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In this study, a flexible ultrasonic transducer (FUT) was applied in a laser ultrasonic technique (LUT) for non-destructive characterization of metallic pipes at high temperatures of up to 176 °C. Compared with normal ultrasound transducers, a FUT is a piezoelectric film made of a PZT/PZT sol-gel composite which has advantages due to its high sensitivity, curved surface adaptability and high temperature durability. By operating a pulsed laser in B-scan mode along with the integration of FUT and LUT, a multi-mode dispersion spectrum of a stainless steel pipe at high temperature can be measured. In addition, dynamic wave propagation behaviors are experimentally visualized with two dimensional scanning. The images directly interpret the reflections from the interior defects and also can locate their positions. This hybrid technique shows great potential for non-destructive evaluation of structures with complex geometry, especially in high temperature environments.

In this study, we investigate the potential of cold atmospheric plasma (CAP) as a non-contact excitation device, comparing its performance with an ultrasound transmitter. Utilizing a scanning Laser Doppler Vibrometer (LDV), we visualize the acoustic wavefront generated by a CAP probe and an ultrasound sensor within a designated 50 mm × 50 mm area in front of each probe. Our focus lies in assessing the applicability of a CAP probe for exciting a small polymethyl methacrylate (PMMA) sample. By adjusting the dimensions of the sample to resonate at the excitation frequency of the probe, we can achieve high vibrational velocities, enabling further mechanical analysis. In contrast with traditional vibration excitation techniques such as electrodynamical shakers and hammer impact excitation, a plasma probe can offer distinct advantages without altering the structure’s dynamics since it is contactless. Furthermore, in comparison with laser excitation, plasma excitation provides a higher power level. Additionally, while pressurized air systems are applicable for limited low frequencies, plasma probes can perform at higher frequencies. Our findings in this study suggest that CAP is comparable with acoustic excitation, indicating its potential as an effective mechanical excitation method.

Ureteral injuries represent a major concern during a range of surgical procedures, due to the proximity of the ureter to target surgical structures. Intraoperative identification of the ureter is critical to prevent this accidental damage. We demonstrate the first known photoacoustic imaging of the ureter in swine following intravenous administration of FDA-approved methylene blue, enabled by a software-hardware integration that has not been previously reported in the literature. Photoacoustic channel data from the ureters of two swine were acquired using a Vevo F2 ultrasound system and an Opotek Phocus Mobile laser. Images were beamformed using a delay-and-sum algorithm. Photoacoustic image quality was evaluated using contrast, signal-to-noise ratio (SNR), and generalized contrast-to-noise ratio (gCNR) metrics, measured 10 to 80 min after methylene blue injection. Across the 10- to 80-min imaging window, median contrast (3.46-11.43 dB), SNR (2.84-6.99), and gCNR (0.27-0.64) confirmed sustained ureter visibility with methylene blue. Maximum image quality was observed 20- to 30-min after methylene blue injection, with significantly higher contrast, SNR, and gCNR values compared with earlier or later time points ( ). results demonstrate that methylene-blue-enhanced photoacoustic imaging can visualize the ureter over a time duration that is consistent with the length of surgical procedures, providing initial feasibility for real-time photoacoustic-guided surgery applications.

We present the Twente Photoacoustic Mammoscope 2, a photoacoustic breast imaging system employing a tomographic configuration. It images one breast pendant inside an imaging tank filled with water while a woman lies prone on a bed. A dual-head laser (755 and 1064 nm) illuminates the breast with one beam directed at the nipple and nine beams directed at the sides. Ultrasound signals are detected using 12 arc-shaped arrays, each curving along the pendant breast. Each array comprises 32 piezocomposite elements each with a center frequency of 1 MHz. The imaging tank and the ultrasound arrays rotate around the breast in steps to obtain additional multiple projections. Three-dimensional images are reconstructed using a filtered backprojection algorithm. The system is described in detail, and measurements on a test object are presented. As part of a preliminary study to assess the system’s in vivo performance, the breasts of two healthy volunteers were imaged. These images show the breast contour, the nipple, and the vascular anatomy within the breast. In the nipple of one case, multiple high-intensity “hot spots” are observed, which we suspect are associated with the lactiferous ducts terminating in the nipple.

Significance: Laser speckle contrast imaging (LSCI) has emerged as a promising tool for intraoperative cerebral blood flow (CBF) monitoring because it produces real-time full-field blood flow maps noninvasively and label free. Aim: We aim to demonstrate the ability of LSCI to continuously visualize blood flow during neurovascular procedures. Approach: LSCI hardware was attached to the surgical microscope and did not interfere with the normal operation of the microscope. To more easily visualize CBF in real time, LSCI images were registered with the built-in microscope white light camera such that LSCI images were overlaid on the white light images and displayed to the neurosurgeon continuously in real time. Results: LSCI was performed throughout each surgery when the microscope was positioned over the patient, providing the surgeon with real-time visualization of blood flow changes before, during, and after aneurysm clipping or arteriovenous malformation (AVM) resection in humans. LSCI was also compared with indocyanine green angiography (ICGA) to assess CBF during aneurysm clipping and AVM surgery; integration of the LSCI hardware with the microscope enabled simultaneous acquisition of LSCI and ICGA. Conclusions: The results suggest that LSCI can provide continuous and real-time CBF visualization without affecting the surgeon workflow or requiring a contrast agent. The results also demonstrate that LSCI and ICGA provide different, yet complementary information about vessel perfusion.

BackgroundBiliary stricture evaluation with brush cytology and intraductal forceps biopsy carries a low sensitivity, but the combination of newer modalities may improve sensitivity.AimTo determine whether the addition of advanced modalities increases diagnostic yield of ERCP-based sampling.MethodsThis single-center retrospective study evaluates patients with biliary strictures sampled using brush cytology. Operating characteristics were calculated for individual and combinations of modalities including cholangioscopy, fluoroscopy- and cholangioscopy-directed intraductal biopsy, fluorescence in situ hybridization (FISH), and confocal laser endomicroscopy. Analyses under Standard Criteria (SC) included malignant results as “positive” and Expanded Criteria (EC) included “suspicious” and “high-grade dysplasia” results as “positive.”ResultsA total of 614 patients were included, and 354 (57.8%) received brush cytology alone, which had a sensitivity of 38.5% (SC) to 40.3% (EC) and a specificity of 97.8% (EC) to 99.3% (SC). Combining brush cytology with fluoroscopy-guided biopsy (n = 259, 42.2%) had a sensitivity of 62.5% (SC) to 67.9% (EC) and specificity of 90.2% (EC) to 96.7% (SC). Adding FISH to brush cytology had a sensitivity of 84.2% (SC) to 87.5% (EC) and specificity of 54.1% (SC and EC), while cholangioscopy visualization addition resulted in a sensitivity of 80.4% (SC) to 92.2% (EC) and specificity of 67.3% (EC) to 89.1% (SC). There were no significant differences in sensitivity and specificity using SC and EC.ConclusionsBrush cytology has a low sensitivity, but the addition of other modalities increases sensitivity. There was no difference in specificity between the SC and the EC, supporting the inclusion of “suspicious” impressions with malignant results at our center.

Background Medical treatment is ineffective in controlling the intraocular pressure (IOP) in primary angle-closure glaucoma (PACG) with extensive peripheral anterior synechia (PAS), and surgery should be considered. This study aimed to evaluate the efficacy and safety of phacogoniosynechialysis (Phaco-GSL) with viscocanalostomy and Ologen implant for the management of medically uncontrolled PACG with PAS ≥ 270°. Methods This retrospective cohort study included 27 eyes from 27 patients with PACG who had one eye with medically uncontrolled PACG with or without cataract. These eyes had ≥ 270° of PAS, the IOP was above 21 mmHg with maximum topical antiglaucoma treatment or less than 21 mmHg with glaucoma medication intolerance. All eyes were treated with Phaco-GSL combined with viscocanalostomy and an Ologen implant. The follow-up period was one year. Results One year postoperatively, complete success was achieved in 19 cases (70.4%), qualified success in 6 cases (22.2%), and failure in 2 cases (7.4%). The mean decrease in IOP was 13.33 ± 4.07 mmHg, the mean reduction of antiglaucoma medications was 2.74 ± 1.10, and the mean percentage of reduction in IOP was 48.11 ± 9.85%. There was a statistically significant decrease in IOP and antiglaucoma medications. Malignant glaucoma occurred in three patients. It was treated successfully; other complications were trivial. Goniopuncture was needed after surgery in 18 eyes (66.7%) to control the IOP. Conclusion Phaco-GSL with viscocanalostomy with Ologen implant is an effective procedure in PACG to reach the target IOP and decrease the number of antiglaucoma medications.

Microfocused ultrasound (MFU) has been recently developed to meet the ever-growing public demand for achieving significant, noninvasive skin lifting and tightening. MFU can be focused on subcutaneous tissue where the temperature briefly reaches greater than 60°C, producing small (<1 mm(3)) thermal coagulation points to a depth of up to 5 mm within the mid-to-deep reticular layer of the dermis and subdermis. The intervening papillary dermal and epidermal layers of skin remain unaffected. The application of heat at these discrete thermal coagulation points causes collagen fibers in the facial planes such as the superficial musculoaponeurotic system and platysma, as well as the deep reticular dermis, to become denatured, contracting and stimulating de novo collagen. A commercially available device combines MFU with high-resolution ultrasound imaging (MFU-V), which enables visualization of tissue planes to a depth of 8 mm and allows the user to see where the MFU energy will be applied (Ultherapy(®); Ulthera Inc., Mesa, AZ, USA). Using different transducers, MFU-V treatment can be customized to meet the unique physical characteristics of each patient by adjusting energy and focal depth of the emitted ultrasound. By targeting the facial superficial musculoaponeurotic system, noninvasive tightening and lifting of sagging facial and neck skin and improvements in the appearance of wrinkles can be achieved. MFU-V can also improve lines and wrinkles of the décolleté. Treatment protocols for the use of MFU-V continue to be refined, and its use in combination with other rejuvenation techniques has been demonstrated. Brief discomfort that often occurs during treatment can be minimized with oral nonsteroidal anti-inflammatory drugs. Other treatment-related adverse events include transient erythema, edema, and occasional bruising. MFU-V is best suited for patients with mild-to-moderate skin and soft tissue laxity. For older patients with severe skin laxity and marked platysmal banding, surgical treatment should be considered.

Photoacoustic imaging using endogenous chromophores as a contrast has been widely applied in biomedical studies owing to its functional imaging capability at the molecular level. Various exogenous contrast agents have also been investigated for use in contrast-enhanced imaging and functional analyses. This review focuses on contrast agents, particularly in the wavelength range, for use in photoacoustic imaging. The basic principles of photoacoustic imaging regarding light absorption and acoustic release are introduced, and the optical characteristics of tissues are summarized according to the wavelength region. Various types of contrast agents, including organic dyes, semiconducting polymeric nanoparticles, gold nanoparticles, and other inorganic nanoparticles, are explored in terms of their light absorption range in the near-infrared region. An overview of the contrast-enhancing capacity and other functional characteristics of each agent is provided to help researchers gain insights into the development of contrast agents in photoacoustic imaging.

We present work to detect and visualize near-surface damage in concrete using contactless ultrasonic wavefield imaging technology. A fully contactless ultrasonic scanning system that utilizes a micro-electro-mechanical systems (MEMS) ultrasonic microphone array is used to collect ultrasonic surface wave data from a concrete sample. The obtained wavefield data sets are processed with a frequency-wavenumber (f-k) domain wavefield filtering approach to extract non-propagating oscillatory fields set up by near-surface concrete cracking damage. The experimental results demonstrate that near-surface concrete damage can be detected and visualized using the proposed ultrasonic wavefield imaging approach.