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Behind the scenes of indie film marketing : a FilmSnobbery field guide
\"This book provides current and incoming filmmakers with a comprehensive overview of how to create business and marketing plans to prepare their movies for distribution. Nicholas LaRue combines experienced insights into aesthetics and creativity, with logical data-driven conclusions to provide an analysis of independent film promotion. The book first presents a view of sales and marketing in the independent film industry, as well as exploring the new digital tools available to filmmakers, and tried-and-true methods that have served industry professionals well for years in promoting their films. This is then complemented by a wide array of interviews from veteran filmmakers (Kevin Smith, Brea Grant, Joe Lynch, Roger Corman, and more), prominent independent film critics, press relations who specialize in working with indie filmmakers, film festival directors, and podcasters. Given this diversity of perspective, this text will be an integral resource for new indie filmmakers, as well as those wishing to perfect their craft in whatever facet of independent filmmaking promotion\"-- Provided by publisher.
Book
Phase 1 Trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD
Homozygosity for the
PNPLA3
risk allele is linked to liver fat accumulation. In phase 1 trials, JNJ-75220795, a hepatocyte-targeted GalNAc-conjugated PNPLA3 siRNA, reduced liver fat in PNPLA3 I148M homozygous patients with metabolic dysfunction–associated fatty liver disease.
Journal Article
A companion to American indie film
A Companion to American Indie Film features a comprehensive collection of newly commissioned essays that represent a state-of-the-art resource for understanding key aspects of the field of indie films produced in the United States.
eBook
Factors related to health-related quality of life in older people with multimorbidity and high health care consumption over a two-year period
Background
The prevalence of multimorbidity is increasing worldwide, and older people with multimorbidity are frequent users of health care services. Since multimorbidity has a significant negative impact on Health-related Quality of Life (HrQoL) and is more common in older age it would be expected that factors related to HrQoL in this group might have been thoroughly researched, but this is not the case. Furthermore, it is important to look at old people living at home, considering the shift from residential to home-based care. Therefore, we aim to investigate factors that are related to HrQoL in older people with multimorbidity and high health care consumption, living at home.
Methods
This is a secondary analysis of a RCT study conducted in a municipality in south-eastern Sweden. The study had a longitudinal design with a two-year follow-up period assessing HrQoL, symptom burden, activities of daily living, physical activity and depression.
Results
In total, 238 older people with multimorbidity and high health care consumption, living at home were included (mean age 82, 52% female). A multiple linear regression model including symptom burden, activities of daily living and depression as independent variables explained 64% of the HrQoL. Higher symptom burden, lower ability in activities of daily living and a higher degree of depression were negatively related to HrQoL. Depression at baseline and a change in symptom burden over a two-year period explained 28% of the change in HrQoL over a two-year period variability. A higher degree of depression at baseline and negative change in higher symptom burden were related to a decrease in HrQoL over a two-year period.
Conclusion
In order to facilitate better delivery of appropriate health care to older people with high health care consumption living at home it is important to assess HrQoL, and HrQoL over time. Symptom burden, activities of daily living, depression and change in symptom burden over time are important indicators for HrQoL.
Trial registration
Clinicaltrials.gov identifier:
NCT01446757
, the trial was registered prospectively with the date of trial registration October 5
th
, 2011.
Journal Article