirds and sea turtles, roosting sites for migratory shorebirds, and refugia for Oceania's unique lowland flora and fauna. While atolls were extensively surveyed for their island biodiversity in the second half of the twentieth century, many remain unmapped, leaving important knowledge gaps for Pacific biodiversity, biogeography, and conservation. Here, we report on a terrestrial biodiversity survey of Manuae atoll, Cook Islands. Our assessment revealed that Manuae atoll harbors seabird colonies and is an important green sea turtle nesting site. Furthermore, we found at least 100 bristle-thighed curlews (Numenius tahitiensis) overwintering on the island (ca. 1% of the estimated global population), which under international evaluation criteria renders the atoll an important overwintering area that warrants protection and recognition. While our island biodiversity assessment and mapping, including vascular plants, land crabs, reptiles, and birds, reveals that Manuae atoll is an important refuge for lowland island biota within the Cook Islands, we also documented the presence of key introduced species, including Pacific rats (Rattus exulans) and yellow crazy ants (Anoplolepis gracilipes), and a colonial legacy in the overall habitat composition from the abandoned copra plantation. Our findings on the terrestrial biodiversity of Manuae atoll fill an important knowledge gap in island biodiversity data from the Cook Islands. This information can support future ecological and biodiversity research, as well as inform management, protection, and restoration planning.

The epidermis is equipped with specialized mechanosensory organs that enable the detection of tactile stimuli. Here, by examining the differentiation of the tactile bristles, mechanosensory organs decorating the Drosophila adult epidermis, we show that neighbouring epidermal cells are essential for touch perception. Each mechanosensory bristle signals to the surrounding epidermis to co-opt a single epidermal cell, which we named the F-Cell. Once specified, the F-Cell adopts a specialized morphology to ensheath each bristle. Functional assays reveal that adult mechanosensory bristles require association with the epidermal F-Cell for touch sensing. Our findings underscore the importance of resident epidermal cells in the assembly of functional touch-sensitive organs. Mangione et al. report that sensory bristles co-opt neighbouring epidermal cells, which adopt a special morphology and contribute to touch sensing in Drosophila .

During development, cells in tissues must be patterned correctly in order to support tissue function and shape. The sensory bristles of the peripheral nervous system on the thorax of Drosophila melanogaster self-organizes from a unpatterned epithelial tissue to a regular spot pattern during pupal stages. Wild type patterning requires Notch-mediated lateral inhibition. Scabrous is a protein that can bind to and modify Notch receptor activity. Scabrous can be secreted, but it is also known to be localized to basal signaling filopodia, or cytonemes, that play a role in long-range Notch signaling. Here we show that Scabrous is primarily distributed basally, within the range of signaling filopodia extension. We show that filamentous actin dynamics are required for the distribution of Scabrous protein during sensory bristle patterning stages. We show that the Notch response of epithelial cells is sensitive to the level of Scabrous protein being expressed by the sensory bristle precursor cell. Our findings at the cell-level suggest a model for how epithelial cells engaged in lateral inhibition at a distance are sensitive local levels of Scabrous protein.

Some animals respond to injury by inducing new growth to regenerate the lost structures. This regenerative growth must be carefully controlled and constrained to prevent aberrant growth and to allow correct organization of the regenerating tissue. However, the factors that restrict regenerative growth have not been identified. Using a genetic ablation system in the Drosophila wing imaginal disc, we have identified one mechanism that constrains regenerative growth, impairment of which also leads to erroneous patterning of the final appendage. Regenerating discs with reduced levels of the RNA-regulator Brain tumor (Brat) exhibit enhanced regeneration, but produce adult wings with disrupted margins that are missing extensive tracts of sensory bristles. In these mutants, aberrantly high expression of the pro-growth factor Myc and its downstream targets likely contributes to this loss of cell-fate specification. Thus, Brat constrains the expression of pro-regeneration genes and ensures that the regenerating tissue forms the proper final structure.

Wind-dispersed plants have evolved ingenious ways to lift their seeds 1 , 2 . The common dandelion uses a bundle of drag-enhancing bristles (the pappus) that helps to keep their seeds aloft. This passive flight mechanism is highly effective, enabling seed dispersal over formidable distances 3 , 4 ; however, the physics underpinning pappus-mediated flight remains unresolved. Here we visualized the flow around dandelion seeds, uncovering an extraordinary type of vortex. This vortex is a ring of recirculating fluid, which is detached owing to the flow passing through the pappus. We hypothesized that the circular disk-like geometry and the porosity of the pappus are the key design features that enable the formation of the separated vortex ring. The porosity gradient was surveyed using microfabricated disks, and a disk with a similar porosity was found to be able to recapitulate the flow behaviour of the pappus. The porosity of the dandelion pappus appears to be tuned precisely to stabilize the vortex, while maximizing aerodynamic loading and minimizing material requirements. The discovery of the separated vortex ring provides evidence of the existence of a new class of fluid behaviour around fluid-immersed bodies that may underlie locomotion, weight reduction and particle retention in biological and manmade structures. The flight of dandelion seeds is enabled by an extraordinary vortex ring, which was revealed by the visualization of the flow around the seed.

Dusky-like (Dyl) is a transmembrane protein containing a zona pellucida domain. Its physiological roles during metamorphosis have been well explored in Drosophila melanogaster and have also been documented in Tribolium castaneum. However, Dyl has undergone a functional shift between Diptera and Coleoptera insects. Further investigation of Dyl in other insects will be helpful to further clarify its function in insect growth and development. Henosepilachna vigintioctopunctata is an important Coleoptera that causes enormous economic losses in agriculture in China. In this study, we found that the expression of Hvdyl was detectable in embryos, larvae, prepupae, pupae, and adults. We knocked down Hvdyl in third- and fourth-instar larvae and pupae with RNA interference (RNAi). RNAi of Hvdyl mainly caused two phenotypic defects. Firstly, the growth of epidermal cellular protuberances was suppressed. Injection of dsdyl (double-stranded dusky-like RNA) at the third-instar larval stage truncated the scoli throughout the thorax and abdomen and shortened the setae on the head capsules and mouthparts of the fourth-instar larvae. Introduction of dsdyl at the third- and fourth-instar stages led to misshapen pupal setae. The setae were shortened or became black nodules. Treatment with dsdyl at the larval and pupal stages resulted in deformed adults with completely suppressed wing hairs. Moreover, the knockdown of Hvdyl at the third-instar stage caused deformed larval mouthparts at the fourth-instar period. As a result, foliage consumption was inhibited, and larval growth was slowed. The results indicate that Dyl is associated with the growth of cellular protuberances throughout development and with the formation of the cuticle in H. vigintioctopunctata.