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Bacteria tightly regulate and coordinate the various events in their cell cycles to duplicate themselves accurately and to control their cell sizes. Growth of Escherichia coli, in particular, follows a relation known as Schaechter’s growth law. This law says that the average cell volume scales exponentially with growth rate, with a scaling exponent equal to the time from initiation of a round of DNA replication to the cell division at which the corresponding sister chromosomes segregate. Here, we sought to test the robustness of the growth law to systematic perturbations in cell dimensions achieved by varying the expression levels of mreB and ftsZ. We found that decreasing the mreB level resulted in increased cell width, with little change in cell length, whereas decreasing the ftsZ level resulted in increased cell length. Furthermore, the time from replication termination to cell division increased with the perturbed dimension in both cases. Moreover, the growth law remained valid over a range of growth conditions and dimension perturbations. The growth law can be quantitatively interpreted as a consequence of a tight coupling of cell division to replication initiation. Thus, its robustness to perturbations in cell dimensions strongly supports models in which the timing of replication initiation governs that of cell division, and cell volume is the key phenomenological variable governing the timing of replication initiation. These conclusions are discussed in the context of our recently proposed “adder-per-origin” model, in which cells add a constant volume per origin between initiations and divide a constant time after initiation.

Bone marrow-derived mesenchymal stem/stromal cells (BMSC) may facilitate bone repair through secretion of factors that stimulate endogenous repair processes or through direct contribution to new bone through differentiation into osteoblast-like cells. BMSC microtissue culture and differentiation has been widely explored recently, with high-throughput platforms making large-scale manufacture of microtissues increasingly feasible. Bone-like BMSC microtissues could offer an elegant method to enhance bone repair, especially in small-volume non-union defects, where small diameter microtissues could be delivered orthoscopically. Using a high-throughput microwell platform, our data demonstrate that (1) BMSC in 3D microtissue culture result in tissue compaction, rather than growth, (2) not all mineralised bone-like matrix is incorporated in the bulk microtissue mass and (3) a significant amount of lipid vacuole formation is observed in BMSC microtissues exposed to BMP-2. These factors should be considered when optimising BMSC osteogenesis in microtissues or developing BMSC microtissue-based therapeutic delivery processes.

This paper attempts to provide a general characterization of the properties and applications of plant cellulose (PC) based on literature data regarding its sources, discovery, fractional composition and cell dimensions, the microphysical structure of the fibrous component, its content in wood and non-woody plants, functional properties, traditional uses, and selected contemporary opportunities to expand the use of this material in the production of new types of industrial products. This topic can be useful from systematic, informational, and practical perspectives for engineers involved in teaching plant cellulose technology, for researchers and practitioners searching for substitute materials as alternatives to synthetic polymers and fossil-fuel-derived chemicals, and for paper mills seeking opportunities to mitigate the effects of declining demand for printing papers through the development of other PC-based products. The issues discussed in this article may serve as a starting point for the development of an expanded version of this study, supplemented with additional PC properties and applications not identified by the author, and ultimately for the preparation of a book that would include a comprehensive discussion of specific PC applications.

Parisite-(Nd) (IMA2024-013), ideally CaNd2(CO3)3F2, as the Nd-dominant analogue of parisite-(Ce), occurs in dolomitic marble in the Bayan Obo Fe-Nb-REE deposit, Inner Mongolia, China. It is associated with calcite, aegirine, magnetite, hematite, fluorite, riebeckite, bastnasite-(Ce), baryte, aeschynite-(Ce), aeschynite-(Nd), monazite and parisite-(Ce). Parisite-(Nd) occurs as subhedral to anhedral irregular grains from 0.02 mm to 1 mm. Parisite-(Nd) is transparent, yellowish-brown colour, with pale yellow streak and displays vitreous to resinous lustre. Cleavage is distinct on pseudo-{001}; fracture is uneven, or conchoidal. The Mohs hardness is 4 to 5, and it is brittle. The calculated density of parisite-(Nd) is 4.357 g/cm3. Parisite-(Nd) is pseudo-uniaxial (+), ω = (1.679) and ε = (1.754). The empirical formula is (Ca0.945Fe0.058Sr0.015Ba0.007)Σ1.025(Nd0.967Ce0.529La0. 191Pr0.137 Gd0.070Sm0.029Th0.022Y0.016Nb0.011Ho0.003)Σ1.975(CO3) 3 F1.893OH0.023. The Raman spectra of parisite-(Nd) show strong and sharp peaks at 1113, 1090, 825, 635 and 1608 cm-1 and moderate to weak bands centred at 255, 392, 739, 924, 1183, 1228, 1296, 1640, 2247, 2924 and 3065 cm-1. Powder X-ray diffraction and TEM studies give the following results: monoclinic, space group: Cc (# 9), a = 12.3283(13) Å, b = 7.1185(4) Å, c = 28.4633(37) Å, β = 98.529(14)°, V = 2470.28(42) Å3 and Z = 12.

The new mineral zincostottite (IMA2024-024), ZnGe(OH)6, was found on specimens from the Tsumeb mine, Tsumeb, Namibia, where it is a secondary oxidation-zone mineral. It occurs as heavily etched remnants of equant or tabular crystals, up to ∼1 mm in diameter. Crystals are colourless and transparent, with vitreous to subadamantine lustre and a white streak. The mineral is brittle with irregular stepped fracture. The Mohs hardness is ∼4.5. Cleavage is good on {100} and poor on {001}. The calculated density is 3.834 g·cm-3. Optically, zincostottite is uniaxial (-) with ω = 1.785(5) and ε = 1.765(5) (white light). The empirical formula is (Zn0.77Fe3+0.23)Σ1.00Ge1.00O6H5.77. Zincostottite is tetragonal, space group P42/n, with cell parameters: a = 7.4522(18), c = 7.4000(8) Å, V = 411.0(2) Å3 and Z = 4. The crystal structure (R1 = 2.65% for 452 I > 2σI reflections) is the same as that of stottite with Zn in place of Fe2+.

Annivite-(Zn), Cu6(Cu4Zn2)Σ6Bi4S13, is a new IMA-approved mineral species from the Geister vein, Jáchymov ore district, Czech Republic. It occurs as anhedral grains, up to 50 µm in size, and growth zones, up to 100 µm in thickness, hosted by oscillatory zoned annivite-(Zn)/tennantite-(Zn) grains, and associated with Bi-rich tennantite-(Zn), tennantite-(Fe), tetrahedrite-(Zn), the not-yet approved 'annivite-(Fe)', bismuth, emplectite, wittichenite and supergene bismite, walpurgite and metazeunerite. In reflected light, annivite-(Zn) is isotropic, pale grey with a brownish shade and very rare pale brown internal reflections. Reflectance data for the four COM wavelengths in air are [λ (nm): R (%)]: 470: 32.3; 546: 32.0; 589: 32.0; 650: 31.6. Electron microprobe analysis gave (in wt.% - average of 5 spot analyses): Cu 36.29, Ag 0.14, Fe 0.08, Zn 7.11, Pb 0.19, As 6.07, Sb 4.50, Bi 21.08, S 23.68, total 99.14. On the basis of ΣMe =16 atoms per formula unit, the empirical formula of annivite-(Zn) is Cu10.13Ag0.02Zn1.93Fe0.03Pb0.02Bi1.79As1.43Sb0.66S13.10. Annivite-(Zn) is cubic, I4̄3m, with unit-cell parameters a = 10.3545(6) Å, V = 1110.16(19) Å3 and Z = 2. Its crystal structure was refined by single-crystal X-ray diffraction data to a final R1 = 0.0493 on the basis of 278 unique reflections with Fo > 4σ(Fo) and 23 refined parameters. Annivite-(Zn) is isotypic with other tetrahedrite-group minerals. Its crystal chemistry is discussed, and previous findings of Bi-rich tetrahedrite-group minerals are briefly reviewed, along with the description of a second finding of annivite-(Zn) from the abandoned Mauritius tin mine, Hrebecná, Krusné hory Mountains, Czech Republic.

A Microsoft Visual Basic software, WinClbclas, has been developed to calculate the chemical formulae of columbite-supergroup minerals based on data obtained from wet-chemical and electron-microprobe analyses and using the current nomenclature scheme adopted by the Commission on New Minerals, Nomenclature and Classification (CNMNC) of the International Mineralogical Association (IMA) for columbite-supergroup minerals. The program evaluates 36 IMA-approved species, three questionable in terms of their unit-cell parameters, four insufficiently studied questionable species and one ungrouped species, all according to the dominant valance and constituent status in five mineral groups including ixiolite (MO2), wolframite (M1M2O4), samarskite (ABM2O8), columbite (M1M2O6) and wodginite (M1M2M32O8). Mineral compositions of the columbite supergroup are calculated on the basis of 24 oxygen atoms per formula unit. However, the formulae of the five ixiolite to wodginite groups can be estimated by the program on the basis of their cation and anion values in their typical mineral formulae (e.g. 4 cations and 8 oxygens for the wodginite group) with normalisation procedures. The Fe3+ and Fe2+ contents from microprobe-derived total FeO (wt.%) amounts are estimated by stoichiometric constraints. WinClbclas allows users to: (1) enter up to 47 input variables for mineral compositions; (2) type and load multiple columbite-supergroup mineral compositions in the data entry section; (3) edit and load the Microsoft Excel files used in calculating, classifying, and naming the columbite-supergroup minerals, together with the total monovalent to hexavalent ion; and (4) store all the calculated parameters in the output of a Microsoft Excel file for further data evaluation. The program is distributed as a self-extracting setup file, including the necessary support files used by the program, a help file and representative sample data files.

Selenolaurite, ideally RuSe2, is a new mineral, the first natural ruthenium selenide. It was discovered in an assemblage with Se-bearing moncheite. Both form xenomorphic inclusions in the crystal aggregates of Os-Ir-Ru minerals found at the Ingul gold placer, Urals, Russia. In addition a mineral with selenolaurite composition was found as a euhedral inclusion within grains of Pt-Fe alloy with isoferroplatinum composition at the Kazan gold placer. These placers are situated in the Chelyabinsk district, South Urals, Russia. The selenolaurite from the Ingul placer forms interstitial grains with maximum size of section of 0.05-0.1 mm. Crystals of the selenolaurite from the Kazan placer reach 20m in size. Selenolaurite is grey with metallic lustre and is isotropic. Reflectance values [R (%) for COM approved wavelengths (nm)] are 45.8(470), 44.3(546), 43.8(589) and 43.1(650). The chemical composition of the holotype from the Ingul placer corresponds to the empirical formula (Ru0.99Ir0.05)Σ1.04(Se1.92Te0.03S0.01)Σ1.96. Selenolaurite is the selenium-dominant analogue of laurite, RuS2 with a pyrite-type structure. It is cubic, space group Pa3̅, a = 5.9424(2) Å, V = 209.84 2) Å3, Z = 4 and Dcalc. = 8.415 g·cm-3 (calculated on the basis of empirical formula and unit-cell parameters refined by the Rietveld method). The crystal structure has been refined from the powder data to RB = 0.0067. The strongest lines of the powder X-ray diffraction pattern [d](Å), (I), (hkl)] are: 3.434(41)(111), 2.973(90)(200), 2.6580(100)(210), 2.4264(84)(211) and 1.7913(87)(311). The possible sources of a Ru-Se mineralisation in the South Urals are ophiolitic ultramafic rocks enriched in Ru and depleted with sulfur.

Automorphism groups of Riemann surfaces have been widely studied for almost 150 years. This area has persisted in part because it has close ties to many other topics of interest such as number theory, graph theory, mapping class groups, and geometric and computational group theory. In recent years there has been a major revival in this area due in part to great advances in computer algebra systems and progress in finite group theory.This volume provides a concise but thorough introduction for newcomers to the area while at the same time highlighting new developments for established researchers. The volume starts with two expository articles. The first of these articles gives a historical perspective of the field with an emphasis on highly symmetric surfaces, such as Hurwitz surfaces. The second expository article focuses on the future of the field, outlining some of the more popular topics in recent years and providing 78 open research problems across all topics. The remaining articles showcase new developments in the area and have specifically been chosen to cover a variety of topics to illustrate the range of diversity within the field.

Hydroxylbastnäsite-(La), the OH- and La-dominant member of the bastnäsite group, in fact known for many years, was studied in detail and has been approved by the IMA-CNMNC as a new mineral species with the ideal, end-member formula La(CO3)(OH). The holotype originates from the Vuoriyarvi (another spelling: Vuorijärvi) alkaline-ultrabasic complex, Northern Karelia, and the cotype from the Mochalin Log REE deposit, Potaniny Mts, South Urals, both in Russia. At Vuoriyarvi, hydroxylbastnäsite-(La) occurs as clusters (up to 1 mm) of light brown, honey-yellow or colourless hexagonal tabular to short-prismatic crystals up to 0.15 mm associated with fluorite and ancylite-(Ce) in cavities of calcite-dolomite carbonatites. At Mochalin Log, hydroxylbastnäsite-(La) forms light brown grains up to 0.2 mm included in massive aggregates of other LREE minerals: bastnäsite-(Ce), bastnäsite-(La), percleveite-(Ce), percleveite-(La), biraite-(Ce), biraite-(La), törnebohmite-(La), ferriperboeite-(Ce), allanite-(Ce), etc. Dmeas is 4.75(2) and Dcalc is 4.778 g cm-3 (holotype). Hydroxylbastnäsite-(La) is optically uniaxial (+), ω = 1.76(1) and ε = 1.86(1) (holotype). The chemical composition (wt.%, electron microprobe, CO2 and H2O calculated: holotype/cotype) is: CaO 0.23/0.00, SrO 0.07/0.00, La2O3 39.47/39.58, Ce2O3 33.51/31.99, Pr2O3 1.03/1.51, Nd2O3 1.95/2.38, F 0.76/3.33, CO2 20.49/20.34, H2O 3.77/2.58, -O=F 0.32/1.40, total 100.96/100.31. The empirical formulae, calculated based on the sum of metal cations of 1 apfu and one CO3 group pfu, are (La0.52Ce0.44Nd0.02Pr0.01Ca0.01)Σ1.00(CO3)[(OH)0.90F0 .09]Σ0.99 (holotype) and (La0.53Ce0.42Nd0.03Pr0.02)Σ1.00(CO3)[(OH)0.62F0.38]#1 S 1.00 (cotype). Hydroxylbastnäsite-(La) is hexagonal, P6̅, unit-cell parameters (from powder XRD data, holotype/cotype) are: a = 12.537(3)/12.533(1), c = 9.968(2)/9.908(1) Å, V = 1356.8(5)/1347.9(3) Å3 and Z = 18. Strong reflections of the powder XRD pattern [d, Å(I)(hkl)] are (holotype): 4.98(39)(002), 3.616(88)(300), 2.926(100)(302), 2.089(41)(330), 2.052(46)(304) and 1.927(40)(332). The crystal structure of holotype hydroxylbastnäsite-(La) was refined by the Rietveld method, Rwp = 0.0071, Rp = 0.0050, Robs = 0.0466. It is isostructural to hydroxylbastnäsite-(Ce) and synthetic bastnäsite-type hydroxyl-carbonates REE3+(CO3)(OH) (REE = La-Er), but differs from fluorine-dominant bastnäsites which adopt the space group P6̅2c.