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The White House is burning, August 24, 1814
\"In this 'biography of a single day,' the burning of the White House by the British during the War of 1812 is told from the viewpoint of the people who were there, including First Lady Dolley Madison, a British officer, and a nine-year-old slave.\"--Amazon.com.
Book
Boron and gadolinium neutron capture therapy for cancer treatment
The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere.
eBook
Effect of Net-Gun Capture on Survival of Mule Deer
Capture techniques to deploy radio-collars often risk mortality and injury to the animal. Capture-induced mortality can affect population sizes but also introduces bias in survival estimates based on data from captured animals. In recent years, a large-scale research and monitoring project in Utah, USA, has involved capturing and radio-collaring hundreds of mule deer (Odocoileus hemionus), a species of great interest in large parts of North America. Our objective was to investigate how the survival rates of these mule deer were affected by capture and handling. During winters of 2014–2018, an experienced capture crew net-gunned and fitted 1,805 animals with global positioning system (GPS)-collars. We estimated survival rates during the first 6 weeks after capture using Cox proportional hazard regression, and compared the survival rates of animals that were captured in a particular year to those of animals that were not captured but fitted with a GPS-collar in a previous year. We used a model selection framework to evaluate how long survival rates of captured animals were different from those of animals that were not captured. Our results indicated that weekly survival rates of captured animals were 0.985 ± 0.003 (SE), 0.988 ± 0.002, and 0.990 ± 0.001 in weeks 1, 2 and 3, respectively. Weekly survival rates of captured deer during weeks 4–6 were 0.993 ± 0.001, the same as those of deer that were not captured at the same time. Furthermore, post-capture survival rates were positively influenced by body size and negatively influenced by age. We conclude that the mortality resulting from helicopter capture was low but recommend comparing newly captured and previously captured individuals to examine what proportion of observed mortality is likely capture-related.
Journal Article
Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy
Boron neutron capture therapy (BNCT) is a binary cancer therapy that involves boron administration and neutron irradiation. The nuclear reaction caused by the interaction of boron atom and neutron produces heavy particles with highly cytocidal effects and destruct tumor cells, which uptake the boron drug. p-Boronophenylalanine (BPA), an amino acid derivative, is used in BNCT. Tumor cells with increased nutrient requirements take up more BPA than normal tissues via the enhanced expression of LAT1, an amino acid transporter. The current study aimed to assess the correlation between the expression of LAT1 and the uptake capacity of BPA using genetically modified LAT1-deficient/enhanced cell lines. We conducted an in vitro study, SCC7 tumor cells wherein LAT1 expression was altered using CRISPR/Cas9 were used to assess BPA uptake capacity. Data from The Cancer Genome Atlas (TCGA) were used to examine the expression status of LAT1 in human tumor tissues, the potential impact of LAT1 expression on cancer prognosis and the potential cancer indications for BPA-based BNCT. We discovered that the strength of LAT1 expression strongly affected the BPA uptake ability of tumor cells. Among the histologic types, squamous cell carcinomas express high levels of LAT1 regardless of the primary tumor site. The higher LAT1 expression in tumors was associated with a higher expression of cell proliferation markers and poorer patient prognosis. Considering that BPA concentrate more in tumors with high LAT1 expression, the results suggest that BNCT is effective for cancers having poor prognosis with higher proliferative potential and nutritional requirements.
Journal Article
A Systematic Review of the Accuracy, Validity, and Reliability of Markerless Versus Marker Camera-Based 3D Motion Capture for Industrial Ergonomic Risk Analysis
Ergonomic risk assessment is crucial for preventing work-related musculoskeletal disorders (WMSDs), which often arise from repetitive tasks, prolonged sitting, and load handling, leading to absenteeism and increased healthcare costs. Biomechanical risk assessment, such as RULA/REBA, is increasingly being enhanced by camera-based motion capture systems, either marker-based (MBSs) or markerless systems (MCBSs). This systematic review compared MBSs and MCBSs regarding accuracy, validity, and reliability for industrial ergonomic risk analysis. A comprehensive search of PubMed, WoS, ScienceDirect, IEEE Xplore, and PEDro (31 May 2025) identified 898 records; after screening with PICO-based eligibility criteria, 20 quantitative studies were included. Methodological quality was assessed with the COSMIN Risk of Bias tool, synthesized using PRISMA 2020, and graded with EBRO criteria. MBSs showed the highest precision (0.5–1.5 mm error) and reliability (ICC > 0.90) but were limited by cost and laboratory constraints. MCBSs demonstrated moderate-to-high accuracy (5–20 mm error; mean joint-angle error: 2.31° ± 4.00°) and good reliability (ICC > 0.80), with greater practicality in field settings. Several studies reported strong validity for RULA/REBA prediction (accuracy up to 89%, κ = 0.71). In conclusion, MCBSs provide a feasible, scalable alternative to traditional ergonomic assessment, combining reliability with usability and supporting integration into occupational risk prevention.
Journal Article
Methods and Techniques for CO2 Capture: Review of Potential Solutions and Applications in Modern Energy Technologies
The paper presents and discusses modern methods and technologies of CO2 capture (pre-combustion capture, post-combustion capture, and oxy-combustion capture) along with the principles of these methods and examples of existing and operating installations. The primary differences of the selected methods and technologies, with the possibility to apply them in new low-emission energy technologies, were presented. The following CO2 capture methods: pre-combustion, post-combustion based on chemical absorption, physical separation, membrane separation, chemical looping combustion, calcium looping process, and oxy-combustion are discussed in the paper. Large-scale carbon capture utilization and storage (CCUS) facilities operating and under development are summarized. In 2021, 27 commercial CCUS facilities are currently under operation with a capture capacity of up to 40 Mt of CO2 per year. If all projects are launched, the global CO2 capture potential can be more than ca. 130–150 Mt/year of captured CO2. The most popular and developed indicators for comparing and assessing CO2 emission, capture, avoiding, and cost connected with avoiding CO2 emissions are also presented and described in the paper.
Journal Article
From Lab to Fab: Development and Deployment of Direct Air Capture of CO2
Direct Air Capture (DAC) is a promising technology to fight climate change by capturing carbon dioxide (CO2) from the air. For DAC to be a negative emissions technology, the captured CO2 must be removed permanently, but can also be used as a net-zero technology to produce sustainable chemicals, fuels or other materials. This review presents a comprehensive survey of recent advancements, challenges, and potential applications of DAC technology, with an emphasis on the recent rapid increase in the number of DAC developers, the majority of them being founded in the past 4 years. Through pilot projects and recent commercial deployments, several DAC companies have made significant advances and demonstrated their scalability. Cost and energy efficiency remain significant impediments to the wide deployment of DAC. Integration with emission-free energy sources and utilization of waste heat are being researched to boost the total energy efficiency of DAC systems. Further research of electrochemical technologies for regeneration or direct capture are needed, as well as the development of new, modified, or hybrid adsorbents for improved capture efficiencies. Moreover, favorable regulations and financial incentives are crucial for enhancing the viability of DAC projects and will need to substantially increase if Paris Agreement goals are to be achieved.
Journal Article
Accuracy, Validity, and Reliability of Markerless Camera-Based 3D Motion Capture Systems versus Marker-Based 3D Motion Capture Systems in Gait Analysis: A Systematic Review and Meta-Analysis
(1) Background: Marker-based 3D motion capture systems (MBS) are considered the gold standard in gait analysis. However, they have limitations for which markerless camera-based 3D motion capture systems (MCBS) could provide a solution. The aim of this systematic review and meta-analysis is to compare the accuracy, validity, and reliability of MCBS and MBS. (2) Methods: A total of 2047 papers were systematically searched according to PRISMA guidelines on 7 February 2024, in two different databases: Pubmed (1339) and WoS (708). The COSMIN-tool and EBRO guidelines were used to assess risk of bias and level of evidence. (3) Results: After full text screening, 22 papers were included. Spatiotemporal parameters showed overall good to excellent accuracy, validity, and reliability. For kinematic variables, hip and knee showed moderate to excellent agreement between the systems, while for the ankle joint, poor concurrent validity and reliability were measured. The accuracy and concurrent validity of walking speed were considered excellent in all cases, with only a small bias. The meta-analysis of the inter-rater reliability and concurrent validity of walking speed, step time, and step length resulted in a good-to-excellent intraclass correlation coefficient (ICC) (0.81; 0.98). (4) Discussion and conclusions: MCBS are comparable in terms of accuracy, concurrent validity, and reliability to MBS in spatiotemporal parameters. Additionally, kinematic parameters for hip and knee in the sagittal plane are considered most valid and reliable but lack valid and accurate measurement outcomes in transverse and frontal planes. Customization and standardization of methodological procedures are necessary for future research to adequately compare protocols in clinical settings, with more attention to patient populations.
Journal Article