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This book focuses on the attempts of three ascetics—John Moschus, Sophronius of Jerusalem, and Maximus Confessor—to determine the Church’s power and place during a period of profound crisis, as the eastern Roman empire suffered serious reversals in the face of Persian and then Islamic expansion. By asserting visions which reconciled long-standing intellectual tensions between asceticism and Church, these authors established the framework for their subsequent emergence as Constantinople's most vociferous religious critics, their alliance with the Roman popes, and their radical rejection of imperial interference in matters of the faith. Situated within the broader religious currents of the fourth to seventh centuries, this book throws new light on the nature not only of the holy man in late antiquity, but also of the Byzantine Orthodoxy that would emerge in the Middle Ages, and which is still central to the churches of Greece and Eastern Europe.

The current increasing volatility in international politics makes it more important to understand how multinational enterprises respond to political tension between host and home countries. This paper explains the impact of macro-level bilateral political tension on micro-level strategy of multinationals in the host country. We developed the idea that patenting may be used to signal a firm’s commitment and contribution to the host country’s economy and development. Data on 437 large multinationals and interviews with senior managers of 20 foreign subsidiaries in China show that patenting local innovation does indeed help an investing firm signal its usefulness to the host country government. It can thus serve as a response to bilateral political tension. The relationship between political tension and local patenting also depends on the relative trade dependence of the home and host countries and on the investing firm’s technology level and its stake in China. The greater the dependence of an MNE and its home country government on the host country, the more likely patenting of local innovations would increase in times of bilateral political tension.

Chronic headache is a serious clinical problem in women which psychological factors play major role and requires an approach with bio-psycho-social integrity. Psychiatric comorbidities such as anxiety disorder and major depression are frequent. Young described Early Maladaptive Schemas (EMS) as maladaptive and dysfunctional patterns that appear due to unpleasant situations occurred between patient and people who were important to him. EMS affect perception, emotions, thoughts and behaviors that makes a basis for many disorders. EMS are found to be related with depression, anxiety and somatization within recent literature. In literature, chronic pain and migraine’s relationship with EMS were studied before in a few separate articles. However, there is a lack of data that compares the relationship between EMS and clearly distinguished headache types: migraine (MH) and tension-type headache (TTH) especially in female patients who are more prone to somatic complaints/findings. Our study directly compared three groups, migraine and tension type headache and healthy controls. 150 female patients with chronic headache were enrolled for study in consecutive fashion. Exclusion criteria were as follows: age < 18 or > 60 years, male gender, existence of comorbidity affecting central nervous system, headache due to drug/substance abuse, previous diagnosis of migraine with aura, previous diagnosis of psychotic disease, mental retardation, cognitive disorders, being in delirium state. Patients were grouped into two categories according to type of headache and a third control group. All patients were evaluated with Young Schema Questionnaire (YSQ) and their scores were noted and categorized in related schema domains. Sociodemographic data were comparable among groups. However, there were significant differences in terms of previous psychiatric diagnosis and psychiatric drug usage. When we compared YSQ scores, groups differed in many schema categories. MH group showed significantly higher scores in dependency/incompetency, unrelenting standards and punitiveness schemas when compared to remaining two groups. TTH group had significantly more points in emotional deprivation, vulnerability to harm or illness schemas among all groups. On the other hand, control group had significantly higher scores in insufficient self-discipline and entitlement/grandiosity schemas when compared to both MH and TTH groups. Presence of EMS in female patients with headache significantly differed from control group. Types of EMS were also significantly different between patients with MH and TTH among this whole headache group. We suggest that a comprehensive psychotherapeutic approach that targets to improve coping methods for distinct EMS in distinct headache types would provide critical aid to general treatment of headaches especially in resistant cases.

Plakophilin 4 (PKP4) is a component of cell–cell junctions that regulates intercellular adhesion and Rho-signaling during cytokinesis with an unknown function during epidermal differentiation. Here we show that keratinocytes lacking PKP4 fail to develop a cortical actin ring, preventing adherens junction maturation and generation of tissue tension. Instead, PKP4-depleted cells display increased stress fibers. PKP4-dependent RhoA localization at AJs was required to activate a RhoA-ROCK2-MLCK-MLC2 axis and organize actin into a cortical ring. AJ-associated PKP4 provided a scaffold for the Rho activator ARHGEF2 and the RhoA effectors MLCK and MLC2, facilitating the spatio-temporal activation of RhoA signaling at cell junctions to allow cortical ring formation and actomyosin contraction. In contrast, association of PKP4 with the Rho suppressor ARHGAP23 reduced ARHGAP23 binding to RhoA which prevented RhoA activation in the cytoplasm and stress fiber formation. These data identify PKP4 as an AJ component that transduces mechanical signals into cytoskeletal organization.

PurposePrior research has highlighted the pervasive importance of digital technologies in business and societal settings, but their enabling role in digital transformation, and effective forms of organization to address tensions that arise during attempts to promote it, have been insufficiently explored. Therefore, the purpose of this paper is to investigate how and why tensions affect clusters established to foster digital transformation.Design/methodology/approachEmpirical data were acquired through a qualitative exploratory holistic single case study, focused on the Swedish Cluster of Forest Technology. This included interviews with informants, selected by homogeneous purposive sampling, and event observation to investigate the personal perspectives of representatives of every company engaged in the cluster, followed by a thematic analysis of their comments.FindingsThe case study revealed three major tensions, between knowledge flow, collaboration and competition, but also others that were interrelated with those major tensions, related to matters such as trust and protection of intellectual property, power equality and hierarchy, and networks that must be managed in digital transformation efforts.Originality/valueThe paper extends understanding of the tensions that arise, and their management, in digital transformation processes.

This article offers a reflective account of co-supervising a doctoral study that drew on elements of Health Sciences and Education to explore interdisciplinary supervision. Rather than uniting entire disciplines, the collaboration brought together specific epistemological and methodological traditions from both fields, grounded in the lived experience of an interdisciplinary doctoral journey. The focus is not the doctoral thesis per se, but the supervisory process and how interdisciplinary practice reshapes research design, supervisory relationships, and student development. Rather than offering a generic account, the article draws on situated experience to provide practical insights into supervision practice, examination challenges, and institutional dynamics. A central tension emerged between institutional commitments to interdisciplinarity and the persistence of disciplinary expectations. The study highlights the challenges of navigating methodological dissonance, sustaining coherence in co-supervision across paradigms, and managing assessment processes that often default to monodisciplinary standards. It underscores the need for better support for both students and supervisors engaged in cross-border research. Ultimately, the article calls for more responsive supervision models and institutional cultures that recognise and accommodate the complexity of interdisciplinary doctoral journeys.ContributionThis article contributes to ongoing debates on interdisciplinary doctoral supervision by offering a grounded, practice-based reflection on how academic structures and supervision models shape knowledge-making across disciplines. It emphasises reflexivity, dialogical engagement, and institutional responsiveness as key enablers of epistemic hybridity, and encourages closer attention to how supervision practices can evolve to support complexity, fluidity, and collaboration in doctoral education.

Public health laws and policies are powerful tools. Yet, they are often at tension with individual rights, including physical integrity, and privacy and family life. For example: extensive quarantines to curb the spread of an infectious disease may restrict freedom of movement; the introduction of compulsory vaccination for pre-school entry may create tension with the freedom of conscience or religion of parents who do not wish to have their children vaccinated; and smoke-free zones can create tension with the rights to privacy and family life. Overcoming such tensions is both an ethical and a legal imperative. The primary legal framework in which this settling of tensions takes place is human rights law, which is binding on all countries around the world. Human rights standards reflect individual values that need to be taken into account when introducing public health measures. However, there is still insufficient understanding as to how the various human rights are to be weighed and integrated into public health laws and policies. Many questions remain, including how to balance public health or the collective ‘right to health' with individual rights. This presentation will identify the most important tensions between public health measures and individual human rights. Subsequently, it will offer some solutions on how to better integrate human rights into public health laws and policies. Specific attention will be paid to the Convention on the Rights of the Child. The point will be made, that the ‘best interest of the child' norm under this Convention may under circumstances set aside other interests, including parental freedoms. The presentation will conclude with the identification of a so-called ‘Human Rights-Based Approach' (HRBA), an integrated approach that may serve to make public health laws and policies ‘human rights proof'.

This paper applies the construct of value tensions to an empirical investigation. Specifically, this work surfaces values tensions in data collected from a prominent online discussion forum about the Arduino electronics prototyping platform. Findings show how two value tensions—easy access versus technical opportunity, and amateur versus expert practices—inform different sentiments toward creative technologies.

Mary McAuliffe’s Dawn of the Belle Epoque took the reader from the multiple disasters of 1870–1871 through the extraordinary re-emergence of Paris as the cultural center of the Western world. Now, in Twilight of the Belle Epoque, McAuliffe portrays Paris in full flower at the turn of the twentieth century, where creative dynamos such as Picasso, Matisse, Stravinsky, Debussy, Ravel, Proust, Marie Curie, Gertrude Stein, Jean Cocteau, and Isadora Duncan set their respective circles on fire with a barrage of revolutionary visions and discoveries. Such dramatic breakthroughs were not limited to the arts or sciences, as innovators and entrepreneurs such as Louis Renault, André Citroën, Paul Poiret, François Coty, and so many others—including those magnificent men and women in their flying machines—emphatically demonstrated. But all was not well in this world, remembered in hindsight as a golden age, and wrenching struggles between Church and state as well as between haves and have-nots shadowed these years, underscored by the ever-more-ominous drumbeat of the approaching Great War—a cataclysm that would test the mettle of the City of Light, even as it brutally brought the Belle Epoque to its close. Through rich illustrations and evocative narrative, McAuliffe brings this remarkable era from 1900 through World War I to vibrant life.

Sleep disorders and primary headaches are frequent health problems in childhood, and they are often comorbid in an individual, linked by a mutual and complex relationship. This comorbidity is frequent and well-documented, but the available literature is usually biased in favor of one aspect or another, mainly depending on the expertise of the authors. The aim of this paper is to review existing literature on the diagnostic assessment of comorbid primary headaches and sleep disorders, so as to propose practical suggestions to accurately investigate the presence of comorbid conditions in children evaluated for primary headaches or for sleep disorders.