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Among the assortment of available dressings aimed at promoting wound healing, moist dressings have gained significant popularity because of their ability to create an optimal environment for wound recovery. This meta‐analysis seeks to compare the effects of moist dressing versus gauze dressing on wound healing time. A comprehensive literature search was conducted, encompassing publications up until April 1, 2023, across multiple databases including PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Cochrane Library. Stringent criteria were used to determine study inclusion and evaluate methodological quality. Statistical analyses were performed utilizing Stata 17.0. A total of 13 articles, encompassing 866 participants, were included in the analysis. The findings indicate that moist dressing surpasses gauze dressing in terms of wound healing time (standard mean difference [SMD] −2.50, 95% confidence interval [CI] −3.35 to −1.66, p < 0.01; I2 = 97.24%), wound site infection rate (odds ratio [OR] 0.30, 95% CI 0.17 to 0.54, p < 0.01; I2 = 39.91%), dressing change times (SMD −3.65, 95% CI −5.34 to −1.97, p < 0.01; I2 = 96.48%), and cost (SMD −2.66, 95% CI −4.24 to −1.09, p < 0.01; I2 = 94.90%). Subgroup analyses revealed possible variations in wound healing time based on wound types and regions. This study underscores the significant advantages associated with the use of moist dressings, including expedited wound healing, reduced infection rates, decreased frequency of dressing changes, and lower overall treatment costs.

A meta‐analysis study to assess the effect of honey dressing (HD) in the management of diabetic foot ulcer (DFU). A comprehensive literature examination till January 2023 was implemented and 1794 linked studies were appraised. The picked studies contained 882 subjects with DFUs were in the picked studies' baseline, 424 of them were using HD, and 458 were using a control. Odds ratio (OR) in addition to 95% confidence intervals (CIs) were used to calculate the consequence of HD in the management of DFUs after DFU by the dichotomous and continuous styles and a fixed or random model. The HD applied to DFUs caused a significantly higher wound healing rate (OR, 2.06; 95% CI, 1.45‐2.93, P < .001) and lower wound healing time (MD, −10.42; 95% CI, −16.27‐ −4.58, P < .001) compared with the control. The HD applied to DFUs caused a significantly higher wound healing rate and lower wound healing time compared with the control. Although precautions should be taken when commerce with the consequences since most of the picked studies for this meta‐analysis was with low sample sizes.

The assessment for safety and effectiveness of surgical interventions in the management of diabetic foot ulcers (DFUs) in comparison to non‐surgical approaches was performed. A comprehensive search was performed across PubMed, MEDLINE, Cochrane Library and EMBASE in order to identify case–control studies, randomized controlled trials (RCTs), observational studies, cohort studies and observational studies pertaining to DFU treatments. Studies conducted in English language and focusing on wound healing rates, recurrence rates, time to healing and complication management met the inclusion criteria. There were six studies included in this meta‐analysis. Surgical procedures, such as debridement, revascularization and skin transplantation, demonstrated significantly superior efficacy in promoting wound healing (84%) and shorter duration of healing (6 weeks) in comparison to non‐surgical approaches, including off‐loading, wound dressings and pharmacological therapies. Surgical interventions for DFUs resulted in a wound recovery rate of 84%, a significantly higher mean rate than non‐surgical approaches (60%) that was observed. In addition, it was observed that the surgical group experienced considerably reduced average healing period of 9 weeks, in contrast to the non‐surgical group's mean healing period of 12 weeks. Nevertheless, it is imperative to acknowledge that surgical procedures were notably correlated with a heightened occurrence of complications, such as amputations, which transpired in 19% of instances. Surgical interventions for DFUs may provide superior short‐term results with regard to healing rates and recovery time, as indicated by this meta‐analysis. However, they are additionally correlated with the heightened likelihood of complications. Although non‐surgical techniques offered comparatively secure option, they were also less reliable. Individualized treatment modalities should be chosen in consideration of patient‐specific factors and comparative advantages and disadvantages.

Negative Pressure Wound Therapy (NPWT) is a standard treatment for chronic wounds. In 2017, NPWT with instillation and dwell time (NPWTi‐d) was approved for insurance coverage in Japan. This study aimed to identify optimal NPWTi‐d parameter settings for hard‐to‐heal wounds with necrotic tissue. We conducted a retrospective observational study of consecutive patients treated with NPWTi‐d between August 2017 and February 2019. Parameters analyzed included dressing change frequency (three times per week vs. once per week), therapy duration (2, 3, or 3.5 h), negative pressure levels (50–125 mmHg), dwell time (1–10 min), and instillation volume (mL/cm3 of foam). Fifty‐six patients were included. Among the 52 patients managed with once‐weekly dressing changes, five developed infections. A dwell time of ≥ 5 min significantly shortened the median treatment period to 11 days, compared to 26 days in those with shorter dwell times. NPWTi‐d is more effective when treatment parameters are optimized. A dwell time over 5 min and once‐per‐week dressing replacement are sufficient, reducing both patient burden and healthcare provider workload. These findings provide evidence‐based guidance for the efficient clinical use of NPWTi‐d.

A meta‐analysis research was implemented to appraise the effect of antibiotic bone cement (ABC) in treating infected diabetic foot wounds (IDFWs). Inclusive literature research till April 2023 was done and 1237 interconnected researches were revised. The 15 selected researches enclosed 895 IDFWs persons were in the utilized researchers' starting point, 449 of them were utilizing ABC, and 446 were in the control group. Odds ratio and 95% confidence intervals were utilized to appraise the consequence of ABC in treating IDFWs by the contentious approach and a fixed or random model. ABC had significantly lower wound healing time (MD, −9.83; 95% CI, −12.45–−7.20, p < 0.001), and time to bacterial conversion of the wound (MD, −7.30; 95% CI, −10.38–−4.32, p < 0.001) compared to control in IDFWs persons. However, caution needs to be taken when interacting with its values since there was a low sample size of most of the chosen research found for the comparisons in the meta‐analysis.

Diabetic foot ulcers (DFUs) represent a significant challenge in diabetic care, with variable prognoses influenced by factors such as ulcer location, depth, and the presence of infection or ischemia. The Site, Depth, and Infection/Ischemia (SDI) classification system is a potential tool for predicting DFU outcomes, but its prognostic value requires further investigation. This retrospective cohort study, conducted at Qingdao Haici Hospital between January 2021 and December 2022, included 261 diabetic patients with DFUs located at or distal to the ankle joint. The SDI classification system was applied to categorize ulcers based on site, depth, and infection/ischemia. Patient outcomes, including healing time, minor and major amputations, and mortality, were assessed, with follow-up conducted through telephone or outpatient visits. Statistical analysis was performed using SPSS version 27, with p-values < 0.05 considered statistically significant. The study included 240 patients after exclusions. Significant differences in healing time, amputation rates, and mortality were observed across different SDI classifications. Patients with hindfoot ulcers (S3) had the longest healing time (9.3 months) and the highest mortality (23.1%). Deeper ulcers (D3) also exhibited longer healing times (4.3 months) and higher mortality (18.5%). Patients with both infection and ischemia (I3) had the longest healing time (5.6 months), highest amputation rates, and increased mortality. Statistical analyses revealed significant differences in healing time ( p  < 0.001), amputation rates ( p  = 0.000), and mortality ( p  = 0.017) across classification groups. The SDI classification system effectively predicts outcomes in DFU patients, with higher SDI grades associated with longer healing times, higher amputation rates, and increased mortality. This study highlights the clinical utility of the SDI system and underscores the need for its further implementation in clinical practice for better patient management and prognostic assessment.

Scarring and its long-term sequelae, contribute significantly to morbidity following burn injuries. Factors associated with less favourable scar outcomes include the depth of burn, younger age, pigmented skin types and prolonged healing times. The aim of primary burn surgery is to debride non-viable tissue, to enable healing. However, international consensus regarding the optimal timing for debridement and grafting in pediatric patients with burns is lacking. Delayed wound healing is thought to increase the risk of poor scar quality, however, the evidence for this is weak with few studies investigating long-term outcomes in pediatric patients. The aim of this study, therefore, was to investigate the effect of patient and treatment factors on scar quality, one year after skin grafting in pediatric patients with burns. Patient factors included age, skin type, and site of burn, while treatment factors included timing of surgery, type of surgery, and healing times. Pediatric patients (age < 18 years) presenting to a National Burn Unit from 2011 until 2020, inclusive were considered for inclusion in the study. Burn injuries between 1% and 14.9% total body surface area (TBSA) and who required skin grafting for the primary treatment of their burn, were included. Patients who failed to attend their 12-month follow-up visit were excluded. Standardised clinical photographs were assessed using a modified version of the Patient and Observer Scar Assessment Scale, version 2.0 (POSAS). Thirty children (median age 3.9 years) were included. Factors with an independent effect on higher (worse) POSAS scores were younger age at the time of injury ( p  < 0.001), body site of the trunk ( p  < 0.002), or the lower extremity ( p  < 0.001) and a longer duration of healing time after skin grafting ( p  = 0.003). The duration of time between injury and surgery was not an independent factor for POSAS scores ( p  = 0.56). We had insufficient numbers to discriminate differences in scar quality for different graft types; meshed versus non-meshed. In this study, we found that long-term scar outcomes in pediatric burn patients after skin grafting were worse for those injured at a younger age, with burns on the trunk or lower extremity, or with prolonged healing time after grafting. The robustness of this conclusion is limited by the small sample size of the study cohort and by our use of photographic scar assessment .

Background Although the effective application of negative pressure wound therapy (NPWT) has been exemplified in diverse clinical studies, its potential and safety, specifically regarding paediatric burns, are yet to be fully confirmed. Our most recent systematic review and meta-analysis strive to investigate the impact of NPWT within the realm of paediatric burns. Methods We sourced relevant articles from databases including PubMed, Embase, the Cochrane Database, Web of Science, the International Clinical Trials Registry Platform, China National Knowledge Infrastructureris, the VIP Database for Chinese Technical Periodicals, and the Wanfang database. We defined the primary outcome measure as the healing time, while healing rate, numbers of dressing changes, detection rate of positive bacteria, incidence rate of adverse reactions, scar scale scores, and treatment costs were considered as secondary outcome measures. Pooling of data was conducted and the results were articulated as relative risk (RR), mean difference (MD), and standardized mean difference (SMD), all with a 95% confidence interval (CI). Results In this systematic review and meta-analysis, a total of 12 studies involving 1033 individuals were examined, including 559 paediatric burn patients who underwent NPWT (referred to as the treatment group) and 543 patients who received treatments other than NPWT (referred to as the control group). The amalgamated data from these studies exhibited that the treatment group experienced significant reductions in healing time (SMD = -1.60; 95% CI: -2.26 - -0.95; p  < 0.001, I 2  = 92.8%), the number of required dressing changes (SMD = -4.6; 95% CI: -5.84 - -3.36; p  < 0.001, I 2  = 92.4%), positive bacteria detection rate (RR = 0.61; 95% CI: 0.26–1.46; p  = 0.004, I 2  = 81.8%), incidence of adverse reactions (RR = 0.61; 95% CI: 0.33–1.12; p  = 0.005, I 2  = 68%), scar scale scores (SMD = -1.66; 95% CI: -2.54 - -0.79; p  < 0.001, I 2  = 89.4%), as well as in treatment costs (SMD = 0.92; 95% CI: -1.66–3.49; p  < 0.001, I 2  = 98.4%). Additionally, these individuals showed an increased rate of healing (RR = 1.17; 95% CI: 0.99–1.39; p  < 0.001, I 2  = 78%). Subgroup analysis did not find that the degree of burn was one of the sources of high heterogeneity. Conclusion Our meta-analysis points to the effectiveness of NPWT in treating paediatric burns. Notably, it significantly mitigates healing duration, frequency of dressing alterations, positive bacterial detection rate, adverse reactions incidence, scar scale scores and treatment costs, all while propelling the acceleration of wound healing.

The meta‐analysis aimed to assess the efficiency of platelet‐rich plasma (PRP) in the management of burn wounds (BWs). Using dichotomous or contentious random‐ or fixed‐effects models, the outcomes of this meta‐analysis were examined and the odds ratio (OR) and the mean difference (MD) with 95% confidence intervals (CIs) were computed. Thirteen examinations from 2009 to 2023 were enrolled for the present meta‐analysis, including 808 individuals with BWs. PRP had significantly shorter healing time (MD, −5.80; 95% CI, −7.73 to −3.88, p < 0.001), higher healing rate (OR, 3.14; 95% CI, 2.05–4.80, p < 0.001), higher healed area percent (MD, 12.67; 95% CI, 9.79–15.55, p < 0.001) and higher graft take area percent (MD, 4.39; 95% CI, 1.51–7.26, p = 0.003) compared with standard therapy in patients with BW. However, no significant difference was found between PRP and standard therapy in graft take ratio (OR, 1.70; 95% CI, 0.86–3.34, p = 0.13) and infection rate (OR, 0.55; 95% CI, 0.20–1.47, p = 0.23) in patients with BW. The examined data revealed that PRP had a significantly shorter healing time, a higher healing rate, a higher healed area percent and a higher graft take area percent; however, no significant difference was found in graft take ratio or infection rate compared with standard therapy in patients with BW. Yet, attention should be paid to its values since all of the selected examinations had a low sample size and some comparisons had a low number of selected studies.

Background Successful usage of autologous skin cell suspension (ASCS) has been demonstrated in some clinical trials. However, its efficacy and safety have not been verified. This latest systematic review and meta‐analysis aim to examine the effects of autologous epidermal cell suspensions in re‐epithelialization of skin lesions. Methods Relevant articles were retrieved from PubMed, Embase, Cochrane Database, Web of Science, International Clinical Trials Registry Platform, China National Knowledge Infrastructureris, VIP Database for Chinese Technical Periodicals and Wanfang database. The primary output measure was the healing time, and the secondary outputs were effective rate, size of donor site for treatment, size of study treatment area, operation time, pain scores, repigmentation, complications, scar scale scores and satisfaction scores. Data were pooled and expressed as relative risk (RR), mean difference (MD) and standardized mean difference (SMD) with a 95% confidence interval (CI). Results Thirty‐one studies were included in this systematic review and meta‐analysis, with 914 patients who received autologous epidermal cell suspensions (treatment group) and 883 patients who received standard care or placebo (control group). The pooled data from all included studies demonstrated that the treatment group has significantly reduced healing time (SMD = −0.86; 95% CI: −1.59–0.14; p = 0.02, I2 = 95%), size of donar site for treatment (MD = −115.41; 95% CI: −128.74–102.09; p<0.001, I2 = 89%), operation time (MD = 25.35; 95% CI: 23.42–27.29; p<0.001, I2 = 100%), pain scores (SMD = −1.88; 95% CI: −2.86–0.90; p = 0.0002, I2 = 89%) and complications (RR = 0.59; 95% CI: 0.36–0.96; p = 0.03, I2 = 66%), as well as significantly increased effective rate (RR = 1.20; 95% CI: 1.01–1.42; p = 0.04, I2 = 77%). There were no significant differences in the size of study treatment area, repigmentation, scar scale scores and satisfaction scores between the two groups. Conclusion Our meta‐analysis showed that autologous epidermal cell suspensions is beneficial for re‐epithelialization of skin lesions as they significantly reduce the healing time, size of donar site for treatment, operation time, pain scores and complications, as well as increased effective rate. However, this intervention has minimal impact on size of treatment area, repigmentation, scar scale scores and satisfaction scores.