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Impact basin formation is a fundamental process in the evolution of the Moon and records the history of impactors in the early solar system. In order to assess the stratigraphy, sequence, and ages of impact basins and the impactor population as a function of time, we have used topography from the Lunar Orbiter Laser Altimeter (LOLA) on the Lunar Reconnaissance Orbiter (LRO) to measure the superposed impact crater size‐frequency distributions for 30 lunar basins (D ≥ 300 km). These data generally support the widely used Wilhelms sequence of lunar basins, although we find significantly higher densities of superposed craters on many lunar basins than derived by Wilhelms (50% higher densities). Our data also provide new insight into the timing of the transition between distinct crater populations characteristic of ancient and young lunar terrains. The transition from a lunar impact flux dominated by Population 1 to Population 2 occurred before the mid‐Nectarian. This is before the end of the period of rapid cratering, and potentially before the end of the hypothesized Late Heavy Bombardment. LOLA‐derived crater densities also suggest that many Pre‐Nectarian basins, such as South Pole‐Aitken, have been cratered to saturation equilibrium. Finally, both crater counts and stratigraphic observations based on LOLA data are applicable to specific basin stratigraphic problems of interest; for example, using these data, we suggest that Serenitatis is older than Nectaris, and Humboldtianum is younger than Crisium. Sample return missions to specific basins can anchor these measurements to a Pre‐Imbrian absolute chronology. Key Points New measurements of crater statistics and stratigraphy for 30 lunar basins Any transition in lunar impactor populations occurred before the mid‐Nectarian The oldest lunar basins are likely cratered to saturation equilibrium

By using high-resolution altimetric measurements of the Moon, we produced a catalog of all impact craters ≥20 kilometers in diameter on the lunar surface and analyzed their distribution and population characteristics. The most-densely cratered portion of the highlands reached a state of saturation equilibrium. Large impact events, such as Orientale Basin, locally modified the prebasin crater population to ~2 basin radii from the basin center. Basins such as Imbrium, Orientale, and Nectaris, which are important stratigraphie markers in lunar history, are temporally distinguishable on the basis of crater statistics. The characteristics of pre-and postmare crater populations support the hypothesis that there were two populations of impactors in early solar system history and that the transition occurred near the time of the Orientale Basin event.

The objective of this study is to characterize purebred Arab mares' milk through monitoring its physicochemical and microbiological composition during different lactation stages and to test its ability to coagulate. Sixteen purebred Arabian mares were selected among 45 mares with approximately the same foaling dates. Milk samples were collected once a week for each mare during 4 months of lactation and analysed in three replicates for physicochemical composition, nitrogen fractions, somatic cell count and total bacterial count. Coagulation assays were carried out in triplicates on fresh mare's milk using increasing doses of calf rennet, starter (Streptococcus thermophilus) and CaCl2. Arab mare's milk is characterized by an alkaline pH, low-fat and protein contents and high lactose content. The somatic cell and bacterial counts are very low, indicating good health status of mares. Fat and protein contents decreased as the stage of lactation progressed. However, as lactation number increased, fat level tended to increase while protein level tended to decrease. Clotting assays proved that it is possible to coagulate Arabian mare’s milk using appropriate doses of calf rennet and starter, while respecting the coagulation procedures and parameters.

This study reports on 382 COVID-19 patients having undergone allogeneic ( n  = 236) or autologous ( n  = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0–80.3) for allogeneic, and 60.6 years (7.7–81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2–292.7) in allogeneic and 24.6 months (−0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age ( p  = 0.02), need for ICU ( p  < 0.0001) and moderate/high immunodeficiency index ( p  = 0.04) increased the risk while better performance status ( p  = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19.

In the years 2022 and 2023 we investigated the prevalence of the ovulatory failure in 133 mares of different breed, 3 to 24 years old, brought to the Equine clinic of the University of Veterinary Medicine and Pharmacy (UVMP) in Košice. Our research involved the monitoring of the reproduction cycle in these mares with the aim to determine the prevalence of ovulatory failure during the breeding season, focusing on certain specific parameters that were considered sufficiently relevant with respect to the development of such failure. These parameters included environmental temperature and the amount of daylight the mares were exposed to, attributable to the months of the breeding season. In addition, we also evaluated the size of pre-ovulatory follicles and the influence of age of the investigated mares. During the mentioned years, one of the ovulatory failures occurred in 17 out of 133 mares (12.78 %). Examination by ultrasonography (USG) and the subsequent analysis of the occurrence of failures in relation to the investigated parameters allowed us to conclude that the length of daylight, age, and environmental temperature were the most important factors. Our observations indicated that the 15–16 h category of daylight presented the highest risk of development of cycle disorders with the most rapid increase observed for HAF. With respect to age, the highest occurrence of ovulatory failures was observed in the category of 15–24 years. The external temperature in the range of 18.1–23.0 °C affected the most the development of cycle disorders. Again, the effect was most evident with respect to HAF. This resulted in our recommendations for horse breeders that they should manage reproduction of their mares in a way so that the receptive phase of the cycle does not occur in the months during which the daylight length and environmental temperatures support ovulatory failure. We also recommend that if the owner′s wish is to keep in the breeding the mares older than 15 years, regular thorough gynaecological examination of these animals should be ensured, aimed at early diagnosis of ovulatory failure.

New images from the Lunar Reconnaissance Orbiter Camera show the distribution and geological relations of the Sculptured Hills, a geological unit widespread in the highlands between the Serenitatis and Crisium basins. The Sculptured Hills shows knobby, undulating, radially textured, and plains‐like morphologies and in many places is indistinguishable from the similarly knobby Alpes Formation, a facies of ejecta from the Imbrium basin. The new LROC image data show that the Sculptured Hills in the Taurus highlands is Imbrium ejecta and not directly related to the formation of the Serenitatis basin. This occurrence and the geological relations of this unit suggests that the Apollo 17 impact melts may not be not samples of the Serenitatis basin‐forming impact, leaving their provenance undetermined and origin unexplained. If the Apollo 17 melt rocks are Serenitatis impact melt, up to half of the basin and large crater population of the Moon was created within a 30 Ma interval around 3.8 Ga in a global impact “cataclysm.” Either interpretation significantly changes our view of the impact process and history of the Earth‐Moon system. Key Points New images show lunar Serenitatis basin is relatively old, not young An old Serenitatis means that Apollo 17 impact melts may not date that basin Either early Moon had impact cataclysm or geology is not understood

Background and Aim The present study aimed to evaluate and compare the overall and breed‐specific seasonal breeding patterns, fertility rates, cyclicity, and follicular dynamics of Arab, Thoroughbred, and Percheron mares under the subtropical conditions of Pakistan. Materials and Methods A retrospective analysis of climatic data and breeding records of eleven breeding studs spanning four years (2020–2023) was made to find out the overall seasonality in the breeding pattern of mares. Fifty mares of each breed (n = 150 in total) were scanned by ultrasonography for a calendar year to find the cyclicity pattern and follicular dynamics (follicular growth rate, size of ovulatory follicle, and days from estrus till ovulation). Results and Discussion The statistical analysis of breeding records demonstrated a clear pattern of seasonal breeding (p< 0.05). The highest monthly foalings were noted in March (247 ± 45.37), and overall breeding activities peaked in Spring season (p< 0.05). Breed‐specific results of Arab, Thoroughbred, and Percheron mares revealed that Arab mares maintained stable breeding activity throughout the year, with the highest activity in spring and peak conception rate in winter (56.25% ± 32.78; p > 0.05). Thoroughbred mares experienced significant seasonal declines from spring to winter with a peak conception rate in winter (63.89% ± 27.37, p > 0.05). Percherons showed the most pronounced seasonal effects, especially with a high fall conception rate (73.04% ± 19.61) and a sharp decrease in winter breeding metrics (p< 0.05). Furthermore, Thoroughbred and Percheron mares displayed the most pronounced seasonal effects on the percentage of cyclic mares 77.3% and 56% in winters (p< 0.05). Moreover, the follicular dynamics of the three breeds also exhibited significant differences (p< 0.05). Conclusion The current study concludes that seasonal and breed‐specific variability exists among the reproductive parameters of Arab, Thoroughbred, and Percheron mares in subtropics, necessitating breed‐specific reproductive management measures to maximize mare breeding efficiency. Mares exhibit seasonal breeding pattern under subtropical conditions of Pakistan and seasonality has the most pronounced effect on Percheron mares as compared to Arab, and Thoroughbred mares in subtropics. Thoroughbred and Percheron mares displayed the most pronounced seasonal effects on the percentage of cyclic mares in winters (p < 0.05) as compared to Arab Mares. Breed‐specific differences in mares’ follicular dynamics and breeding patterns should be considered for timed breeding and optimum fertility outcomes.

(1) Background: The variation in the concentration of different components found in milk depends on mammalian species, genetic, physiological, nutritional factors, and environmental conditions. Here, we analyse, for the first time, the content of different components (cholesterol concentration and fatty acids composition as well as the overall fat and mineral content determined using the same analytical methods) in milk of different mammal species. (2) Methods: The samples (n = 52) of human, cow, sheep, goat and mare milk were analyzed in triplicate for: cholesterol concentration, fatty acids profile and fat and mineral content (calcium, magnesium, sodium, potassium, iron, zinc). (3) Results: The highest fat content was reported in sheep milk (7.10 ± 3.21 g/dL). The highest cholesterol concentration was observed in bovine (20.58 ± 4.21 mg/dL) and sheep milk (17.07 ± 1.18 mg/dL). The saturated fatty acids were the lowest in human milk (46.60 ± 7.88% of total fatty acids). Goat milk had the highest zinc (0.69 ± 0.17 mg/dL), magnesium (17.30 ± 2.70 mg/dL) and potassium (183.60 ± 17.20 mg/dL) content. Sheep milk had the highest sodium (52.10 ± 3.20 mg/dL) and calcium (181.70 ± 17.20 mg/dL) concentration values. (4) Conclusions: The differences in nutritional value of milk could be perceived as a milk profile marker, helping to choose the best food for human nutrition.