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This study evaluated the impact of a non-repellent liquid termiticide (fipronil) and a chitin synthesis inhibitor (CSI) termite bait (noviflumuron) on whole colonies of Coptotermes gestroi (Wasmann) (Blattodea: Isoptera: Rhinotermitidae) in laboratory conditions, over a 12-m foraging distance.The protocol simulated the implementation of remedial treatment of an infested structure, where the colony has multiple access routes, and where only a portion of the population was directly exposed to the treatment. Within 2 wk after the implementation of fipronil, all termites within 1.5 m away from the treatment died.The accumulation of cadavers near the treated area resulted in secondary repellency and the colonies avoided the treated area for the remaining 10 wk of the experiment, using alternative foraging galleries. At the end of the 12 wk, colonies exposed to fipronil did not have any difference in population size compared with control colonies. Comparatively, colonies exposed to noviflumuron had no change in foraging activity for the first ≈40 d, but then termites progressively ceased their activity throughout their foraging territory. By 12 wk, noviflumuron-exposed colonies were near-elimination, with only a few workers, soldiers remaining, and all colonies were eliminated by 95 d. This study shows that subterranean termite colonies with access to CSI baits are inevitably eliminated, regardless of the position of the bait, while colonies exposed to fipronil are only locally excluded from the area near the treatment, but may maintain their foraging activity in untreated areas, and retain their potential risk for structural damage in the long term.

We investigated the use of termite baiting, a proven system of targeted colony elimination, in an overall area-wide control strategy against subterranean termites. At two field sites, we used microsatellite markers to estimate the total number of Reticulitermes colonies, their spatial partitioning, and breeding structure. Termite pressure was recorded for two years before and after the introduction of Trelona® (active ingredient novaluron) to a large area of one of the sites. Roughly 70% of the colonies in the treatment site that were present at the time of baiting were not found in the site within two months after the introduction of novaluron. Feeding activity of the remaining colonies subsequently ceased over time and new invading colonies were unable to establish within this site. Our study provides novel field data on the efficacy of novaluron in colony elimination of Reticulitermes flavipes, as well as evidence that an area-wide baiting program is feasible to maintain a termite-free area within its native range.

We assessed the efficacy of a discontinuous soil treatment using a diluent of fipronil suspension concentrate in controlling colonies of Coptotermes formosanus and Reticulitermes speratus. In-ground monitoring stations were installed at Isogi Park and Kindai University, and individual termites inhabiting the stations were collected for four or six years to determine the numbers and locations of colonies present in test areas before and after the discontinuous soil treatment. Microsatellite genotyping indicated that two C. formosanus and two R. speratus colonies in the test area at Isogi Park and five R. speratus colonies in the test area at Kindai University were active and that their territories fluctuated every year. One of the two C. formosanus colonies at Isogi Park and one of the five R. speratus colonies at Kindai University were subjected to discontinuous soil treatments with fipronil and were strongly affected by the treatment at the colony level, resulting in the suppression and possible elimination of colonies. Termite activity of the fipronil-treated colony of C. formosanus was detected within one week after the discontinuous soil treatment and was not found for more than two years (28 months), while termite activity of the fipronil-treated colony of R. speratus was detected within four days and three weeks after the discontinuous soil treatment and was not detected thereafter for three years. Fipronil residue analysis showed that workers of C. formosanus moved at least 28 m and that workers of R. speratus moved 6 m from the treated soil locations for up to three weeks.

Abstract Given the traditional use of wood, historical structures are susceptible to termite damage which can irreversibly affect their historical significance. Methods like drilling into the foundation for termiticide injection are impractical and potentially harmful to the structural integrity of these structures. Moreover, the location of these structures in ecologically sensitive areas prohibits the use of soil termiticides due to potential contamination of groundwater, rivers, or oceans. Termite Integrated Pest Management (IPM) strategies include baiting programs that use minimal quantities of benign insecticides to reduce environmental impact. This approach is consistent with the risk management component of termite IPM. Bait systems are proven to be effective in eliminating termite colonies, contributing to the benefit component of IPM by preserving the value of historical sites. This article discusses successful baiting interventions at notable locations such as the Statue of Liberty National Monument, New York, USA, the Christiansted National Historic Site in St. Croix, US Virgin Islands, and the Historic Tzu-Su Temple in Taiwan.

Purpose Granulocyte colony-stimulating factors (G-CSF) are commonly used in clinical practice to prevent febrile neutropenia (FN). US and EU prescribing information and treatment guidelines from the NCCN, ASCO, and EORTC specify that pegfilgrastim, a long-acting (LA) G-CSF, should be administered at least 24 h after myelosuppressive chemotherapy. Nevertheless, many patients receive LA G-CSFs on the same day as chemotherapy. This systematic literature review evaluated the relative merits of same-day versus next-day dosing of LA G-CSFs. Methods A broad Ovid MEDLINE® and Embase® literature search was conducted that examined all publications indexed before May 9, 2016 that compared same-day versus next-day LA G-CSF administration. A congress abstract literature search included congresses from January 1, 2011 to April 6, 2016. The parameters for this review were prospectively delineated in a research protocol and adhered to the PRISMA Guidelines. Results The first part of the systematic literature search identified 1736 publications. After elimination of duplicates, title/abstract screening was conducted on 1440 records, and full text review was conducted on 449 publications. Eleven publications met all criteria and are included in this systematic review; of these, four included data from randomized or single arm prospective studies, and seven were retrospective studies. In most studies included in this review and across a variety of tumor types, administration of pegfilgrastim at least 24 h after myelosuppressive chemotherapy resulted in improved patient outcomes. Conclusions Data from multiple publications support administration of pegfilgrastim at least 1 day after chemotherapy.

Specialized sound localization circuit development requires synapse strengthening, refinement, and pruning. Many of these functions are carried out by microglia, immune cells that aid in regulating neurogenesis, synaptogenesis, apoptosis, and synaptic removal. We previously showed that postnatal treatment with BLZ945 (BLZ), an inhibitor of colony stimulating factor 1 receptor (CSF1R), eliminates microglia in the brainstem and disables calyceal pruning and maturation of astrocytes in the medial nucleus of the trapezoid body (MNTB). BLZ treatment results in elevated hearing thresholds and delayed signal propagation as measured by auditory brainstem responses (ABR). However, when microglia repopulate the brain following the cessation of BLZ, most of the deficits are repaired. It is unknown whether this recovery is achievable without the return of microglia. Here, we induced sustained microglial elimination with a two-drug approach using BLZ and PLX5622 (PLX). We found that BLZ/PLX treated mice had impaired calyceal pruning, diminished astrocytic GFAP in the lateral, low frequency, region of MNTB, and elevated glycine transporter 2 (GLYT2) levels. BLZ/PLX treated mice had elevated hearing thresholds, diminished peak amplitudes, and altered latencies and inter-peak latencies. These findings suggest that microglia are required to repopulate the brain in order to rectify deficits from their ablation.

Integrated process planning and scheduling (IPPS) is an intricate and vital issue in smart manufacturing, requiring the coordinated optimization of both process plans and production schedules under multiple resource and precedence constraints. This paper presents a novel optimization framework, symmetry-aware adaptive Ant Colony Optimization (SA-AACO), designed to resolve key limitations in existing metaheuristic approaches. The proposed method introduces three core innovations: (1) a symmetry-awareness mechanism to eliminate redundant solutions arising from symmetrically equivalent configurations; (2) an adaptive pheromone-updating strategy that dynamically balances exploration and exploitation; and (3) a dynamic idle time penalty system, integrated with time window-based machine selection. Benchmarked across ten IPPS scenarios, SA-AACO achieves a superior makespan in 9/10 cases (e.g., 29.1% improvement over CCGA in Problem 1) and executes 18-part processing within 30 min. While MMCO marginally outperforms SA-AACO in Problem 10 (makespan: 427 vs. 483), SA-AACO’s consistent dominance across diverse scales underscores the feasibility of its application in industry to balance quality and efficiency. By unifying symmetry handling and adaptive learning, this work advances the reconfigurability of IPPS solutions for dynamic industrial environments.

Introduction: The study aimed to determine the apical debris extrusion and microbial elimination from infected root canals after using different irrigant activation methods. Materials and Methods: Forty freshly extracted human mandibular premolars were selected and randomly assigned to four groups (n = 10). The teeth were mechanically prepared, sterilized, and inoculated with Enterococcus faecalis for 1 week. Irrigation was done with 3% sodium hypochlorite following conventional syringe irrigation–Group 1, manual dynamic agitation (MDA)–Group 2, passive ultrasonic irrigation (PUI)-UltraX –Group 3, and sonic irrigation (SI)-EndoActivator -Group 4, and the extruded debris were collected using Myers and Montgomery model. The microbial samples were taken from the canals using sterile paper points, cultured and recorded as colonies. The amount of extruded debris was measured by subtracting the final weight of the Eppendorf tube with debris from the initial weight of the tube. Results: I. Group 3 showed the least apical debris extrusion (P < 0.05), followed by Groups 2 and 1 and the highest with Group 4. II. Group 3 showed the least colony-forming units (CFUs)/ml, followed by Group 4, and finally, Group 2 showed lesser mean CFUs/ml compared to Group 1 (P < 0.05). Conclusion: All the irrigation activation methods were associated with apical debris extrusion, with the PUI system extruding the least amount of debris compared to the other groups. Irrigation activation techniques were beneficial in reducing the microbial load from the infected canals with the PUI system showing a complete elimination of the microbes, followed by SI and MDA.

In this article, the UXE-Type inverter is considered for eleven-level operation. This topology exhibits a boosting capability along with reduced switches and one source. An algorithm that utilizes the redundant states to control the voltage-balance of the auxiliary direct current (DC)-link is presented. The proposed control algorithm is capable of maintaining the voltages of each capacitor at Vdc/4 resulting in a successful multilevel operation for all values of load. The inverter is also compared with 11-level inverters. The modulation of the inverter is performed by employing nearest level control and ant colony optimization based selective harmonic elimination. The maximum inverter efficiency is 98.1% and its performance is validated on an hardware-in-the-loop platform.

A selective harmonic elimination pulse width modulation (SHEPWM) control strategy is proposed to balance the neutral-point potential (NP) of a three-level active neutral-point-clamped (ANPC) converter. In this strategy, the chaotic ant colony algorithm (ACA) is adopted to solve the SHEPWM nonlinear equations, which does not require presetting the initial values of solutions and can get multiple solutions in the same modulation index. The influence of different solutions corresponding to the SHEPWM switching states on the NP is different, namely, some make the NP increase and others make the NP decrease. Therefore, the NP balancing can be effectively controlled by choosing appropriate solutions in different fundamental periods. The simulation and experimental results further verify the feasibility and effectiveness of the control strategy.