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The pulp and pericarp of mangosteen (Garcinia mangostana) fruit are popular food, beverage and health products whereby 60% of the fruit consist of the pericarp. The major metabolite in the previously neglected or less economically significant part of the fruit, the pericarp, is the prenylated xanthone [alpha]-mangostin. This highly bioactive secondary metabolite is typically isolated using solvent extraction methods that involve large volumes of halogenated solvents either via direct or indirect extraction. In this study, we compared the quantities of [alpha]-mangostin extracted using three different extraction methods based on the environmentally friendly solvents methanol and ethyl acetate. The three solvent extractions methods used were direct extractions from methanol (DM) and ethyl acetate (DEA) as well as indirect extraction of ethyl acetate obtained via solvent partitioning from an initial methanol extract (IEA). Our results showed that direct extraction afforded similar and higher quantities of [alpha]-mangostin than indirect extraction (DM: 318 mg; DEA: 305 mg; IEA: 209 mg per 5 g total dried pericarp). Therefore, we suggest that the commonly used method of indirect solvent extraction using halogenated solvents for the isolation of [alpha]-mangostin is replaced by single solvent direct extraction using the environmentally friendly solvents methanol or ethyl acetate.

Mangosteen (Garcinia mangostana L.) fruits are high in nutrients and phytochemical compounds. The use of fresh whole mangosteen fruit pulp, including the seeds (MFS), instead of flour and sugar in crackers not only enhances the functional nutritional and medicinal benefits for consumers but also adds value to the products. The study investigated the nutritional value of MFS and then employed MFS to formulate MFS-based crackers with varying levels of MFS substitution in order to develop crackers enriched with functional ingredients. Proximate compositions, amino acids, sugars, minerals, fatty acids, color, texture, and antiradical properties were analyzed in fresh MFS and MFS-based crackers. The results indicated that MFS can be a source of crude fiber, minerals, amino acids, omega-6, and omega-9 fatty acids. Adding 13%, 18%, and 23% ground MFS to the crackers improved their nutritional value and physical characteristics compared to the control (0% MFS). MFS-based crackers promoted significantly (p < 0.05) higher fiber (4.04 ± 0.00–5.66 ± 0.01%gdw), ash (2.45 ± 0.00–2.74 ± 0.01%gdw), and protein (4.72 ± 0.00–7.72 ± 0.05%gdw) than the control without MFS addition. Carbohydrates (including dietary fiber) and total sugar decreased significantly (p < 0.05) to 57.68 ± 0.00–55.21 ± 0.11%gdw and 2.37 ± 0.00–4.42 ± 0.01%gdw, respectively, in all MFS-based crackers compared to the control basal cracker with added sugar. Moreover, MFS-based crackers contained oleic acid (C18:1, omega-9) at 5.19–5.78%gdw and linoleic acid (C18:2, omega-6) at 0.63–0.77%gdw. Furthermore, the MFS-based crackers had higher levels of minerals (i.e., potassium, phosphorus, sulfur, calcium, and magnesium) and bioactive compounds such as total phenolic acid and total flavonoid, as well as antiradical activity. This study revealed that MFS can be applied as an alternative functional ingredient in the manufacturing of nutritious cracker products, and the findings could potentially be implemented to promote the utilization of mangosteen seed as a sustainable agricultural product and waste-reducing method.

This study introduced an innovative sequential extraction methodology designed for the efficient recovery of alpha-mangostin (âº-M) from mangosteen pericarps. Alpha-mangostin, renowned for its pharmacological properties including anti-inflammatory, anti-cancer, and anti-bacterial effects, has garnered significant attention across diverse industries. The proposed method of sequential extraction achieved 73% recovery and a yield of 46.75 mg/g based on the weight/weight percentage of the mass of âº-M extracted from the sequence and the mass of raw material. Furthermore, the purity of the dried product was 67.9%. The sequence solvent extraction system, comprising water, hexane, and acetonitrile, plays a pivotal role in enhancing the efficacy of the extraction process. Notably, this methodology offers a cost-effective alternative to conventional extraction methods. It reduces the need for complex equipment and processes, positioning it as a resource-efficient extraction technique in comparison to existing methodologies. This novel sequential extraction method presents a promising avenue for the economical and sustainable recovery of alpha-mangostin (âº-M) from pericarps.

Mangosteen (Garcinia mangostana L.) rind is a rich source of bioactive phenolics but is highly prone to degradation. This study evaluated the effect of wall-material composition on the physicochemical and functional properties of spray-dried mangosteen rind microcapsules. Maltodextrin was combined with gum Arabic, inulin, whey protein isolate (WPI), or soy protein isolate (SPI). Encapsulation yield ranged from 44.56% (maltodextrin 100%, M100) to 61.91% (80:20 maltodextrin:WPI, M80WPI20), while total phenolic content and antioxidant activity (IC50, ppm) were 41.68–46.16 mg GAE·g−1 and 55.39–96.23 ppm, respectively (p < .05). Carbohydrate-based carriers promoted better color and phenolic preservation, whereas protein-based systems enhanced drying efficiency. Correlation analysis revealed strong relationships (|r| ≥ 0.70) between physicochemical and functional properties. The maltodextrin – inulin blend (M80I20) exhibited the most balanced performance, combining high yield, strong antioxidant activity, and excellent color stability. This formulation provides a scalable strategy for producing stable, anthocyanin-rich functional powders.

Mangosteen fruit has been widely consumed and used as a source of antioxidants, either in the form of fresh fruit or processed products. However, mangosteen peel only becomes industrial waste due to its bitter taste, low content solubility, and poor stability. Therefore, this study aimed to design mangosteen peel extract microcapsules (MPEMs) and tablets to overcome the challenges. The fluidized bed spray-drying method was used to develop MPEM, with hydroxypropyl methylcellulose (HPMC) as the core mixture and polyvinyl alcohol (PVA) as the coating agent. The obtained MPEM was spherical with a hollow surface and had a size of 411.2 µm. The flow rate and compressibility of MPEM increased significantly after granulation. A formula containing 5% w/w polyvinyl pyrrolidone K30 (PVP K30) as a binder had the best tablet characteristics, with a hardness of 87.8 ± 1.398 N, friability of 0.94%, and disintegration time of 25.75 ± 0.676 min. Microencapsulation of mangosteen peel extract maintains the stability of its compound (total phenolic and α-mangosteen) and its antioxidant activity (IC50) during the manufacturing process and a month of storage at IVB zone conditions. According to the findings, the microencapsulation is an effective technique for improving the solubility and antioxidant stability of mangosteen peel extract during manufacture and storage.

SARS-CoV-2 remains a global health concern, with active cases and new variants still reported in mid-2025, especially among vulnerable groups with comorbidities. Orange and mangosteen peels contain bioactive compounds, such as flavonoids and xanthones, with potential antiviral activity. This study aimed to analyze and predict their pharmacokinetic, toxicity, and binding-affinity properties as antiviral agents using an in silico approach through ADMET-toxicity screening via pkCSM and molecular docking. Twenty-five compounds were tested as ligands, along with one native ligand as a positive control. Seven active compounds from both peels met criteria for good oral drug candidates and were suitable for further docking analysis. All showed stronger binding affinity than the positive control. Orange-peel compounds such as Valencene, α-Phellandrene, α-Terpinol, and a-Copaene could disrupt RBD-ACE2 interactions, while Valencene and Cadinene may inhibit RBD allosterically. Mangosteen-peel compounds—including Smeathxanthone A, Garcinone B, Mangostenon A, Tovophyllin B, and Anthocyanins—also demonstrated potential allosteric inhibition. These findings highlight citrus and mangosteen peels as promising natural antiviral sources. Further in vitro and in vivo studies are required to validate these results and explore structural refinement of the most potent compounds.

In alignment with the United Nations’ Sustainable Development Goals (SDGs) 12 (Responsible Consumption and Production) and 13 (Climate Action), this research explores the sustainable valorization of mangosteen peels into mangosteen peel powder (MPP), a value-added product with pharmaceutical properties. Mangosteen peels are an abundant agricultural waste in Thailand. This study evaluates six MPP production schemes, each employing different drying methods. Life Cycle Assessment (LCA) is utilized to assess the global warming potential (GWP) of these schemes, and the quality of the MPP produced is also compared. The results show that a combination of frozen storage and freeze-drying (scheme 4) has the highest GWP (1091.897 kgCO2eq) due to substantial electricity usage, whereas a combination of frozen storage and sun-drying (scheme 5) has the lowest GWP (0.031 kgCO2eq) but is prone to microbial contamination. Frozen storage without coarse grinding, combined with hot-air drying (scheme 6), is identified as the optimal scheme in terms of GWP (11.236 kgCO2eq) and product quality. Due to the lack of an onsite hot-air-drying facility, two transportation strategies are integrated into scheme 6 for scenarios A and B. These transportation strategies include transporting mangosteen peels from orchards to a facility in another province or transporting a mobile hot-air-drying unit to the orchards. The analysis indicates that scenario B is more favorable both operationally and environmentally, due to its lower emissions. This research is the first to comparatively assess the GWP of different MPP production schemes using LCA. Furthermore, it aligns with the growing trend in international trade which places greater emphasis on environmentally friendly production processes.

This research investigated the protecting properties of polyphenols and flavonoids in phytonutrient pellets formulated from lemongrass powder and mangosteen peel (LEMANGOS pellets) through the microencapsulation and named microencapsulated LEMANGOS (mLEMANGOS). For this purpose, the effects of mLEMANGOS supplementation at various R:C ratios of 60:40 and 20:80 were evaluated and compared with monensin (antibiotic) supplementation under an in vitro study technique. Treatments were randomly assigned in a 2 × 4 × 2 factorial arrangement in a completely randomised design consisting of factors A: R:C ratios (60:40 and 80:20), factor B: mLEMANGOS supplementation (0, 2, 4, and 6% DM), and factor C: monensin supplementation (0 and 20% DM). There was an interaction between the R:C ratio and both mLEMANGOS and monensin supplements on the in vitro gas production kinetics, ruminal by-product fermentation, methane production, and rumen microbial population (p < 0.001, 0.01, 0.05). Results indicated that each supplementation influenced the gas production kinetics, while there was decreased cumulative gas production in the mLEMANGOS supplemented. Consequently, the supplemented group buffered ruminal pH and increased the in vitro dry matter degradability (IVDMD) and ammonia nitrogen (NH3-N) concentrations. Moreover, the additional treatment of mLEMANGOS supplementation (6% DM at R:C ratios of 60:40 and 20:80) significantly reduced the number of Methanobacteriales to 53.5% and 50.4% after 24 h, respectively. Results from those supplements can reduce methane production to 99.2% and 97.9% (p < 0.001), respectively. This research suggests that phytonutrient-based antimicrobial in the mLEMANGOS supplement could potentially be used as ruminant feed additives and as antimicrobial substances.HIGHLIGHTMicroencapsulated LEMANGOS was formulated by biopolymer using green technique to retain the phytonutrients and their long-term release.The mLEMANGOS supplementation (at 6% of total DM) can be used as a synthetic bio-antibiotic for inhibiting methanogens-archaea population.The mLEMANGOS supplementation (at 6% of total DM) can enhance rumen nutrients degradability, ruminal end-products, and mitigate methane production.

New N-containing xanthone analogs of α-mangostin were synthesized via one-pot Smiles rearrangement. Using cesium carbonate in the presence of 2-chloroacetamide and catalytic potassium iodide, α-mangostin (1) was subsequently transformed in three steps to provide ether 2, amide 3, and amine 4 in good yields at an optimum ratio of 1:3:3, respectively. The evaluation of the biological activities of α-mangostin and analogs 2–4 was described. Amine 4 showed promising cytotoxicity against the non-small-cell lung cancer H460 cell line fourfold more potent than that of cisplatin. Both compounds 3 and 4 possessed antitrypanosomal properties against Trypanosoma brucei rhodesiense at a potency threefold stronger than that of α-mangostin. Furthermore, ether 2 gave potent SARS-CoV-2 main protease inhibition by suppressing 3-chymotrypsinlike protease (3CL[sup.pro] ) activity approximately threefold better than that of 1. Fragment molecular orbital method (FMO–RIMP2/PCM) indicated the improved binding interaction of 2 in the 3CL[sup.pro] active site regarding an additional ether moiety. Thus, the series of N-containing α-mangostin analogs prospectively enhance druglike properties based on isosteric replacement and would be further studied as potential biotically active chemical entries, particularly for anti-lung-cancer, antitrypanosomal, and anti-SARS-CoV-2 main protease applications.

Xanthones are significant bioactive compounds and secondary metabolites in mangosteen pericarps. A xanthone is a phenolic compound and versatile scaffold that consists of a tricyclic xanthene-9-one structure. A xanthone may exist in glycosides, aglycones, monomers or polymers. It is well known that xanthones possess a multitude of beneficial properties, including antioxidant activity, anti-inflammatory activity, and antimicrobial properties. Additionally, xanthones can be used as raw material and/or an ingredient in many food, pharmaceutical, and cosmetic applications. Although xanthones can be used in various therapeutic and functional applications, their properties and stability are determined by their extraction procedures. Extracting high-quality xanthones from mangosteen with effective therapeutic effects could be challenging if the extraction method is insufficient. Although several extraction processes are in use today, their efficiency has not yet been rigorously evaluated. Therefore, selecting an appropriate extraction procedure is imperative to recover substantial yields of xanthones with enhanced functionality from mangosteens. Hence, the present review will assist in establishing a precise scenario for finding the most appropriate extraction method for xanthones from mangosteen pericarp by critically analyzing various conventional and unconventional extraction methods and their ability to preserve the stability and biological effects of xanthones.