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The production of human recombinant proteins to be used for therapeutic or nutritional purposes must focus on obtaining a molecule that is as close as possible to the native human protein. This biotechnological tool has been documented in various studies published in recent decades, with lactoferrin being one of those that has generated the most interest, being a promising option for recombinant technology. However, stability studies including thermodynamic parameters have not been reported for recombinant lactoferrin (Lf). The objective of this work was to obtain the human recombinant protein using the yeast Komagataella phaffii to study structural changes modifying pH and temperature using circular dichroism spectroscopy (CD). Thermodynamic parameters such as ΔH, ΔS and Tm were calculated and compared with commercial human lactoferrin. We propose the potential use of CD and thermodynamic parameters as a criterion in the production of recombinant proteins to be used in the production of specialized recombinant proteins.

This book offers a timely, critical and multifaceted examination of the Western revival of citizenship revocation in the 21st century and the practice's justification within international human rights law, moral philosophy and political theory.

PurposeThe city of Fortaleza, capital of the state of Ceará in the north-east of Brazil, presents a paradox as a present-day tourist destination, while also marked by features and processes characteristic of cities in the Global South, such as high levels of social inequality with fragmented urban margins and vulnerabilities. This research problematizes the idea of “historical ruins” proposed by Walter Benjamin as a viable way to understand how the organization process of today's city margins can be “denaturalized” by the past. The objective of this research is to assess how the urban margins of the city were organized as a history of resistance.Design/methodology/approachIn theoretical terms, this research links critical urban studies with critical approaches to organizational history (COH) based on Walter Benjamin's philosophical concepts of “ruins” and “progress”. The historical and archival methodology, consisting of 193 documents, suggests the existence of a philosophical–historical nexus that helps explain the spatial fragmentation of the city, and especially the urban margins in the western region of Fortaleza.FindingsThe Benjaminian notion of “historical ruins” has been exemplified by the Brazilian government practices confining migrants fleeing drought in internment camps on the margins of the city of Fortaleza in three waves beginning in 1877, 1915 and 1932 respectively. The effects of such confinement policies put into practice in the name of “progress” influenced the organization of large urban spaces on the city's margins, whereas on the other hand, the analyses advanced in this research reflect on alternatives to re-frame the history of the organization of the margins of Fortaleza through a set of practices of resistance.Originality/valueBased on the concept of “denaturalization”, and through re-activation of the memory of a circumstantial past, the gaze of the “ruins”, as represented by the belief in “progress” addressed in official reports of government confinement policies, spaces of resistance have emerged where new possibilities for the future of the city can be imagined.

The United States entered the Second World War following the Japanese attack on Pearl Harbor. During the war, Japanese Americans faced persecution and even imprisonment due to their national heritage. The primary objective of this paper is to highlight that it was not only U.S. citizens of Japanese or German descent, but also Hungarian Americans, who could become targets of American authorities, albeit not to the same severe extent. The wartime atmosphere was so tense that the FBI responded to even the slightest rumors, launching investigations against law-abiding citizens who had no intention of undermining the American war effort. This paper examines the case of one Hungarian immigrant family—the Gondos family—as an illustrative example of how U.S. wartime intelligence targeted American citizens of “enemy alien” descent based solely on unsubstantiated rumors. Analyzing this case offers valuable insight into the experiences of wartime minorities in the United States. Therefore, the findings contribute to the historiography of twentieth-century American history, Hungarian migration history, and the academic field of American Studies.

By what standard of proof--and by what procedures--can the U.S. government challenge citizenship status? That question has taken on greater urgency in recent years. News reports discuss cases of individuals whose passports were suddenly denied, even after the government had previously recognized their citizenship for years or even decades. The government has also stepped up efforts to reevaluate the naturalization files of other citizens and has asked for funding to litigate more than a thousand denaturalization cases. Likewise, citizens have gotten swept up in immigration enforcement actions, and thousands of citizens have been erroneously detained or removed from the United States. Most scholarly treatment of citizenship rights has focused on the substantive protection of those rights. But the procedures by which citizenship cases are litigated are just as important--and sometimes more important--to ensure that citizenship rights are safe.

In three common law countries - the UK, Canada and Australia - recent legislation significantly expanded the grounds on which nationals can be stripped of their citizenship. In each country, two justifications were invoked to support the expanded grounds for citizenship deprivation: a symbolic justification, asserting that citizens who engage in particular behaviour do not deserve to retain their citizenship, and a security justification, which cast citizenship stripping as a necessary device to neutralise threats from within the citizenry. In this article, we examine the denationalisation laws introduced in each of the three countries and analyse the extent to which each law served these symbolic and security justifications.

This book investigates politics of denaturalisation as a system of thought that influences seminal cultural political values, such as community, nationality, citizenship, selfhood and otherness. The context of the analysis is the politics of citizenship and nationality in France. Combining research insights from history, legal studies, security studies, and border studies, the book demonstrates that the language of denaturalisation shapes national identity as a form of formal legal attachment but also, and more counter-intuitively, as a mode of emotional belonging. As such, denaturalisation operates as an instrumental frame to maintain and secure the national community. Going back to eighteenth-century France and to both World Wars, periods during which governments deployed denaturalisation as a technology against \"threatening\" subjects, the analysis exposes how the language of denaturalisation interweaves concerns about immigration and national security. It is this historical backdrop that helps understand the political impact of denaturalisation in contemporary counterterrorism politics, and what is at stake when borders and identities become affective technologies.

Critical management studies (CMS) has emerged as an influential paradigm for organization and management researchers in the last three decades. While various strands of CMS have been adopted to conceptualize or empirically investigate a myriad of organizational phenomena, researchers in the field have yet to substantively apply this paradigm to the study of business ethics. This is unfortunate inasmuch as CMS potentially offers important analytical tools from which to address a range of germane issues pertaining to business ethics. As such, the aim of this article is to broadly introduce CMS to the business ethics scholarly community, underscoring particularly its central ontological and epistemological commitments. This article further identifies several important CMS-inflected research trajectories that scholars may pursue to explore pressing questions related to business ethics. In sum, the authors underscore the utility of CMS to the study business ethics and call for increased inquiry in this intersectional domain.