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Glass-ionomer-cement (GIC) is helpful in Minimal Intervention Dentistry because it releases fluoride ions and is highly biocompatible. The aim of this study is to investigate the mechanisms by which hydroxyapatite (HAp) improves the mechanical strength and bioactive functioning of GIC when these materials are combined to make apatite ionomer cement (AIC). A conventional GIC powder was mixed with porous, spherical-HAp particles (HApS), crystalline HAp (HAp200) or one of two types of cellulose. The micro-compressive strengths of the additive particles were measured, and various specimens were evaluated with regard to their compressive strengths (CS), fluoride release concentrations (fluoride electrode) and multi-element release concentrations. The AIC was found to release higher concentrations of fluoride (1.2 times) and strontium ions (1.5 times) compared to the control GIC. It was detected the more release of calcium originated from HApS than HAp200 in AIC. The CS of the AIC incorporating an optimum level of HAp was also significantly higher than that of the GIC. These results suggest that adding HAp can increase the release concentration of ions required for remineralization while maintaining the CS of the GIC. This effect does not result from a physical phenomenon, but rather from chemical reactions between the HAp and polyacrylic acid of GIC.

Fluoride varnishes, both the first and the second generations, are effective in inhibiting caries, especially in children and adolescents, by reducing it on average by 43% for permanent teeth and 37% for deciduous teeth. The aim of this study was to evaluate the dynamics of in vitro fluoride ion release from first- (Duraphat) and second-generation (MI Varnish and Embrace Varnish) fluoride varnishes and the impact of the type of varnish, the time from its application and the pH of the environment on this process. Materials and methods: The test material (90 specimens), prepared from extracted human teeth, were divided into nine groups of 10 specimens each. Measured amounts of the examined varnishes were applied onto specimens and the levels of fluoride release were assessed at the baseline and after 1, 2, 24, 48 and 168 h from the application with the use of an ion-specific electrode. The specimens were immersed into artificial saliva with pH adjusted to 4, 5 and 7. The highest cumulative release of fluoride was obtained by MI Varnish (11.52 ppm/mg), regardless of the pH of the environment, whereas the lowest released fluoride concentration was achieved by Embrace Varnish (4.82 ppm/mg). In the acidic environment, the release of fluoride was significantly higher than in the neutral environment for all investigated varnishes, with no change in the overall fluoride release profile and with maximum fluoride release in the first two hours after application. The findings of this study indicate that all examined fluoride varnishes released the maximum amount of fluoride within the first hours after application and that it was related to the acidity of the immersion medium.

Objective: This study aimed to assess the effect of adding fluorescent dyes & color change dyes in different concentration to bioactive orthodontic adhesive on fluoride release. Material and Methods: We used Bioactive BEAUTIFIL Injectable XSL (S-PRG), from (Giomer, Shofu, Japan) mixed with color change dye, Black changing to Colorless, (Atlanta chemical engineering, USA). 0.02%, 0.2% and 2% of weight concentrations were tested and with fluorescence dye (Strontium aluminate), and White Glow in the Dark Powder (Techno Glow Inc., USA), using in 5%, 10% and 15% of weight concentrations. For fluoride release, 40 samples prepared and divided into 4 groups with 10 samples as following: Group 1: BEAUTIFIL Injectable XSL Adhesive (control group), Group 2: BEAUTIFIL Injectable XSL with 0.02% color change material and 5% fluorescence material. Group3: BEAUTIFIL Injectable XSL with 0.2% color change material and 10% fluorescence material. Group 4: BEAUTIFIL Injectable XSL with 2% fluorescence material and 15% fluorescence material. fluoride Ion Selective Electrode. Eutech ION 2700.) Thermo Fisher scientific inc. Singapore) used to measure the release of fluoride ion. Results: The use of dyes with bioactive adhesive showed statistically significant differences. There was a decrease in fluoride ion with increase dye concentration. Conclusion: Acceptable fluoride ion release within bioactive adhesive with color change and fluorescence properties was obtained but with increase concentration of dyes the ion release decreased.

The aim of this study is to investigate the resistance of various fluoride-releasing restorative materials against the demineralization and remineralization of enamel surfaces, including those that have been recently introduced to the market. Three different fluoride-releasing restorative materials were considered: glass ionomer (FI), resin-modified glass ionomer (RL), and an alkasite restorative material (CN). The acid neutralization ability was investigated using pH measurement, and the concentrations of released fluoride and calcium ions were measured. Finally, the demineralization resistance and remineralization effects of enamel were observed using a microhardness tester and SEM. CN showed an initial substantial increase in pH followed by a steady increase, with values higher than those of the other groups (p < 0.05). All three groups released fluoride ions, and the CN group released more calcium ions than the other groups (p < 0.05). In the acid resistance test, from the microhardness and SEM images, the CN group showed effective resistance to demineralization. In the remineralization test, the microhardness results showed that the FI and CN groups recovered the microhardness from the values of the demineralized enamel surface (p < 0.05). This was confirmed by the SEM images from remineralization tests; the CN group showed a recovered demineralized surface when immersed in artificial saliva for 7 days. In conclusion, alkasite restorative material can be an effective material when used in cariogenic environments.

The main objective of the current study is to compare short-term fluoride release of three ion releasing restorative materials and assess their inhibitory effect on secondary caries. Materials used in this study included, Self-adhesive hybrid composite (group A), Ion releasing flowable composite liner (group B), and alkasite restorative material (group C). Twenty-two discs were fabricated from each material for short-term fluoride release test, conducted on days 1, 7, and 14. For assessing secondary caries inhibition, sixty-six sound molar teeth were used and standardized class V cavities were prepared. Teeth were divided into three groups according to each material, followed by 800 cycles of thermocycling. Subsequently, teeth were immersed in a solution containing cariogenic bacteria for 30 days. After that, teeth were sectioned bucco-lingually and analyzed using a polarized light microscope to measure inhibition area, outer lesion depth, and extension. Data was statistically analyzed using different tests. The study results revealed a statistically significant differences in fluoride release existed among materials. Self-adhesive hybrid composite exhibited the highest fluoride release. Lesion extension and depth were statistically significantly greater next to Ion-releasing flowable composite liner. The inhibition areas next to the Self-adhesive hybrid composite were statistically significantly larger than the other two materials. In conclusion, all tested ion-releasing restorative materials displayed fluoride release and the potential to inhibit secondary caries formation. Self-adhesive hybrid composite demonstrated the highest fluoride-releasing potential and the greatest ability to inhibit secondary caries. Conversely, Ion-releasing flowable composite liner exhibited the least fluoride release with minimal secondary caries inhibition. Increasing fluoride release correlated with larger inhibition areas and reduced outer lesion depth and extension.

Objective: This systematic review evaluates the evidence on factors affecting fluoride release from compomer restorative materials to provide clinicians with insights for optimizing their use in caries prevention. Methods: In February 2025, an extensive digital search was conducted across reputable databases such as PubMed, Web of Science, and Scopus. The search utilized carefully chosen keywords: “fluoride release” AND “compomer” and followed the PRISMA guidelines. Initially, 287 articles were identified, but after applying the inclusion criteria, 34 studies were selected for review. Results: This review found that fluoride release from compomers follows an initial burst phase before stabilizing at lower levels. Fifteen studies proved that compomers release less fluoride than glass ionomer cements but more than composite resins, as concluded from six studies. The release rate is significantly influenced by pH, with acidic conditions enhancing fluoride diffusion. Some studies also highlighted the potential for fluoride recharge through external applications such as toothpaste or varnish. Conclusion: Compomer restorative materials offer a steady, moderate fluoride release that supports caries prevention. Their effectiveness is enhanced in acidic environments, supporting their use in high-risk patients.

Develop a fissure sealant containing chitosan/fluoride microparticles (C/F) with antibacterial, fluoride release and recharge ability. Chitosan/fluoride microparticles were synthesized and added to Bis-GMA as C/F. The experimental group comprised 0%, 2%, 4% C/F, with Clinpro TM fissure sealant as control. Antibacterial activity was detected by Alamar Blue assay and colony-forming units (CFU). Biocompatibility was determined by WST-1 and LDH test. Curing depth, flowability, tensile strength and flexural strength were measured according to the ISO standard; microhardness by Vickers hardness test. Fluoride release and recharge were recorded through ionic chromatography. Statistical analysis was performed with an independent t-test, one-way and two-way ANOVA. P values less than 0.05 were considered significant. 2% and 4% C/F showed antibacterial ability with CFU ratios decreasing to 10% and 25% respectively (P < 0.01). Nonetheless, 4% C/F was concerned because biocompatibility revealed cytotoxicity compared to medium (P < 0.001). 2% C/F had superior mechanical properties to Clinpro TM fissure sealant in terms of curing depth (P < 0.001), microhardness and tensile strength (P < 0.01). It had good fluoride release and recharge ability (P = 0.67). 2% C/F could be an antibacterial sealant with good mechanical strength, fluoride release and recharge ability.

The enhancement of the antibacterial properties of glass ionomer cement has gained substantial importance in contemporary restorative dentistry, as microbial biofilms are the primary cause of secondary caries and restoration failure. Recent advances focus on modifying glass ionomer cement by incorporating antimicrobial agents to significantly improve its antibacterial activity. Therefore, this study aims to evaluate the antimicrobial effect, compressive strength, and fluoride release of glass ionomer cement modified with Triphala. This in vitro study included a total of 78 glass ionomer specimens, which were allocated into three primary testing categories: antibacterial activity, compressive strength, and fluoride release. Specifically, ( n  = 24) specimens were designated for the antibacterial test, ( n  = 33) specimens for evaluating compressive strength, and ( n  = 21) specimens for assessing fluoride release. Each testing category was further subdivided into three groups based on the incorporation of Triphala into the glass ionomer cement. Group A served as the control, consisting of glass ionomer without Triphala, Group B included glass ionomer specimens modified with 1.25%wt Triphala, and Group C comprised glass ionomer specimens modified with 3%wt Triphala. There was a significant difference among the three groups in terms of antibacterial activity and fluoride release tests, with Group C exhibiting the highest values in both tests. However, no significant difference was reported between the mean compressive strength of the control group and the experimental groups. Results revealed that Triphala enhances the antibacterial and fluoride-releasing abilities without compromising the compressive strength of GIC.

Objectives To estimate the effect of fluoride slow‐release glass devices on the levels of fluoride in a pooled sample of human gingival crevicular fluid and in human saliva. Materials and Methods Ten healthy adult volunteers wore fluoride slow‐release glass devices for 3 months in a longitudinal experimental clinical pilot study. Whole unstimulated human saliva and gingival crevicular fluid were collected using paper points at baseline, after 2 weeks and at 3 months and analysed for their fluoride levels using ion chromatography and fluoride electrode. Results No adverse effects were reported, and the Löe Plaque and Gingival Index remained low (0.22). The saliva determination of fluoride using the fluoride electrode showed an increase after 3 months from 0.02 ± 0.04 ppm to 0.06 ± 0.12 ppm, whereas the ion chromatography showed an increase from 0.15 ± 0.10 ppm to 0.44 ± 0.36 ppm. The fluoride levels in a pooled sample of gingival crevicular fluid from four intraoral sites were determined using the ion chromatography, and the results showed that after 3 months, the fluoride levels were still low (0.71 ± 0.34 ppb) similar to those at baseline (0.74 ± 0.31 ppb). Conclusions The fluoride concentration in a pooled sample of gingival crevicular fluid was reported to be low with a range from 0.46 to 0.75 ppb and was not changed by placement of fluoride slow‐release glass devices. The fluoride concentration in unstimulated human saliva showed an increase after 3 months when the fluoride slow‐release glass devices were attached when determined with both the fluoride electrode (from .02 ± 0.04 ppm to 0.06 ± 0.12 ppm) and ion chromatography (from 0.15 ± 0.10 ppm to 0.44 ± 0.36 ppm).

Objective: Fluoride is widely recognized for its preventive role against secondary caries. This systematic review aimed to evaluate how environmental and material factors influence fluoride ion release from metal-reinforced glass ionomer cements. Methods: A structured literature search was performed in March 2025 across PubMed, Scopus, and Web of Science databases. Search terms included combinations of fluoride release AND glass ionomer AND silver OR zinc OR strontium OR copper. The study selection process followed PRISMA 2020 guidelines and was organized using the PICO framework. Out of 281 initially identified records, 153 were screened based on titles and abstracts. After applying predefined eligibility criteria, 23 studies met the inclusion requirements and were included in the qualitative analysis. Results: Among the 23 included publications, 12 involved glass ionomers modified with silver, and 6 of these reported an increase in fluoride release. Seven studies focused on zinc-modified cements, and four examined materials reinforced with strontium. Conclusions: The addition of strontium, titanium oxide, silver nanoparticles, or zirconium oxide increases the release of fluoride ions, while sintered silver reduces it. There is a great discrepancy among researchers regarding the effect of the addition of zinc oxide and its appropriate amount in the glass ionomer material.