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Rationale Although psilocybin and dextromethorphan (DXM) are hallucinogens, they have different receptor mechanisms of action and have not been directly compared. Objective This study compared subjective, behavioral, and physiological effects of psilocybin and dextromethorphan under conditions that minimized expectancy effects. Methods Single, acute oral doses of psilocybin (10, 20, 30 mg/70 kg), DXM (400 mg/70 kg), and placebo were administered under double-blind conditions to 20 healthy participants with histories of hallucinogen use. Instructions to participants and staff minimized expectancy effects. Various subjective, behavioral, and physiological effects were assessed after drug administration. Results High doses of both drugs produced similar increases in participant ratings of peak overall drug effect strength, with similar times to maximal effect and time-course. Psilocybin produced orderly dose-related increases on most participant-rated subjective measures previously shown sensitive to hallucinogens. DXM produced increases on most of these same measures. However, the high dose of psilocybin produced significantly greater and more diverse visual effects than DXM including greater movement and more frequent, brighter, distinctive, and complex (including textured and kaleidoscopic) images and visions. Compared to DXM, psilocybin also produced significantly greater mystical-type and psychologically insightful experiences and greater absorption in music. In contrast, DXM produced larger effects than psilocybin on measures of disembodiment, nausea/emesis, and light-headedness. Both drugs increased systolic blood pressure, heart rate, and pupil dilation and decreased psychomotor performance and balance. Conclusions Psilocybin and DXM produced similar profiles of subjective experiences, with psilocybin producing relatively greater visual, mystical-type, insightful, and musical experiences, and DXM producing greater disembodiment.

Media theory has long overlooked the built environment and its communicative capacity: how built structures and spaces convey meaning through material embodiment and symbolization.Architecture as Communication advances the idea that built environments function as media of communication. Using practice theory in conjunction with the concept of style, this book is anchored in three historical determinants: the quest for perfect proportion in buildings, the belief in architectural determinism, and the ongoing efforts within other media to influence how those who experience built environments understand them. Ross Eaman explores how houses, schools, places of worship, factories, office buildings, stores, malls, opera houses, plazas, and parks have meaning for people as subjective life-worlds. Architecture as Communication proposes media theory that articulates the social construction of meaning as a unique way of understanding the built environment – one in which the users and observers of structures and spaces participate along with architects and designers. Architecture, according to Eaman, encompasses the multiplicity of communication as human interaction, preparing people for what they are about to encounter, signalling how they should act, and selectively enabling them to perform their expected role.Using examples across many historical periods and cultures, Architecture as Communication argues that we judge our built environments by the values they communicate.

RationaleAlthough both psilocybin and dextromethorphan (DXM) produce psychedelic-like subjective effects, rates of non-medical use of psilocybin are consistently greater than DXM.ObjectiveNew data are presented from a study of psilocybin and DXM relevant to understanding the features of psilocybin subjective effects that may account for its higher rates of non-medical use.MethodsSingle, acute oral doses of psilocybin (10, 20, 30 mg/70 kg), DXM (400 mg/70 kg), and placebo were administered under double-blind conditions to 20 healthy participants with histories of hallucinogen use.ResultsHigh doses of both drugs produced similar time courses and increases in participant ratings of peak overall drug effect strength. Nine subjective effect domains are proposed to be related to the reinforcing effects of psilocybin: liking, visual effects, positive mood, insight, positive social effects, increased awareness of beauty (both visual and music), awe/amazement, meaningfulness, and mystical experience. For most ratings, (1) psilocybin and DXM both produced effects significantly greater than placebo; (2) psilocybin showed dose-related increases; 3, DXM was never significantly higher than psilocybin; (4) the two highest psilocybin doses were significantly greater than DXM. These differences were consistent with two measures of desire to take the drug condition again.ConclusionsThis analysis provides new information about domains of psilocybin subjective effects proposed to be related to its reinforcing effects (alternatively described as the “motivation” to use). Observed differences on these domains between psilocybin and DXM are consistent with the relative rates of non-medical use of psilocybin and DXM.

Insightful problem solving (IPS) attracts widespread attention in creative thinking domains. However, the neural underpinnings of individual differences in IPS are still unclear. The purpose of this research was to investigate inherent full-brain connectivity patterns at voxel-level in IPS. Sixty-two healthy participants were enrolled in the study. We used a voxelwise full-brain network measurement, degree centrality (DC), to depict the characteristics of cerebral network involved in individual differences in IPS. For each participant, we employed a chunk decomposition paradigm, using Mandarin characters as stimuli, to estimate the individual differences in IPS. Results showed that DC in the inferior frontal gyrus, and the middle frontal gyrus/precentral gyrus positively correlated with IPS, while the anterior cingulate cortex, and the brainstern/cerebellum/thalamus exhibited negative correlations with IPS. Using each cluster above as a seed, we performed seed-based functional connectivity analysis further. Results showed that IPS was mainly involved in the default mode network, containing the key regions of precuneus and medial prefrontal cortex. All in all, this research may shed new lights on understanding the neural underpinnings of individual differences in IPS.

The band gap is a key parameter in semiconductor materials that is essential for advancing optoelectronic device development. Accurately predicting band gaps of materials at low cost is a significant challenge in materials science. Although many machine learning (ML) models for band gap prediction already exist, they often suffer from low interpretability and lack theoretical support from a physical perspective. In this study, we address these challenges by using a combination of traditional ML algorithms and the ‘white-box’ sure independence screening and sparsifying operator (SISSO) approach. Specifically, we enhance the interpretability and accuracy of band gap predictions for binary semiconductors by integrating the importance rankings of support vector regression (SVR), random forests (RF), and gradient boosting decision trees (GBDT) with SISSO models. Our model uses only the intrinsic features of the constituent elements and their band gaps calculated using the Perdew–Burke–Ernzerhof method, significantly reducing computational demands. We have applied our model to predict the band gaps of 1208 theoretically stable binary compounds. Importantly, the model highlights the critical role of electronegativity in determining material band gaps. This insight not only enriches our understanding of the physical principles underlying band gap prediction but also underscores the potential of our approach in guiding the synthesis of new and valuable semiconductor materials.

Over half of all American Jewish children are being raised by intermarried parents. This demographic group will have a tremendous impact on American Judaism as it is lived and practiced in the coming decades. To date, however, in both academic studies about Judaism and in the popular imagination, such children and their parents remain marginal. Jennifer A. Thompson takes a different approach. InJewish on Their Own Terms, she tells the stories of intermarried couples, the rabbis and other Jewish educators who work with them, and the conflicting public conversations about intermarriage among American Jews. Thompson notes that in the dominant Jewish cultural narrative, intermarriage symbolizes individualism and assimilation. Talking about intermarriage allows American Jews to discuss their anxieties about remaining distinctively Jewish despite their success in assimilating into American culture. In contrast, Thompson uses ethnography to describe the compelling concerns of all of these parties and places their anxieties firmly within the context of American religious culture and morality. She explains how American and traditional Jewish gender roles converge to put non-Jewish women in charge of raising Jewish children. Interfaith couples are like other Americans in often harboring contradictory notions of individual autonomy, universal religious truths, and obligations to family and history. Focusing on the lived experiences of these families,Jewish on Their Own Termsprovides a complex and insightful portrait of intermarried couples and the new forms of American Judaism that they are constructing.

This is an insightful, highly original ethnographic interpretation of the hunting life of the Yukaghirs, a little-known group of indigenous people in the Upper Kolyma region of northeastern Siberia. Basing his study on firsthand experience with Yukaghir hunters, Rane Willerslev focuses on the practical implications of living in a \"hall-of-mirrors\" world—one inhabited by humans, animals, and spirits, all of whom are understood to be endless mimetic doubles of one another. In this world human beings inhabit a betwixt-and-between state in which their souls are both substance and nonsubstance, both body and soul, both their own individual selves and reincarnated others. Hunters are thus both human and the animals they imitate, which forces them to steer a complicated course between the ability to transcend difference and the necessity of maintaining identity.

In this insightful and pathbreaking reflection on \"doing nothing,\" Billy Ehn and Orvar Löfgren take us on a fascinating tour of what is happening when, to all appearances, absolutely nothing is happening. Sifting through a wide range of examples drawn from literature, published ethnographies, and firsthand research, they probe the unobserved moments in our daily lives—waiting for a bus, daydreaming by the window, performing a routine task—and illuminate these \"empty\" times as full of significance. Creative, insightful, and profound, The Secret World of Doing Nothing leads us to rethink the ordinary and find meaning in today’s hypermodern reality.

In this insightful and pathbreaking reflection on \"doing nothing,\" Billy Ehn and Orvar Löfgren take us on a fascinating tour of what is happening when, to all appearances, absolutely nothing is happening. Sifting through a wide range of examples drawn from literature, published ethnographies, and firsthand research, they probe the unobserved moments in our daily lives-waiting for a bus, daydreaming by the window, performing a routine task-and illuminate these \"empty\" times as full of significance. Creative, insightful, and profound,The Secret World of Doing Nothingleads us to rethink the ordinary and find meaning in today's hypermodern reality.

The Anatomy of Harpo Marx is a luxuriant, detailed play-by-play account of Harpo Marx’s physical movements as captured on screen. Wayne Koestenbaum guides us through the thirteen Marx Brothers films, from The Cocoanuts in 1929 to Love Happy in 1950, to focus on Harpo’s chief and yet heretofore unexplored attribute—his profound and contradictory corporeality. Koestenbaum celebrates the astonishing range of Harpo’s body—its kinks, sexual multiplicities, somnolence, Jewishness, \"cute\" pathos, and more. In a virtuosic performance, Koestenbaum’s text moves gracefully from insightful analysis to cultural critique to autobiographical musing, and provides Harpo with a host of odd bedfellows, including Walter Benjamin and Barbra Streisand.