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Background and purpose The validity, reliability, and longitudinal performance of the Patient‐Determined Disease Steps (PDDS) scale is unknown in people with multiple sclerosis (MS) with mild to moderate disability. We aimed to examine the psychometric properties and longitudinal performance of the PDDS. Methods We included relapsing–remitting MS patients with an Expanded Disability Status Scale (EDSS) score of less than 4. Validity and test–retest reliability was examined. Longitudinal data were analysed with mixed‐effect modelling and Cohen's kappa for concordance in confirmed disability progression (CDP). Results We recruited a total of 1093 participants, of whom 904 had complete baseline data. The baseline correlation between PDDS and EDSS was weak (ρ = 0.45, p < 0.001). PDDS had stronger correlations with patient‐reported outcomes (PROs). Conversely, EDSS had stronger correlations with age, disease duration, Kurtzke's functional systems and processing speed test. PDDS test–retest reliability was good to excellent (concordance correlation coefficient = 0.73–0.89). Longitudinally, PDDS was associated with EDSS, age and depression. A higher EDSS score was associated with greater PDSS progression. The magnitude of these associations was small. There was no concordance in CDP as assessed by PDDS and EDSS. Conclusion The PDDS has greater correlation with other PROs but less correlation with other MS‐related outcome measures compared to the EDSS. There was little correlation between PDDS and EDSS longitudinally. Our findings suggest that the PDDS scale is not interchangeable with the EDSS.

The present study integrates self-determined needs satisfaction into a relationship between product design (eg, aesthetic, functional, and symbolic design) and consumer behavior (eg, willingness-to-pay [WTP] a premium and negative word-of-mouth [WOM]) and to explore whether gender can differentiate the effects of aesthetic, functional, and symbolic product designs on self-determined needs satisfaction. To this end, participants from Pakistan and China were recruited, and the hypotheses for this study were tested using structural equation modeling and SPSS-PROCESS. The effects of three product designs on self-determined needs satisfaction were significantly positive across samples. The results further show that self-determined needs satisfaction had the strongest positive effect on WTP a premium and the strongest negative effect on vindictive WOM for Pakistanis. Self-determined needs frustration had the strongest negative effect on the WTP a premium for Chinese participants and an equivalent magnitude effect on vindictive WOM for Pakistani and Chinese participants. The cross-cultural gender-specific findings revealed that Pakistani men are more aesthetic and hedonic than women in Pakistan. Surprisingly, Chinese women resemble Pakistani men in the sense that they prefer aesthetically pleasing products. Chinese men resemble Pakistani women in terms of little interest in symbolic products, whereas Chinese women and Pakistani men respond similarly regarding their decisions to choose symbolic products. To the best of the authors' knowledge, the present study is one of the initial attempts to integrate self-determined needs into the relationship between product design and consumer WTP a premium and WOM, and further explore cross-cultural gender-specific differences across Pakistan and China. The findings of the present study may help international marketers in terms of segmenting, targeting, and positioning their markets.

This study aimed to examine variations in motivational regulation and the intention to remain in swimming training across a competitive season, considering different age groups. A total of 154 competitive swimmers participated and were categorised as young, youth, junior, and senior. Data were collected at three points during the 2023–2024 season (December, March, and June), using the Behavioral Regulation Sport Questionnaire and specific intention items. Results indicated that younger swimmers maintained higher levels of self-determined motivation throughout the season, whereas youth and junior groups experienced greater motivational shifts and a decrease in intention. Interestingly, senior swimmers reported higher levels of controlled motivation, along with increased intention to remain. These findings suggest that both motivation and intention to continue training are age-dependent, emphasizing the importance of age-sensitive strategies to support sustained engagement in competitive swimming. El presente estudio buscó analizar las variaciones en la regulación motivacional y la intención de continuar en el entrenamiento de natación a lo largo de una temporada competitiva, en función de la edad. Participaron 154 nadadores federados, agrupados en categorías infantil, juvenil, júnior y sénior. La recogida de datos se realizó en tres momentos diferentes de la temporada (diciembre, marzo y junio), utilizando el Cuestionario de Regulación Conductual en el Deporte y tres ítems específicos de intención. Los resultados mostraron que los nadadores más jóvenes mantuvieron altos niveles de motivación autodeterminada, mientras que los grupos juvenil y júnior presentaron mayores fluctuaciones motivacionales y un descenso progresivo en la intención. En contraste, los nadadores sénior manifestaron un incremento en la motivación controlada y una mayor intención de continuar. Estos hallazgos sugieren que la motivación y la intención en la práctica deportiva evolucionan de forma diferenciada según la edad, lo que subraya la necesidad de adaptar las estrategias motivacionales a cada etapa del desarrollo deportivo. Este estudo objetivou analisar as variações na regulação motivacional e na intenção de permanecer no treino de natação ao longo de uma época competitiva, em diferentes grupos etários. Participaram 154 nadadores federados, divididos em quatro escalões: jovens, juvenis, juniores e seniores. A recolha de dados ocorreu em três momentos da época desportiva (dezembro, março e junho), através do Questionário de Regulação Comportamental no Desporto e de itens específicos de intenção. Os resultados revelaram padrões distintos entre os grupos: os mais jovens mantiveram elevados níveis de motivação autodeterminada, enquanto os juvenis e juniores apresentaram flutuações nas formas de motivação e declínio na intenção. Por outro lado, os seniores demonstraram maior motivação controlada, associada a um aumento na intenção de permanecer. As diferenças observadas sugerem que a motivação e a intenção para a prática desportiva evoluem com a idade, sendo necessário considerar estratégias específicas para promover o envolvimento sustentado no treino.

This study aimed to investigate the contribution of teacher support and parental monitoring to academic performance over three years, testing the mediating role of self-determined motivation and academic self-efficacy and establishing whether the role of teachers and parents varies over time. A total of 419 adolescents—201 males (48%) and 218 females (52%), M age = 14.34 years ( SD = .90)—attending at T1 the ninth grade of schooling participated in the study. The questionnaires were administered three times over three years in February 2016 (T1), February 2017 (T2), and February 2018 (T3). Specifically, at T1, the students answered questionnaires regarding parental monitoring and teacher support. At T2 and T3, the students completed questionnaires about self-determined motivation and academic self-efficacy. At the end of each school year, in June 2017 (T2b) and June 2018 (T3b), the teachers’ assessments of the students’ academic performance expressed in school marks were collected. A structural equation model was used to test the hypothesised longitudinal relations between the study variables. The results showed that teacher support and parental monitoring directly and positively affected motivation and self-efficacy over time, which, in turn, impacted academic performance positively. The results also indicated that teacher support and parental monitoring indirectly affected academic performance over time through the mediation of motivation and self-efficacy and that the parents’ influence was highest on motivation, while the teachers’ influence was highest on self-efficacy. These results suggest the importance of implementing interventions aimed at enhancing parental monitoring and teacher support to improve students’ academic performance.

Background Although anxiety disorders are one of the most prevalent mental disorders, their underlying biological mechanisms have not yet been fully elucidated. In recent years, genetically determined metabolites (GDMs) have been used to reveal the biological mechanisms of mental disorders. However, this strategy has not been applied to anxiety disorders. Herein, we explored the causality of GDMs on anxiety disorders through Mendelian randomization study, with the overarching goal of unraveling the biological mechanisms. Methods A two-sample Mendelian randomization (MR) analysis was implemented to assess the causality of GDMs on anxiety disorders. A genome-wide association study (GWAS) of 486 metabolites was used as the exposure, whereas four different GWAS datasets of anxiety disorders were the outcomes. Notably, all datasets were acquired from publicly available databases. A genetic instrumental variable (IV) was used to explore the causality between the metabolite and anxiety disorders for each metabolite. The MR Steiger filtering method was implemented to examine the causality between metabolites and anxiety disorders. The standard inverse variance weighted (IVW) method was first used for the causality analysis, followed by three additional MR methods (the MR-Egger, weighted median, and MR-PRESSO (pleiotropy residual sum and outlier) methods) for sensitivity analyses in MR analysis. MR-Egger intercept, and Cochran’s Q statistical analysis were used to evaluate possible heterogeneity and pleiotropy. Bonferroni correction was used to determine the causative association features ( P  < 1.03 × 10 –4 ). Furthermore, metabolic pathways analysis was performed using the web-based MetaboAnalyst 5.0 software. All statistical analysis were performed in R software. The STROBE-MR checklist for the reporting of MR studies was used in this study. Results In MR analysis, 85 significant causative relationship GDMs were identified. Among them, 11 metabolites were overlapped in the four different datasets of anxiety disorders. Bonferroni correction showing1-linoleoylglycerophosphoethanolamine (OR fixed-effect IVW  = 1.04; 95% CI 1.021–1.06; P fixed-effect IVW  = 4.3 × 10 –5 ) was the most reliable causal metabolite. Our results were robust even without a single SNP because of a “leave-one-out” analysis. The MR-Egger intercept test indicated that genetic pleiotropy had no effect on the results (intercept = − 0.0013, SE = 0.0006, P  = 0.06). No heterogeneity was detected by Cochran’s Q test (MR-Egger. Q = 7.68, P  = 0.742; IVW. Q = 12.12, P  = 0.436). A directionality test conducted by MR Steiger confirmed our estimation of potential causal direction ( P  < 0.001). In addition, two significant pathways, the “primary bile acid biosynthesis” pathway ( P  = 0.008) and the “valine, leucine, and isoleucine biosynthesis” pathway ( P  = 0.03 ) , were identified through metabolic pathway analysis. Conclusion This study provides new insights into the causal effects of GDMs on anxiety disorders by integrating genomics and metabolomics. The metabolites that drive anxiety disorders may be suited to serve as biomarkers and also will help to unravel the biological mechanisms of anxiety disorders.

We investigated the Hankel determinant H 3 (1) for functionals in the analytic function class and obtained the sharp bound for the third Hankel determinant | e 3 e 5 − e 4 2 | for a subclass of analytic functions in this paper.

In this paper, we introduce the concepts of Q∗-determined spaces and Q∗-determined posets. We show that every Q∗-determined space is homeomorphic to the Q∗-spectrum of its Smyth hyperspace with the Scott topology. Similarly, every Q∗-determined poset is order isomorphic to the Q∗-spectrum of its Smyth powerdomain. So for any two Q∗-determined spaces or Q∗-determined posets X, Y with the Scott topology, X is homeomorphic to Y if and only if QX is order isomorphic to QY. Moreover, based on the Hofmann-Mislove Theorem, we propose a counterexample for the following problem posed in Gierz et al. (2003): Is OFilt(S), the semilattice of all open filters of S, distributive for a distributive continuous semilattice S?

Background Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is the leading cause of pain and disability in the aged population. However, the underlying biological mechanism has not been fully understood. This study aims to reveal the causal effect of circulation metabolites on OA susceptibility. Methods A two-sample Mendelian Randomization (MR) analysis was performed to estimate the causality of GDMs on OA. A genome-wide association study (GWAS) of 486 metabolites was used as the exposure, whereas 8 different OA phenotypes, including any-site OA (All OA), knee and/or hip OA (knee/hip OA), knee OA, hip OA, spine OA, finger and/or thumb OA (hand OA), finger OA, thumb OA, were set the outcomes. Inverse-variance weighted (IVW) was used for calculating causal estimates. Methods including weight mode, weight median, MR-egger, and MR-PRESSO were used for the sensitive analysis. Furthermore, metabolic pathway analysis was performed via the web-based Metaconflict 4.0. All statistical analyses were performed in R software. Results In this MR analysis, a total of 235 causative associations between metabolites and different OA phenotypes were observed. After false discovery rate (FDR) correction and sensitive analysis, 9 robust causative associations between 7 metabolites (e.g., arginine, kynurenine, and isovalerylcarnitine) and 5 OA phenotypes were finally identified. Additionally, eleven significant metabolic pathways in 4 OA phenotypes were identified by metabolic pathway analysis. Conclusion The finding of our study suggested that identified metabolites and metabolic pathways can be considered useful circulating metabolic biomarkers for OA screening and prevention in clinical practice, and can also serve as candidate molecules for future mechanism exploration and drug target selection.

Climate change is a major challenge for Indonesia due to its impact on food, water, energy sustainability, and environmental health. Almost all Indonesian regions are exposed to floods, landslides, soil erosion, drought, and heavy rains. In response to these challenges, the Government of Indonesia has determined integrated watershed management (IWM) to be one of the key programs to reduce greenhouse gas (GHG) emissions, as stated in the updated Indonesian nationally determined contribution (NDC). This paper intends to review Indonesia′s efforts in mitigating and adapting to climate change through an IWM approach, and its attempts to realize a decent life and environment for all communities. Improvement of the IWM can be conducted by strengthening the synergy between the responsible institutions for watershed management and the responsible institutions for handling mitigation and adaptation of climate change impacts. In addition, it is important to prioritize coordination, participation, and collaboration not only at the national government level but also at the international level, since numerous problems may exist in the transboundary between countries, and finding solutions should involve planning, implementation, monitoring, and evaluation. Implementing the micro watershed model (MWM), supported by culture, local wisdom, and traditional knowledge in communities, can be used to improve the current IWM.