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Figure S3: Download corrected item. https://doi.org/10.1371/annotation/ecd1e074-2618-4ad0-95c0-efdb467c714b.s003.cn Figure S5: Download corrected item. https://doi.org/10.1371/annotation/ecd1e074-2618-4ad0-95c0-efdb467c714b.s005.cn Citation: Forterre A, Jalabert A, Berger E, Baudet M, Chikh K, Errazuriz E, et al. (2014) Correction: Proteomic Analysis of C2C12 Myoblast and Myotube Exosome-Like Vesicles: A New Paradigm for Myoblast-Myotube Cross Talk?

Abiotic stresses are the primary sources of crop losses globally. The identification of key mechanisms deployed and established by plants in response to abiotic stresses is necessary for the maintenance of their growth and persistence. Recent discoveries have revealed that phytohormones or plant growth regulators (PGRs), mainly jasmonic acid (JA), have increased our knowledge of hormonal signaling of plants under stressful environments. Jasmonic acid is involved in various physiological and biochemical processes associated with plant growth and development as well as plant defense mechanism against wounding by pathogen and insect attacks. Recent findings suggest that JA can mediate the effect of abiotic stresses and help plants to acclimatize under unfavorable conditions. As a vital PGR, JA contributes in many signal transduction pathways, i.e., gene network, regulatory protein, signaling intermediates and enzymes, proteins, and other molecules that act to defend cells from the harmful effects of various environmental stresses. However, JA does not work as an independent regulator, but acts in a complex signaling pathway along other PGRs. Further, JA can protect and maintain the integrity of plant cells under several stresses by up-regulating the antioxidant defense. In this review, we have documented the biosynthesis and metabolism of JA and its protective role against different abiotic stresses. Further, JA-mediated antioxidant potential and its crosstalk with other PGRs have also been discussed.

Transcriptional regulation is a central process in plant immunity. The induction or repression of defense genes is orchestrated by signaling networks that are directed by plant hormones of which salicylic acid (SA) and jasmonic acid (JA) are the major players. Extensive cross-communication between the hormone signaling pathways allows for fine tuning of transcriptional programs, determining resistance to invaders and trade-offs with plant development. Here, we give an overview of how SA can control transcriptional reprogramming of JA-induced genes in Arabidopsis thaliana. SA can influence activity and/or localization of transcriptional regulators by post-translational modifications of transcription factors and co-regulators. SA-induced redox changes, mediated by thioredoxins and glutaredoxins, modify transcriptional regulators that are involved in suppression of JA-dependent genes, such as NPR1 and TGA transcription factors, which affects their localization or DNA binding activity. Furthermore, SA can mediate sequestering of JA-responsive transcription factors away from their target genes by stalling them in the cytosol or in complexes with repressor proteins in the nucleus. SA also affects JA-induced transcription by inducing degradation of transcription factors with an activating role in JA signaling, as was shown for the ERF transcription factor ORA59. Additionally, SA can induce negative regulators, among which WRKY transcription factors, that can directly or indirectly inhibit JA-responsive gene expression. Finally, at the DNA level, modification of histones by SA-dependent factors can result in repression of JA-responsive genes. These diverse and complex regulatory mechanisms affect important signaling hubs in the integration of hormone signaling networks. Some pathogens have evolved effectors that highjack hormone crosstalk mechanisms for their own good, which are described in this review as well.

Real‐time detection and differentiation of diverse external stimuli with one tactile senor remains a huge challenge and largely restricts the development of electronic skins. Although different sensors have been described based on piezoresistivity, capacitance, and triboelectricity, and these devices are promising for tactile systems, there are few, if any, piezoelectric sensors to be able to distinguish diverse stimuli in real time. Here, a human skin‐inspired piezoelectric tactile sensor array constructed with a multilayer structure and row+column electrodes is reported. Integrated with a signal processor and a logical algorithm, the tactile sensor array achieves to sense and distinguish the magnitude, positions, and modes of diverse external stimuli, including gentle slipping, touching, and bending, in real time. Besides, the unique design overcomes the crosstalk issues existing in other sensors. Pressure sensing and bending sensing tests show that the proposed tactile sensor array possesses the characteristics of high sensitivity (7.7 mV kPa−1), long‐term durability (80 000 cycles), and rapid response time (10 ms) (less than human skin). The tactile sensor array also shows a superior scalability and ease of massive fabrication. Its ability of real‐time detection and differentiation of diverse stimuli for health monitoring, detection of animal movements, and robots is demonstrated. Human skin‐inspired piezoelectric tactile sensor array can sense and distinguish the magnitude, positions, and modes of diverse external stimuli in real time. The dual‐layer comb structures of the sensor array with row+column electrodes eliminate crosstalk and reduce the number of connection wires. It excavates enormous applications in various settings, such as health monitoring, detection of animal movements, and robots.

Silicon (Si) is the most copious element of existence in the lithosphere but still it has not been added into the essential element list. The imperative role of Si in triggering growth and development of plants has been identified. It is of paramount importance in regulating overall physiological and metabolic characteristics of the plants. Being considered as a non-essential element, it has been known to occur at about 30%, majority of its presence is there in rocks as mineral salts. It has been regarded as multitalented or quasi-element on earth's crust that can be efficiently taken up by plants and translocated further towards aerial parts via transpiration phenomenon. It has also been known to mitigate different biotic and abiotic stressed conditions from plants as the need of the hour owing to its eco-friendly nature. However, the mechanisms associated with their stress attenuation are associated with Reactive Oxygen Species (ROS) scavenging, activation of antioxidative defense responses and phytohormonal signaling. Also, biotic stress factors can be ameliorated through accumulation of Si within epidermal tissues or pathogenesis-related host defense mechanisms. To explore further, omics-mediated studies have been further discussed to shed light on the stress mitigating processes. Further, to improve our understanding for Si-mediated benefits in plants we need to explore the molecular mechanisms of Si uptake, transport and gene expression studies revealing their mitigate properties. In the present review, we have evolved the Si-based studies in plants associated with its transport, uptake and accumulation. Apart from this, we have also discussed about their role in ameliorating stresses from plants by activating their defenses. Moreover, their roles in plant hormonal crosstalk have also been elucidated. Above all, we have also revealed the role of Si-Nanoparticles (SiNPs) in improving stress potential of plants along with stimulation of plant productivities via omics-based approaches.

Key messageRecent updates in JA biosynthesis, signaling pathways and the crosstalk between JA and others phytohormones in relation with plant responses to different stresses.In plants, the roles of phytohormone jasmonic acid (JA), amino acid conjugate (e.g., JA-Ile) and their derivative emerged in last decades as crucial signaling compounds implicated in stress defense and development in plants. JA has raised a great interest, and the number of researches on JA has increased rapidly highlighting the importance of this phytohormone in plant life. First, JA was considered as a stress hormone implicated in plant response to biotic stress (pathogens and herbivores) which confers resistance to biotrophic and hemibiotrophic pathogens contrarily to salicylic acid (SA) which is implicated in plant response to necrotrophic pathogens. JA is also implicated in plant responses to abiotic stress (such as soil salinity, wounding and UV). Moreover, some researchers have recently revealed that JA controls several physiological processes like root growth, growth of reproductive organs and, finally, plant senescence. JA is also involved in the biosynthesis of various metabolites (e.g., phytoalexins and terpenoids). In plants, JA signaling pathways are well studied in few plants essentially Arabidopsis thaliana, Nicotiana benthamiana, and Oryza sativa L. confirming the crucial role of this hormone in plants. In this review, we highlight the last foundlings about JA biosynthesis, JA signaling pathways and its implication in plant maturation and response to environmental constraints.

Phytohormones are ubiquitously involved in plant biological processes and regulate cellular signaling pertaining to unheralded environmental cues, such as salinity, drought, extreme temperature and nutrient deprivation. The association of phytohormones to nearly all the fundamental biological processes epitomizes the phytohormone syndicate as a candidate target for consideration during engineering stress endurance in agronomically important crops. The drought stress response is essentially driven by phytohormones and their intricate network of crosstalk, which leads to transcriptional reprogramming. This review is focused on the pivotal role of phytohormones in water deficit responses, including their manipulation for mitigating the effect of the stressor. We have also discussed the inherent complexity of existing crosstalk accrued among them during the progression of drought stress, which instigates the tolerance response. Therefore, in this review, we have highlighted the role and regulatory aspects of various phytohormones, namely abscisic acid, auxin, gibberellic acid, cytokinin, brassinosteroid, jasmonic acid, salicylic acid, ethylene and strigolactone, with emphasis on drought stress tolerance.

Over-production of reactive oxygen species (ROS) in plants under stress conditions is a common phenomenon. Plants tend to counter this problem through their ability to synthesize ROS neutralizing substances including non-enzymatic and enzymatic antioxidants. In this context, ascorbic acid (AsA) is one of the universal non-enzymatic antioxidants having substantial potential of not only scavenging ROS, but also modulating a number of fundamental functions in plants both under stress and non-stress conditions. In the present review, the role of AsA, its biosynthesis, and cross-talk with different hormones have been discussed comprehensively. Furthermore, the possible involvement of AsA-hormone crosstalk in the regulation of several key physiological and biochemical processes like seed germination, photosynthesis, floral induction, fruit expansion, ROS regulation and senescence has also been described. A simplified and schematic AsA biosynthetic pathway has been drawn, which reflects key intermediates involved therein. This could pave the way for future research to elucidate the modulation of plant AsA biosynthesis and subsequent responses to environmental stresses. Apart from discussing the role of different ascorbate peroxidase isoforms, the comparative role of two key enzymes, ascorbate peroxidase (APX) and ascorbate oxidase (AO) involved in AsA metabolism in plant cell apoplast is also discussed particularly focusing on oxidative stress perception and amplification. Limited progress has been made so far in terms of developing transgenics which could over-produce AsA. The prospects of generation of transgenics overexpressing AsA related genes and exogenous application of AsA have been discussed at length in the review.

Strigolactones (SLs), a group of terpenoid lactones derived from carotenoids, are plant hormones that control numerous aspects of plant development. Although the framework of SL signaling that the repressor DWARF 53 (D53) could be SL-dependently degraded via the SL receptor D14 and F-box protein D3 has been established, the downstream response genes to SLs remain to be elucidated. Here we show that the cytokinin (CK) content is dramatically increased in shoot bases of the rice SL signaling mutant d53. By examining transcript levels of all the CK metabolism-related genes after treatment with SL analog GR24, we identified CYTOKININ OXIDASE/DEHYDROGENASE 9 (OsCKX9) as a primary response gene significantly up-regulated within 1 h of treatment in the wild type but not in d53. We also found that OsCKX9 functions as a cytosolic and nuclear dual-localized CK catabolic enzyme, and that the overexpression of OsCKX9 suppresses the browning of d53 calli. Both the CRISPR/Cas9-generated OsCKX9 mutants and OsCKX9-overexpressing transgenic plants showed significant increases in tiller number and decreases in plant height and panicle size, suggesting that the homeostasis of OsCKX9 plays a critical role in regulating rice shoot architecture. Moreover, we identified the CK-inducible rice type-A response regulator OsRR5 as the secondary SL-responsive gene, whose expression is significantly repressed after 4 h of GR24 treatment in the wild type but not in osckx9. These findings reveal a comprehensive plant hormone cross-talk in which SL can induce the expression of OsCKX9 to down-regulate CK content, which in turn triggers the response of downstream genes.

The advent of neuroimmunology has dismantled the traditional doctrine of the brain's immune privilege, uncovering a sophisticated and dynamic bidirectional regulatory interplay between the nervous and immune systems. This review synthesizes pivotal advances in neuroimmunology, integrating recent anatomical and molecular discoveries to refine the understanding of neuro‐immune communication. It highlights the pathological roles of neurotransmitters, cytokines, and their signaling networks in neurodegenerative, psychiatric, and neoplastic diseases, while critically examining contested regulatory mechanisms. The review further evaluates the clinical translational potential and challenges of innovative strategies such as vagus nerve stimulation, optogenetics, multiomics sequencing, and cytokine‐targeted therapies. By integrating multidisciplinary perspectives, this review consolidates a theoretical framework for neuro‐immune research and provides insights into precision medicine for related diseases. On the basis of synthesizing existing knowledge, it proposes promising research directions, identifies priorities and potential challenges for future investigations, and emphasizes the value of neuro‐immune mechanisms in guiding therapeutic development—including target identification, design of individualized treatment strategies, and cross‐disciplinary collaborative innovation to advance clinical interventions for neuro‐immune diseases. Finally, the review delves into the recent advances and challenges in combined neuromodulation‐immunotherapy strategies. Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor progression and stromal remodeling. Immune cells, in turn, feedback regulate neuronal excitability and function via the secretion of cytokines (e.g., TNF‐α and IL‐1β), and further recruit or suppress other cell types. These two systems are intricately intertwined, working in concert to regulate the immune status, nutrient supply, and tissue architecture of the microenvironment, thereby collectively promoting or inhibiting disease progression.