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The Dalai Lama has represented Buddhism as a religion of non-violence, compassion, and world peace, but this does not reflect how monks learn their vocation. This book shows how monasteries use harsh methods to make monks of men, and how this tradition is changing as modernist reformers—like the Dalai Lama—adopt liberal and democratic ideals, such as natural rights and individual autonomy. In the first in-depth account of disciplinary practices at a Tibetan monastery in India, Michael Lempert looks closely at everyday education rites—from debate to reprimand and corporal punishment. His analysis explores how the idioms of violence inscribed in these socialization rites help produce educated, moral persons but in ways that trouble Tibetans who aspire to modernity. Bringing the study of language and social interaction to our understanding of Buddhism for the first time, Lempert shows and why liberal ideals are being acted out by monks in India, offering a provocative alternative view of liberalism as a globalizing discourse.

CALM (Clathrin Assembly Lymphoid Myeloid Leukemia)‐AF10, a fusion gene commonly associated with acute myeloid leukemia (AML), arises from the t(10;11) translocation and is linked to poor prognosis. In this study, we demonstrate that the CCCTC‐binding factor (CTCF) plays a critical role in both the initiation and maintenance of CALM‐AF10‐induced AML (CALM‐AF10 AML). In vivo, CTCF deficiency significantly extended the survival of CALM‐AF10 AML mice. In vitro, CTCF knockout (KO) reduced the colony‐forming capacity of CALM‐AF10 AML cells and induced their differentiation into macrophage‐like cells. RNA sequencing (RNA‐seq) of CTCF KO cells revealed that Transglutaminase 2 (TGM2) was the most significantly downregulated gene. Chromatin immunoprecipitation sequencing (ChIP‐seq) analysis indicated increased repressive histone mark, H3K27 trimethylation (H3K27me3), accompanied by reduced active histone marks, including H3K4 trimethylation (H3K4me3) and H3K27 acetylation (H3K27ac), at the transcription start site (TSS) of Tgm2 following CTCF KO. Knockdown of Tgm2 using short hairpin RNA (shRNA) in CALM‐AF10 AML cells and in the human leukemic cell line U937 harboring the CALM‐AF10 fusion gene resulted in reduced colony formation and proliferation. This also promoted differentiation into macrophage‐like cells, recapitulating the effects observed with CTCF KO. Similarly, comparable outcomes were observed with GK921, a TGM2 inhibitor, highlighting the impact of TGM2 blockade. These findings suggest that CTCF regulates TGM2 expression by modulating post translational modifications of histones at its TSS, thereby preserving the undifferentiated state of CALM‐AF10 AML cells. The demonstrated efficacy of TGM2 inhibitors further underscores the importance of TGM2 in this subtype of leukemia. CTCF regulates TGM2 gene expression by modulating key histone modifications, including increased acetylation of H3K27 (H3K27ac) and trimethylation of H3K4 (H3K4me3), along with decreased trimethylation of H3K27 (H3K27me3). These epigenetic changes are critical for maintaining the stem‐like properties of CALM‐AF10‐induced AML. Pharmacological inhibition of TGM2 activity using GK921 effectively suppresses the growth of CALM‐AF10‐induced AML cells, highlighting TGM2 as a promising therapeutic target for this leukemia subtype.

To better understand the ecological and hydrological responses to climatic and cryospheric changes, the spatiotemporal variations in the active layer thickness (ALT) need to be scrupulously studied. Based on more than 230 sites from the circumpolar active layer monitoring network, the spatiotemporal characteristics of the ALT across the northern hemisphere during 1990–2015 were investigated. Results indicate that the ALT exhibits substantial spatial variations across the northern hemisphere, ranging from approximately 30 cm in the arctic and subarctic regions to greater than 10 m in the mountainous permafrost regions at mid-latitudes. Regional averages of ALT are 48 cm in Alaska, 93 cm in Canada, 164 cm in the Nordic countries (including Greenland and Svalbard) and Switzerland, 330 cm in Mongolia, 476 cm in Kazakhstan, and 230 cm on the Qinghai-Tibetan Plateau (QTP), respectively. In Russia, the regional averages of ALT in European North, West Siberia, Central Siberia, Northeast Siberia, Chukotka, and Kamchatka are 110, 92, 69, 61, 53 and 60 cm, respectively. Increasing trends of ALT were not uniformly present in the observational records. Significant changes in the ALT were observed at 73 sites, approximately 43.2 % of the investigated 169 sites that are available for statistical analysis. Less than 25 % Alaskan sites and approximately 33 % Canadian sites showed significant increase in the ALT. On the QTP, almost all the sites showed significant ALT increases. Insignificant increase and even decrease in the ALT were observed in some parts of the northern hemisphere, e.g., Mongolia, parts of Alaska and Canada. The air and ground temperatures, vegetation, substrate, microreliefs, and soil moisture in particular, play decisive roles in the spatiotemporal variations in the ALT, but the relationships among each other are complicated and await further studies.

Objective: To evaluate the effectiveness and feasibility of Managing Cancer and Living Meaningfully (CALM), which is used to reduce chemotherapy-related cognitive impairment (CRCI), relieve psychological distress, and improve quality of life (QOL) in Chinese breast cancer survivors (BCs). Methods: Seventy-four BCs were enrolled in this study. All patients were randomly assigned to either the CALM group or the care as usual (CAU) group. All patients were evaluated by the Functional Assessment of Cancer Therapy–Cognitive Function (FACT-Cog), Distress Thermometer (DT), and the Functional Assessment of Cancer Therapy–Breast (FACT-B) before and after CALM or CAU application to BCs with CRCI. We compared the differences in all these scores between the CALM group and the control group and analyzed the correlation between cognitive function and QOL. Results: Compared with the CAU group, the performance of the CALM group on the FACT-Cog, DT, and FACT-B showed significant differences before and after CALM (t = −18.909, −5.180, −32.421, P = .000, .000, .000, respectively). Finally, there was a positive correlation between cognitive function and QOL in breast cancer patients before (r = 0.579, P = .000) and after (r = 0.797, P = .000) treatment. Conclusions: The present results indicated that CALM has salutary effects on the improvement of cognitive impairment and QOL and relieves psychological distress in breast cancer patients, which may be due to a positive correlation between psychological distress and cognitive function or QOL.

Genistein has a neuroprotective effect in Alzheimer's disease, but its mechanism of action needs further clarification. Accumulating evidence suggests that excessive phosphorylation of tau protein causes production of neurofibrillary tangles, which is one of the main pathological characteristics of Alzheimer's disease, and tau protein can be phosphorylated by calcium/calmodulin dependent protein kinase IV (CAMK4). After 7 days of pre-administration of genistein (90 mg/kg), an Alzheimer's disease rat model was established using an intraperitoneal injection of D-galactose combined with an intracerebral injection of amyloid-β peptide (25-35). The rat was then continuously administered genistein (90 mg/kg) for 42 days. The Morris water maze test, western blotting and hematoxylin-eosin staining results showed that genistein significantly decreased the escape latency and increased the number of times crossing the platform, reduced p-tau, CALM, CAMKK1 and p-CAMK4 protein levels in the hippocampus, and alleviated hippocampal neuron damage. These findings indicate that genistein may play a neuroprotective role in Alzheimer's disease through regulating CAMK4 to modulate tau hyperphosphorylation.

The application of marine bonded hoses has increased in recent times, due to the need for more flexible conduits and flexible applications in the offshore industry. These marine structures include Catenary Anchor Leg Moorings (CALM) buoys and ocean monitoring buoys. Their attachments include floating hoses, submarine hoses and submarine cables. However, the structural performance challenges of a CALM buoy system from its hydrodynamics water waves and other global loadings, have led to the need for this investigation. In this study, a detailed presentation on the motion characterisation of the CALM buoy hose system is presented. The CALM buoy is a structure with six degrees of freedom (6DoF). A well-detailed experimental presentation on the CALM buoy hose model conducted in Lancaster University Wave Tank is presented using three novel techniques, which are: a digital image captured using Imetrum systems, using an Akaso 4K underwater camera, using wave gauges arranged in a unique pattern and using underwater Bluetooth sensors. The buoy model was also found to respond uniquely for each motion investigated under water waves. The results showed that the higher the profile, the higher the response of the buoy. Thus, this study confirms the existence of flow patterns of the CALM buoy while floating on the water body.

Background Managing Cancer and Living Meaningfully (CALM) is an evidence-based, brief, semi-structured psychotherapy designed to help patients with advanced cancer cope with the practical and profound challenges of their illness. However, no study to date has investigated its feasibility, acceptability, and preliminary effectiveness in adults with malignant glioma, despite the well-documented incidence of psychological distress in this vulnerable and underserved population. Methods Fourteen patients with glioma and elevated symptoms of depression and/or death anxiety enrolled in the trial: 83% glioblastoma, 75% female, M age  = 56 years (SD = 15.1; range = 27–81). Feasibility was assessed based on established metrics. Acceptability was measured by post-session surveys and post-intervention interviews. Preliminary intervention effects were explored using paired t-tests, comparing psychological distress at baseline and post-intervention. Results Of the 14 enrolled patients, 12 were evaluable. Nine completed the study (75% retention rate). Three patients withdrew due to substantial disease progression which affected their ability to participate. Participants reported high perceived benefit, and all recommended the program to others. Baseline to post-intervention assessments indicated reductions in death anxiety, generalized anxiety, and depression, and increases in spirituality. Quality of life and fear of cancer recurrence remained stable throughout the study period. Conclusions CALM appears feasible for use with adults with malignant glioma. Enrollment and retention rates were high and comparable to psychotherapy trials for patients with advanced cancer. High perceived benefit and reductions in symptoms of death anxiety, generalized anxiety, and depression were reported by participants. These findings are extremely encouraging and support further study of CALM in neuro-oncology. Trial Registration Number NCT04646213 registered on 11/27/2020.

In everyday life, we are able to perceive information and perform physical actions in the background or periphery of attention. Inspired by this observation, several researchers have studied interactive systems that display digital information in the periphery of attention. To broaden the scope of this research direction, a few recent studies have focused on interactive systems that can not only be perceived in the background but also enable users to physically interact with digital information in their periphery. Such peripheral interaction designs can support computing technology to fluently embed in and become a meaningful part of people’s everyday routines. With the increasing ubiquity of technology in our everyday environment, we believe that this direction is highly relevant nowadays. This paper presents an in-depth analysis of three case studies on peripheral interaction. These case studies involved the design and development of peripheral interactive systems and deployment of these systems in the real context of use for a number of weeks. Based on the insights gained through these case studies, we discuss generalized characteristics and considerations for peripheral interaction design and evaluation. The aim of the work presented in this paper is to support interaction design researchers and practitioners in anticipating and facilitating peripheral interaction with the designs they are evaluating or developing.

The dependence of fluxes on the wind speed near the surface of the stable nocturnal boundary layer has been organized in terms of a threshold wind speed. When the wind speed is smaller than the threshold speed (near-calm conditions), the eddies at the observational level tend to be decoupled from the surface. When the wind speeds are larger than the threshold value, the main eddies are thought to directly interact with the underlying surface. As an example, the threshold wind speed at the 2-m observational level is typically 1 m s-1. Investigation of the heat flux as a function of the wind speed is relatively straightforward. The dependence of the friction velocity u∗ on the wind speed requires somewhat different strategies. The friction velocity is derived from the momentum flux averaged in different ways. For near-calm conditions, the stress vector and wind vector are often not aligned. The wind direction frequently varies rapidly with height near the surface for near-calm conditions.

Most past research on positive affect and emotion has focused exclusively on high-arousal positive affect (HAPA: e.g., excited), however, low-arousal positive affect (LAPA: e.g., calm) increasingly is included in emotion research. As such, there is a need to synthesize knowledge about the similarities and differences between LAPA and HAPA, the operationalization of LAPA and HAPA, and the distinct characteristics and importance of LAPA within emotional life. A systematic search identified 226 research papers comparing LAPA with HAPA from a broad spectrum of research topics; this review provides a narrative summary of their findings. Indications of differences between LAPA and HAPA were found in 89% of comparisons, with LAPA having a consistently distinguishable relationship to variables such as brain activity, cardiovascular health, decision-making, memory, mindfulness, personality, and solitude, among others. Other notable aspects of LAPA were found, including its role in stress, work, positive sociality, and well-being, as well as its importance in older adults and women. An analysis of items used to measure LAPA and HAPA revealed nuanced differences in conceptualizations, as well as emerging consensus around specific item usage. While considering item use in light of approach-avoidance motivation, we identified three possible LAPA subtypes: calm (a steady state of neither approach nor avoidance), satisfaction (having successfully approached), and relief (having successfully avoided). This review clarifies LAPA’s role in affective life, underscoring that LAPA’s differences from HAPA should be considered in research involving positive affect.