Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
189,280
result(s) for
"dermatology"
Sort by:
Quiz dermatologiczny
Mężczyzna, lat 53 zgłosił się z powodu występujących od 7 miesięcy różowo-czerwonych grudek o średnicy 3–5 mm zlokalizowanych na skórze kończyn górnych i dolnych oraz tułowiu (ryc. 1, 2). W chwili zgłoszenia u pacjenta stwierdzono poniżej 10 zmian skórnych na różnym etapie ewolucji. Grudki otoczone były promieniście teleangiektatycznymi naczyniami, a w części centralnej dłużej trwających zmian obecne było białawe przejaśnienie przypominające bliznę. Zmianom towarzyszył lekki świąd. Pacjent stosował miejscowo glikokortykosteroidy i inhibitory kalcyneuryny, bez istotnej poprawy. Poza tłuszczakowatością mnogą o rodzinnym występowaniu nie podawał żadnych chorób przewlekłych i nie przyjmował żadnych leków. Był w dobrym stanie ogólnym. Na rycinach 3 i 4 przedstawiono obraz dermoskopowy zmian, a na rycinie 5 obraz histopatologiczny wycinka zmiany skórnej. Obraz zmiany w liniowej konfokalnej optycznej tomografii koherentnej (LC-OCT) zaprezentowano na rycinie 6.Najbardziej prawdopodobne rozpoznanie to:A. Choroba DegosaB. Twardzina ograniczona, postać grudkowaC. Zespół antyfosfolipidowyD. Toczeń rumieniowaty skórnyE. Cysty folikularnePrawidłowa odpowiedź na stronie 473.Quiz dermatologiczny 6/2024Poniżej prawidłowa odpowiedź.A. Choroba DegosaChoroba Degosa, znana również jako grudkowatość zanikowa (atrophic papulosis), to rzadkie schorzenie. Choroba może być ograniczona do skóry i wtedy jest łagodna (benign atrophic papulosis), może też występować w postaci ogólnej (malignant atrophic papulosis) obejmującej, oprócz skóry, m.in. układ pokarmowy, ośrodkowy układ nerwowy, płuca, serce lub nerki i ma poważne rokowanie [1]. Łagodna forma występuje u 15% pacjentów. W większości przypadków choroba pojawia się między drugą a piątą dekadą życia, ale może dotyczyć także populacji dziecięcej [2]. Patogeneza choroby jest nieznana. Rozważane są czynniki genetyczne, infekcje wirusowe, nieprawidłowe krzepnięcie oraz zaburzenia autoimmunologiczne [3]. Za najbardziej prawdopodobny uważa się defekt komórek śródbłonka, które indukują na swojej powierzchni wykrzepianie, co prowadzi do zamknięcia naczynia i zawału tkanki.W wyniku zmian zakrzepowych dochodzi do zamknięcia przepływu krwi w powierzchownych tętniczkach i do niedokrwienia skóry właściwej, która ulega martwicy i przebudowie. To miejsce odpowiada centralnej części grudki [1]. W obrazie...View full text...
Journal Article
Prurigo Pigmentosa (Keto Rash) Secondary to an Eating Disorder: A Case Report and Proposed Diagnostic Criteria
Prurigo pigmentosa is a rare inflammatory dermatosis increasingly reported in association with ketogenic diets, fasting, diabetes, and eating disorders. We describe a 21-year-old female admitted after an intentional overdose of nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin, who presented with a pruritic, symmetric erythematous papular eruption involving the trunk, neck, upper arms, and back, which evolved into a reticulated hyperpigmented pattern. Urinalysis confirmed ketonuria. Histology demonstrated chronic lymphohistiocytic perivascular inflammation, melanophages, and pigment incontinence, consistent with the evolving subacute prurigo pigmentosa. This case highlights a frequently misdiagnosed eruption that can mimic common dermatoses. To address this diagnostic challenge, we propose a set of practical diagnostic criteria based on clinical features, disease course, and the context of ketosis. Early recognition, aided by these criteria, is essential for effective management through dietary modifications, thereby reducing unnecessary investigations and facilitating prompt resolution.
Journal Article
Second-Degree Burns Following Intense Pulsed Light Therapy in a Patient With Fitzpatrick Skin Type IV: A Case Report
Intense pulsed light (IPL) therapy is widely used in cosmetic dermatology for the treatment of unwanted hair, vascular lesions, pigmentary disorders, and acne-related sequelae. We present a case of a male in his late 20s with Fitzpatrick skin type IV who sustained second-degree burns following IPL therapy for post-acne erythema performed by a non-medical operator. The patient developed erythema, blisters, and desquamation. He was treated with oral medications (acyclovir and cephalexin), corticosteroid ointment, and medicated powder dressings. Subsequent treatment included light-emitting diode (LED) therapy, picosecond laser sessions, and topical depigmenting agents. Significant improvement was noted after four months with minimal residual hyperpigmentation. This case highlights the risks associated with IPL treatment administered by untrained personnel and underscores the importance of professional oversight and patient-specific parameter adjustments.
Journal Article
Refractory Condyloma Acuminatum in Two Pediatric Patients
Condyloma acuminatum (CA) is thought to be a sexually transmitted disease caused by human papillomavirus, most commonly types 6 and 11. Pediatric cases are relatively rare, and the routes of transmission remain controversial. We report two cases of refractory pediatric CA involving the perianal and genital areas. Both cases were resistant to topical therapies, including imiquimod and cryotherapy, and eventually required multiple surgical interventions. Neither case presented any clinical or historical evidence suggestive of sexual abuse, and the mode of transmission remained unclear.
Journal Article
Alopecia as an Emerging Adverse Effect Associated With Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists for Weight Loss: A Scoping Review
Alopecia has recently been reported as a potential emerging adverse effect associated with glucagon-like peptide-1 receptor agonists (GLP-1RAs), which are widely prescribed for weight loss. While gastrointestinal symptoms remain the most frequently documented adverse effects, an increasing number of reports describe hair loss events in patients treated with semaglutide, liraglutide, tirzepatide, and dulaglutide. This scoping review aimed to synthesize the available evidence regarding this potential association. A systematic literature search was conducted across PubMed, Scopus, Google Scholar, Cochrane, and the Latin American and Caribbean Literature on Health Sciences (LILACS) database through May 24, 2025. Nine studies met the inclusion criteria, comprising randomized clinical trials, cohort studies, and pharmacovigilance analyses. Most studies lacked dermatological diagnostic confirmation, and only one described the clinical pattern of alopecia, identifying telogen effluvium and androgenetic alopecia as the most frequent subtypes. The findings suggest that GLP-1RAs may alter the hair follicle cycle. More than 1,000 spontaneous cases have been reported in the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS). Although a causal relationship cannot be confirmed, the recurrence of cases across diverse settings signals a potential safety concern that warrants clinical attention. Awareness of this possible effect may improve therapeutic adherence and prevent unnecessary diagnostic interventions. Further dermatological research is needed to better characterize the frequency, temporality, and underlying mechanisms of GLP-1RA-associated alopecia.
Journal Article
Efficacy and Safety of Non-cross-Linked Hyaluronic Acid Injections for Facial Skin Biorevitalization: A Single-Center, Open-Label, Single-Arm, Uncontrolled, Post-marketing Study
Biorevitalization is a minimally invasive cosmetic procedure that involves the targeted intradermal injection of bioactive substances designed to enrich the skin and stimulate its natural regenerative capabilities. The aim of this single-center, open-label, single-arm, uncontrolled, post-marketing study was to examine the effectiveness and safety of biostimulatory injections using a proprietary, sterile gel containing non-cross-linked hyaluronic acid (Foliage Hydrofil
) for facial skin rejuvenation.
The trial was registered with ClinicalTrials.gov (NCT07010549). The intended target population comprised adults with mild-to-moderate facial photoaging and Fitzpatrick skin types III-IV, without active inflammatory dermatoses or recent aesthetic interventions. Twenty-four Caucasian subjects (21 women, three men; mean age: 44 ± 7.1 years) received three intradermal injections of the study product at three-week intervals. The primary endpoint was the change from baseline in skin capacitance, an objective measure of hydration, assessed via corneometry. Secondary endpoints included investigator and subject assessments of aesthetic improvement, while safety was evaluated through continuous adverse event monitoring.
The mean skin capacitance was 23.1 arbitrary units (a.u.) at baseline and increased to 33.2 a.u. at the end of the study, indicating a significant improvement in skin hydration (p < 0.05). Secondary outcomes showed moderate improvements in skin texture and tone, and high levels of participant satisfaction with the treatment. No adverse events were reported.
This study demonstrated that the tested non-cross-linked hyaluronic acid gel safely improves skin hydration and patient satisfaction in facial biorevitalization. Although promising, these findings are constrained by the study's uncontrolled, small-scale design; therefore, larger randomized controlled trials are required to confirm these outcomes and evaluate their long-term durability.
Journal Article
Koebnerization in Vasculitis: An Unusual Clinical Observation
Koebner's phenomenon (KP) refers to the development of isomorphic lesions of an existing dermatosis in otherwise uninvolved skin following trauma. While this response is well-established in conditions like psoriasis, lichen planus, and vitiligo, its occurrence in cutaneous vasculitis is exceedingly rare, with few reported cases. The authors present a rare case of a 47-year-old female with drug-induced vasculitis showing koebnerization, highlighting trauma as a potential exacerbating factor in vasculitic dermatoses. Trauma-induced vascular inflammation, immune complex deposition, or local cytokine release may be implicated in this unusual presentation.
Journal Article