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Pharmacological Treatment of Fibromyalgia Syndrome: A Practice-Based Review
by
Giorgi, Valeria
,
Sarzi-Puttini, Piercarlo
,
Coaccioli, Stefano
in
Analgesics - therapeutic use
,
Anticonvulsants - therapeutic use
,
Antidepressants
2024
Purpose of Review
Fibromyalgia Syndrome (FMS) is a complex chronic pain condition characterized by widespread musculoskeletal pain and numerous other debilitating symptoms. The purpose of this review is to provide a comprehensive overview, based on everyday clinical practice, of the drugs presently employed in the treatment of FMS.
Recent Findings
The treatment of FMS is based on a multimodal approach, with pharmacologic treatment being an essential pillar. The drugs used include tricyclic antidepressants, serotonin and noradrenaline reuptake inhibitors, other antidepressants, anticonvulsants, myorelaxants, and analgesics. The effectiveness of these medications varies, and the choice of drug often depends on the specific symptoms presented by the patient. Many drugs tend to either address only some domains of the complex FMS symptomatology or have a limited effect on pain.
Summary
Each treatment option comes with potential side effects and risks that necessitate careful consideration. It may be beneficial to divide patients into clinical subpopulations, such as FMS with comorbid depression, for more effective treatment. Despite the complexities and challenges, the pharmacological treatment remains a crucial part for the management of FMS. This review aims to guide clinicians in prescribing pharmacological treatment to individuals with FMS.
Journal Article
Behavioural Skills for Effective Policing
2022
Behavioural skills are essential to effective policing practice and professional development, and are also embedded within the policing competency frameworks. As the police service looks to further redefine its role in the twenty-first century, this critical handbook covers the full range of these proficiencies, from building rapport, applying emotional intelligence, building empathy and resilience to diversity and difference, understanding ethics, and developing coaching and leadership skills.Each chapter is written by a distinguished serving or former senior police leader and/or policing scholar, bringing together a wealth of experience and understanding and applying this knowledge in context through key case studies and examples. Suitable for serving police officers at all levels, as well as policing lecturers and students aspiring to join the police, this book encourages and enables a people-centred approach to policing that balances the debate that has given disproportionate credence to transactional skills at the expense of a more transformational approach.
Does Tension Headache Have a Central or Peripheral Origin? Current State of Affairs
by
Repiso-Guardeño, Ángela
,
Armenta-Peinado, Juan Antonio
,
Moreno-Morales, Noelia
in
Headaches
,
Hot Topics in Pain and Headache (N Rosen
,
Hot Topics in Pain and Headache (N Rosen, Section Editor)
2023
Purpose of Review
The aim of this narrative review is to analyze the evidence about a peripheral or central origin of a tension headache attack in order to provide a further clarification for an appropriate approach.
Recent Findings
Tension headache is a complex and multifactorial pathology, in which both peripheral and central factors could play an important role in the initiation of an attack. Although the exact origin of a tension headache attack has not been conclusively established, correlations have been identified between certain structural parameters of the craniomandibular region and craniocervical muscle activity. Future research should focus on improving our understanding of the pathology with the ultimate goal of improving diagnosis.
Summary
The pathogenesis of tension-type headache involves both central and peripheral mechanisms, being the perpetuation over time of the headache attacks what would favor the evolution of an episodic tension-type headache to a chronic tension-type headache. The unresolved question is what factors would be involved in the initial activation in a tension headache attack. The evidence that favors a peripheral origin of the tension headache attacks, that is, the initial events occur outside the brain barrier, which suggests the action of vascular and musculoskeletal factors at the beginning of a tension headache attack, factors that would favor the sensitization of the peripheral nervous system as a result of sustained sensory input.
Journal Article