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This paper presents a novel adaptive reinforcement learning control method with interval type‐3 fuzzy neural networks to improve the trajectory tracking control performance of quadrotor unmanned aerial vehicles in challenging flight conditions. The proposed reinforcement learning controller is independent of the system's dynamics, and only relies on measurable signals of the system. An adaptive robust controller in collaboration with the suggested reinforcement learning method is designed to significantly improve the robustness of the control system. The maximum overshoot/undershoot, convergence rate and final tracking accuracy are ensured a priori by the prescribed performance control methodology. To develop the proposed controller and to achieve a high‐performance closed‐loop system, a high‐gain observer is employed in order to estimate the velocity and acceleration of the quadrotor unmanned aerial vehicles system. The uniform ultimate boundedness stability of the proposed control algorithm is achieved by a Lyapunov‐based stability analysis. Finally, in the simulation section, it is shown that the presented intelligent controller with the proposed learning algorithm result in a better performance in contrast to the other kind of conventional control techniques. 1. A novel adaptive reinforcement learning controller with interval type‐3 fuzzy neural networks is proposed for quadrotor unmanned aerial vehicles. 2. The transient and steady‐state characteristics are guaranteed a priori by prescribed performance control. 3. A high‐gain observer is employed to estimate the velocity and acceleration of quadrotor unmanned aerial vehicles.