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Surface acoustic wave (SAW) resonators represent some of the most prominent acoustic devices for chemical sensing applications. As their frequency ranges from several hundred MHz to GHz, therefore they can record remarkably diminutive frequency shifts resulting from exceptionally small mass loadings. Their miniaturized design, high thermal stability and possibility of wireless integration make these devices highly competitive. Owing to these special characteristics, they are widely accepted as smart transducers that can be combined with a variety of recognition layers based on host-guest interactions, metal oxide coatings, carbon nanotubes, graphene sheets, functional polymers and biological receptors. As a result of this, there is a broad spectrum of SAW sensors, i.e., having sensing applications ranging from small gas molecules to large bio-analytes or even whole cell structures. This review shall cover from the fundamentals to modern design developments in SAW devices with respect to interfacial receptor coatings for exemplary sensor applications. The related problems and their possible solutions shall also be covered, with a focus on emerging trends and future opportunities for making SAW as established sensing technology.

In this paper, a three-dimensional finite element analysis (3D-FEA) model for shear horizontal surface acoustic wave (SH-SAW) torque sensors is presented. Torque sensors play a significant role in various fields to ensure a reliable torque transmission in drivelines. Featured with the advantages of high propagation velocity, large Q-value, and good power capacity, SH-SAW based torque sensors are promising but very few studies have been carried out. In order to develop a successful sensor, understanding the characteristics of SH-SAWs produced on piezoelectric substrates and torque sensing modes is indispensable. Therefore, in this study, we first investigated the effect on the generation of waves when different Y-cut quartz substrates are engaged. Thereafter, analyses and comparisons, regarding the effect on the polarized displacement, wave guidance, and wave mode, were conducted for different configurations of wave-guide layer thickness to wavelength ratios (hlayer/λ) and materials. Results show that Y-cut quartz at an angle close to 36° with a gold (Au) layer varying from hAu/λ = 0.02 to 0.03 thickness could be the most effective configuration for the excitation of SH-SAWs, compared to other combinations using platinum (Pt), titanium (Ti) and silicon dioxide (SiO2). Finally, based on the FEA SH-SAW torque sensor model configuring with a Y+36° quartz substrate and 0.025 λ-thick gold layer, the relationship between the applied torque and sensed voltage was examined, which shows a perfect linearity demonstrating the performance of the sensors.

Atherosclerosis is an inflammatory disease of the arteries associated with alterations in lipid and other metabolism and is a major cause of cardiovascular disease (CVD). LDL consists of several subclasses with different sizes, densities, and physicochemical compositions. Small dense LDL (sd-LDL) is a subclass of LDL. There is growing evidence that sd-LDL-C is associated with CVD risk, metabolic dysregulation, and several pathophysiological processes. In this study, we present a straightforward membrane device filtration method that can be performed with simple laboratory methods to directly determine sd-LDL in serum without the need for specialized equipment. The method consists of three steps: first, the precipitation of lipoproteins with magnesium harpin; second, the collection of effluent from a 100 nm filter; and third, the quantification of sd-LDL-ApoB in the effluent with an SH-SAW biosensor. There was a good correlation between ApoB values obtained using the centrifugation (y = 1.0411x + 12.96, r = 0.82, n = 20) and filtration (y = 1.0633x + 15.13, r = 0.88, n = 20) methods and commercially available sd-LDL-C assay values. In addition to the filtrate method, there was also a close correlation between sd-LDL-C and ELISA assay values (y = 1.0483x - 4489, r = 0.88, n = 20). The filtration treatment method also showed a high correlation with LDL subfractions and NMR spectra ApoB measurements (y = 2.4846x + 4.637, r = 0.89, n = 20). The presence of sd-LDL-ApoB in the effluent was also confirmed by ELISA assay. These results suggest that this filtration method is a simple and promising pretreatment for use with the SH-SAW biosensor as a rapid in vitro diagnostic (IVD) method for predicting sd-LDL concentrations. Overall, we propose a very sensitive and specific SH-SAW biosensor with the ApoB antibody in its sensitive region to monitor sd-LDL levels by employing a simple delay-time phase shifted SH-SAW device. In conclusion, based on the demonstration of our study, the SH-SAW biosensor could be a strong candidate for the future measurement of sd-LDL.

On site monitoring of engine oil is required. The features of a shear horizontal surface acoustic wave (SH-SAW) sensor include simultaneous detection of mechanical and electrical properties of liquids (such as viscosity, relative permittivity, and conductivity) and loaded mass on the sensor surface. In this paper, the used engine oil extracted from a motorbike was measured using the SH-SAW sensor. The degradation factors of the used engine oil were experimentally discussed. Especially, the influences of the particles in the engine oil, heating effect, and water contained in the engine oil were considered by comparing the differences between new and used engine oils. The results indicate that the influence of the water contained in the engine oil is the primary cause of the degradation of the used engine oil.

Detection and quantification of cell viability and growth in two-dimensional (2D) and three-dimensional (3D) cell cultures commonly involve harvesting of cells and therefore requires a parallel set-up of several replicates for time-lapse or dose-response studies. Thus, developing a non-invasive and touch-free detection of cell growth in longitudinal studies of 3D tumor spheroid cultures or of stem cell regeneration remains a major unmet need. Since surface acoustic waves (SAWs) permit mass loading-based biosensing and have been touted due to their many advantages including low cost, small size and ease of assembly, we examined the potential of SAW-biosensing to detect and quantify cell growth. Herein, we demonstrate that a shear horizontal-surface acoustic waves (SH-SAW) device comprising two pairs of resonators consisting of interdigital transducers and reflecting fingers can be used to quantify mass loading by the cells in suspension as well as within a 3D cell culture platform. A 3D COMSOL model was built to simulate the mass loading response of increasing concentrations of cells in suspension in the polydimethylsiloxane (PDMS) well in order to predict the characteristics and optimize the design of the SH-SAW biosensor. The simulated relative frequency shift from the two oscillatory circuit systems (one of which functions as control) were found to be concordant to experimental data generated with RAW264.7 macrophage and A549 cancer cells. In addition, results showed that SAW measurements per se did not affect viability of cells. Further, SH-SAW biosensing was applied to A549 cells cultured on a 3D electrospun nanofiber scaffold that generate tumor spheroids (tumoroids) and the results showed the device's ability to detect changes in tumor spheroid growth over the course of eight days. Taken together, these results demonstrate the use of SH-SAW device for detection and quantification of cell growth changes over time in 2D suspension cultures and in 3D cell culture models, which may have potential applications in both longitudinal 3D cell cultures in cancer biology and in regenerative medicine.

It is known that each compact connected orientable 3-manifold M with boundary admits an H′ -splitting H 1 ∪ F H 2 , where F is a compact connected orientable surface properly embedded in M and splits M into two handlbodies H 1 and H 2 . In this paper, we show that a non-completely L -reducible and minimal H′ -splitting surface for a compact connected irreducible orientable anannular Seifert 3-manifold with boundary is horizontal, and give a necessary and sufficient condition for an amalgamation of two compact connected orientable 3-manifolds along a compact connected surface to be a Seifert manifold with boundary, and describe a characteristic of some H′ -splittings to denote a Seifert 3-manifold with boundary. For a compact connected orientable Seifert manifold M with a semi-bundle structure M 1 ∪ F M 2 , we give an upper bound of the genus of the base surface.

This work aims to provide a fundamental understanding on the dispersive behaviors of shear horizontal (SH) surface waves propagating in a layered piezoelectric nanostructure consisting of an elastic substrate and a piezoelectric nanofilm by considering the surface effects. Theoretical derivation based on the surface piezoelectricity model was conducted for this purpose, and analytic expressions of the dispersion equation under the nonclassical mechanical and electrical boundary conditions were obtained. Numerical solutions were given to investigate the influencing mechanism of surface elasticity, surface piezoelectricity, surface dielectricity, as well as the surface density upon the propagation characteristics of SH surface waves, respectively. The results also reveal the size-dependence of dispersive behaviors, which indicates that the surface effects make a difference only when the thickness of the piezoelectric nanofilm stays in a certain range.

A three-dimensional Monte Carlo model was developed to simulate the deposition of aerosol particles onto horizontal solid surfaces. The random walk method was employed to solve the particle transport equation, which allowed obtaining the trajectory of particle motion by a combined mechanism of Brownian diffusion and gravity sedimentation. The particle transport mechanism was described in terms of a Peclet number (Pe). The local structures of the dust layer, the relationship between the structure of the dust layer and particle transport mechanisms, and the number of the particles attached to the solid surface were investigated. The results showed that for a small Pe, when Brownian diffusion was a controlling mechanism for aerosol transport, the dust layer might exhibit a more open and looser structure, while for a large Pe, the dust layer was dense and tight. The differences of deposition morphologies under different transport mechanisms were caused by the different random intensities of particle motion. There was an upper limit of the maximum number of particles attached to the surface, and it strongly depended on particle transport mechanisms and size distributions. Additionally, the deposit morphologies obtained with the 3D Monte Carlo model were in good agreement with the experimental results found in the literature.

The seawall slamming has become increasingly important as coastal engineering experiencing larger loads during the seawall impacts against surface wave which can result in structural damage and crew injury. It is necessary to characterize the hydrodynamic loading during wave impacts. This paper aims to study the wave impact on different stepped seawall structures through physical modeling experiments. Five types of stepped seawall structures were designed according to seawall slope and step height. The dynamic pressures exerted by different incident waves acting on the stepped seawall structure were measured and the data was collected. Data analysis was performed to investigate the relation of dynamic pressures with seawall slopes and seawall step heights. Results showed that when the incident wave and the seawall step height remained unchanged, the dynamic pressures acting on horizontal and vertical surface of seawall steps decreased with decreasing seawall slope (within a certain range of seawall slope). Additionally, when the incident wave and the seawall slope remained unchanged, the dynamic wave pressures acting on horizontal and vertical surface of seawall steps increased with increasing seawall step height. These results might provide a theoretical basis for the design of safety stepped seawall structures.

The surface deformation caused by underground coal mining will cause great damage to the surface buildings. Especially for the strip foundation buildings, the surface horizontal deformation will cause the walls to crack and open, threatening the safe use of buildings. However, there is lacking research on the failure mechanism of strip foundation buildings caused by surface horizontal deformation. Therefore, it is particularly important to study the mechanism. In this paper, a mechanical model of additional stress distribution in the strip foundation under surface horizontal deformation is established. Based on the model, the internal stress variation characteristics of the longitudinal wall of strip foundation buildings are studied with different factors: friction coefficient, surface curvature, foundation load and foundation length under the surface horizontal deformation. The internal stress variation of the transverse wall of the strip foundation buildings is analysed. The theory is verified by numerical simulation and a case study from Fengfeng coalmine China. Finally, the protection methods of the strip foundation buildings under the surface horizontal deformation are proposed.