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Since the 1970s, a great deal of attention has been paid to the development of semiconductor-based biosensors because of the numerous advantages they offer, including high sensitivity, faster response time, miniaturization, and low-cost manufacturing for quick biospecific analysis with reusable features. Commercial biosensors have become highly desirable in the fields of medicine, food, and environmental monitoring as well as military applications, whereas increasing concerns about food safety and health issues have resulted in the introduction of novel legislative standards for these sensors. Numerous devices have been developed for monitoring biological processes such as nucleic acid hybridization, protein–protein interaction, antigen–antibody bonds, and substrate–enzyme reactions, just to name a few. Since the 1980s, scientific interest moved to the development of semiconductor-based devices, which also include integrated front-end electronics, such as the extended-gate field-effect transistor (EGFET) biosensor, one of the first miniaturized chemical sensors. This work is intended to be a review of the state of the art focused on the development of biosensors and chemosensors based on extended-gate field-effect transistor within the field of bioanalytical applications, which will highlight the most recent research reported in the literature. Moreover, a comparison among the diverse EGFET devices will be presented, giving particular attention to the materials and technologies.

Soft robotic grippers have emerged as crucial tools for safe and adaptive manipulation of delicate and different objects, enabled by their compliant structures. These grippers need embedded sensing that offers proprioceptive and exteroceptive feedback in order to function consistently. Resistive sensing is unique among transduction processes since it is easy to use, scalable, and compatible with deformable materials. The three main classes of resistive sensors used in soft robotic grippers are systematically examined in this review: ionic sensors, which are emerging multimodal devices that can capture both mechanical and environmental cues; tactile sensors, which detect contact, pressure distribution, and slip; and strain sensors, which monitor deformation and actuation states. Their methods of operation, material systems, fabrication techniques, performance metrics, and integration plans are all compared in the survey. The results show that sensitivity, linearity, durability, and scalability are all trade-offs across sensor categories, with ionic sensors showing promise as a new development for multipurpose soft grippers. There is also a discussion of difficulties, including hysteresis, long-term stability, and signal processing complexity. In order to move resistive sensing from lab prototypes to reliable, practical applications in domains like healthcare, food handling, and human–robot collaboration, the review concludes that developments in hybrid material systems, additive manufacturing, and AI-enhanced signal interpretation will be crucial.

A temperature sensor that uses temperature-sensitive fluorescent dyes is developed. The droplet sensor has a diameter of 40 µm and uses 1 g/L of Rhodamine B (RhB) and 0.5 g/L of Rhodamine 110 (Rh110), which are fluorescent dyes that are dissolved in an ionic liquid (1-ethyl-3-methylimidazolium ethyl sulfate) to function as temperature indicators. This ionic liquid is encapsulated using vacuum Parylene film deposition (which is known as the Parylene-on-liquid-deposition (PoLD) method). The droplet is sealed by the chemically stable and impermeable Parylene film, which prevents the dye from interacting with the molecules in the solution and keeps the volume and concentration of the fluorescent material fixed. The two fluorescent dyes enable the temperature to be measured ratiometrically such that the droplet sensor can be used in various applications, such as the wireless temperature measurement of microregions. The sensor can measure the temperature of such microregions with an accuracy of 1.9 °C, a precision of 3.7 °C, and a fluorescence intensity change sensitivity of 1.0%/K. The sensor can measure temperatures at different sensor depths in water, ranging from 0 to 850 µm. The droplet sensor is fabricated using microelectromechanical system (MEMS) technology and is highly applicable to lab-on-a-chip devices.

Flexible ionic pressure sensors (FIPS) have emerged as promising candidates for bridging the gap between electronics and biologically compatible interfaces. Unlike previous reviews, which focused primarily on materials or devices, this review presents a classification of FIPS based on mechanisms into two distinct categories: the migration‐electronic type and the emerging iontronic type. Eight representative sensing mechanisms are systematically analyzed, including ionic piezoresistive, capacitive, piezoelectric and triboelectric effects (migration‐electronic), as well as ionic diode, potentiometric transduction, nanofluidic and coupled nanofluidic–potentiometric transduction mechanisms (emerging iontronic). The basic force‐electric response principles of each type of sensor have been described, combining theoretical derivation formulas followed by a comparative analysis of advantages, disadvantages, and key performance indicators, which have both comprehensiveness and originality. Furthermore, we highlight advanced engineering approaches integrating ionic transport materials, flexible substrates, and novel electrodes to enhance sensitivity, stability, and multi‐modal responsiveness. Finally, we outline current challenges and future prospects of wearable electronics, healthcare monitoring, and intelligent robotics. By mapping the evolution of sensing mechanisms and their associated architectures, this review provides a comprehensive and forward‐looking perspective on the development of next‐generation ionic sensing systems. image

Miniaturized sensors possess many advantages, such as rapid response, easy chip integration, a possible lower concentration of target compound detection, etc. However, a major issue reported is a low signal response. In this study, a catalyst, the atomic gold clusters of Aun where n = 2, was decorated at a platinum/polyaniline (Pt/PANI) working electrode to enhance the sensitivity of butanol isomers gas measurement. Isomer quantification is challenging because this compound has the same chemical formula and molar mass. Furthermore, to create a tiny sensor, a microliter of room-temperature ionic liquid was used as an electrolyte. The combination of the Au2 clusters decorated Pt/PANI and room temperature ionic liquid with several fixed electrochemical potentials was explored to obtain a high solubility of each analyte. According to the results, the presence of Au2 clusters increased the current density due to electrocatalytic activity compared to the electrode without Au2 clusters. In addition, the Au2 clusters on the modified electrode had a more linear concentration dependency trend than the modified electrode without atomic gold clusters. Finally, the separation among butanol isomers was enhanced using different combination of room-temperature ionic liquids and fixed potentials.

Cystathionine-β-synthase (CBS) domains are found in >4,000 proteins in species from all kingdoms of life, yet their functions are largely unknown. Tandem CBS domains are associated with membrane transport proteins, most notably members of the ATP-binding cassette (ABC) superfamily; voltage-gated chloride channels and transporters; cation efflux systems; and various enzymes, transcription factors, and proteins of unknown function. We now show that tandem CBS domains in the osmoregulatory ABC transporter OpuA are sensors for ionic strength that control the transport activity through an electrostatic switching mechanism. The on/off state of the transporter is determined by the surface charge of the membrane and the internal ionic strength that is sensed by the CBS domains. By modifying the CBS domains, we can control the ionic strength dependence of the transporter: deleting a stretch of C-terminal anionic residues shifts the ionic strength dependence to higher values, whereas deleting the CBS domains makes the system largely independent of ionic strength. We present a model for the gating of membrane transport by ionic strength and propose a new role for CBS domains.

This review covers the evolution of flexible mechanical sensors from an “electronic” language to an “ionic” language, which provides key reference information for the development of next‐generation bio‐intelligent sensing devices. Unlike sensors that rely solely on electron modulation, the core feature of the ionic flexible mechanical sensor (IFMS) is the ability of mechanical deformation to induce ion transport and compensation, thus demonstrating their conceptual similarity to biomechanical strain systems. Here, the basic design principles of flexible mechanical sensors modulated by ion transport are highlighted. This review provides a detailed description of the mechanotransduction mechanisms of IFMS devices based on ion transport modulation. First, although with similar mechanisms to conventional flexible mechanical sensors via piezoresistive, piezoelectric, and triboelectric transduction mechanisms, the core driver for IFMS devices is ions (not electrons). In addition, the transduction models and principles of action of novel transduction mechanisms that have been explored in the last decade are described in detail, which include interfacial iontronic sensing and potentiometric and electrokinetic energy conversion. According to the characteristics of the device, the relevant structural engineering is further highlighted. A comprehensive review of important IFMS application approaches (human–machine interfaces, life and health applications) is presented. Importantly, future challenges and possible solutions for IFMS devices are presented based on the existing research.

Single Ionic gas sensor (IGS) was fabricated to measure pressure, humidity and recognizes the gases. Anodic method was used to create TiO2 nanotubes (TNTs) (with internal diameter from 45 to 90 nm) on the surfaces of pure Ti and Ti-6Al-7Nb alloy. Covered surface with TNTs was operated as negative electrode to build high localized electric field and minimize breakdown voltage (Vbd). The distance between the electrodes was fixed at 60 µm. Local electric field enhancement β factor was calculated by Fowler-Nordheim plot. Its value was 857 for anodized Ti (ATi). After annealing at 800 °C; TNTs on pure Ti surface transformed to parallel rods with diameters (from 95 to 550 nm). But on alloy surface, TNTs were transformed to protrusions. Sensitivity of measuring pressure for anodized samples decreased with increasing mean free path of testing gases. For all gases; there was increment in Vbd with pressure increasing. For each gas there was specific Vbd at definite pressure and humidity; this value represented a \"fingerprint\" for each gas recognized it from other gases. Sensitivity of humidity for both anodized and annealed IGSs increased with increasing of relative humidity (%RH). (Vbd, Humidity) curve was approximately linear for annealed Ti and its alloy.

This paper reviews the primary literature reporting the use of ionic liquids (ILs) in optical sensing technologies. The optical chemical sensors that have been developed with the assistance of ILs are classified according to the type of resultant material. Key aspects of applying ILs in such sensors are revealed and discussed. They include using ILs as solvents for the synthesis of sensor matrix materials; additives in polymer matrices; matrix materials; modifiers of the surfaces; and multifunctional sensor components. The operational principles, design, texture, and analytical characteristics of the offered sensors for determining CO2, O2, metal ions, CN−, and various organic compounds are critically discussed. The key advantages and disadvantages of using ILs in optical sensing technologies are defined. Finally, the applicability of the described materials for chemical analysis is evaluated, and possibilities for their further modernization are outlined.

Development of MXene (Ti 3 C 2 Cl 2 )-based sensing platforms by exploiting their inherent active electrochemistry is highly challenging due to their characteristic poor stability in air and water. Herein, we report a cost-effective methodology to deposit MXene on a conductive graphitic pencil electrode (GPE). MXenes can provide active surface area due to their clever morphology of accordion-like sheets; however, the disposition to stack together limits their potential applications. A task-specific ionic liquid (1-methyl imidazolium acetate) is utilized as a multiplex host material to engineer MXene interface via π-π interactions as well as to act as a selective binding site for biomolecules. The resulting IL-MXene/GPE interface proved to be a highly stable interface owing to good interactions between MXene and IL that inhibited electrode leaching and boosted electron transfer at the electrode–electrolyte interface. It resulted in robust dopamine (DA) oxidation with amplified faradaic response and enhanced sensitivity (9.61 µA µM −1  cm −2 ) for DA detection. This fabricated sensor demonstrated large linear range (10 µM − 2000 µM), low detection limit (702 nM), high reproducibility, and good selectivity. We anticipate that such platform will pave the way for the development of stable and economically viable MXene-based sensors without sacrificing their inherent properties. Graphical abstract Scheme 1 Schematic illustration of the IL-MXene/GPE fabrication and oxidative process towards non-enzymatic dopamine sensor