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result(s) for
"capsules"
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Nancy Clancy sees the future ; Nancy Clancy : secret of the silver key
Third-grader Nancy tries telling fortunes but learns it is a bit more complicated than she thought, and after learning about time capsules, she and Bree discover an old silver key and investigate its story in the hope of finding treasure.
BOOK
Benefits and costs of a hypercapsule and the mechanism of its loss in a clinical isolate of Acinetobacter baumannii
Acinetobacter baumannii is a clinically important opportunistic pathogen that exhibits striking phenotypic diversity. In particular, some clinical isolates produce unusually thick capsules, which are thought to contribute to immune evasion and persistence, while others lack the capsule altogether. However, the biological significance of these contrasting phenotypes has remained unclear. We analyzed a clinical isolate that spontaneously gives rise to capsule-deficient variants from a hypercapsulated form. We found that the conversion is driven by spontaneous mutations in capsule biosynthesis genes, including de novo mutations arising during liquid culture, while the expansion of capsule-deficient cells is promoted under oxygen-limited conditions. The two variants differed in serum resistance, desiccation tolerance, growth characteristics, and antibiotic responses, revealing a trade-off between protective barriers and environmental adaptability. These findings provide new insights into how A. baumannii may balance survival strategies through genetic and phenotypic heterogeneity, with potential implications for diagnosis, treatment, and bacterial persistence in clinical settings.
Journal Article
Remembrance of things present : the invention of the time capsule
\"Time capsules offer unexpected insights into how people view their own time, place, and culture, as well as their duties to future generations. Remembrance of Things Present traces the birth of this device to the Gilded Age, when growing urban volatility prompted doubts about how the period would be remembered--or if it would be remembered at all. Yablon details how diverse Americans - from presidents and mayors to advocates for the rights of women, blacks, and workers - constructed prospective memories of their present. They did so by contributing not just written testimony to time capsules but also sources that historians and archivists considered illegitimate, such as photographs, phonograph records, films, and everyday artifacts. By offering a direct line to posterity, time capsules stimulated various hopes for the future. Remembrance of Things Present delves into these treasure chests to unearth those forgotten futures.\"--Book cover flap.
Book
Rotation versus non-rotation of intraocular lens for prevention of posterior capsular opacification
Purpose:
To study the effect of rotation of intraocular lens (IOL) on posterior capsular opacification (PCO) in eyes with phacoemulsification.
Methods:
This was a prospective, comparative, randomized case series. One eye of each patient was randomized to one of two groups. The 360-degree rotation of IOL was carried out after its placement in the capsular bag (rotation group). The control group had no rotation of IOL. PCO was analyzed by an independent observer on EPCO computer analysis system at 6, 12, 24, and 36 months.
Results:
The study included 50 patients (100 eyes) with senile cataracts scheduled for phacoemulsification and IOL implantation. The median age in 2 groups was 66 years. 25% quartile age in both the group was 62 years (P = 0.06). There were 30 males, and 20 females. The median PCO score at 6, 12 and 24 months was significantly low in the rotation group (0.15, 0.13, 0.22) compared to the control group (0.22, 0.23, 0.25). There was no significant difference in PCO score between the two groups from 24-36 months. The median PCO score at 36 months was 0.2 in both the groups. At the end of three years, 4 eyes (8%) in the rotation group, and 10 eyes (20%) in the control group needed Nd:YAG capsulotomy (P = 0.04).
Conclusion:
Rotation of IOL in the capsular bag decreases PCO and Nd:YAG capsulotomy rate.
Journal Article
Breakout
From multiple perspectives, tells of a time capsule project and the middle schoolers who contribute, including future journalist Nora Tucker and newcomer Elidee Jones, whose brother is in the local prison.
Book
Comparative phase I randomized open-label pilot clinical trial of Gynophilus® (Lcr regenerans®) immediate release capsules versus slow release muco-adhesive tablets
Gynophilus® (Lcr regenerans®) is a live biotherapeutic product (LBP) that contains the live biotherapeutic microorganism Lactobacillus rhamnosus Lcr35®, which is indicated to restore vaginal health. The aim of the study was to compare the safety, ease of use, and compliance of two formulations (immediate release: IR capsule and slow release: SR muco-adhesive tablets) as well as the colonization of Lcr35® in healthy women. This phase I study (Comprigel) is a parallel, randomized, 4-arm, and open-label clinical trial evaluating an IR daily capsule formulation vs. a SR tablet administered every 3, 4, or 5 days for 21 days. Self-collected vaginal swabs were used to quantify Lcr35® and characterize the composition and structure of the vaginal microbiota. Both LBPs were well-tolerated, and no severe adverse effects were reported. All groups had Lcr35® vaginal concentrations over 107 colony forming unit per milliliter of vaginal secretion on each day in the study. The new Gynophilus® slow release tablets administered either every 3, 4, or 5 days provided vaginal concentrations that were not significantly different from those of classic Gynophilus® (capsule) once-a-day regimen. The LBPs and the different regimens did not adversely influence the abundance of native Lactobacillus spp. and indeed tended to favor their growth and reduce colonization by non-Lactobacillus spp. This study illustrates that the SR muco-adhesive LBP tablet (Gynophilus® SR) administered every 3 or 4 days as a safe, well-tolerated, and efficacious alternative to a more demanding IR daily capsule and could protect women’s healthy vaginal microbiome by promoting endogenous Lactobacillus spp.
Journal Article
Time thief
Nancy and her friends watch the principal dig up the school's time capsule, buried over thirty years ago, but when an important vintage doll is discovered missing from the capsule, the Clue Crew is called in to investigate.
Book
Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus
Active inflammatory bowel disease (IBD) often coincides with increases of Ruminococcus gnavus, a gut microbe found in nearly everyone. It was not known how, or if, this correlation contributed to disease. We investigated clinical isolates of R. gnavus to identify molecular mechanisms that would link R. gnavus to inflammation. Here, we show that only some isolates of R. gnavus produce a capsular polysaccharide that promotes a tolerogenic immune response, whereas isolates lacking functional capsule biosynthetic genes elicit robust proinflammatory responses in vitro. Germ-free mice colonized with an isolate of R. gnavus lacking a capsule show increased measures of gut inflammation compared to those colonized with an encapsulated isolate in vivo. These observations in the context of our earlier identification of an inflammatory cell-wall polysaccharide reveal how some strains of R. gnavus could drive the inflammatory responses that characterize IBD.
Journal Article
Abuela's special letters
Sofia is making a family time capsule, filled with pictures and mementos from their lives, to be opened in fifteen years, and Abuela contributes letters to each of her grandchildren--but Sofia is so consumed with curiosity that she decides to sneak a peak at what her letter says.
Book
Anterior and posterior capsular opacification with the Tecnis ZCB00 and AcrySof SA60AT IOLs: a randomised intraindividual comparison
Purpose To evaluate and compare the 1-year postoperative levels of posterior capsule opacification (PCO) as well as the level of anterior capsule retraction and opacification (ACO) after implantation of two single-piece hydrophobic acrylic intraocular lens (IOL) models. Methods Randomised, controlled, prospective and double-blind study including 148 eyes of 74 patients (age range, 61–80 years) with bilateral senile cataract. Each patient underwent surgery with implantation of an AcrySof SA60AT (Group A) in one eye and Tecnis ZCB00 (Group B) in the fellow eye by the same experienced surgeon. Lens allocation to the first or second operated eye followed a randomisation process. At 12 months postoperatively, the PCO level was evaluated with the Evaluation of Posterior Capsule Opacification software, whereas the level of ACO and capsule retraction was evaluated and graded subjectively. Results All surgeries were uneventful. The mean PCO scores were 0.10±0.17 and 0.21±0.89 in Groups A and B, respectively, with no statistically significant differences between the groups (p=0.47). No significant correlation was found between the PCO scores in Groups A and B (r=0.16, p=0.17). Regarding ACO, it was present in 15 eyes (20.3%) and two eyes (2.7%) in Groups A and B, respectively (p=0.37). Capsular phimosis (13 eyes, 17.6%) was only observed in Group A. Conclusions Both IOLs had a similar low rate of PCO 1 year after surgery. However, there seems to be a difference in the anterior capsule behaviour between both IOL models.
Journal Article